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1. 发明申请

WO2013043744A2 TRICYCLIC COMPOUNDS USEFUL AS NEUROGENIC AND NEUROPROTECTIVE AGENTS 审中-公开
标题翻译：三环类化合物可用于神经原性和神经保护药物
公开(公告)号：WO2013043744A2
公开(公告)日：2013-03-28
申请号：PCT/US2012/056143
申请日：2012-09-19
申请人： INCEPTION 1, INC. , CHEN, Austin, Chih-Yu , SCOTT, Jill, Melissa , STEARNS, Brian, Andrew , STOCK, Nicholas, Simon , TRUONG, Yen, Pham
发明人： CHEN, Austin, Chih-Yu , SCOTT, Jill, Melissa , STEARNS, Brian, Andrew , STOCK, Nicholas, Simon , TRUONG, Yen, Pham
IPC分类号： C07D491/04 , C07D417/06 , C07D279/18 , A61K31/5415 , A61P25/00
CPC分类号： C07D279/28 , C07D487/10 , C07D491/107
摘要： The invention disclosed herein is direct to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in treating neurodegenerative diseases and promoting the generation or survival of neurons in the mammalian brain. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to a method of promoting the generation or survival of neurons in a patient in need thereof in neurodegenerative and related diseases.
摘要翻译：本文公开的发明直接涉及式I化合物及其药学上可接受的盐，其可用于治疗神经退行性疾病并促进哺乳动物脑中神经元的生成或存活。本发明还包括药物组合物，其包含治疗有效量的式I化合物或其药学上可接受的盐。本文公开的发明还涉及促进神经变性和相关疾病中需要其的患者中神经元的产生或存活的方法。

2. 发明申请

WO2012125327A3 ROOF MOUNT ASSEMBLY 审中-公开
标题翻译：屋顶安装组件
公开(公告)号：WO2012125327A3
公开(公告)日：2012-12-27
申请号：PCT/US2012027798
申请日：2012-03-06
申请人： VERMONT SLATE & COPPER SERVICES INC , STEARNS BRIAN CECIL
发明人： STEARNS BRIAN CECIL
IPC分类号： E04D3/36 , E04D13/18
CPC分类号： F24J2/5228 , E04D13/00 , E04D13/10 , E04D13/1407 , E04G21/328 , F24J2/5245 , F24J2002/4676 , G09F7/18 , G09F2007/186 , H01Q1/1221 , Y02B10/20 , Y02E10/47
摘要： A roof attachment assembly for mounting to a roof substrate. The roof attachment assembly comprises a plate having a substantially frustoconical protrusion defining an aperture extending therethrough, the plate defining a first surface and a second surface, the first surface facing the roof substrate and the second surface spaced from the roof substrate. The roof attachment assembly also comprises a membrane positioned adjacent one of the first surface and the second surface of the plate, and a bracket positioned proximate the second surface of the plate, the bracket operable to support one or more roof mounted fixtures. The roof attachment assembly further comprises a fastener extending through the bracket, the membrane and the plate, the fastener operable to couple the bracket, the membrane and the plate together, wherein the roof substrate is contiguous adjacent to an end of the fastener.
摘要翻译：用于安装到屋顶基材上的屋顶附件组件。屋顶附接组件包括板，该板具有限定穿过其延伸的孔的大致截头圆锥形的突出部，板限定第一表面和第二表面，第一表面面向屋顶基板并且第二表面与屋顶基板间隔开。屋顶附接组件还包括邻近板的第一表面和第二表面中的一个定位的膜片以及邻近板的第二表面定位的支架，该支架可操作以支撑一个或多个屋顶安装的固定装置。屋顶附接组件还包括延伸穿过支架，膜和板的紧固件，紧固件可操作以将支架，膜和板联接在一起，其中屋顶基板邻近紧固件的端部邻接。

