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1. 发明申请

WO2008107137A3 COMPOSITIONS COMPRISING A PHYSIOLOGICAL COOLANT 审中-公开
标题翻译：包含生理冷却剂的组合物
公开(公告)号：WO2008107137A3
公开(公告)日：2009-03-26
申请号：PCT/EP2008001644
申请日：2008-03-03
申请人： GIVAUDAN NEDERLAND SERVICES B , WATSON MICHAEL STEVEN , WATKINS STEPHEN DAVID , TONDEUR SANDER
发明人： WATSON MICHAEL STEVEN , WATKINS STEPHEN DAVID , TONDEUR SANDER
IPC分类号： A61K8/42 , A61K8/34 , A61Q11/00 , A61Q19/00
CPC分类号： A61Q11/00 , A61K8/42 , A61K8/55 , A61K2800/244 , A61Q15/00 , A61Q19/00 , A61Q19/004
摘要： The present invention concerns enhancements in the cooling effects of certain physiological coolant-containing compositions such as topically applied cosmetic, toiletry or pharmaceutical products, wherein the cooling effect of the physiological coolants is enhanced by the addition of a substance according to formula (I) or dermatologically acceptable salts thereof: R1-CR2(OR3)-CO-NR4-CR5R6-X-OR7 (I). It was found that substances represented by formula (I) are capable of bringing about greater cooling effects from reduced concentrations of physiological coolants without behaving as physiological coolants themselves, thereby enabling the preparation of compositions that do not necessarily have the characteristic minty odour of menthol-containing products and/or to allow greater freedom in creating perfumed products.
摘要翻译：本发明涉及某些生理学含冷冻剂组合物如局部应用的化妆品，化妆品或药物产品的冷却效果的增强，其中通过加入根据式（I）的物质或生物冷却剂的冷却效果其皮肤病学上可接受的盐：R1-CR2（OR3）-CO-NR4-CR5R6-X-OR7（I）。发现由式（I）表示的物质能够降低生理冷却剂浓度而产生更大的冷却效果，而不用作为生理冷却剂本身，从而使得可以制备不一定具有薄荷醇的特征性微小气味的组合物，含有产品和/或允许更大的自由创造加香产品。

2. 发明申请

WO2008107137A2 COMPOSITIONS COMPRISING A PHYSIOLOGICAL COOLANT 审中-公开
标题翻译：包含生理冷却剂的组合物
公开(公告)号：WO2008107137A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008/001644
申请日：2008-03-03
申请人： QUEST INTERNATIONAL SERVICES B.V. , WATSON, Michael, Steven , WATKINS, Stephen, David , TONDEUR, Sander
发明人： WATSON, Michael, Steven , WATKINS, Stephen, David , TONDEUR, Sander
IPC分类号： A61K8/42 , A61K8/55 , A61Q11/00 , A61Q19/00 , A61Q15/00
CPC分类号： A61Q11/00 , A61K8/42 , A61K8/55 , A61K2800/244 , A61Q15/00 , A61Q19/00 , A61Q19/004
摘要： The present invention concerns enhancements in the cooling effects of certain physiological coolant-containing compositions such as topically applied cosmetic, toiletry or pharmaceutical products, wherein the cooling effect of the physiological coolants is enhanced by the addition of a substance according to formula (I) or dermatologically acceptable salts thereof: R 1 -CR 2 (OR 3 )-CO-NR 4 -CR 5 R 6 -X-OR 7 (I). It was found that substances represented by formula (I) are capable of bringing about greater cooling effects from reduced concentrations of physiological coolants without behaving as physiological coolants themselves, thereby enabling the preparation of compositions that do not necessarily have the characteristic minty odour of menthol-containing products and/or to allow greater freedom in creating perfumed products.
摘要翻译：本发明涉及某些生理学含冷冻剂组合物如局部应用的化妆品，化妆品或药物产品的冷却效果的增强，其中通过加入根据式（I）的物质或生物冷却剂的冷却效果其皮肤病学上可接受的盐：R 1 -CR 2（或3个）-CO-NR 4 -CR （I）。发现由式（I）表示的物质能够降低生理冷却剂浓度而产生更大的冷却效果，而不用作为生理冷却剂本身，从而使得可以制备不一定具有薄荷醇的特征性微小气味的组合物，含有产品和/或允许更大的自由创造加香产品。

