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1. 发明申请

WO2012116957A1 ELECTROCOAGULATION DEVICE WITH LIMITED HEAT DAMAGE 审中-公开
标题翻译：具有有害热损伤的电动装置
公开(公告)号：WO2012116957A1
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053282
申请日：2012-02-27
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , VÖRÖS, Janos , MACKENZIE, Robert Neil , EBERLI, Daniel , HEFERMEHL, Lukas John
发明人： VÖRÖS, Janos , MACKENZIE, Robert Neil , EBERLI, Daniel , HEFERMEHL, Lukas John
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B2018/00005 , A61B2018/00125 , A61B2018/00136 , A61B2018/0063
摘要： An electrocoagulation device, such as a bipolar device for use in an electrosurgery procedure, comprises first and second electrode members (1A, 2A) each made of an electrically conductive material and having a contact surface for contacting the electrode member and a tissue portion of an object or subject to be treated with said procedure. At least one of said electrode members comprises a heat sink region (1B and/or 2B) comprising a phase change material (4) or a combination thereof, said phase change material or combination thereof having a phase transition temperature in the range of 25°C to 60°C.
摘要翻译：诸如用于电外科程序的双极器件的电凝装置包括第一和第二电极部件（1A，2A），每个第一和第二电极部件（1A，2A）均由导电材料制成并且具有用于接触电极部件的接触表面和用于接触电极部件的组织部分对象或受到所述程序的处理。所述电极构件中的至少一个包括包含相变材料（4）或其组合的散热区域（1B和/或2B），所述相变材料或其组合具有25°的相变温度 C至60°C。

2. 发明申请

WO2013030362A1 MODULATORS OF MIR-323-3P FOR THE PREVENTION OR TREATMENT OF RHEUMATOID ARTHRITIS 审中-公开
标题翻译： MIR-323-3P调节剂用于预防或治疗湿疹性肾炎
公开(公告)号：WO2013030362A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/067011
申请日：2012-08-31
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , GAY, Steffen , CONNOLLY, Mary , OSPELT, Caroline
发明人： GAY, Steffen , CONNOLLY, Mary , OSPELT, Caroline
IPC分类号： C12N15/113 , A61K31/7088 , A61P19/02
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/3231 , C12N2310/3515 , C12N2310/3521
摘要： A mi R-323-3p inhibitor is provided for the prevention or therapy of rheumatoid arthritis, comprising a sequence capable of forming a hybrid to mi R-323-3p as an oligonucleotide or a vector from which such oligonucleotide is transcribed, or as a mi RNA decoy or sponge.
摘要翻译：提供mi R-323-3p抑制剂用于预防或治疗类风湿性关节炎，其包含能够形成与作为寡核苷酸的寡核苷酸或载体的mi R-323-3p的杂交的序列，或者作为 mi RNA诱饵或海绵。

