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1. 发明申请

WO2007133712A3 ANTIMICROBIAL THERAPY FOR BACTERIAL INFECTIONS 审中-公开
公开(公告)号：WO2007133712A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/011466
申请日：2007-05-11
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , NIZET, Victor , LIU, George, Y. , OLDFIELD, Eric , SONG, Yongcheng
发明人： NIZET, Victor , LIU, George, Y. , OLDFIELD, Eric , SONG, Yongcheng
IPC分类号： A01N57/10 , A61K31/66
摘要： The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.

2. 发明申请

WO2019210998A1 METHOD FOR ACIDIFICATION OF MANURE 审中-公开
公开(公告)号：WO2019210998A1
公开(公告)日：2019-11-07
申请号：PCT/EP2019/025103
申请日：2019-04-16
申请人： LINDE AKTIENGESELLSCHAFT , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
发明人： BYRON, Makini , RAJAGOPALAN, Nandakishore
IPC分类号： A01C3/00 , A01C23/00 , C02F1/66
摘要： The invention relates to a method and a device for the acidification of manure.

3. 发明申请

WO2004094465A2 SYNTHETIC MOLECULES THAT MIMIC CHEMOKINES 审中-公开
标题翻译：合成分子，MIMIC CHEMOKINES
公开(公告)号：WO2004094465A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012708
申请日：2004-04-23
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS OFFICE OF TECHNOLOGY MANAGEMENT UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , HUANG, Ziwei
发明人： HUANG, Ziwei
IPC分类号： C07K14/00
CPC分类号： C07K14/522 , A61K38/00 , C07K2319/00 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , G01N2500/10
摘要： The invention is directed to synthetic polypeptides that mimic chemokine function. These polypeptides are useful for the treatment of chemokine-related disorders, as well as the treatment and prevention of HIV infection. Novel synthetic methods for these polypeptides are also provided.
摘要翻译：本发明涉及模拟趋化因子功能的合成多肽。这些多肽可用于治疗趋化因子相关病症，以及治疗和预防HIV感染。还提供了这些多肽的新合成方法。

4. 发明申请

WO2017132556A2 SYSTEM FOR CLEANING FRESH AND FRESH-CUT PRODUCE 审中-公开
标题翻译：用于清洁新鲜和新鲜切割产品的系统
公开(公告)号：WO2017132556A2
公开(公告)日：2017-08-03
申请号：PCT/US2017/015423
申请日：2017-01-27
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
发明人： LUO, Yaguang , ZHOU, Bin , MILLNER, Patricia D. , PEARLSTEIN, Anne J.
IPC分类号： B08B3/02 , B08B3/08
CPC分类号： A23B7/144 , A23B7/157 , A23B7/158 , A23B7/16
摘要： The system for cleaning fresh and freshly-cut produce is designed to clean produce as soon as practicable after the produce is cut. As the produce falls downwardly, a spray manifold directs a produce-washing liquid upwardly so that the produce-washing liquid directly sprays and impacts the falling produce. The impact of the produce-washing liquid causes the produce to tumble and the descent of the produce is slowed, and consequently the produce is thoroughly coated and cleaned by the produce-washing liquid. In an alternative embodiment, a suspending fluid (preferably air) is simultaneously directed to the falling produce to slow the descent of the produce and further ensure that the produce is thoroughly washed and directly sprayed by the produce-washing liquid.
摘要翻译：清洁新鲜和新鲜农产品的系统设计用于在农产品切割后尽快清洁农产品。当产品落下时，喷雾歧管向上引导生产清洗液，使得生产清洗液直接喷洒并冲击掉落的产品。生产清洗液的冲击导致产品翻滚并且产品的下降减慢，因此产品被生产清洗液彻底涂覆和清洁。在一个可供选择的实施方案中，悬浮液（优选空气）被同时引导至落下的产品，以减缓产品的下降，并进一步确保产品被彻底清洗并直接由产品清洗液喷洒。

5. 发明申请

WO2007126813A2 CROSS-REACTIVE MONOCLONAL ANTIBODIES RECOGNIZING ALS FAMILY PROTEINS 审中-公开
标题翻译：识别ALS家族蛋白的交叉反应性单克隆抗体
公开(公告)号：WO2007126813A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007566
申请日：2007-03-29
申请人： INHIBITEX, INC. , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , PATTI, Joseph, M. , HUTCHINS, Jeff, T. , VERNACHIO, John , GOROVITS, Elena , SANTOS, Linda , ZHAO, Hongyuan , HOYER, Lois , ZHAO, Xiaomin
发明人： PATTI, Joseph, M. , HUTCHINS, Jeff, T. , VERNACHIO, John , GOROVITS, Elena , SANTOS, Linda , ZHAO, Hongyuan , HOYER, Lois , ZHAO, Xiaomin
IPC分类号： A61K48/00
CPC分类号： C07K16/14 , A61K2039/505 , C07K2317/76
摘要： Monoclonal antibodies which can bind to AIs proteins from Candida albicans are provided which can be useful in the treatment and protection against infection from yeast such as Candida albicans. The monoclonal antibodies of the invention are advantageous in that they are cross-reactive and can recognize multiple proteins from the AIs family. Suitable pharmaceutical compositions, vaccines and kits based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.
摘要翻译：提供可以结合来自白色念珠菌的AIs蛋白质的单克隆抗体，其可用于治疗和防止来自诸如白色假丝酵母等酵母的感染。本发明的单克隆抗体的优点在于它们是交叉反应性的并且能够识别来自AIs家族的多种蛋白质。还提供了基于本发明的单克隆抗体的合适的药物组合物，疫苗和试剂盒，以及它们的使用方法。

