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1. 发明申请

WO2022263556A1 COMPLEXES OF CU(I) AS ANTITUMOR AGENTS 审中-公开
公开(公告)号：WO2022263556A1
公开(公告)日：2022-12-22
申请号：PCT/EP2022/066390
申请日：2022-06-15
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GANDIN, Valentina , MARZANO, Cristina , PORCHIA, Marina , TISATO, Francesco
IPC分类号： C07F9/50 , A61P35/00 , C07F9/6544 , C07F9/6536 , C07F9/6509
摘要： The invention relates to a Cu(l) complex of Formula (I), wherein L is a ligand of Formula (II), wherein n1, n2, n3 are independently to each other, an integer from 0 to 1, A1, A2 and A3 are independently from each other,- a phenyl optionally substituted with (C1-C3)alkoxy, (C1-C3)alkyl, F, formyl, carboxyl, sulphonyl hydroxyl, hydroxyl, methoxy(C1-C3)alkoxy or - an heterocyclic ring selected from piperazinyl, morpholynyl, thiomorpholynyl, optionally substituted with (C1-C3)alkyl, where the heterocyclic ring is linked with the nitrogen atom to -CH2- residue, with the proviso that when A1, A2 or A3 is optionally substituted phenyl, then n1, n2 or n3, respectively, is 0, and when A1, A2 or A3 is optionally substituted heterocyclic ring, then n1, n2 or n3, respectively, is 1, for use in the treatment of tumours.

2. 发明申请

WO2022058806A1 RADIAL DISCHARGE PLASMA REACTOR FOR THE TREATMENT OF CONTAMINATED LIQUIDS 审中-公开
公开(公告)号：WO2022058806A1
公开(公告)日：2022-03-24
申请号：PCT/IB2021/057137
申请日：2021-08-04
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： SALEEM, Mubbshir , MAROTTA, Ester , PARADISI, Cristina
IPC分类号： C02F1/46 , C02F101/30 , C02F101/36
摘要： The invention relates to a plasma reactor for the removal of recalcitrant organic and inorganic contaminants from liquids with high or low electrical conductivity. The reactor comprises a tank (10) in which the liquid (11) to be treated is contained, a first high-voltage electrode (1) oriented towards the free surface of the liquid (11), and a second electrode (2) electrically associated with the first one for the generation of radial electric arcs of the plasma. The second electrode (2) is substantially configured as a ring concentrical to the first electrode (1), and is raised above the free surface of the liquid or partially emerging therefrom.

3. 发明申请

WO2022009140A1 METHOD FOR MANAGING THE STATE OF CHARGE OF REDOX FLOW BATTERIES, AND REDOX FLOW BATTERY 审中-公开
公开(公告)号：WO2022009140A1
公开(公告)日：2022-01-13
申请号：PCT/IB2021/056134
申请日：2021-07-08
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GUARNIERI, Massimo , TROVÒ, Andrea , PICANO, Francesco
IPC分类号： H01M8/18
摘要： The present invention relates to a redox flow battery and a method for managing the state of charge of a redox flow battery wherein, in particular, the battery comprises: at least one module (110, 120, 130) comprising a plurality of electrochemical cells (10), each cell (10) being divided into a pair of half-cells (13, 15) separated by an ion exchange septum (11), each half-cell (13, 15) housing a first quantity of a respective electrolyte and a respective electrode (17, 19). The battery further comprises a pair of tanks (20, 30), each tank housing a second quantity of a corresponding electrolyte and being hydraulically connected to the half-cell (13, 15) which houses the same electrolyte by means of a corresponding loading conduit (21, 31) and a discharge conduit (23, 33). The battery further comprises a battery management system (70), configured to control the operation of the battery (100), and a power management system (60), connected to said at least one module (110, 120, 130). The power management system (60) is configured to supply electrical energy generated by the battery (100) to a load (L) connected thereto or to absorb electricity from a generator (G) connected to the battery (100). The battery (100) further comprises one or more sensor elements (80) configured to acquire at least a state of charge of said at least one module (110, 120, 130). The tanks (20, 30) comprise at least two compartments (90) superimposed and separated by means of a separation element (91) comprising at least one opening (93) and each compartment (90) comprises at least one sensor (80) configured to acquire at least one state of charge of the compartment (90) and at least one mobile device (25) apt to regulate the passage of electrolyte between two adjacent compartments (90), through said at least one opening (93). Each compartment (90) is in hydraulic connection with said loading and discharge conduits (21, 23, 31, 33), and the passage of the electrolyte between each compartment (90) and the relative loading conduit (21, 31) or discharge conduit (23, 33) is regulated through a flow regulation device managed by the battery management system (70) on the basis at least of the state of charge values of the individual compartments (90) detected by sensors (80).

