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1. 发明申请

WO2009085096A2 NON-LEACHING, NON-FOULING ANTIMICROBIAL COATINGS 审中-公开
标题翻译：非浸出，非脱落抗微生物涂料
公开(公告)号：WO2009085096A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/013425
申请日：2008-12-05
申请人： SEMPRUS BIOSCIENCES CORPORATION , O'SHAUGHNESSEY, William, Shannan , ZHANG, Zheng , HENCKE, Michael , WOOD, Kris , SQUIER, Trevor, Lee , LOOSE, Christopher, R.
发明人： O'SHAUGHNESSEY, William, Shannan , ZHANG, Zheng , HENCKE, Michael , WOOD, Kris , SQUIER, Trevor, Lee , LOOSE, Christopher, R.
IPC分类号： A61L29/16 , A61K38/16 , A61K38/10 , C07K14/00 , C07K7/04 , A61L15/44 , A61L31/16 , A61L27/54 , A61P31/04
CPC分类号： C07K17/08 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/404 , C07K7/08 , C07K14/43563 , C09D5/1637
摘要： Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic.
摘要翻译：本文描述了包含固定在具有相关生物环境中的活性的基质上的一种或多种类型的膜靶向抗微生物剂的组合物及其制备和使用方法。抗微生物剂在血液蛋白质存在下和/或体内保留其活性，因为改进的分子结构允许固定化剂和抵抗非特异性蛋白质吸附的亲水化学物质的协同作用。合适的分子结构包括支链结构，例如树枝状聚合物和无规分支的聚合物。分子结构还可以包括提供灵活性和对非特异性蛋白质吸附的抗性的亲水系链。膜靶向抗微生物剂涂层可以应用于各种不同类型的基底，包括医疗植入物，例如血管移植物，矫形装置，透析入口移植物和导管; 手术工具，手术衣服; 和绷带。基板可以由金属材料，陶瓷，聚合物，纤维，惰性材料如硅构成，以及它们的组合。本文所述的组合物基本上是非浸出的，对非特异性蛋白质吸附抗性和非溶血性的。

2. 发明申请

WO2009085096A3 NON-LEACHING, NON-FOULING ANTIMICROBIAL COATINGS 审中-公开
标题翻译：非浸出，非污染抗微生物涂料
公开(公告)号：WO2009085096A3
公开(公告)日：2009-11-26
申请号：PCT/US2008013425
申请日：2008-12-05
申请人： SEMPRUS BIOSCIENCES CORP , O'SHAUGHNESSEY WILLIAM SHANNAN , ZHANG ZHENG , HENCKE MICHAEL , WOOD KRIS , SQUIER TREVOR LEE , LOOSE CHRISTOPHER R
发明人： O'SHAUGHNESSEY WILLIAM SHANNAN , ZHANG ZHENG , HENCKE MICHAEL , WOOD KRIS , SQUIER TREVOR LEE , LOOSE CHRISTOPHER R
IPC分类号： C07K17/08 , A01N25/10 , A01N37/46 , A61L27/22 , A61L29/08
CPC分类号： C07K17/08 , A61L15/46 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/404 , C07K7/08 , C07K14/43563 , C09D5/1637
摘要： Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic.
摘要翻译：本文描述了含有一种或多种类型的靶向膜的抗微生物剂的组合物，所述抗微生物剂固定在相关生物环境中具有活性的底物上，以及其制备和使用方法。由于改进的分子结构使得抗微生物剂在血蛋白存在下和/或在体内保持其活性，所述分子结构允许固定剂和亲水化学物质协同作用，所述化学物质抵抗非特异性蛋白质吸附。合适的分子结构包括支化结构，例如树枝状聚合物和无规支化聚合物。分子结构还可以包括对非特异性蛋白吸附提供弹性和抗性的亲水链。膜靶向抗微生物剂涂层可以应用于各种不同类型的基底，包括医用植入物如血管移植物，矫形装置，透析通路移植物和导管; 手术工具，外科手术服装; 和绷带。基材可以由金属材料，陶瓷，聚合物，纤维，惰性材料如硅及其组合组成。本文所述的组合物基本上不浸出，对非特异性蛋白质吸附具有抗性，并且不具有溶血性。

3. 发明申请

WO2009075788A1 SYNTHETIC NON-FOULING AMINO ACIDS 审中-公开
标题翻译：合成不溶性氨基酸
公开(公告)号：WO2009075788A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/013419
申请日：2008-12-05
申请人： SEMPRUS BIOCIENCES CORPORATION , ZHANG, Zheng , O'SHAUGHNESSEY, William, Shannan , HENCKE, Michael , SQUIER, Trevor, Lee , LOOSE, Christopher, R.
发明人： ZHANG, Zheng , O'SHAUGHNESSEY, William, Shannan , HENCKE, Michael , SQUIER, Trevor, Lee , LOOSE, Christopher, R.
IPC分类号： C07C229/26 , C07K2/00
CPC分类号： C07C229/26 , C07C233/47
摘要： Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: (I), where L is a linker group and Z is a non-fouling group including, but not limited to, polyethylene glycol (PEG); oligoethylene glycol (OEG); zwitterionic group, such as phosphorycholine, carboxybetaine, and sulfobetaine; groups that are hydrogen bond acceptors but not hydrogen bond donors. The non-fouling amino acids can be incorporated into a bioactive peptide as single amino acid residues, multiples amino acid residues, or as blocks of amino acids. The non-fouling amino acids, or peptides containing one or more non-fouling amino acids, can be applied to surfaces in order to improve biocompatibility, reduce thrombogenesis, and/or reduce fouling by proteins or bacteria present in solution.
摘要翻译：含有一个或多个非结垢基团或部分的合成氨基酸在本文中描述。在一个实施方案中，氨基酸具有以下化学式：（I），其中L是连接基团，Z是非结垢基团，包括但不限于聚乙二醇（PEG）; 低聚乙二醇（OEG）; 两性离子基团，如磷酸胆碱，羧基甜菜碱和磺基甜菜碱; 基团是氢键受体而不是氢键供体。非结垢的氨基酸可以作为单个氨基酸残基，多个氨基酸残基或作为氨基酸的嵌段结合到生物活性肽中。含有一个或多个非结垢性氨基酸的非结垢性氨基酸或多肽可以施用于表面，以便提高溶液中存在的蛋白质或细菌的生物相容性，减少血栓发生和/或减少结垢。

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