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    • 2. 发明申请
    • CEREBROSPINAL DIFFUSION PHANTOM
    • 骨髓扩张剂
    • WO2017035626A1
    • 2017-03-09
    • PCT/CA2015/050849
    • 2015-09-04
    • SYNAPTIVE MEDICAL (BARBADOS) INC.KERINS, FergalWHITTON, Gregory AllanGMEINER, Timotheus AntonSTAINSBY, Jeff AlanHARRIS, Chad TylerTHINGVOLD, Sheryl Rae
    • KERINS, FergalWHITTON, Gregory AllanGMEINER, Timotheus AntonSTAINSBY, Jeff AlanHARRIS, Chad TylerTHINGVOLD, Sheryl Rae
    • G09B23/30A61B5/055
    • G01R33/58A61B5/055G01R33/4806G01R33/56341G09B23/30
    • Disclosed herein are cerebrospinal diffusion phantoms which include a housing having a shape and size configured for insertion into a magnetic resonance coil in one or more preselected poses. A scaffold support structure is mounted on an interior of said housing and a plurality of elongated diffusion mimicking members supported on the support array. The elongated diffusion mimicking members are affixed to the scaffold support structure such that elongated diffusion mimicking members extend in directions needed to substantially emulate a 3 dimensional arrangement of cerebrospinal diffusion fiber tracts in a living organism; as well as modules for elimination of resolution based-bias, angular accuracy evaluation, diffusion rate calibration, and quality assurance image referencing. Each elongated diffusion mimicking member includes an aqueous component which can undergo diffusion along the elongated diffusion mimicking member. The phantom includes a cerebrospinal tissue mimic matrix material contained in the housing enveloping the array of elongated diffusion mimicking members. The housing is made of a material whose magnetic susceptibility substantially matches that of the cerebrospinal mimic matrix material.
    • 这里公开的是脑脊液扩散体,其包括壳体,该壳体的形状和尺寸被配置为在一个或多个预选姿势中插入到磁共振线圈中。 脚手架支撑结构安装在所述壳体的内部和支撑在支撑阵列上的多个细长扩散模拟构件。 细长的扩散模拟构件被固定到支架支撑结构上,使得细长的扩散模拟构件在基本上模拟生物体中脑脊髓扩散纤维束的3维排列所需的方向上延伸; 以及用于消除基于分辨率偏差,角度精度评估,扩散速率校准和质量保证图像引用的模块。 每个细长扩散模拟构件包括可以沿着细长扩散模拟构件扩散的水性组分。 幻影包括包含在壳体中的脑脊液组织模拟基质材料,其包围细长的扩散模拟构件阵列。 壳体由其磁化率基本上与脑脊液模拟基质材料的磁化率相匹配的材料制成。