3. 发明申请

WO2012159970A1 DEVICE FOR COOPERATIVE HAND FUNCTION TRAININGS IN REHABILITATION AND CORRESPONDING METHOD 审中-公开
标题翻译：康复和相关方法中的合作手写功能训练装置
公开(公告)号：WO2012159970A1
公开(公告)日：2012-11-29
申请号：PCT/EP2012/059200
申请日：2012-05-16
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE (ETH) , DIETZ, Volker , RIENER, Robert , ROTTA, Alessandro , WIRZ, Markus
发明人： DIETZ, Volker , RIENER, Robert , ROTTA, Alessandro , WIRZ, Markus
IPC分类号： A61H1/02 , A63B23/14 , A63B23/16 , A63B23/035 , A63B22/00
CPC分类号： A63B23/14 , A61H1/0285 , A61H2201/5061 , A61H2201/5069 , A61H2205/065 , A61H2205/067 , A61H2230/60 , A63B21/00185 , A63B21/157 , A63B21/4035 , A63B21/4049 , A63B23/03533 , A63B23/16 , A63B24/0062 , A63B2022/0092 , A63B2022/0094
摘要： The invention is directed to a device to train bilateral, cooperative hand functions of a subject with housing means, handle means comprising two exchangeable handles (1), namely a left handle and a right handle, shaft means comprising multiple shafts and couplings for coupling said shafts (2), clutching means comprising variable slipping clutches (3), said slipping clutches being adjustable, first sensor means (4) for measuring the angular position of each of said handles (1), second sensor means (5) for measuring the torque which is applied by the subject onto each of said handles (1), locking means (6) for locking said shaft means (2) wherein both handles can be rotated independently when said locking means are locked, wherein said locking means are positioned between said second sensor means so that said second sensor means for the left handle can measure the torque applied onto the left handle and said second sensor means for the right handle can measure the torque applied onto the right handle when the locking means are locked and said second sensor means for the left handle said second sensor means for the right handle can measure the torque applied onto either of said handles when said locking means are unlocked and bearing means (8) for said shaft means, said bearing means being mounted to the housing of a device.
摘要翻译：本发明涉及一种用于利用壳体装置来训练对象的双边的，协作的手功能的装置，包括两个可更换手柄（1）的手柄装置，即左手柄和右手柄，包括多个轴和联接器的轴装置，用于联接所述轴（2），包括可变滑移离合器（3）的离合装置，所述滑动离合器是可调节的，用于测量每个所述手柄（1）的角位置的第一传感器装置（4）由主体施加到每个所述手柄（1）上的扭矩，用于锁定所述轴装置（2）的锁定装置（6），其中当所述锁定装置被锁定时，两个手柄可以独立地旋转，其中所述锁定装置位于所述第二传感器装置使得用于左手柄的所述第二传感器装置可以测量施加到左手柄上的扭矩，并且用于右手柄的所述第二传感器装置可以测量施加到第二当锁定装置被锁定时，右手柄和用于左手柄的所述第二传感器装置用于右手柄的第二传感器装置可以测量当所述锁定装置被解锁时施加在任一个手柄上的扭矩和用于所述锁定装置的支承装置（8）轴装置，所述轴承装置安装到装置的壳体上。

4. 发明申请

WO2010022882A2 ADJUSTABLE VIRTUAL REALITY SYSTEM 审中-公开
标题翻译：可调虚拟现实系统
公开(公告)号：WO2010022882A2
公开(公告)日：2010-03-04
申请号：PCT/EP2009/006003
申请日：2009-08-19
申请人： Universität Zürich Prorektorat MNW , ENG, Kynan , PYK, Pawel , CHEVRIER, Edith , HOLPER, Lisa , KIPER, Daniel
发明人： ENG, Kynan , PYK, Pawel , CHEVRIER, Edith , HOLPER, Lisa , KIPER, Daniel
IPC分类号： A61F13/06 , A61F4/00 , G06F3/01
CPC分类号： A63F13/212 , A61F4/00 , A63F13/06 , A63F13/211 , A63F13/218 , A63F13/235 , A63F13/24 , A63F2300/1012 , G06F3/011 , G06F3/017
摘要： Disclosed are virtual reality systems, in particular immersive virtual reality systems, their parts, construction and use. The systems and/or parts thereof may be used by adults or children, and may be adapted to support, often within a single device, a large range of users of different sizes and medical condition. Users with physical disabilities have difficulties using existing immersive technologies such as those using accessories like head-mounted displays and data gloves. Such users are provided with immersive virtual reality outputs that allow them to see virtual representations of their body parts which appear in a correct spatial position relative to the users' viewpoint.
摘要翻译：公开了虚拟现实系统，特别是沉浸式虚拟现实系统，其部件，构造和使用。系统和/或其部件可以由成人或儿童使用，并且可以适于经常在单个装置内支持不同尺寸和医疗状况的大范围的使用者。身体残疾的使用者使用现有的身临其境的技术，例如使用头戴式显示器和数据手套等配件。这样的用户被提供了沉浸式的虚拟现实输出，允许他们看到相对于用户观点出现在正确空间位置的身体部位的虚拟表示。

