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1. 发明申请

WO2014102596A3 CYCLIC CATIONIC PEPTIDES WITH ANTIBMICROBIAL ACTIVITY 审中-公开
标题翻译：具有抗微生物活性的周期性阳离子肽
公开(公告)号：WO2014102596A3
公开(公告)日：2014-08-21
申请号：PCT/IB2013002893
申请日：2013-12-30
申请人： UNIV PARMA , AZIENDA OSPEDALIERO UNIVERSITARIA DI PARMA
发明人： BARONI MARIA CRISTINA , CABASSI CLOTILDE SILVIA , ROMANI ANTONELLO
IPC分类号： A61K38/04 , A61K38/16 , C07K7/08 , C07K7/50 , C07K14/00
CPC分类号： C07K7/08 , A61K38/00 , A61K38/04 , A61K38/10 , A61K38/16 , C07K7/50 , C07K14/00
摘要： A series of cationic cyclic peptides, useful for the treatment of infectious diseases in both human and veterinary clinical/surgical environment are described herein. The peptides of the invention have a length of 15 to 21 amino acids, and show a sequence A-B-C- D-C'-B'-A', wherein units A and A' correspond to -NH2 terminal and - COOH terminal regions; units B and B' correspond to cyclizable amino acids containing sulfur; units C and C are sequences of 5 amino acids selected among hydrophobic amino acids, basic amino acids and amino acids forming hydrogen bonds; unit D is a dipeptide consisting of glycine and one basic amino acid. Said peptides show significant antibacterial activity, associated with high stability and resistance to the action of bacterial endopeptidases, and weak or null toxicity against eukaryotic cells.
摘要翻译：本文描述了一系列用于治疗人和兽医临床/手术环境中的感染性疾病的阳离子环肽。本发明的肽具有15至21个氨基酸的长度，并且显示序列A-B-C-D-C'-B'-A'，其中单元A和A'对应于-NH 2末端和-COOH末端区; 单元B和B'对应于含有硫的可环化氨基酸; 单元C和C是选自疏水氨基酸，碱性氨基酸和形成氢键的氨基酸中的5个氨基酸的序列; 单位D是由甘氨酸和一个碱性氨基酸组成的二肽。所述肽显示出显着的抗菌活性，与细菌内肽酶的作用具有高稳定性和抗性，对真核细胞具有弱或无毒性。

2. 发明申请

WO2008087157A3 DEVICE FOR THE TREATMENT OF TINNITUS 审中-公开
标题翻译：治疗TINNITUS的装置
公开(公告)号：WO2008087157A3
公开(公告)日：2008-09-18
申请号：PCT/EP2008050446
申请日：2008-01-16
申请人： UNIV PARMA , LUGLI MARCO , PARMIGIANI STEFANO , ROMANI ROMANO
发明人： LUGLI MARCO , PARMIGIANI STEFANO , ROMANI ROMANO
IPC分类号： H04R25/00 , A61F11/00
CPC分类号： A61F11/00 , A61B5/128 , H04R25/75
摘要： Device for the treatment of tinnitus, comprising generator means (12) able to generate an audio signal, and transducer means (16) connected to the generator means (12) in order to reproduce the audio signal. The device also comprises filter means (14) interposed between the generator means (12) and the transducer means (16) in order to filter and substantially suppress the audio signal at least in correspondence with an interval of frequencies around the dominant frequency (Ft) of tinnitus, so as to obtain a silent window (silent band) having a selected width or amplitude around said dominant frequency (Ft) of tinnitus.
摘要翻译：用于治疗耳鸣的装置，包括能够产生音频信号的发生器装置（12）和连接到发生器装置（12）的换能器装置（16），以便再现音频信号。该装置还包括介于发生器装置（12）和换能器装置（16）之间的滤波器装置（14），以便至少对应于主频率（Ft）周围的频率间隔过滤和基本上抑制音频信号，的耳鸣，以便获得在耳鸣的主要频率（Ft）周围具有选定的宽度或幅度的无声窗口（无声频带）。

