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1. 发明申请

WO2011109422A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2011109422A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/026727
申请日：2011-03-01
申请人： THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , KLINMAN, Dennis , SHIROTA, Hidekazu
发明人： KLINMAN, Dennis , SHIROTA, Hidekazu
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/549
摘要： Methods for inducing an immune response to a tumor in a subject are disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the CpG ODN is a K-type or a D-type CpG ODN. Methods for treating a tumor in a subject are also disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the tumor cells are autologous. In additional embodiments, the tumor is a lymphoma, cervical cancer, prostate cancer, breast cancer, colon cancer or a lung cancer.
摘要翻译：本文公开了诱导受试者对肿瘤的免疫应答的方法。这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。在一些实施方案中，CpG ODN是K型或D型CpG ODN。本文还公开了治疗受试者中的肿瘤的方法。这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。在一些实施方案中，肿瘤细胞是自体的。在另外的实施方案中，肿瘤是淋巴瘤，宫颈癌，前列腺癌，乳腺癌，结肠癌或肺癌。

2. 发明申请

WO2009032904A1 PROBE AND METHOD FOR OBTAINING THREE-DIMENSIONAL COMPOSITIONAL MAPS OF A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于获得生物样品三维组合物的探针和方法
公开(公告)号：WO2009032904A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075224
申请日：2008-09-04
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , SUBRAMANIAM, Sriram
发明人： SUBRAMANIAM, Sriram
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , B82Y35/00 , G01N33/5082 , H01J37/28 , H01J37/3053 , H01J49/0004 , H01J2237/26 , H01J2237/28 , H01J2237/31745 , H01J2237/31749
摘要： The invention provides a probe and a method of obtaining a three-dimensional compositional map of one or more targets in a biological sample, or a portion thereof, comprising: (a) milling a surface layer of a biological sample with a focused ion beam, thereby creating a newly exposed surface layer of the biological sample; (b) imaging the newly exposed surface layer of the biological sample; (c) identifying the chemical composition of the newly exposed surface layer of the biological sample, or a portion thereof, with a mass spectrometer; and (d) repeating (a) to (c) until a three-dimensional compositional map of one or more targets in the biological sample, or portion thereof, is obtained. Uses of the three-dimensional map obtained from the inventive method are further provided.
摘要翻译：本发明提供一种探针和一种获得生物样品或其一部分中的一种或多种靶的三维组成图的方法，其包括：（a）用聚焦离子束研磨生物样品的表面层，从而产生生物样品的新暴露的表面层; （b）对生物样品的新暴露的表面层进行成像; （c）用质谱仪鉴定生物样品的新暴露表面层或其一部分的化学成分; 和（d）重复（a）至（c），直到得到生物样品中的一种或多种目标或其部分的三维组成图。还提供了从本发明方法获得的三维图的使用。

3. 发明申请

WO2009023707A1 METHOD OF TREATING DISEASE INVOLVING MYELIN AND/OR AXONAL LOSS 审中-公开
标题翻译：治疗涉及髓质和/或轴向损失的疾病的方法
公开(公告)号：WO2009023707A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/073007
申请日：2008-08-13
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , QUANDT, Jacqueline A. , MITCHELL, James B. , SOWERS, Anastasia , KRISHNA, Murali C.
发明人： QUANDT, Jacqueline A. , MITCHELL, James B. , SOWERS, Anastasia , KRISHNA, Murali C.
IPC分类号： A61K31/454 , A61P19/00
CPC分类号： A61K31/454
摘要： Disclosed is a method of treating a disease involving myelin and/or axonal loss, such as a demyelinating disease, in a mammal comprising administering a compound of formula I, in which R 1 -R 11 and n are defined herein. Also disclosed are methods of using a compound of formula 1 to treat neurodegeneration associated with inflammation and to reduce myelin and/or axonal loss.
摘要翻译：公开了一种在哺乳动物中治疗涉及髓磷脂和/或轴突损失（例如脱髓鞘疾病）的疾病的方法，包括给予式I化合物，其中R1-R11和n定义在本文中。还公开了使用式1化合物治疗与炎症相关的神经变性并减少髓磷脂和/或轴突损失的方法。

