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1. 发明申请

WO2017184562A1 CMV NEUTRALIZING ANTIGEN BINDING PROTEINS 审中-公开
标题翻译： CMV中和抗原结合蛋白
公开(公告)号：WO2017184562A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028062
申请日：2017-04-18
申请人： MERCK SHARP & DOHME CORP. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FU, Tong-Ming , TANG, Aimin , WANG, Dai , AN, Zhiqiang , ZHANG, Ningyan , HA, Sha
发明人： FU, Tong-Ming , TANG, Aimin , WANG, Dai , AN, Zhiqiang , ZHANG, Ningyan , HA, Sha
IPC分类号： A61K39/00 , A61K39/245 , A61K39/395 , A61K39/42 , C12N7/00 , C12P21/00
摘要： The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that specifically bind to and preferably neutralize human cytomegalovirus (CMV). The antigen binding proteins of the invention are useful as a prophylactic and/or therapeutic agent for preventing and/or treating CMV infections in a patient in need thereof. Also encompassed by the invention are pharmaceutical compositions comprising the antigen binding proteins of the invention and a pharmaceutically acceptable carrier. The invention further relates to methods of using the antigen binding proteins and pharmaceutical compositions of the invention for the prevention or treatment of CMV infection in patients in need thereof.
摘要翻译：本发明涉及抗原结合蛋白，其包括但不限于特异性结合并优选中和人巨细胞病毒（CMV）的单克隆抗体及其抗原结合片段。本发明的抗原结合蛋白可用作在有此需要的患者中预防和/或治疗CMV感染的预防和/或治疗剂。本发明还涵盖包含本发明的抗原结合蛋白和药学上可接受的载体的药物组合物。本发明进一步涉及使用本发明的抗原结合蛋白和药物组合物在有需要的患者中预防或治疗CMV感染的方法。

2. 发明申请

WO2015077624A1 ADENOVIRUS EXPRESSING IMMUNE CELL STIMULATORY RECEPTOR AGONIST(S) 审中-公开
标题翻译： ADENOVIRUS表达免疫细胞刺激受体激动剂（S）
公开(公告)号：WO2015077624A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066920
申请日：2014-11-21
申请人： DNATRIX, INC. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： TUFARO, Frank , FUEYO-MARGARETO, Juan , GOMEZ-MANZANO, Candelaria , CONRAD, Charles , YUNG, W.K., Alfred , JIANG, Hong
IPC分类号： C12N15/63
CPC分类号： C12N7/00 , A61K31/495 , A61K35/761 , A61K38/217 , A61K45/06 , C07K14/52 , C12N2710/10021 , C12N2710/10034 , C12N2840/203
摘要： Certain embodiments include the enhancement of effectiveness for an adenoviral cancer therapy.
摘要翻译：某些实施方案包括增强腺病毒癌疗法的有效性。

3. 发明申请

WO2010088079A2 AUTOMATIC FOCUSING APPARATUS AND METHOD FOR DIGITAL IMAGES USING AUTOMATIC FILTER SWITCHING 审中-公开
标题翻译：利用自动滤波器切换的数字图像的自动聚焦装置和方法
公开(公告)号：WO2010088079A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/021276
申请日：2010-01-15
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , GAMADIA, Mark, N. , KEHTARNAVAZ, Nasser
发明人： GAMADIA, Mark, N. , KEHTARNAVAZ, Nasser
IPC分类号： G03B13/20 , G03B13/18 , G02B7/09
CPC分类号： H04N5/23212
摘要： An apparatus and method for automatically focusing a lens of a digital imaging device, such as a digital still or video camera or camera phone, that reduces the auto focus time while not compromising image sharpness quality and simultaneously reducing device power consumption due to focus actuator movement, all without tuning or adjustment of thresholds or parameters is disclosed. The present invention automatically computes a set of digital band-pass filters matched to the imaging device specifications along with corresponding step-size magnitudes. A filter-switching search for the in-focus focus actuator position is formulated such that filters are switched and step-sizes are reduced as the search gets closer to the in-focus position by utilizing local estimates of the first and second-order differential information of the focus value surface.
摘要翻译：用于自动聚焦诸如数字静止或视频照相机或照相手机的数字成像设备的镜头的设备和方法，其减少自动对焦时间，同时不损害图像清晰度质量并同时减小公开了由于聚焦致动器移动引起的设备功耗，所有这些都没有调整或调整阈值或参数。本发明自动计算与成像设备规格匹配的一组数字带通滤波器以及相应的步长大小。对焦点聚焦致动器位置的滤波器切换搜索被制定为使得通过利用一阶和二阶差分信息的局部估计，当搜索靠近焦点对准位置时切换滤波器并且减小步长的焦点价值表面。