3. 发明申请

WO2014144547A2 AMIDE DERIVATIVES OF LACTAM BASED N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) INHIBITORS 审中-公开
标题翻译：基于乳糖的N-酰基乙酰胺酸氨基酸（NAAA）抑制剂的酰胺衍生物
公开(公告)号：WO2014144547A2
公开(公告)日：2014-09-18
申请号：PCT/US2014029007
申请日：2014-03-14
申请人： UNIV CALIFORNIA , UNI DEGLI STUDI DI URBINO CARLO BO , FOND ISTITUTO ITALIANO DI TECNOLOGIA , UNIV PARMA
发明人： PIOMELLI DANIELE , MOR MARCO , TARZIA GIORGIO , BERTOZZI FABIO , NUZZI ANDREA , FIASELLA ANNALISA , BANDIERA TIZIANO , REGGIANI ANGELO MARIO
IPC分类号： A61K31/397
CPC分类号： C07D205/085
摘要： Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.
摘要翻译：本文描述了抑制N-酰基乙醇胺酸酰胺酶（NAAA）的化合物和药物组合物。本文描述的是合成本文所列化合物的方法和将这些化合物配制成包括这些化合物的药物组合物的方法。本文还描述了抑制NAAA的方法，以在NAE浓度降低的条件下维持作为NAAA底物的棕榈酰乙醇酰胺（PEA）和其它N-酰基乙醇胺（NAE）的水平。此外，这里描述的是治疗和改善疼痛，炎症，炎性疾病和其中调节脂肪酸乙醇酰胺临床或治疗相关或其中NAE水平降低与该病症相关的其它病症的方法。

4. 发明申请

WO2006116773A2 METHODS, COMPOSITIONS, AND COMPOUNDS FOR MODULATION OF MONOACYLGLYCEROL LIPASE, PAIN, AND STRESS-RELATED DISORDERS 审中-公开
标题翻译：方法，组合物和化合物用于调节单糖胆碱脂质，疼痛和压力相关疾病
公开(公告)号：WO2006116773A2
公开(公告)日：2006-11-02
申请号：PCT/US2006016843
申请日：2006-04-26
申请人： UNIV CALIFORNIA , UNIV GEORGIA RES FOUND , UNIV DEGLI STUDI URBINO , UNIV PARMA , PIOMELLI DANIELE , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GIORGIO , HOHMANN ANDREA
发明人： PIOMELLI DANIELE , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GIORGIO , HOHMANN ANDREA
IPC分类号： A61K31/4025
CPC分类号： A61K31/17
摘要： Methods, compositions, and compounds for inhibiting monoacyglycerol lipase, and for treating pain, for modulating stress-induced analgesia or for treating stress-induced disorders in mammals are provided.
摘要翻译：提供了用于抑制单甘油脂肪酶和用于治疗疼痛，调节应激诱发的镇痛或用于治疗哺乳动物中的应激诱导的疾病的方法，组合物和化合物。

5. 发明申请

WO2007132332A3 SURGICAL INSTRUMENT FOR CORNEAL TRANSPLANTS 审中-公开
标题翻译：手术器械用于角膜移植
公开(公告)号：WO2007132332A3
公开(公告)日：2008-01-24
申请号：PCT/IB2007001238
申请日：2007-05-14
申请人： UNIV PARMA , MACALUSO CLAUDIO
发明人： MACALUSO CLAUDIO
IPC分类号： A61F2/14 , A61F9/00 , A61F9/007
CPC分类号： A61F9/007 , A61F2/142 , A61F2/1664 , A61F9/0017 , A61F9/013
摘要： A surgical instrument (20) for manipulating and inserting into an eye a lamina of cells (7), such as a thin stroma support with Descemet membrane and endothelial cells for corneal transplants, or other types of laminas, comprises a hollow tubular body (1) able to contain the lamina of cells (7) immersed in a maintenance solution. The hollow tubular body (1) comprises a distal part (5), tapered and open at the end, and the section of the distal part (5) diminishes towards the end of the hollow tubular body (1) so that, during use, the lamina of cells (7), emerging from the distal part (5), is able to be configured tubularly, adapting to the section of the end of the distal part (5).
摘要翻译：用于操纵和插入细胞层（7）的手术器械（20），例如具有脱皮膜的薄基质支架和用于角膜移植的内皮细胞或其它类型的层压体，包括中空管状体（1））能够容纳浸入维护溶液中的细胞层（7）。中空管状体（1）包括远端部分（5），在远端部分（5）的锥形和开口，并且远端部分（5）的部分朝着中空管状体（1）的端部减小，使得在使用期间，从远端部分（5）出来的细胞层（7）能够被构造成管状地适应远端部分（5）端部的部分。