4. 发明申请

WO2009006046A1 DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY 审中-公开
标题翻译： GPCR超级药物的激素和拮抗剂的抑制剂
公开(公告)号：WO2009006046A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/067683
申请日：2008-06-20
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , INSERM , JACOBSON, Kenneth A. , KIM, Yoonkyung , KLUTZ, Athena , HECHLER, Beatrice , GACHET, Christian
发明人： JACOBSON, Kenneth A. , KIM, Yoonkyung , KLUTZ, Athena , HECHLER, Beatrice , GACHET, Christian
IPC分类号： A61K47/48 , A61K49/00 , A61P35/00 , A61P29/00 , A61P31/00 , A61P25/00 , A61P1/00 , A61P13/00 , A61P9/00
CPC分类号： A61K49/0054 , A61K47/59 , A61K47/595 , A61K47/60 , A61K49/0041
摘要： Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A 1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N 6 position of the purine nucleoside moiety, wherein the functional group has the formula (I): N 6 H-Ar 1 -CH 2 -C(=0)NH-R 1 (I), wherein Ar 1 and R 1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.
摘要翻译：公开了包含树枝状大分子和配体的缀合物，其是G-蛋白质偶联受体（GPCR）超家族的受体的激动剂或拮抗剂的官能化同族物，其中所述官能化同系物是具有嘌呤核苷部分和嘌呤核苷部分的N6位置的官能团，其中官能团具有式（I）：N6H-Ar1-CH2-C（= O）NH-R1（I），其中Ar1和R1 如本文所定义。还公开了药物组合物，治疗各种疾病的方法和使用这种缀合物的诊断方法。

5. 发明申请

WO2008131426A1 RIBOSOMAL PROTEIN S3: A FUNCTIONAL COMPONENT OF NF-KAPPA B p65 BINDING COMPLEXES 审中-公开
标题翻译： RIBOSOMAL蛋白S3：NF-KAPPA B p65结合复合物的功能组分
公开(公告)号：WO2008131426A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/061306
申请日：2008-04-23
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , LENARDO, Michael , WAN, Fengyi
发明人： LENARDO, Michael , WAN, Fengyi
IPC分类号： C12N15/11
CPC分类号： C07K14/47 , A61K38/00 , C12N15/113 , C12N2310/111 , C12N2310/14
摘要： The invention provides a method of inhibiting the expression of NF-kB target genes in a mammal comprising administering an effective amount of an inhibitor of ribosomal protein S3 (RPS3) to the mammal. The invention also provides a method of inhibiting the induction of immunoglobulin k light chain gene expression in B cells comprising administering an effective amount of an inhibitor of RPS3 to the B cells. The invention further provides a method of treating an inflammatory disease or disorder in a mammal comprising administering an effective amount of an inhibitor of RPS3 to the mammal.
摘要翻译：本发明提供抑制哺乳动物中NF-kB靶基因表达的方法，包括向哺乳动物施用有效量的核糖体蛋白S3（RPS3）抑制剂。本发明还提供抑制B细胞中免疫球蛋白k轻链基因表达诱导的方法，包括向B细胞施用有效量的RPS3抑制剂。本发明进一步提供了治疗哺乳动物炎性疾病或病症的方法，包括向哺乳动物施用有效量的RPS3抑制剂。

6. 发明申请

WO2008112647A3 NITROXIDE RADICAL AS A TREATMENT FOR NEURODEGENERATION 审中-公开
公开(公告)号：WO2008112647A3
公开(公告)日：2008-09-18
申请号：PCT/US2008/056429
申请日：2008-03-10
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , ROUAULT, Tracey , MITCHELL, James, B. , CHERUKURI, Murali, Krishna , GHOSH, Manik
发明人： ROUAULT, Tracey , MITCHELL, James, B. , CHERUKURI, Murali, Krishna , GHOSH, Manik
IPC分类号： A61K31/445 , A61P25/16 , A61P25/28
摘要： A method of treating or preventing neurodegeneration in a mammal comprising administering to the mammal an effective amount of a stable nitroxide radical, such as Tempol, as well as related methods.