6. 发明申请

WO2007043987A2 NANO-MOLDING PROCESS 审中-公开
标题翻译：纳米成型工艺
公开(公告)号：WO2007043987A2
公开(公告)日：2007-04-19
申请号：PCT/US2005/032852
申请日：2005-09-15
申请人： DOW CORNING CORPORATION , UNIVERSITY OF ILLINOIS AT URBANA/CHAMPAIGN , ROGERS, John , HUA, Feng , SHIM, Anne
发明人： ROGERS, John , HUA, Feng , SHIM, Anne
IPC分类号： H01L21/00
CPC分类号： B81C1/0046 , B81C99/009 , B82Y30/00
摘要： A nano-molding process including an imprint process that replicates features sizes less than 7 nanometers. The nano-molding process produces a line edge roughness of the replicated features that is less than 2 nanometers. The nano-molding process including the steps of: a) forming a first substrate having nano-scale features formed thereon, b) casting at least one polymer against the substrate, c) curing the at least one polymer forming a mold, d) removing the mold from the first substrate, e) providing a second substrate having a molding material applied thereon, f) pressing the mold against the second substrate allowing the molding material to conform to a shape of the mold, g) curing the molding material, and h) removing the mold from the second substrate having the cured molding material revealing a replica of the first substrate.
摘要翻译：纳米模塑工艺，包括复制特征尺寸小于7纳米的压印工艺。纳米成型工艺产生小于2纳米的复制特征的线边缘粗糙度。纳米模塑方法包括以下步骤：a）形成其上形成有纳米尺度特征的第一基底，b）将至少一种聚合物浇铸到基底上，c）固化形成模具的至少一种聚合物，d）去除所述模具从所述第一基板获得，e）提供具有施加在其上的成型材料的第二基板，f）将所述模具压在所述第二基板上，使所述模制材料符合所述模具的形状，g）固化所述模制材料，以及 h）从具有固化的模制材料的第二基底上移除模具，露出第一基底的复制品。

7. 发明申请

WO2003072726A2 NAD PHOSPHITE OXIDOREDUCTASE A NOVEL CATALYST FROM BACTERIA FOR REGENERATION OF NAD(P)H 审中-公开
标题翻译： NAD磷酸氧化酶从用于再生NAD（P）H的细菌的新型催化剂
公开(公告)号：WO2003072726A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005360
申请日：2003-02-21
申请人： BIOTECHNOLOGY RESEARCH AND DEVELOPMENT CORPORATION , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , METCALF, William , van der DONK, Wilfred, A. , VRTIS, Jennifer, M. , WHITE, Andrea, K. , GARCIA COSTAS, Amaya, M.
发明人： METCALF, William , van der DONK, Wilfred, A. , VRTIS, Jennifer, M. , WHITE, Andrea, K. , GARCIA COSTAS, Amaya, M.
IPC分类号： C12N
CPC分类号： C12N9/0036 , C12N9/0004 , C12P19/36 , Y02P20/584
摘要： A gene encoding an enzyme required for operation of a novel biochemical pathway for oxidation of the reduced phosphorus (P) compound phosphite was cloned from Pseudomonas and also found in other bacteria. The enzyme (designated PtxD) was overproduced in the host Escherichia coli by use of a recombinant system and purified to homogeneity via a two-step affinity protocol and characterized. The enzyme stoichiometrically produces NADH and phosphate from NAD and phosphite. Mechanistic studies indicate stereoselective transfer of hydride from phosphite to the Re-face of NAD + with observed steady-state kinetic isotope effects of 2.1 on V max and 1.8 on V max /Km. The novel enzyme is useful for methods requiring regenerating the cofactor NADH, for use in synthetic oxidoreductases, and to synthesize chiral compounds, complex carbohydrates, and isotopically-labelled compounds.
摘要翻译：从假单胞菌中克隆了编码还原磷（P）复合亚磷酸氧化的新型生物化学途径所需的酶的基因，并在其他细菌中发现。该酶（称为PtxD）在宿主大肠杆菌中通过使用重组体系过量产生，并通过两步亲和方案纯化至均质并表征。酶化学计量地从NAD和亚磷酸盐产生NADH和磷酸盐。机理研究表明氢化物从亚磷酸盐立即选择性转移到NAD +的再面，观察到的稳态动力学同位素效应为2.1，Vmax为1.8，Vmax / Km为1.8。该新型酶可用于需要再生辅因子NADH的方法，用于合成的氧化还原酶，以及合成手性化合物，复合碳水化合物和同位素标记的化合物。

