专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004030685A3 USE OF IL-2 RECEPTOR ANTIBODIES TO PREVENT TOXICITY ASSOCIATED WITH AMPHOTERICIN B ANTIMYCOTIC THERAPY 审中-公开
标题翻译：使用IL-2受体抗体以预防与AMPHOTERICIN B抗生素治疗相关的毒性
公开(公告)号：WO2004030685A3
公开(公告)日：2004-06-17
申请号：PCT/EP0310888
申请日：2003-10-01
申请人： HOFFMANN LA ROCHE , UNIV MISSISSIPPI , UNIV MISSISSIPPI MEDICAL CT
发明人： CHAPMAN STANLEY WILLETTS , CLEARY JOHN D , GORDON ROBERT D
IPC分类号： A61K31/7048 , A61K39/395 , A61P33/00 , A61K38/20
CPC分类号： A61K31/7048 , A61K39/3955 , A61K2300/00
摘要： This invention relates to a method for treating a patient having a fungal infection. The invention comprises administering to the patient a therapeutically effective amount of a polyene antifungal (e.g., amphotericin B) in association with a therapeutically effective amount of a interleukin-2 inhibitor (e.g., chimeric or humanized monoclonal antibody that binds to the p55 subunit of the human interleukin-2 receptor and inhibits binding of interleukin-2 to an interleukin-2 receptor).
摘要翻译：本发明涉及一种治疗患有真菌感染的患者的方法。本发明包括向患者施用治疗有效量的多烯抗真菌剂（例如两性霉素B），其与治疗有效量的白细胞介素-2抑制剂（例如，嵌合或人源化单克隆抗体结合，其与p55亚基的p55亚基结合人白细胞介素-2受体并抑制白细胞介素-2与白细胞介素-2受体的结合）。

2. 发明申请

WO2014201052A3 MEDICAL IMAGE PROCESSING METHOD 审中-公开
标题翻译：医学图像处理方法
公开(公告)号：WO2014201052A3
公开(公告)日：2015-01-29
申请号：PCT/US2014041793
申请日：2014-06-10
申请人： UNIV MISSISSIPPI MEDICAL CT
发明人： SMITH ANDREW
IPC分类号： G09G5/02
CPC分类号： G06T11/001 , G06T5/002 , G06T7/0012 , G06T2207/10072 , G06T2207/20182 , G06T2210/41
摘要： The present disclosure provides methods for colorizing and/or standardizing a medical image, comprising, for example, the steps of (i) receiving, in an image processing unit, digital image data obtained by an image capture device, wherein the digital image data includes a medical image; (ii) analyzing the data with the image processing unit to identify a region of interest; (iii) segmenting said region of interest; (iv) obtaining a measure of the pixel intensities in the segmented region of interest; (v) selecting an optimized color spectrum from a plurality of color spectra using the result of the measure of the pixel intensities in the segmented region of interest; (vi) colorizing the digital image data by mapping the selected color spectrum to the region of interest; and (vii) displaying the colorized medical image.
摘要翻译：本公开提供了用于使医学图像着色和/或标准化的方法，包括例如以下步骤：（i）在图像处理单元中接收由图像捕获装置获得的数字图像数据，其中数字图像数据包括医学形象; （ii）利用图像处理单元分析数据以识别感兴趣的区域; （iii）分割所述感兴趣的区域; （iv）获得所分割的感兴趣区域中的像素强度的度量; （v）使用感兴趣的分割区域中的像素强度的测量结果从多个色谱中选择优化的色谱; （vi）通过将所选择的色谱映射到感兴趣的区域来对数字图像数据进行着色; 和（vii）显示彩色医疗图像。