5. 发明申请

WO2009040075A1 BLOCKERS OF SEROTONIN AND ITS RECEPTORS FOR THE TREATMENT OF HEPATITIS 审中-公开
标题翻译：塞来昔宁的阻断剂及其治疗乙型肝炎的受体
公开(公告)号：WO2009040075A1
公开(公告)日：2009-04-02
申请号：PCT/EP2008/007974
申请日：2008-09-22
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , LANG, Karl , LANG, Philipp , HENGARTNER, Hans , ZINKERNAGEL, Rolf , GEORGIEV, Panco
发明人： LANG, Karl , LANG, Philipp , HENGARTNER, Hans , ZINKERNAGEL, Rolf , GEORGIEV, Panco
IPC分类号： A61K31/138 , A61K31/15 , A61K31/445 , A61K31/135 , A61K39/00 , A61P1/16
CPC分类号： A61K31/135 , A61K31/138 , A61K31/15 , A61K31/445 , A61K2039/505 , C07K16/26
摘要： The present invention relates to a method of treating hepatitis comprising administering a serotonin blocker, and the use of such blockers in said treatment and in the manufacture of medicaments for treating hepatitis.
摘要翻译：本发明涉及一种治疗肝炎的方法，包括施用5-羟色胺阻断剂，以及在所述治疗和制备用于治疗肝炎的药物中的用途。

6. 发明申请

WO2014060365A1 BISPECIFIC HER2 LIGANDS FOR CANCER THERAPY 审中-公开
标题翻译： BISPECIFIC HER2用于癌症治疗的配偶
公开(公告)号：WO2014060365A1
公开(公告)日：2014-04-24
申请号：PCT/EP2013/071443
申请日：2013-10-14
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW
发明人： TAMASKOVIC, Rastislav , SCHWILL, Martin , PLÜCKTHUN, Andreas , JOST, Christian
IPC分类号： C07K14/47 , A61K47/48 , C07K16/32
CPC分类号： C07K16/2863 , C07K16/32 , C07K2317/22 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/70 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/00
摘要： The invention relates to a bispecific HER2-targeting agent comprising a.) a first polypeptide ligand that binds to HER2 extracellular domain 1, b.) a second polypeptide ligand that binds to HER2 extracellular domain 4 and c.) a linker covalently attaching said first polypeptide ligand to said second polypeptide ligand.
摘要翻译：本发明涉及双特异性HER2靶向剂，其包含a）结合HER2细胞外结构域1的第一多肽配体，b）结合HER2细胞外结构域4的第二多肽配体和c）共价连接所述第一个多肽配体。

7. 发明申请

WO2013045488A1 APC-MEDIATED TOLERANCE INDUCTION FOR THERAPY OF MULTIPLE SCLEROSIS 审中-公开
标题翻译： APC介入耐多药诱发多发性硬化症的治疗
公开(公告)号：WO2013045488A1
公开(公告)日：2013-04-04
申请号：PCT/EP2012/068954
申请日：2012-09-26
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , DRESCH, Christiane , DE ANDRADE PEREIRA, Bruna , ACKERMANN, Mathias , FRAEFEL, Cornel
发明人： DRESCH, Christiane , DE ANDRADE PEREIRA, Bruna , ACKERMANN, Mathias , FRAEFEL, Cornel
IPC分类号： A61K48/00
CPC分类号： A61K35/76 , A61K31/10 , A61K35/12 , A61K48/0058 , C12N15/11 , C12N2830/008
摘要： The invention relates to transgene expression constructs -particularly self inactivating lentiviral vectors- comprising a dendritic cell specific promoter controlling the expression of autoantigen proteins, namely myelin basic protein, proteolipid protein and myelin oligodendrocyte glycoprotein, for use in the therapy of multiple sclerosis.
摘要翻译：本发明涉及特异性自身灭活慢病毒载体的转基因表达构建体，其包含控制自身抗原蛋白（即髓鞘碱性蛋白，蛋白脂蛋白和髓鞘少突胶质细胞糖蛋白）表达的树突状细胞特异性启动子，用于治疗多发性硬化症。