3. 发明申请

WO2005102071B1 TASTE IMPROVING SUBSTANCES 审中-公开
标题翻译：改善物质
公开(公告)号：WO2005102071B1
公开(公告)日：2006-02-23
申请号：PCT/NL2005000262
申请日：2005-04-06
申请人： QUEST INT , QUEST INT SERV BV , RENES HARRY , WINKEL CHRIS , DE LAMARLIERE CAROLINE , KOENIG THORSTEN , VAN OMMEREN ESTHER , TONDEUR SANDER
发明人： RENES HARRY , WINKEL CHRIS , DE LAMARLIERE CAROLINE , KOENIG THORSTEN , VAN OMMEREN ESTHER , TONDEUR SANDER
IPC分类号： A23L1/226 , A23L1/227
CPC分类号： A23L27/21 , A23L27/202
摘要： The present invention in a first aspect relates to taste improvement of foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a substance according to formula (I) or formula (II), or edible salts thereof: R 1 -CR 7 (OR 4 )-CO-NR 2 -CR 8 R 3 -X-OR 5 (I); R 6 -CR 7 (OR 4 )-CO-Az (II). It was found that substances represented by formula (I) and/or formula (II) are capable of modulating and complementing the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavour compositions, foodstuffs, beverages, pharmaceutics, tobacco products and oral care products. Typical examples of flavour improving substances according to the present invention include N-lactoyl ethanolamine, N-lactoyl ethanolamine phosphate, N-a-hydroxy-butanoyl ethanolamine, N-lactoyl diethanolamine, N-lactoyl-2-amino-l,3-propanediol, N-lactoyl-3-amino-l, 2-propanediol, N-lactoyl-3-amino-l-propanol, N-gluconyl-2-amino-l, 3-propanediol, N-gluconyl-3-amino-l, 2-propanediol, N-mannonyl ethanolamine, N-glycolyl ethanolamine, 2-hydroxyethyl-N-tartaramide, 2-hydroxyethyl-N-malamide, 2-hydroxyethyl-N-citramide and N-gluconyl-Az.
摘要翻译：本发明的第一方面涉及使用根据式（I）或式（II）的物质或其食用盐的食品，饮料，制药，烟草制品和口腔护理产品的味道改进：R 1 -CR ^{7 （OR ^{4 ） - CO-NR ^{2 -CR ^{8 - [R ^{（3）-X-OR 5（I）; （OR 4） - CO-Az（II）。发现由式（I）和/或式（II）表示的物质能够调节和补充味道赋予物质的感官影响。因此，本发明的味道改善物质有利地用于风味组合物，食品，饮料，药物，烟草制品和口腔护理产品中。根据本发明的风味改善物质的典型实例包括N-乳酰乙醇胺，N-乳酰乙醇胺磷酸盐，Na-羟基丁酰乙醇胺，N-乳酰二乙醇胺，N-乳酰-2-氨基-1,3-丙二醇，N 1-乳酰基-3-氨基-1,2-丙二醇，N-乳酰基-3-氨基-1-丙醇，N-葡糖基-2-氨基-1,3-丙二醇，N-葡萄糖基-3-氨基-1,2 丙二醇，N-甘露糖醇乙醇胺，N-乙醇酰乙醇胺，2-羟乙基-N-酒石酸，2-羟乙基-N-异丙酰胺，2-羟乙基-N-乙酰丙酰胺和N-葡糖基-Z11。}}}}}

4. 发明申请

WO2008075942A1 N-SUBSTITUTED-P-MENTHANE-3-CARBOXAMIDE AND USES THEREOF 审中-公开
标题翻译： N-取代的P-MENTHANE-3-CARBOXAMIDE及其用途
公开(公告)号：WO2008075942A1
公开(公告)日：2008-06-26
申请号：PCT/NL2007/050609
申请日：2007-11-30
申请人： QUEST INTERNATIONAL SERVICES B.V. , GIVAUDAN S.A. , FURRER, Steffan , TONDEUR, Sander , WINKEL, Chris , RENES, Harry
发明人： FURRER, Steffan , TONDEUR, Sander , WINKEL, Chris , RENES, Harry
IPC分类号： A23L1/226 , C07C233/00 , A61Q11/00 , A24B15/30
CPC分类号： A23G4/06 , A23L27/20 , A23L27/204 , A24B15/301 , A61K8/42 , A61K2800/244 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q19/00 , C07C233/58 , C07C233/60 , C07C2601/02 , C07C2601/14
摘要： The present invention relates to substances and compositions having a physiological cooling effect on the skin and the mucosa of the body, especially of the oral cavity, throat and nose. More in particular, the present invention relates to N- substituted-p-menthane-3-carboxamides represented by the following formula (I): and esters thereof. These substances are capable of imparting and/or enhancing a physiological cooling effect in a product in which they are incorporated, much more effectively than the heretofore known N-substituted-p-menthane-3-carboxamides.
摘要翻译：本发明涉及具有对身体，特别是口腔，喉咙和鼻子的皮肤和粘膜的生理冷却作用的物质和组合物。更具体地，本发明涉及由下式（I）表示的N-取代对 - 薄荷烷-3-甲酰胺及其酯。这些物质能够赋予和/或增强其所掺入的产品中的生理冷却效果，比迄今为止已知的N-取代对薄荷烷-3-甲酰胺更有效。