3. 发明申请

WO2013036803A1 PREPARATION OF PRE-COATED RP-ROTORS AND UNIVERSAL CHROMATOROTORS, CHROMATOGRAPHIC SEPARATION DEVICES AND METHODS FOR CENTRIFUGAL PREPARATIVE CHROMATOGRAPHY 审中-公开
标题翻译：预涂覆的RP-旋转器和通用色谱仪的制备，色谱分离装置和用于离心制备色谱法的方法
公开(公告)号：WO2013036803A1
公开(公告)日：2013-03-14
申请号：PCT/US2012054220
申请日：2012-09-07
申请人： UNIV MISSISSIPPI , LLIAS MUHAMMAD , SAMOYLENKO VOLODYMYR , GILLUM VAN DOUGLAS
发明人： LLIAS MUHAMMAD , SAMOYLENKO VOLODYMYR , GILLUM VAN DOUGLAS
IPC分类号： B01D15/26 , B01D15/08 , G01N9/30 , G01N30/02
CPC分类号： B01D15/02 , B01D15/1892 , B01D15/325 , G01N30/38
摘要： Reversed phase solid silica gel sorbent layers which can adhere with appropriate binders to a solid surface were developed. Pre- coated RP-rotors of different thickness were used Thes pre-coated RP-rotors can be used for Centrifugal Preparative Thin-layer Chromatography (CPTLC) using any appropriate device for Centrifugal Chromatography, like Chromatotron® or Cyclograph. Organic compounds including very polar ones can be separated and /or purified in a preparative scale from mixtures by these pre-coated RP-rotors, using different solvent systems. Also described is a new chromatographic separating device (hereinafter Chromato Rotor) and a method for separation of constituents from natural products or mixture of organic compounds using a centrifugal preparative chromatographic instrument with a separating element which contains a binder free sorbent layer packed or loaded between tvvo supporting rotors and retained from moving outside by a porous filter. Only eluants pass through. ChromatoRotors with different sorbentswith different dimensions and capacity can be prepared and used for centrifugal chromatographic separation. Virtually any classes of organic compounds including very polar natural products can be separated or purified from a mixture by using these rotors due to the unlimited combination of sorbents and mixture of mobile phases, including but not limited to aqueous-based solvents. These plates can also be used for CPTLC using any appropriate device for Centrifugal Chromatography like Chromatotron® or Cyclograph® instruments.
摘要翻译：开发了可以用适当的粘合剂粘附到固体表面的反相固体硅胶吸附剂层。使用不同厚度的预包被的RP-转子Thes预涂覆的RP-转子可以用于离心色谱的离心制备薄层色谱（CPTLC），如Chromatotron®或Cyclograph。使用不同的溶剂体系，包括极性极性的有机化合物可以通过这些预涂覆的RP-转子的混合物以制备规模分离和/或纯化。还描述了一种新的色谱分离装置（以下称为Chromato Rotor）以及使用离心制备型色谱仪器从天然产物或有机化合物混合物中分离组分的方法，所述离心制备色谱仪器具有分离元件，该分离元件包含在tvvo之间填充或装载的无粘合剂吸附剂层支撑转子并通过多孔过滤器保持向外移动。只有洗脱液通过。可以制备具有不同尺寸和容量的不同吸附剂的Chromato转子并用于离心色谱分离。由于吸附剂和流动相混合物（包括但不限于水基溶剂）的无限组合，实际上可以通过使用这些转子从混合物中分离或纯化任何类别的有机化合物，包括极性极强的天然产物。这些板也可以用于CPTLC，使用任何合适的离心色谱仪如Chromatotron®或Cyclograph®仪器。