6. 发明申请

WO2004096826A3 METHOD FOR SELECTIVE INHIBITION OF HUMAN N-MYC GENE IN N-MYC EXPRESSING TUMORS THROUGH ANTISENSE AND ANTIGEN PEPTIDO-NUCLEIC ACIDS (PNA) 审中-公开
标题翻译：通过抗原和抗原肽核酸（PNA）在N-MYC表达肿瘤中选择性抑制人N-MYC基因的方法
公开(公告)号：WO2004096826A3
公开(公告)日：2005-05-26
申请号：PCT/IB2004001297
申请日：2004-04-29
申请人： UNIV BOLOGNA , UNIV PARMA , TONELLI ROBERTO , FRONZA RAFFAELE , PESSION ANDREA , SFORZA STEFANO , CORRADINI ROBERTO , MARCHELLI ROSANGELA
发明人： TONELLI ROBERTO , FRONZA RAFFAELE , PESSION ANDREA , SFORZA STEFANO , CORRADINI ROBERTO , MARCHELLI ROSANGELA
IPC分类号： A61K38/00 , A61K47/48 , C07H21/00 , C12N15/113 , C12N15/11
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/3181 , C12N2310/3513
摘要： The present invention refers to sense and antisense peptido-nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases.
摘要翻译：本发明涉及有义和反义肽 - 核酸（PNA）。本发明还涉及所述PNA用于制备用于治疗遗传性疾病的药物的用途。

7. 发明申请

WO2013028570A3 META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS 审中-公开
标题翻译：金属取代的联苯二烯外围限制性FAAH抑制剂
公开(公告)号：WO2013028570A3
公开(公告)日：2013-04-18
申请号：PCT/US2012051478
申请日：2012-08-17
申请人： UNIV CALIFORNIA , FOND ISTITUTO ITALIANO DI TECNOLOGIA , UNI DEGLI STUDI DI URBINO CARLO BO , UNIV PARMA , PIOMELLI DANIELE , MORENO-SANZ GUILLERMO , BANDIERA TIZIANO , MOR MARCO , TARZIA GIORGIO
发明人： PIOMELLI DANIELE , MORENO-SANZ GUILLERMO , BANDIERA TIZIANO , MOR MARCO , TARZIA GIORGIO
IPC分类号： C07C233/06 , A61K31/165 , A61P29/00 , C07C233/23 , C07D309/14
CPC分类号： C07C271/56 , C07C269/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D309/14
摘要： The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.
摘要翻译：本发明提供制备和使用脂肪酸酰胺水解酶（FAAH）的外周限制性抑制剂的方法。本发明提供抑制FAAH活性并增加中枢神经系统（CNS）外的氨基酰胺水平的化合物和组合物。本发明还提出了抑制FAAH的方法以及治疗诸如但不限于疼痛，炎症，免疫病症，皮炎，粘膜炎，周围感觉神经元，神经性皮炎和膀胱过度活动症的过度反应的病症的方法。因此，本发明还提供了用于治疗其中选择性抑制外周FAAH（与CNS FAAH相反））有益的化合物，方法和药物组合物。