7. 发明申请

WO2008070357A2 SMOOTHENED POLYPEPTIDES AND METHODS OF USE 审中-公开
标题翻译：平滑聚合物和使用方法
公开(公告)号：WO2008070357A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/083027
申请日：2007-10-30
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , TARASOVA, Nadya , DEAN, Michael , LOU, Hong
发明人： TARASOVA, Nadya , DEAN, Michael , LOU, Hong
CPC分类号： C07K14/705
摘要： Disclosed is an isolated or purified polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, wherein the portion comprises an amino acid sequence of any of the intracellular loops of the SMO protein, a functional fragment thereof, or a functional variant of either the portion or the functional fragment, wherein the functional fragment comprises at least 7 contiguous amino acids of the intracellular loops, and wherein the functional fragment or functional variant inhibits proliferation of a diseased cell, or a fatty acid derivative thereof. Related conjugates, nucleic acids, recombinant expression vectors, host cells, and pharmaceutical compositions are further provided. Methods of inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention.
摘要翻译：公开了一种分离或纯化的多肽或肽模拟物，其包含Smoothened（SMO）蛋白的一部分的氨基酸序列，其中该部分包含SMO蛋白的任何细胞内环的氨基酸序列，其功能片段或该部分或功能性片段的功能性变体，其中所述功能片段包含细胞内环的至少7个连续氨基酸，并且其中所述功能片段或功能变体抑制病变细胞或其脂肪酸衍生物的增殖。进一步提供相关缀合物，核酸，重组表达载体，宿主细胞和药物组合物。本发明进一步提供了抑制病变细胞增殖，治疗或预防癌症，治疗肿瘤或银屑病以及抑制Hedgehog信号通路参与基因表达从而抑制Hedgehog信号通路的方法。

8. 发明申请

WO2008060287A1 METHOD FOR DETERMINING RISK OF ELDERLY PATIENT UNDER MEDICAL TREATMENT AND RELATED SYSTEMS 审中-公开
标题翻译：用于确定医疗治疗和相关系统下老年患者风险的方法
公开(公告)号：WO2008060287A1
公开(公告)日：2008-05-22
申请号：PCT/US2006/044718
申请日：2006-11-17
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , ABERNETHY, Darrell, R. , MAGER, Donald, E. , HILMER, Sarah
发明人： ABERNETHY, Darrell, R. , MAGER, Donald, E. , HILMER, Sarah
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , G06F19/326 , G16H50/20
摘要： Disclosed are methods for determining risk of a therapeutic treatment regimen and for providing a safe therapeutic treatment regimen comprising calculating a total drug burden index of an elderly patient taking at least one medication, e.g., using the equation: TDB = B AC + B s wherein TDB is the total drug burden index, B AC is a drug burden associated with anticholinergic medications, and Bs is a drug burden associated with sedative medications, wherein B AC and B s are each a sum of the expression, D/(δ + D), for every anticholinergic or sedative medication to which the patient is exposed, wherein D is the daily dose of the medication and δ is the recommended minimum daily dose. The invention also provides related systems and computer readable media.
摘要翻译：公开了用于确定治疗性治疗方案的风险和提供安全的治疗方案的方法，其包括计算服用至少一种药物的老年患者的总药物负荷指数，例如使用以下等式：TDB = 其中TDB是总药物负荷指数，B是与抗胆碱能药物相关的药物负荷，Bs是与镇静药物相关的药物负荷其中每个抗胆碱能药或镇静药物暴露于患者时，其中B和/或B各自为表达D /（d + D）的总和，其中D是药物的日剂量，d是推荐的最小日剂量。本发明还提供了相关系统和计算机可读介质。