3. 发明申请

WO2010057118A3 HETEROCYCLIC ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
公开(公告)号：WO2010057118A3
公开(公告)日：2010-05-20
申请号：PCT/US2009/064630
申请日：2009-11-16
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John Howard , STOCK, Nicholas Simon , ROPPE, Jeffrey Roger , STEARNS, Brian Andrew , PARR, Timothy
发明人： HUTCHINSON, John Howard , STOCK, Nicholas Simon , ROPPE, Jeffrey Roger , STEARNS, Brian Andrew , PARR, Timothy
IPC分类号： C07D403/06 , C07D401/06 , C07D231/14 , A61K31/4178 , A61K31/4174 , A61P9/00 , A61P11/00
摘要： Described herein are heteroaryl compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

4. 发明申请

WO2010057118A2 HETEROCYCLIC ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译： PROSTAGLANDIN D2受体的异位拮抗剂
公开(公告)号：WO2010057118A2
公开(公告)日：2010-05-20
申请号：PCT/US2009064630
申请日：2009-11-16
申请人： AMIRA PHARMACEUTICALS INC , HUTCHINSON JOHN HOWARD , STOCK NICHOLAS SIMON , ROPPE JEFFREY ROGER , STEARNS BRIAN ANDREW , PARR TIMOTHY
发明人： HUTCHINSON JOHN HOWARD , STOCK NICHOLAS SIMON , ROPPE JEFFREY ROGER , STEARNS BRIAN ANDREW , PARR TIMOTHY
IPC分类号： C07D403/06 , A61K31/4174 , A61K31/4178 , A61P9/00 , A61P11/00 , C07D231/14 , C07D401/06
CPC分类号： C07D403/06 , A61K31/4174 , A61K31/4178 , C07D231/12 , C07D271/06
摘要： Described herein are heteroaryl compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the heteroaryl compounds described. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译：本文描述的是作为PGD 2受体拮抗剂的杂芳基化合物。还描述了包括所述杂芳基化合物的药物组合物和药物。本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

5. 发明申请

WO2009140642A3 TRICYCLIC ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译： PROSTAGLANDIN D2受体的TRICYCLIC ANTAGONISTS
公开(公告)号：WO2009140642A3
公开(公告)日：2010-03-11
申请号：PCT/US2009044219
申请日：2009-05-15
申请人： AMIRA PHARMACEUTICALS INC , HUTCHINSON JOHN HOWARD , STEARNS BRIAN ANDREW , CLARK RYAN
发明人： HUTCHINSON JOHN HOWARD , STEARNS BRIAN ANDREW , CLARK RYAN
IPC分类号： C07D487/04 , A61K31/445 , A61P11/00 , A61P29/00 , C07D487/02
CPC分类号： C07D471/14
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译：本文描述的是作为PGD 2受体拮抗剂的化合物。还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

6. 发明申请

WO2010008864A3 CYCLOALKANE[B]INDOLE ANGTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
公开(公告)号：WO2010008864A3
公开(公告)日：2010-01-21
申请号：PCT/US2009/048327
申请日：2009-06-23
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John Howard , STEARNS, Brian Andrew , TRUONG, Yen Pham
发明人： HUTCHINSON, John Howard , STEARNS, Brian Andrew , TRUONG, Yen Pham
IPC分类号： C07D209/88 , C07D209/82 , A61K31/403 , A61P9/06
摘要： Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD 2 receptors. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.

7. 发明申请

WO2010003127A2 ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译： PROSTAGLANDIN D2受体的拮抗剂
公开(公告)号：WO2010003127A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049631
申请日：2009-07-02
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , WANG, Bowei , ARRUDA, Jeannie, M. , STEARNS, Brian, Andrew , ROPPE, Jeffrey, Roger
发明人： HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , WANG, Bowei , ARRUDA, Jeannie, M. , STEARNS, Brian, Andrew , ROPPE, Jeffrey, Roger
IPC分类号： C07C69/736 , C07C317/00 , C07C323/57 , C07C323/41 , A61K31/216 , A61K31/10 , A61P37/08 , A61P11/06
CPC分类号： C07C323/42 , A61K31/235 , C07C317/28 , C07C323/41 , C07C323/44 , C07C323/49 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists Of PGD 2 receptors. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.
摘要翻译：本文描述的是作为PGD 2受体拮抗剂的化合物。还描述了药物组合物和药物，其包括本文所述的化合物是PGD 2受体的拮抗剂。本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。