4. 发明申请

WO2021165421A1 SYSTEM OF MARINE MAMMALS LIVE CELLS FOR CELL BIOLOGY STUDIES, TOXICOLOGICAL TESTS AND LARGE-SCALE RESEARCH APPLICATIONS 审中-公开
公开(公告)号：WO2021165421A1
公开(公告)日：2021-08-26
申请号：PCT/EP2021/054068
申请日：2021-02-18
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： PERUFFO, Antonella , GIACOMELLO, Marta , CENTELLEGHE, Cinzia
IPC分类号： C12N5/077 , C12N5/071 , G01N33/18 , C12N5/10
摘要： The invention concerns a kit named "Sea Sentinels System" which includes cell lines, obtained from muscle and skin tissue samples belonging to 3 species of marine mammals (Tursiops truncatus, Ziphius cavirostris and Grampus griseus). The invention of the Sea Sentinels System represents a multifunctional system that offers the possibility of combining different variables in relation to each other from a phylogenetic point of view (comparison between 3 species of cetaceans) and functional (comparison between different tissues, or the same tissue between different species, or comparison between different tissues belonging to the same individual). In this synergy, each cell line makes its own contribution to a common goal.

5. 发明申请

WO2021043862A1 THIORIDAZINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2021043862A1
公开(公告)日：2021-03-11
申请号：PCT/EP2020/074529
申请日：2020-09-03
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA , ISTITUTO DI RICERCA PEDIATRICA CITTÀ DELLA SPERANZA
发明人： PIGAZZI, Martina , TREGNAGO, Claudia , ROMAGNOLI, Romeo
IPC分类号： A61P35/02 , C07D417/06 , A61K31/5415
摘要： The present invention relates to novel thioridazine analogue compounds of formula (I): wherein R1 is OCH3 or NH2 , particularly suitable to be used in the treatment of pediatric acute myeloid leukemia harboring the t(6;11)(q27;q23) KMT2A/AFDN rearrangement.

6. 发明申请

WO2020170125A2 SAFETY APPARATUS FOR MILLIBARIC PRESSURE CONTROL IN INERT ATMOSPHERE FOR HIGH REACTIVITY LIQUID SOLUTION, AND TANK AND FLOW BATTERY COMPRISING SUCH SAFETY APPARATUS 审中-公开
公开(公告)号：WO2020170125A2
公开(公告)日：2020-08-27
申请号：PCT/IB2020/051332
申请日：2020-02-18
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GUARNIERI, Massimo , TROVO', Andrea
摘要： A safety apparatus (12; 12') for millibaric pressure control in an inert atmosphere for liquid solutions (14; 14') with high reactivity contained inside a tank (16; 16') comprises: a differential U-shaped pressure gauge (18; 18') suitable for use with a non-reactive liquid, having a first end (20; 20') and a second end (22; 22'). The first end (20; 20') is in fluid connection with an environment having a known pressure; and the second end (22; 22') is in fluid connection with said tank (16; 16'), and with an output line (24; 24') for said inert gas contained inside said tank (16; 16').

7. 发明申请

WO2020165851A1 EXTRACELLULAR VESICLES ISOLATED FROM GENETICALLY MODIFIED CELLS OVER-EXPRESSING SERPINB3 FOR USE IN MEDICINE 审中-公开
公开(公告)号：WO2020165851A1
公开(公告)日：2020-08-20
申请号：PCT/IB2020/051244
申请日：2020-02-14
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： PONTISSO, Patrizia , MURACA, Maurizio , BIASIOLO, Alessandra , QUARTA, Santina , RUVOLETTO, Mariagrazia , VILLANO, Gianmarco
IPC分类号： A61K35/12 , A61K35/28 , A61K38/57 , A01N1/02 , A61P29/00 , A61P43/00
摘要： The present invention concerns the therapeutic use of extracellular vesicles isolated from a genetically modified cell line over-expressing SerpinB3. In particular, said therapeutic use aimed at the treatment of acute pathologies characterized by ischemic or inflammatory tissue damage or by cell injury due to oxidative stress, such as cardiac, cerebral, intestinal, renal or limb ischaemia. Further examples of use consist of the preservation of transplant organs, including heart, lung, liver, bladder, pancreas and intestine. In a further aspect the invention relates to the use of a pharmaceutical composition comprising extracellular vesicles isolated from a genetically modified cell line over- expressing SerpinB3 and a pharmaceutically acceptable vehicle.

