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1. 发明申请

WO2006096834A2 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH 审中-公开
标题翻译：水解物，核酸编码方法及提高纸张强度的方法
公开(公告)号：WO2006096834A2
公开(公告)日：2006-09-14
申请号：PCT/US2006/008555
申请日：2006-03-08
申请人： DIVERSA CORPORATION , KEROVUO, Janne, S. , MCCANN, Ryan , WEINER, David , SOLBAK, Arne, I., Jr.
发明人： KEROVUO, Janne, S. , MCCANN, Ryan , WEINER, David , SOLBAK, Arne, I., Jr.
IPC分类号： C12N9/42
CPC分类号： C12P7/6454 , C11C1/045 , C11C3/08 , C11C3/10 , C12N9/16 , C12N9/20 , C12P7/62 , C12P7/6418 , C12P7/6427 , Y10T442/20
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). In another aspect, the invention provides methods for hydrolyzing steryl esters and triglycerides (e.g., in a paper pulp), into sterols, glycerol and free fatty acids, using enzyme(s) of the invention. The invention provides enzymes and methods for decreasing the amount of lipophilic extracts ("pitch") in a pulp- comprising composition. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括耐热和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。另一方面，本发明提供了使用本发明的酶将甾醇酯和甘油三酯（例如在纸浆中）水解成甾醇，甘油和游离脂肪酸的方法。本发明提供用于减少含纸浆组合物中的亲脂性提取物（“沥青”）量的酶和方法。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。

2. 发明申请

WO2010135588A3 PHYTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： PHYTASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：WO2010135588A3
公开(公告)日：2011-01-13
申请号：PCT/US2010035667
申请日：2010-05-20
申请人： VERENIUM CORP , WEINER DAVID P , SOLBAK ARNE I JR , MCCANN RYAN
发明人： WEINER DAVID P , SOLBAK ARNE I JR , MCCANN RYAN
IPC分类号： C07H21/04
CPC分类号： C12N9/16 , Y02E50/17 , Y10T428/2982
摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The invention further provides phytases which have increased gastric lability. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate.
摘要翻译：本发明涉及植酸酶，编码它们的多核苷酸，本发明的多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生和分离。特别地，本发明提供了在高温条件下具有植酸酶活性的多肽，以及暴露于高温后保留活性的植酸酶。本发明还提供了具有增加的胃不适性的植酸酶。本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以配制成食品或饲料或补充剂，以便例如帮助消化植酸盐。

3. 发明申请

WO2010135588A2 PHYTASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： PHYTASES，NUCLEIC ACID ENCODING THEM AND METHODS FOR MAKING AND USING THEM
公开(公告)号：WO2010135588A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035667
申请日：2010-05-20
申请人： VERENIUM CORPORATION , WEINER, David, P. , SOLBAK, Arne, I., Jr. , MCCANN, Ryan
发明人： WEINER, David, P. , SOLBAK, Arne, I., Jr. , MCCANN, Ryan
IPC分类号： A01K67/027 , A01H5/00
CPC分类号： C12N9/16 , Y02E50/17 , Y10T428/2982
摘要： This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The invention further provides phytases which have increased gastric lability. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.
摘要翻译：本发明涉及植酸酶，编码它们的多核苷酸，本发明的多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生和分离。特别地，本发明提供了在高温条件下具有植酸酶活性的多肽，以及暴露于高温后保留活性的植酸酶。本发明还提供了具有增加的胃不适性的植酸酶。本发明的植酸酶可用于食品中以改善富含植酸盐的成分的摄食量。本发明的植酸酶可以配制成食物或饲料或补充剂，用于例如帮助消化植酸盐。本发明的食品或饲料可以是丸粒，液体，粉末等的形式。在一个方面，本发明的植酸酶在造粒期间对于热变性是稳定的; 并且这降低了植酸酶产品的成本，同时保持了体内功效并检测了饲料中的活性。

4. 发明申请

WO2006096834A3 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH 审中-公开
标题翻译：水解物，核酸编码方法及提高纸张强度的方法
公开(公告)号：WO2006096834A3
公开(公告)日：2009-08-27
申请号：PCT/US2006008555
申请日：2006-03-08
申请人： DIVERSA CORP , KEROVUO JANNE S , MCCANN RYAN , WEINER DAVID , SOLBAK ARNE I JR
发明人： KEROVUO JANNE S , MCCANN RYAN , WEINER DAVID , SOLBAK ARNE I JR
IPC分类号： C12P21/06 , A23L35/00 , C07H21/00 , C07K14/00 , C12N1/21 , C12N5/10 , C12N9/14 , C12N15/00 , C12Q1/34
CPC分类号： C12P7/6454 , C11C1/045 , C11C3/08 , C11C3/10 , C12N9/16 , C12N9/20 , C12P7/62 , C12P7/6418 , C12P7/6427 , Y10T442/20
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). In another aspect, the invention provides methods for hydrolyzing steryl esters and triglycerides (e.g., in a paper pulp), into sterols, glycerol and free fatty acids, using enzyme(s) of the invention. The invention provides enzymes and methods for decreasing the amount of lipophilic extracts ('pitch') in a pulp- comprising composition. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括耐热和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。另一方面，本发明提供了使用本发明的酶将甾醇酯和甘油三酯（例如在纸浆中）水解成甾醇，甘油和游离脂肪酸的方法。本发明提供用于减少含纸浆组合物中亲脂性提取物（“沥青”）量的酶和方法。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。

5. 发明申请

WO2006096834A8 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH 审中-公开
标题翻译：水解物，核酸编码方法及提高纸张强度的方法
公开(公告)号：WO2006096834A8
公开(公告)日：2007-05-10
申请号：PCT/US2006008555
申请日：2006-03-08
申请人： DIVERSA CORP , KEROVUO JANNE S , MCCANN RYAN , WEINER DAVID , SOLBAK ARNE I JR
发明人： KEROVUO JANNE S , MCCANN RYAN , WEINER DAVID , SOLBAK ARNE I JR
IPC分类号： C12N9/42 , A23L35/00
CPC分类号： C12P7/6454 , C11C1/045 , C11C3/08 , C11C3/10 , C12N9/16 , C12N9/20 , C12P7/62 , C12P7/6418 , C12P7/6427 , Y10T442/20
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). In another aspect, the invention provides methods for hydrolyzing steryl esters and triglycerides (e.g., in a paper pulp), into sterols, glycerol and free fatty acids, using enzyme(s) of the invention. The invention provides enzymes and methods for decreasing the amount of lipophilic extracts ("pitch") in a pulp- comprising composition. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和D活性，patatin活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括热稳定和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间脂肪酸的交换）酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。另一方面，本发明提供了使用本发明的酶将甾醇酯和甘油三酯（例如在纸浆中）水解成甾醇，甘油和游离脂肪酸的方法。本发明提供用于减少含纸浆组合物中的亲脂性提取物（“沥青”）量的酶和方法。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。

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