5. 发明申请

WO2005102071A1 TASTE IMPROVING SUBSTANCES 审中-公开
标题翻译：改善物质
公开(公告)号：WO2005102071A1
公开(公告)日：2005-11-03
申请号：PCT/NL2005/000262
申请日：2005-04-06
申请人： QUEST INTERNATIONAL B.V. , QUEST INTERNATIONAL SERVICES B.V. , RENES, Harry , WINKEL, Chris , DE LAMARLIERE, Caroline , KÖNIG, Thorsten , VAN OMMEREN, Esther , TONDEUR, Sander
发明人： RENES, Harry , WINKEL, Chris , DE LAMARLIERE, Caroline , KÖNIG, Thorsten , VAN OMMEREN, Esther , TONDEUR, Sander
IPC分类号： A23L1/227
CPC分类号： A23L27/21 , A23L27/202
摘要： The present invention in a first aspect relates to taste improvement of foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a substance according to formula (I) or formula (II), or edible salts thereof: R 1 -CR 7 (OR 4 )-CO-NR 2 -CR 8 R 3 -X-OR 5 (I); R 6 -CR 7 (OR 4 )-CO-Az (II). It was found that substances represented by formula (I) and/or formula (II) are capable of modulating and complementing the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavour compositions, foodstuffs, beverages, pharmaceutics, tobacco products and oral care products. Typical examples of flavour improving substances according to the present invention include N-lactoyl ethanolamine, N-lactoyl ethanolamine phosphate, N-α-hydroxy-butanoyl ethanolamine, N-lactoyl diethanolamine, N-lactoyl-2-amino-l,3-propanediol, N-lactoyl-3-amino-l, 2-propanediol, N-lactoyl-3-amino-l-propanol, N-gluconyl-2-amino-l, 3-propanediol, N-gluconyl-3-amino-l, 2-propanediol, N-mannonyl ethanolamine, N-glycolyl ethanolamine, 2-hydroxyethyl-N-tartaramide, 2-hydroxyethyl-N-malamide, 2-hydroxyethyl-N-citramide and N-gluconyl-Az.
摘要翻译：本发明的第一方面涉及使用根据式（I）或式（II）的物质或其食用盐的食品，饮料，药物，烟草制品和口腔护理产品的味道改进：R 1 - CR 7（OR 4） - CO-NR 2 -CR 8 R 3 -X-OR 5（I）; R 6 -CR 7（OR 4） - CO-Az（II）。发现由式（I）和/或式（II）表示的物质能够调节和补充味道赋予物质的感官影响。因此，本发明的味道改善物质有利地用于风味组合物，食品，饮料，药物，烟草制品和口腔护理产品中。根据本发明的风味改善物质的典型实例包括N-乳酰乙醇胺，N-乳酰乙醇胺磷酸盐，N-α-羟基丁酰乙醇胺，N-乳酰二乙醇胺，N-乳酰-2-氨基-1,3-丙二醇，N-乳酰基-3-氨基-1,2-丙二醇，N-乳酰-3-氨基-1-丙醇，N-葡萄糖基-2-氨基-1,3-丙二醇，N-葡萄糖基-3-氨基-1 2-丙二醇，N-甘露糖醇乙醇胺，N-乙醇酰乙醇胺，2-羟乙基-N-苯甲酰胺，2-羟乙基-N-异丙酰胺，2-羟乙基-N-乙酰丙酰胺和N-葡萄糖基-Za。

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