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    • 10. 发明申请
    • PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
    • 作为用于治疗与相关疾病相关的疾病的5-HT2A丝氨酸受体的调节剂的吡唑衍生物
    • WO2006060762A2
    • 2006-06-08
    • PCT/US2005043893
    • 2005-12-01
    • ARENA PHARM INCSTRAH-PLEYNET SONJATEEGARDEN BRADLEYUNETT DAVID J
    • STRAH-PLEYNET SONJATEEGARDEN BRADLEYUNETT DAVID J
    • C07D231/38A61K31/415A61P25/00C07D401/12
    • C07D231/38C07D401/12C07D405/12C07D409/12C07D413/12
    • The present invention relates to certain pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HT2A serotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.
    • 本发明涉及式(Ia)的某些吡唑衍生物及其调节5-HT2A 5-羟色胺受体活性的药物组合物。 化合物及其药物组合物涉及可用于治疗血小板聚集,冠状动脉疾病,心肌梗死,短暂性脑缺血发作,心绞痛,中风,心房颤动,降低血块形成风险,哮喘或其症状,激动或 症状,行为障碍,药物诱发的精神病,兴奋性精神病,吉列斯·杜列特综合征,躁狂症,有机或NOS精神病,精神病,精神病,急性精神分裂症,慢性精神分裂症,精神分裂症精神分裂症和相关疾病,睡眠障碍,糖尿病相关 疾病,进行性多灶性脑白质病等。 本发明还涉及与单独或一起施用的其它药剂组合治疗5-HT2A 5-羟色胺受体介导的病症的方法。