4. 发明申请

WO2010033862A2 METHODS FOR TREATING CANCER 审中-公开
标题翻译：治疗癌症的方法
公开(公告)号：WO2010033862A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057571
申请日：2009-09-18
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CARNEY, Darrell, H.
发明人： CARNEY, Darrell, H.
IPC分类号： A61P35/00 , A61K38/48
CPC分类号： A61K38/4833
摘要： The present invention includes methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist.
摘要翻译：本发明包括治疗受试者的癌症的方法，包括向受试者施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂。

5. 发明申请

WO2010025423A2 MULTIMODE INTERFERENCE COUPLER FOR USE WITH SLOT PHOTONIC CRYSTAL WAVEGUIDES 审中-公开
标题翻译：多功能干涉仪与SLOT PHOTONIC CRYSTAL WAVEGUIDES一起使用
公开(公告)号：WO2010025423A2
公开(公告)日：2010-03-04
申请号：PCT/US2009/055446
申请日：2009-08-28
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CHEN, Xiaonan , CHEN, Ray, T.
发明人： CHEN, Xiaonan , CHEN, Ray, T.
IPC分类号： G02B6/12 , G02B6/26
CPC分类号： G02B6/1225 , B82Y20/00 , G02B6/29344
摘要： The present invention provides an optical apparatus having a multimode interference coupler configured to optically couple a strip waveguide to a slot photonic crystal waveguide. The multimode interference coupler has a coupling efficiency to the slot photonic crystal waveguide greater than or equal to 90%, a width that is approximately equal to a defect width of the slot photonic crystal waveguide, a length that is equal to or less than 1.5 μm, and interfaces with the slot photonic crystal waveguide at an edge of a period that gives a termination parameter of approximately zero. The optical apparatus may also include an insulation gap disposed between the multimode interference coupler and the slot photonic crystal waveguide, wherein the length of the multimode interference coupler is reduced by approximately one half of a width of the insulation gap.
摘要翻译：本发明提供了一种具有多模干涉耦合器的光学装置，其被配置为将条形波导光学耦合到时隙光子晶体波导。多模干扰耦合器对槽隙光子晶体波导具有大于或等于90％的耦合效率，大约等于槽光子晶体波导的缺陷宽度的宽度，等于或小于1.5μm的长度并且在给出约为零的终止参数的周期的边缘处与时隙光子晶体波导接口。光学装置还可以包括设置在多模干涉耦合器和狭缝光子晶体波导之间的绝缘间隙，其中多模干涉耦合器的长度减小绝缘间隙的宽度的大约一半。

6. 发明申请

WO2009070719A1 IMPLANTED DRIVER WITH RESISTIVE CHARGE BALANCING 审中-公开
标题翻译：具有电荷充电平衡的内置驱动器
公开(公告)号：WO2009070719A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/084951
申请日：2008-11-26
申请人： MICRO TRANSPONDER INC. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CAULLER, Lawrence
发明人： CAULLER, Lawrence
IPC分类号： H04B1/04 , A61F2/02
CPC分类号： A61N1/37229 , A61B5/6849 , A61B2560/0219 , A61B2562/028 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N1/3756
摘要： A transponder includes a stimulus driver configured to discharge an electrical stimulus when a trigger signal is received. A first conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus discharged by the stimulus driver. A second conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus conducted by the first conducting electrode. A depolarization resistance connects the first conducting electrode to the second conducting electrode in response to the trigger signal.
摘要翻译：应答器包括被配置为当接收到触发信号时放电电刺激的激励驱动器。第一导电电极耦合到刺激驱动器并且传导由刺激驱动器释放的电刺激。第二导电电极耦合到刺激驱动器并且传导由第一导电电极传导的电刺激。去极化电阻响应于触发信号将第一导电电极连接到第二导电电极。

7. 发明申请

WO2009070709A1 IMPLANTABLE DRIVER WITH CHARGE BALANCING 审中-公开
标题翻译：带有电荷平衡的可移植驱动器
公开(公告)号：WO2009070709A1
公开(公告)日：2009-06-04
申请号：PCT/US2008/084926
申请日：2008-11-26
申请人： MICRO TRANSPONDER INC. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CAULLER, Lawrence
发明人： CAULLER, Lawrence
IPC分类号： H04B1/04 , A61F2/02
CPC分类号： A61N1/37229 , A61B5/6849 , A61B2560/0219 , A61B2562/028 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N1/3756
摘要： A transponder includes a stimulus driver configured to discharge an electrical stimulus when a trigger signal is received. A first conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus discharged by the stimulus driver. A second conducting electrode is coupled to the stimulus driver and conducts the electrical stimulus conducted by the first conducting electrode. A depolarization switch is gated by the trigger signal and connects the first conducting electrode to the second conducting electrode in response to the trigger signal.
摘要翻译：应答器包括被配置为当接收到触发信号时放电电刺激的激励驱动器。第一导电电极耦合到刺激驱动器并且传导由刺激驱动器释放的电刺激。第二导电电极耦合到刺激驱动器并且传导由第一导电电极传导的电刺激。去极化开关由触发信号选通，并响应于触发信号将第一导电电极连接到第二导电电极。