4. 发明申请

WO2012075287A2 NOVEL SELECTIVE INHIBITORS OF PROLYLCARBOXYPEPTIDASE 审中-公开
标题翻译：新型选择性抑制剂的高效液相色谱法
公开(公告)号：WO2012075287A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062889
申请日：2011-12-01
申请人： UNIV MISSISSIPPI , SHARIAT-MADAR ZIAEDDIN , RIMOLDI JOHN MATTHEW , GADEPALLI RAMA SARMA VENKATA SUBBARAHMANYA
发明人： SHARIAT-MADAR ZIAEDDIN , RIMOLDI JOHN MATTHEW , GADEPALLI RAMA SARMA VENKATA SUBBARAHMANYA
CPC分类号： C07K5/06165 , C07D205/04 , C07D207/16 , C07D403/06 , C07K5/0205 , C07K5/06139
摘要： The present invention relates to compounds of the formulae: Formula (I), (II), (III), (IV), (V), (VI) in which R is C5-C16 alkyl, R1 is Formula (VII), or Formula (VIII) and isosteres and saltes therof. These compounds are serine protease procarboxypeptidase (FRCP) inhibitors and can be used in the field of weight management and in the preparation of medications for the treatment and management of obesity. Further, the present invention relates to new anorexigenic and anti-inflammatory drugs, acting through PRCP-mediated mechanisms.
摘要翻译：本发明涉及其中R为C 5 -C 16烷基的式（I），（II），（III），（IV），（V），（VI）），R 1为式（VII）或式（VIII）和等离子体和盐。这些化合物是丝氨酸蛋白酶前羧肽酶（FRCP）抑制剂，可用于体重管理和制备用于治疗和管理肥胖症的药物领域。此外，本发明涉及通过PRCP介导的机制起作用的新的厌食和抗炎药物。

5. 发明申请

WO2011155998A2 ORAL VACCINATION OF FISH WITH LIVE ATTENUATED EDWARDSIELLA ICTALURI VACCINES 审中-公开
标题翻译：鱼类与野生型慢性乙型肝炎疫苗接种疫苗的口服疫苗
公开(公告)号：WO2011155998A2
公开(公告)日：2011-12-15
申请号：PCT/US2011001047
申请日：2011-06-09
申请人： UNIV MISSISSIPPI STATE , WISE DAVID J , GREENWAY TERRENCE , BYARS TODD
发明人： WISE DAVID J , GREENWAY TERRENCE , BYARS TODD
IPC分类号： A61K39/02
CPC分类号： A61K39/025 , A01K61/80 , A61K2039/522 , A61K2039/542 , A61K2039/552 , A61K2039/55566
摘要： The present invention is directed to a novel live attenuated isolate and sub-isolets thereof of a strain of the pathogen Edwardsiella ictaluri for protecting fish from ESC infection or disease, a vaccine composition comprising the isolet, a method of oral delivery of the vaccine and any vaccine, and an apparatus designed to effectively mix the vaccine with fish feed and deliver the vaccine to fish.
摘要翻译：本发明涉及一种用于保护鱼类免受ESC感染或疾病的病原体爱德华病毒菌株的新的活减毒分离物及其亚介体，包含异径体的疫苗组合物，口服疫苗的方法和任何疫苗和旨在有效地将疫苗与鱼饲料混合并将疫苗递送到鱼类的装置。

6. 发明申请

WO2007037899A3 TERMITE CONTROL METHODS AND APPARATUS 审中-公开
标题翻译：终止控制方法和装置
公开(公告)号：WO2007037899A3
公开(公告)日：2009-04-23
申请号：PCT/US2006033897
申请日：2006-08-30
申请人： UNIV MISSISSIPPI , RAGON KEVIN , DONOHOE J PATRICK , AMBURGEY TERRY , SANDERS MICHAEL
发明人： RAGON KEVIN , DONOHOE J PATRICK , AMBURGEY TERRY , SANDERS MICHAEL
IPC分类号： A01M17/00 , A01M1/02 , A01M1/22
CPC分类号： A01M1/02 , A01M1/226 , A01M29/28
摘要： The present invention provides methods and apparatus for controlling insect population or activity by using electromagnetic field source of certain frequency and intensity coupled with insect food sources/attractants. The present invention can be used to protect a natural or man-made structure from termite infestation. The present invention can also be used for controlling activity of other social insects such as ants, bees and wasps.
摘要翻译：本发明提供了通过使用与昆虫食物来源/引诱剂结合的一定频率和强度的电磁场源来控制昆虫种群或活动的方法和装置。本发明可用于保护天然或人造结构免受白蚁侵袭。本发明还可用于控制其他社会昆虫如蚂蚁，蜜蜂和黄蜂的活动。