8. 发明申请

WO2009108720A2 ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译：前列腺素D2受体的拮抗剂
公开(公告)号：WO2009108720A2
公开(公告)日：2009-09-03
申请号：PCT/US2009/035174
申请日：2009-02-25
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John Howard , STEARNS, Brian Andrew , SEIDERS, Thomas Jon , SCOTT, Jill Melissa , ARRUDA, Jeannie M. , WANG, Bowei
发明人： HUTCHINSON, John Howard , STEARNS, Brian Andrew , SEIDERS, Thomas Jon , SCOTT, Jill Melissa , ARRUDA, Jeannie M. , WANG, Bowei
IPC分类号： C07D285/04
CPC分类号： C07D285/04 , C07D233/06 , C07D263/22 , C07D263/52
摘要： Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD 2 receptors described herein, as well as methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.
摘要翻译：本文描述的是作为PGDα2受体拮抗剂的化合物。还描述了包含本文描述的PGDα2受体拮抗剂的药物组合物和药物，以及单独或与其组合使用PGDα2受体拮抗剂的方法其他化合物，用于治疗呼吸系统疾病，心血管疾病和其他PGD 2依赖性或PGD 2介导的病症或疾病。

9. 发明申请

WO2009102893A2 CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译：循环二醛化合物作为PROSTAGLANDIN D2受体的拮抗剂
公开(公告)号：WO2009102893A2
公开(公告)日：2009-08-20
申请号：PCT/US2009/033961
申请日：2009-02-12
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , STEARNS, Brian, Andrew , WANG, Bowei , TRUONG, Yen Pham , ARRUDA, Jeannie, M.
发明人： HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , STEARNS, Brian, Andrew , WANG, Bowei , TRUONG, Yen Pham , ARRUDA, Jeannie, M.
IPC分类号： C07D285/04 , A61P37/08 , A61P29/00
CPC分类号： C07D233/32 , C07D207/38 , C07D263/22 , C07D263/52 , C07D413/12 , C07D417/12
摘要： Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD 2 receptors described herein, as well as methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.
摘要翻译：本文描述的是作为PGD 2受体拮抗剂的化合物。还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法介导的病症或疾病。

10. 发明申请

WO2009099902A1 N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开
标题翻译：二取代N，N个接收器前列腺素D <子拮抗剂联苯衍生物
公开(公告)号：WO2009099902A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/032499
申请日：2009-01-29
申请人： AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John Howard , STEARNS, Brian Andrew , SCOTT, Jill Melissa , TRUONG, Yen Pham , ROPPE, Jeffrey Roger , STOCK, Nicholas Simon , ARRUDA, Jeannie M. , SEIDERS, Thomas Jon , WANG, Bowei , VOLKOTS, Deborah
发明人： HUTCHINSON, John Howard , STEARNS, Brian Andrew , SCOTT, Jill Melissa , TRUONG, Yen Pham , ROPPE, Jeffrey Roger , STOCK, Nicholas Simon , ARRUDA, Jeannie M. , SEIDERS, Thomas Jon , WANG, Bowei , VOLKOTS, Deborah
IPC分类号： C07C235/34 , C07C237/10 , C07C313/06
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD 2 receptors. Also described herein are methods of using such antagonists of PGD 2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.
摘要翻译：本发明涉及的化合物PGD 2受体的拮抗剂。本发明还涉及药物组合物和包含，单独地或与其他化合物组合，其是PGD 2受体拮抗剂的上述化合物，以及使用所述PGD 2受体的药物的方法，pourtraiter呼吸系统疾病，由PGD 2或PGD 2依赖性介导的心血管或其它疾病状态或病症。

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