8. 发明申请

WO2012015704A2 PERIPHERALLY RESTRICTED FAAH INHIBITORS 审中-公开
标题翻译：外用限制性FAAH抑制剂
公开(公告)号：WO2012015704A2
公开(公告)日：2012-02-02
申请号：PCT/US2011045114
申请日：2011-07-22
申请人： UNIV CALIFORNIA , UNI DEGLI STUDI DI URBINO CARLO BO , UNIV PARMA , PIOMELLI DANIELE , CLAPPER JASON R , MORENO-SANZ GUILLERMO , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GIORGIO
发明人： PIOMELLI DANIELE , CLAPPER JASON R , MORENO-SANZ GUILLERMO , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GIORGIO
IPC分类号： C07C271/56 , A61K31/27 , A61P29/00 , A61P37/00
CPC分类号： C07C271/56 , C07C2601/14
摘要： Peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH) are provided. The compounds can suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). Despite their relative inability to access brain and spinal cord, the compounds attenuate behavioral responses indicative of persistent pain in rodent models of inflammation and peripheral nerve injury, and suppresses noxious stimulus-evoked neuronal activation in spinal cord regions implicated in nociceptive processing. CBi receptor blockade prevents these effects. Accordingly, the invention also provides methods, and pharmaceutical compositions for treating conditions in which the inhibition of peripheral FAAH would be of benefit. The compounds of the invention are according to the formula (I): in which R1 is a polar group. In some embodiments, R1 is selected from the group consisting of hydroxy and the physiologically hydro lysable esters thereof. R2 and R3 are independently selected from the group consisting of hydrogen and substituted or unsubstituted hydrocarbyl; each R4 is independently selected from the group consisting of halogen and substituted or unsubstituted hydrocarbyl and n is an integer from 0 to 4; each R5 is independently selected from the group consisting of halo and substituted or unsubstituted hydrocarbyl and m is an integer from 0 to 3; and R6 is substituted or unsubstituted cyclohexyl; and the pharmaceutically acceptable salts thereof.
摘要翻译：提供脂肪酸酰胺水解酶（FAAH）的外周限制性抑制剂。该化合物可以抑制FAAH活性，并增加中枢神经系统（CNS）外的氨基酰胺水平。尽管它们相对不能进入脑和脊髓，但化合物减弱了指示炎症和周围神经损伤的啮齿动物模型中的持续疼痛的行为反应，并且抑制了牵连伤害性处理的脊髓区域中的有害刺激诱发的神经元激活。 CBi受体阻断防止这些影响。因此，本发明还提供了用于治疗其中外周FAAH的抑制将是有益的病症的方法和药物组合物。本发明的化合物是根据式（I）：其中R 1是极性基团。在一些实施方案中，R 1选自羟基及其生理上可水解的酯。 R2和R3独立地选自氢和取代或未取代的烃基; 每个R 4独立地选自卤素和取代或未取代的烃基，n是0至4的整数; 每个R 5独立地选自卤素和取代或未取代的烃基，m是0-3的整数; 并且R 6是取代或未取代的环己基; 及其药学上可接受的盐。

9. 发明申请

WO2010003465A3 A DRUG POWDER FOR INHALATION ADMINISTRATION AND A PROCESS THEREOF 审中-公开
标题翻译：一种用于吸入管理的药物粉末及其制备方法
公开(公告)号：WO2010003465A3
公开(公告)日：2010-04-08
申请号：PCT/EP2008059110
申请日：2008-07-11
申请人： UNIV PARMA , BUTTINI FRANCESCA , COLOMBO PAOLO , PARLATI CHIARA
发明人： BUTTINI FRANCESCA , COLOMBO PAOLO , PARLATI CHIARA
IPC分类号： A61K47/12 , A61K9/00 , A61K31/00
CPC分类号： A61K9/0075 , A61K31/00 , A61K31/7036 , A61K47/12
摘要： A drug powder is described and a process for its preparation, which comprises drug particles in amounts equal to or higher than 90% w/w, wherein said drug particles are at least partially coated with an amount lower than or equal to 2.0% w/w of an adjuvant which consists of one or a mixture of C12-C18 saturated fatty acid or their salts. The invention relates particularly to powder of tobramycin.
摘要翻译：描述了药物粉末及其制备方法，其包含等于或高于90％w / w的量的药物颗粒，其中所述药物颗粒至少部分地以低于或等于2.0％w / w的佐剂，其由C12-C18饱和脂肪酸或其盐的一种或混合物组成。本发明特别涉及妥布霉素的粉末。

10. 发明申请

WO2007052326B1 METHOD FOR CONVERSION OF URIC ACID TO ALLANTOIN AND RELATED ENZYMES 审中-公开
标题翻译：用于将脲酸转化成ALLANTOIN和相关酶的方法
公开(公告)号：WO2007052326B1
公开(公告)日：2008-02-07
申请号：PCT/IT2006000778
申请日：2006-11-07
申请人： UNIV PARMA , PERCUDANI RICARDO , FOLLI CLAUDIA , RAMAZZINA ILEANA
发明人： PERCUDANI RICARDO , FOLLI CLAUDIA , RAMAZZINA ILEANA
IPC分类号： C12N9/78 , A61K38/17 , C07K14/47 , C12N9/88
CPC分类号： C07K14/4702 , A61K38/00 , C12N9/78 , C12N9/88
摘要： It is described a polypeptide molecule able to selectively modulate uric acid conversion into S(+)-allantoin. A pharmaceutical composition for treating uric acid related disorders and a process to selectively modulate uric acid conversion into S(+)-allantoin are also disclosed.
摘要翻译：描述了能够选择性调节尿酸转化成S（+） - 尿囊素的多肽分子。还公开了用于治疗尿酸相关病症的药物组合物和选择性调节尿酸转化成S（+） - 尿囊素的方法。

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