8. 发明申请

WO2020065693A1 HEATING DEVICE WITH PHASE-CHANGE MATERIAL 审中-公开
公开(公告)号：WO2020065693A1
公开(公告)日：2020-04-02
申请号：PCT/IT2019/050214
申请日：2019-09-26
申请人： DE' LONGHI APPLIANCES S.R.L. CON UNICO SOCIO , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： BELLOMARE, Filippo , MONTICELLI, Enrica , PAVAN, Claudio , ZILIO, Claudio , MANCIN, Simone
IPC分类号： F28D20/02 , A47J36/24 , A61F7/02 , C09K5/06 , D06F75/24
摘要： Heating device, suitable to heat by contact or by irradiation parts of the body or objects which then transfer the heat to the body, such as blankets, clothing, towels or suchlike, or as a device for heating objects or rooms in general, which comprises at least one container (11) configured to contain a phase-change heat accumulation mean (13), and at least one heating element (12) configured to heat the heat accumulation mean (13).

9. 发明申请

WO2019229686A1 SYSTEM FOR DETECTING MALFUNCTIONS IN INSULIN DELIVERY DEVICES 审中-公开
公开(公告)号：WO2019229686A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/054470
申请日：2019-05-30
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： DEL FAVERO, Simone , MENEGHETTI, Lorenzo , TERZI, Matteo , SUSTO, Gian Antonio , COBELLI, Claudio
IPC分类号： G16H40/40 , A61M5/14 , G16H20/17 , G16H20/10
摘要： The present invention involves a system (11) for detecting malfunctions in devices (1) for the administration of insulin, comprising a data processing unit (111) adapted to receive measurements of the glucose concentration from a sensor (21) of glucose monitoring and measurements of the amount of insulin infused by an infusion pump (31), a data input unit (311) operatively connected to the data processing unit (111) and adapted to receive estimates of assumed carbohydrates from a user, a storage unit (211) operatively connected to the data processing unit (111) and adapted to store the glucose concentration measurements, the measurements of the amount of infused insulin, the measurements of the amount of carbohydrates taken; in which the data processing unit (111) is able to calculate the value of a DCOB variable (t) called "weighted glucose variation": in which the data processing unit (111) is further adapted to calculate an ICOB variable (t) named "weighted residual insulin": wherein IOB(t) is the variable which describes the estimate of the residual insulin in the blood over time, γ and δ are two positive constants, and wherein the data processing unit (111) is able to execute at least one anomaly detection algorithm of the unsupervised type configured for assigning an anomaly score to data in a patient data set, based on at least one criterion selected among: - "Density-based"; - "Isolation-based"; - "Statistics-based", and - "hypersurface-based", wherein each patient data in said set, at a given time, comprises at least a triad of values, said triad of values being constituted by a value of the variable DCOB(t) at a given time, a value of the variable ICOB(t) in said given time, and a measurement of glucose concentration by said sensor (21) at said given time, and wherein said data processing unit (111) is able to generate an alert signal if said algorithm detects at least one anomaly within the patient data set, said data processing unit (111) detecting at least one anomaly within the patient data set if said anomaly detection algorithm generates an anomaly score out of a predefined range of threshold values.

10. 发明申请

WO2019224695A1 A FENESTRATED ENDOPROSTHESIS FOR THE CORRECTION OF AORTIC ANEURYSMS 审中-公开
公开(公告)号：WO2019224695A1
公开(公告)日：2019-11-28
申请号：PCT/IB2019/054149
申请日：2019-05-20
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GREGO, Franco
IPC分类号： A61F2/07
摘要： A fenestrated endoprosthesis for the correction of aortic arch aneurysms comprising: a stent (20) having a first oblong lateral hole (23) having an area equal to the total area occupied by the innominate artery (11) and by the carotid artery (12); said stent (20) comprises a metal skeleton (21) covered with a fabric (22); characterized by comprising a flexible sac (30) that covers said stent (20) covered with fabric (22); said sac (30) comprises a second lateral hole (32) having an area larger than said first hole (23), so that the edges (26) of said stent (20) covered with fabric (22) that delimit said first hole (23) are visible; the edges (33) of said sac (30) that delimit the hole (32) are welded to said stent (20) covered with fabric (22); a volume (31) is created between said stent (20) covered with fabric (22) and said sac (30); said volume (31) is filled with a polymer.

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