8. 发明申请

WO2012140148A2 JUNCTION PLAKOGLOBIN FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES 审中-公开
标题翻译：用于诊断心血管疾病的结核菌素
公开(公告)号：WO2012140148A2
公开(公告)日：2012-10-18
申请号：PCT/EP2012/056693
申请日：2012-04-12
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW , COOKSLEY-DECASPER, Seraina , HOF, Danielle , VON ECKARDSTEIN, Arnold
发明人： COOKSLEY-DECASPER, Seraina , HOF, Danielle , VON ECKARDSTEIN, Arnold
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/795 , G01N2800/32 , G01N2800/323
摘要： The invention relates to a method for diagnosis of cardiovascular disease in a patient, com detecting, in a sample obtained from said patient, junction plakoglobin (SEQ ID 001) or a polypeptide related thereto. It further relates to devices and kits for detection of junction plakoglobin.
摘要翻译：本发明涉及一种用于诊断患者心血管疾病的方法，在从所述患者获得的样品中检测连接蛋白（SEQ ID 001）或与其相关的多肽。它还涉及用于检测连接蛋白激酶的装置和试剂盒。

9. 发明申请

WO2016192788A1 METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING CAT OR DOG DANDER ALLERGY 审中-公开
标题翻译：用于预防和治疗猫或狗牙齿过敏症的方法和组合物
公开(公告)号：WO2016192788A1
公开(公告)日：2016-12-08
申请号：PCT/EP2015/062394
申请日：2015-06-03
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW
发明人： KÜNDIG, Thomas , SENTI, Gabriela , BACHMANN, Martin
IPC分类号： A61K47/48
CPC分类号： A61K47/6901 , A61K39/35 , A61K2039/577 , A61K2039/62 , C12N2795/18123
摘要： The invention relates to the use of a composition in a method of reducing the allergenicity of an animal, preferably of a cat or a dog, wherein said composition is administered to said animal, and wherein said composition comprises an animal dander antigen comprised in, or covalently linked to, a virus-like particle.
摘要翻译：本发明涉及组合物在降低动物，优选猫或狗的变应原性的方法中的用途，其中所述组合物被施用于所述动物，并且其中所述组合物包含动物皮屑包含在或与病毒样颗粒共价连接。

10. 发明申请

WO2013104686A1 CELLULAR HIGH THROUGHPUT ENCAPSULATION FOR SCREENING OR SELECTION 审中-公开
标题翻译：用于筛选或选择的细孔高通量封装
公开(公告)号：WO2013104686A1
公开(公告)日：2013-07-18
申请号：PCT/EP2013/050330
申请日：2013-01-09
申请人： UNIVERSITÄT ZÜRICH PROREKTORAT MNW
发明人： SCOTT, Daniel , PLÜCKTHUN, Andreas
IPC分类号： C12N15/10 , C40B30/06 , C40B50/06 , C07K14/47
CPC分类号： C12N15/1037 , C12N15/1058 , C12N15/1068
摘要： The invention relates to a method for selecting a sequence set from a library of expressed nucleic acid sequences, wherein cells are provided, each cell comprises an expressed nucleic acid sequence expressed as a target protein. The cells are encapsulated by treating them with a cationic polysaccharide and subsequently treating them with an anionic polysaccharide, yielding encapsulated cells, perforating the membrane of the encapsulated cells, yielding solubilized compartments, contacting them with a ligand to said target protein, the ligand bearing a detectable label, and selecting a subset of solubilized compartments as a function of detectable label and isolating the expressed nucleic acid sequences from the selection as a selected sequence set.
摘要翻译：本发明涉及从表达的核酸序列文库中选择序列的方法，其中提供了细胞，每个细胞包含表达为靶蛋白的表达的核酸序列。通过用阳离子多糖处理细胞并随后用阴离子多糖处理细胞来封装细胞，产生封闭的细胞，穿孔包封的细胞的膜，产生溶解的隔室，使其与配体接触所述靶蛋白，携带a 并且选择可溶性隔室的子集作为可检测标记的函数，并将所选择的表达的核酸序列作为选择的序列组分离。

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