7. 发明申请

WO2009026227A2 HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS 审中-公开
标题翻译：高选择性SIGMA受体配体
公开(公告)号：WO2009026227A2
公开(公告)日：2009-02-26
申请号：PCT/US2008073478
申请日：2008-08-18
申请人： UNIV MISSISSIPPI , MCCURDY CHRISTOPHER R , MESANGEAU CHRISTOPHE , NARAYANAN SANJU , MATSUMOTO RAE REIKO , POUPAERT JACQUES HENRI
发明人： MCCURDY CHRISTOPHER R , MESANGEAU CHRISTOPHE , NARAYANAN SANJU , MATSUMOTO RAE REIKO , POUPAERT JACQUES HENRI
IPC分类号： C07D277/68 , A61K31/425 , A61K31/445 , A61P25/00 , C07D417/02
CPC分类号： C07D277/70 , A61K51/0455 , A61K51/0459 , A61K51/0468 , C07D235/26 , C07D263/58 , C07D277/68 , C07D401/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07D491/10 , C07D491/107
摘要： A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula ( I ) in which R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-l,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): R2,3,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH2, O, S, OCH2, N-R, N-Ar, C-R, C-Ar; Z can be either H, O, S, S-R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls; "n" can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging R1 and N can be optionally substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C3-C5 cycloalkyl group, aromatic and heterocyclic group.
摘要翻译：可用于治疗需要治疗涉及σ受体的受试者或用于缓解由具有通式（I）的药物滥用引起的影响的化合物的化合物，其中R 1可以是任选取代的C-4至C-7N- 杂环，例如任选取代的哌啶基，任选取代的哌嗪基，任选取代的四氢吡啶基，任选取代的氮杂环庚烷，叔胺（环状或非环状），异吲哚啉-1,3-二酮或任选取代的四氢异喹诺酮（芳族取代的）： R2,3,4,5,6可各自独立地为下列部分中的任何一种或组合：氰基，硝基，酰基，烷基，酰氨基，叠氮基，异硫氰酸酯，异氰酸酯任选取代的苯胺基，卤素，醚，磺酰胺，硫代酰基，硝基芳族，杂环，烯属，乙炔，氘或氚; Y可以是CH，CH 2，O，S，OCH 2，N-R，N-Ar，C-R，C-Ar; Z可以是H，O，S，S-R或NR。 R基团可以是H，芳基，烷基或环烷基; “n”可以是长度为1至5个碳原子，立体异构体，功能类似物和其药学上可接受的盐，其中桥接R 1和N的部分可以是任选取代的亚烷基，任选取代的亚烯基或任选取代的亚炔基，并且其中亚烷基可以包括插入的C 3 -C 5环烷基，芳族和杂环基。

8. 发明申请

WO2008031092A9 IMMUNOSTIMULATORY COMPOSITION COMPRISING LIPOPROTEIN IN MICROALGAE EXTRACT 审中-公开
标题翻译：微生物提取物中包含脂蛋白的免疫组织
公开(公告)号：WO2008031092A9
公开(公告)日：2008-07-31
申请号：PCT/US2007078008
申请日：2007-09-10
申请人： UNIV MISSISSIPPI , PASCO DAVID STANLEY , PUGH NIRMAL DEREK CERI
发明人： PASCO DAVID STANLEY , PUGH NIRMAL DEREK CERI
IPC分类号： C07K14/405 , A61K38/16 , A61P37/04
CPC分类号： C07K14/405 , A61K35/748 , A61K38/00
摘要： Potent immunostimulatory lipoproteins have been identified within the following microalgae and extracts thereof: Spirulina species, Chlorella species, Haematococcus pluvialis and Aphanizomenon flos-aquae. This lipoprotein component can be extracted from the microalgae or microalgae spent material using various procedures. The resulting preparations exhibit extremely potent immunostimulatory activity. These preparations are potentially useful as a botanical or pharmaceutical preparation to improve immune function. Methods are also disclosed for the chemical and bioactivity based standardization of immunostimulatory microalgae extracts and the raw material.
摘要翻译：已经鉴定了以下微藻及其提取物中的潜在免疫刺激性脂蛋白：螺旋藻种类，小球藻种，红球藻（Hememococcus pluvialis）和Aphanizomenon flos-aquae。可以使用各种方法从微藻或微藻废料中提取该脂蛋白组分。所得制剂显示出非常有效的免疫刺激活性。这些制剂作为改善免疫功能的植物药物或药物制剂是潜在有用的。还公开了用于免疫刺激微藻提取物和原料的基于化学和生物活性的标准化方法。