8. 发明申请

WO2021074779A1 PROVIDING DIRECT DATA ACCESS BETWEEN ACCELERATORS AND STORAGE IN COMPUTING ENVIRONMENT 审中-公开
公开(公告)号：WO2021074779A1
公开(公告)日：2021-04-22
申请号：PCT/IB2020/059590
申请日：2020-10-13
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , IBM UNITED KINGDOM LIMITED , IBM (CHINA) INVESTMENT COMPANY LIMITED
发明人： QURESHI, Zaid , CHUNG, I-Hsin , HWU, Wen-Mei , XIONG, Jinjun
IPC分类号： G06F12/0842
摘要： A method for providing direct access to non-volatile memory in a computing environment by a processor, comprises providing one or more accelerators via an application programming interface ("API") direct access to non-volatile storage independent of a host central processing unit ("CPU") on a control path or data path to perform a read operation and write operation of data.

9. 发明申请

WO2017132556A3 SYSTEM FOR CLEANING FRESH AND FRESH-CUT PRODUCE 审中-公开
公开(公告)号：WO2017132556A3
公开(公告)日：2017-08-03
申请号：PCT/US2017/015423
申请日：2017-01-27
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE , UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
发明人： LUO, Yaguang , ZHOU, Bin , MILLNER, Patricia D. , PEARLSTEIN, Anne J.
IPC分类号： B08B3/02 , B08B3/08
摘要： The system for cleaning fresh and freshly-cut produce is designed to clean produce as soon as practicable after the produce is cut. As the produce falls downwardly, a spray manifold directs a produce-washing liquid upwardly so that the produce-washing liquid directly sprays and impacts the falling produce. The impact of the produce-washing liquid causes the produce to tumble and the descent of the produce is slowed, and consequently the produce is thoroughly coated and cleaned by the produce-washing liquid. In an alternative embodiment, a suspending fluid (preferably air) is simultaneously directed to the falling produce to slow the descent of the produce and further ensure that the produce is thoroughly washed and directly sprayed by the produce-washing liquid.

10. 发明申请

WO2008063899A2 METHOD FOR EXCHANGING MESSAGE AND VERIFYING THE AUTHENTICITY OF THE MESSAGES IN AN AD HOC NETWORK 审中-公开
标题翻译：交换信息的方法，并验证广告网络中的信息的正确性
公开(公告)号：WO2008063899A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/084044
申请日：2007-11-08
申请人： TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC. , THE BOARD OF TRUSTEES, UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN , LABERTEAUX, Kenneth, P. , HU, Yih-Chun
发明人： LABERTEAUX, Kenneth, P. , HU, Yih-Chun
IPC分类号： H04L9/00
CPC分类号： H04L9/006 , H04L9/3247 , H04L9/3263 , H04L2209/38 , H04L2209/80 , H04L2209/84 , H04W4/046 , H04W4/80 , H04W12/10
摘要： A method for exchanging messages containing reliable information between nodes in an ad hoc network, such as a vehicle ad hoc network. The method includes the steps of providing a public key for a PKI encrypted certificate authority signature to all nodes known to transmit reliable information. Each node transmits a signal containing node identification information and the PKI encrypted certificate authority signature associated with that node. Each node also receives like signals from other nodes and then decrypts the certificate authority signatures from the received signals by using the certificate authority public key to ascertain the authenticity of the received certificate authority signatures and the reliability of the received message. Thereafter, the nodes receive and accept messages with a TESLA encrypted signature only with nodes identified to have authentic certificate authority signatures until the occurrence of a subsequent predefined event, such as a new node in the network or the elapse of a predetermined time period.
摘要翻译：一种在诸如车辆自组织网络的自组织网络中的节点之间交换包含可靠信息的消息的方法。该方法包括以下步骤：向已知传送可靠信息的所有节点提供用于PKI加密证书授权签名的公共密钥。每个节点发送包含节点标识信息和与该节点相关联的PKI加密证书授权签名的信号。每个节点还接收来自其他节点的类似信号，然后通过使用证书颁发机构公开密钥来确认接收到的证书颁发机构签名的真实性和接收到的消息的可靠性，从接收到的信号中解密证书颁发机构签名。此后，节点接收和接受具有TESLA加密签名的消息，只有被识别为具有真实证书授权签名的节点，直到发生后续预定义事件，例如网络中的新节点或经过预定时间段。

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