8. 发明申请

WO2009029613A1 APPARATUS FOR PERFORMING MAGNETIC ELECTROPORATION 审中-公开
标题翻译：用于执行磁电气的装置
公开(公告)号：WO2009029613A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/074310
申请日：2008-08-26
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , DAVEY, Kent
发明人： DAVEY, Kent
IPC分类号： C12N13/00
CPC分类号： C12M35/02 , C12N3/00
摘要： An apparatus for performing magnetic electroporation is disclosed. A required electric field for electroporation is generated using a pulsed magnetic field through a closed magnetic yoke, such as a toroid, placed in a flow path of a fluid medium to be processed. The fluid medium flows through the orifice of the magnetic yoke, with the fluid medium flowing through and around the yoke. The required power to send a maximum flux through the magnetic yoke is less than the required power in a conventional apparatus for performing electroporation.
摘要翻译：公开了一种用于执行磁电穿孔的装置。使用放置在要处理的流体介质的流路中的闭环磁轭（例如环形线圈）使用脉冲磁场产生电穿孔所需的电场。流体介质流过磁轭的孔口，流体介质流过轭环。通过磁轭发送最大磁通的所需功率小于用于进行电穿孔的常规装置中所需的功率。

9. 发明申请

WO2007011976A2 CRASH PREDICTION NETWORK WITH VISUAL INPUT FOR VEHICLE 审中-公开
标题翻译：用于车辆视觉输入的CRASH预测网络
公开(公告)号：WO2007011976A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027960
申请日：2006-07-19
申请人： TOYOTA ENGINEERING & MANUFACTURING NORTH AMERICA, INC. , THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , SHERONY, Rini , MIIKKULAINEN, Risto, P. , STANLEY, Kenneth, O. , KOH, Nathaniel, F.
发明人： SHERONY, Rini , MIIKKULAINEN, Risto, P. , STANLEY, Kenneth, O. , KOH, Nathaniel, F.
IPC分类号： G06F15/18
CPC分类号： G06N3/02 , B60W30/095 , G06K9/00805
摘要： A method for facilitating the avoidance of a vehicle collision with an object includes the following steps: a) providing an environment for generating training examples, b) evolving a good driver using a visual input, c) evolving a crash predictor using a visual input, and d) outputting a warning signal.
摘要翻译：一种便于避免与物体的车辆碰撞的方法包括以下步骤：a）提供用于产生训练示例的环境，b）使用可视输入演进好的驾驶员，c）使用视觉输入演进碰撞预测器，以及d）输出警告信号。

10. 发明申请

WO2003061690A1 STIMULATION OF BONE GROWTH AND CARTILAGE FORMATION WITH THROMBING PEPTIDE DERIVATIVES 审中-公开
标题翻译：刺激骨形成蛋白和骨形成蛋白与硫蛋白衍生物
公开(公告)号：WO2003061690A1
公开(公告)日：2003-07-31
申请号：PCT/US2002/001451
申请日：2002-01-17
申请人： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CARNEY, Darrell, H. , CROWTHER, Roger, S. , SIMMONS, David, J. , YANG, Jinping , REDIN, William, R. , STIERNBERG, Janet , BERGMANN, John
发明人： CARNEY, Darrell, H. , CROWTHER, Roger, S. , SIMMONS, David, J. , YANG, Jinping , REDIN, William, R. , STIERNBERG, Janet , BERGMANN, John
IPC分类号： A61K38/48
CPC分类号： A61L27/3817 , A61K38/4833 , A61K2035/128 , A61L27/18 , A61L27/227 , A61L27/3852 , A61L27/3895 , C12N5/0655 , C12N2501/70 , C12N2533/40 , C08L67/04
摘要： Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction or cartilage repair. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site. Also disclosed is a method of stimulating the proliferation and expansion of chrondroxytes in vitro . The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist.
摘要翻译：公开了一种在需要骨诱导或软骨修复的受试者的部位刺激骨生长的方法。该方法包括向该部位施用治疗有效量的非蛋白水解活化的凝血酶受体激动剂的步骤。还公开了一种在体外刺激角质层增生和扩张的方法。该方法包括在刺激量的NPAR激动剂存在下培养软骨细胞。

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