9. 发明申请

WO2007035570A3 METHOD FOR EPITAXIAL GROWTH OF SILICON CARBIDE 审中-公开
标题翻译：碳化硅外延生长方法
公开(公告)号：WO2007035570A3
公开(公告)日：2007-11-15
申请号：PCT/US2006036183
申请日：2006-09-16
申请人： UNIV MISSISSIPPI , KOSHKA YAROSLAV
发明人： KOSHKA YAROSLAV
IPC分类号： C30B28/14 , B05D3/14 , C01B31/36 , C30B15/14 , C30B19/00 , H01L21/331
CPC分类号： C30B25/02 , C23C16/325 , C30B29/36
摘要： A method for epitaxial growth of silicon carbide using chemical vapor deposition (CVD) is provided. This method utilizes halogenated carbon precursors and control of the gas-phase interaction of halogen-containing intermediate chemical products involving silicon and carbon, which ensures quality and homogeneity across the silicon carbide crystals. It also ensures a possibility to achieve device-quality epitaxial layers at lower growth temperatures as well as on on-axis or low off-angle substrate surfaces. The growth method can be applied to forming SiC device regions of desirable shape and dimensions by restricting the growth into windows formed in non-silicon carbide region on the top of SiC substrate. Application of the methods described herein will greatly benefit the production of high quality silicon carbide materials and devices.
摘要翻译：提供了一种使用化学气相沉积（CVD）进行外延生长的碳化硅的方法。该方法利用卤代碳前体和控制涉及硅和碳的含卤素中间体化学产品的气相相互作用，确保碳化硅晶体之间的质量和均匀性。它还确保了在较低生长温度以及在轴上或低偏角基板表面上实现器件质量外延层的可能性。通过将生长方法限制在SiC衬底顶部的非碳化硅区域中形成的窗口，可以将生长方法应用于形成所需形状和尺寸的SiC器件区域。本文描述的方法的应用将极大地有利于生产高质量的碳化硅材料和器件。

10. 发明申请

WO2007070834A2 CONTROLLING TOXICITY OF AMINOQUINOLINE COMPOUNDS 审中-公开
标题翻译：控制氨基喹啉化合物的毒性
公开(公告)号：WO2007070834A2
公开(公告)日：2007-06-21
申请号：PCT/US2006062037
申请日：2006-12-13
申请人： UNIV MISSISSIPPI , WALKER LARRY , TEKWANI BABU , TRIPATHI LALIT M
发明人： WALKER LARRY , TEKWANI BABU , TRIPATHI LALIT M
IPC分类号： A61K31/4706
CPC分类号： A61K31/4706 , A61K31/47 , A61K31/496 , A61K36/752 , A61K36/79 , A61K45/06 , A61K2300/00
摘要： A method of controlling toxicity to a user caused by administration to the user of an aminoquinoline compound comprising administering to the user a toxicity controlling amount of at least one inhibitor of a cytochrome P450 (CYP) enzyme.
摘要翻译：一种通过向使用者施用氨基喹啉化合物而控制使用者的毒性的方法，包括向使用者施用毒性控制量的至少一种细胞色素P450（CYP）酶抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式