9. 发明申请

WO2008024893A2 METHOD OF TREATING OR PREVENTING OXIDATIVE STRESS-RELATED DISEASE 审中-公开
标题翻译：治疗或预防氧化应激相关疾病的方法
公开(公告)号：WO2008024893A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/076597
申请日：2007-08-23
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , GREIG, Nigel, H. , MATTSON, Mark, P. , HABERMAN, Frank , YU, Qian-sheng , ARUMUGAM, Thiruma
发明人： GREIG, Nigel, H. , MATTSON, Mark, P. , HABERMAN, Frank , YU, Qian-sheng , ARUMUGAM, Thiruma
IPC分类号： A61K31/52 , A61K31/522 , A61P17/02 , A61P25/00
CPC分类号： A61K31/52 , A61K31/522
摘要： Disclosed is a method of treating or preventing an oxidative stress-related disease in a mammal in need thereof comprising administering an effective amount of a compound of formula (I) to the mammal, wherein R 1 -R 4 and X 1 -X 3 are as described herein. Examples of the oxidative stress-related diseases are a neurological disorder, a cardiovascular disorder, and a wound.
摘要翻译：公开了一种在有需要的哺乳动物中治疗或预防氧化应激相关疾病的方法，包括向哺乳动物施用有效量的式（I）化合物，其中R 1〜 SUP 4+和X 1 -X 3如本文所述。氧化应激相关疾病的实例是神经障碍，心血管疾病和伤口。

10. 发明申请

WO2008013910A2 METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS 审中-公开
标题翻译：确定，诊断和预测淋巴瘤生存的方法
公开(公告)号：WO2008013910A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016843
申请日：2007-07-25
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BRITISH COLUMBIA CANCER AGENCY (BCCA) , CATALAN INSTITUTE OF ONCOLOGY , RIKSHOSPITALET-RADIUMHOSPITALET MEDICAL CENTER , ST. BARTHOLOMEW'S HOSPITAL , UNIVERSITY OF ARIZONA CANCER CENTER , UNIVERSITY OF BARCELONA , UNIVERSITY OF NEBRASKA MEDICAL CENTER , UNIVERSITY OF ROCHESTER MEDICAL CENTER , UNIVERSITY OF WÜRZBURG , POWELL, John I. , STAUDT, Louis M. , WRIGHT, George , DAVE, Sandeep , TAN, Bruce , WILSON, Wyndham , JAFFE, Elaine , CHAN, Wing C. , GREINER, Timothy C. , WEISENBURGER, Dennis , ARMITAGE, James , FU, Kai , FISHER, Richard I. , RIMSZA, Lisa , MILLER, Thomas , GROGAN, Thomas , CAMPO, Elias , BEA, Silvia M. , SALAVERRIA, Itziar , LOPEZ-GUILLERMO, Armando , MONTSERRAT, Emili , MORENO, Victor , ZETTL, Andreas , OTT, German , MULLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , VOSE, Julie , GASCOYNE, Randy , CONNORS, Joseph , SMELAND, Erlend , KVALOY, Stein , HOLTE, Harald , DELABIE, Jan , LISTER, T. Andrew
发明人： STAUDT, Louis M. , WRIGHT, George , DAVE, Sandeep , TAN, Bruce , WILSON, Wyndham , JAFFE, Elaine , CHAN, Wing C. , GREINER, Timothy C. , WEISENBURGER, Dennis , ARMITAGE, James , FU, Kai , FISHER, Richard I. , RIMSZA, Lisa , MILLER, Thomas , GROGAN, Thomas , CAMPO, Elias , BEA, Silvia M. , SALAVERRIA, Itziar , LOPEZ-GUILLERMO, Armando , MONTSERRAT, Emili , MORENO, Victor , ZETTL, Andreas , OTT, German , MULLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , VOSE, Julie , GASCOYNE, Randy , CONNORS, Joseph , SMELAND, Erlend , KVALOY, Stein , HOLTE, Harald , DELABIE, Jan , LISTER, T. Andrew
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译：基因表达数据为更准确地鉴定和诊断淋巴增生性疾病提供了基础。此外，基因表达数据可用于开发更准确的生存预测指标。本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴增殖性疾病中存活的方法。本发明公开了用于从淋巴瘤样品获得基因表达数据的新型微阵列，淋巴Dx微阵列。本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测诊断患有特定淋巴瘤的受试者的存活的多种方法。这些信息将有助于开发与特定主题结合使用的治疗方法。

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