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1. 发明申请

WO2010036640A3 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：WO2010036640A3
公开(公告)日：2010-08-12
申请号：PCT/US2009057805
申请日：2009-09-22
申请人： SCHERING CORP , WONG MICHAEL K C , YU WENSHENG , TONG LING , LAVEY BRIAN J , SHANKAR BANDARPALLE B , KOZLOWSKI JOSEPH A , KIM SEONG HEON , ZHOU GUOWEI , YANG DE-YI , RIZVI RAZIA K , CHEN LEI , KOSINSKI ANETA MARIA , ROSNER KRISTEN E , FIRE LUKE , RICHARD JUDSON E , LI DANSU
发明人： WONG MICHAEL K C , YU WENSHENG , TONG LING , LAVEY BRIAN J , SHANKAR BANDARPALLE B , KOZLOWSKI JOSEPH A , KIM SEONG HEON , ZHOU GUOWEI , YANG DE-YI , RIZVI RAZIA K , CHEN LEI , KOSINSKI ANETA MARIA , ROSNER KRISTEN E , FIRE LUKE , RICHARD JUDSON E , LI DANSU
IPC分类号： C07D403/06 , A61K31/33 , A61P19/00 , C07D403/14 , C07D405/14 , C07D491/048
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- a combinations thereof.
摘要翻译：本发明涉及本文定义的式（I） - （IX）：或其药学上可接受的盐，溶剂合物或酯的化合物，其可用于治疗由MMP，ADAM，TACE介导的疾病或病症，聚集蛋白聚糖酶，TNF-它们的组合。

2. 发明申请

WO2010036638A2 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：WO2010036638A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/057798
申请日：2009-09-22
申请人： SCHERING CORPORATION , SHANKAR, Bandarpalle, B. , KIM, Seong, Heon , YU, Wensheng , TONG, Ling , WONG, Michael, K. C. , LAVEY, Brian J. , KOZLOWSKI, Joseph, A. , CHEN, Lei , RIZVI, Razia, K. , KOSINSKI, Aneta, Maria , YANG, De-Yi , ZHOU, Guowei , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
发明人： SHANKAR, Bandarpalle, B. , KIM, Seong, Heon , YU, Wensheng , TONG, Ling , WONG, Michael, K. C. , LAVEY, Brian J. , KOZLOWSKI, Joseph, A. , CHEN, Lei , RIZVI, Razia, K. , KOSINSKI, Aneta, Maria , YANG, De-Yi , ZHOU, Guowei , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
IPC分类号： A61K31/425 , C07D417/02
CPC分类号： C07D403/14 , C07D403/06 , C07D405/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I): [Chemical formula should be inserted here as it appears on abstract in pdf form.] (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）的化合物：[化学式应该在本文中以pdf的形式以抽象形式插入]（I），或其药学上可接受的盐，溶剂合物或酯，其可以是可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖蛋白酶，TNF-或其组合介导的疾病或病症。

3. 发明申请

WO2007084415A3 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
公开(公告)号：WO2007084415A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000930
申请日：2007-01-16
申请人： SCHERING CORPORATION , YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert
发明人： YU, Wensheng , TONG, Ling , CHEN, Lei , KOZLOWSKI, Joseph, A. , LAVEY, Brian, J. , SHIH, Neng-Yang , MADISON, Vincent, S. , ZHOU, Guowei , ORTH, Peter , GUO, Zhuyan , WONG, Michael, K.C. , YANG, De-Yi , KIM, Seong-Heon , SHANKAR, Bandarpalle, B. , SIDDIQUI, M., Arshad , ROSNER, Kristin, E. , DAI, Chaoyang , POPOVICI-MULLER, Janeta , GIRIJAVALLABHAN, Vinay, M. , LI, Dansu , RIZVI, Razia , MICULA, Aneta, S , FELTZ, Robert
IPC分类号： C07D401/14 , C07D403/06 , A61P35/00 , A61K31/4166 , C07D471/04 , C07D473/34 , C07D473/00 , C07D491/04 , C07D495/04 , C07D417/14 , C07D413/14 , C07D405/14 , C07D403/14
摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.

4. 发明申请

WO2007084415A2 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗炎症性疾病的化合物
公开(公告)号：WO2007084415A2
公开(公告)日：2007-07-26
申请号：PCT/US2007000930
申请日：2007-01-16
申请人： SCHERING CORP , YU WENSHENG , TONG LING , CHEN LEI , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , SHIH NENG-YANG , MADISON VINCENT S , ZHOU GUOWEI , ORTH PETER , GUO ZHUYAN , WONG MICHAEL K C , YANG DE-YI , KIM SEONG-HEON , SHANKAR BANDARPALLE B , SIDDIQUI M ARSHAD , ROSNER KRISTIN E , DAI CHAOYANG , POPOVICI-MULLER JANETA , GIRIJAVALLABHAN VINAY M , LI DANSU , RIZVI RAZIA , MICULA ANETA S , FELTZ ROBERT
发明人： YU WENSHENG , TONG LING , CHEN LEI , KOZLOWSKI JOSEPH A , LAVEY BRIAN J , SHIH NENG-YANG , MADISON VINCENT S , ZHOU GUOWEI , ORTH PETER , GUO ZHUYAN , WONG MICHAEL K C , YANG DE-YI , KIM SEONG-HEON , SHANKAR BANDARPALLE B , SIDDIQUI M ARSHAD , ROSNER KRISTIN E , DAI CHAOYANG , POPOVICI-MULLER JANETA , GIRIJAVALLABHAN VINAY M , LI DANSU , RIZVI RAZIA , MICULA ANETA S , FELTZ ROBERT
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D495/04
摘要： This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯或异构体，其可用于治疗由MMP，ADAM，TACE，聚集蛋白聚糖酶，TNF-或其组合介导的疾病或病症。

5. 发明申请

WO2006088921A2 PYRAZINYL SUBSTITUTED PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CXCR3拮抗活性的吡嗪基取代的哌嗪 - 哌啶
公开(公告)号：WO2006088921A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005267
申请日：2006-02-14
申请人： SCHERING CORPORATION , PHARMACOPEIA DRUG DISCOVERY, INC. , ROSENBLUM, Stuart, B. , KIM, Seong, Heon , ZENG, Qingbei , WONG, Michael, K.C. , ANILKUMAR, Gopinadhan, N. , JIANG, Yueheng , YU, Wensheng , KOZLOWSKI, Joseph, A. , SHIH, Neng-Yang , SHANKAR, Bandarpalle, B. , MCGUINNESS, Brian, F. , DONG, Guizhen , ZAWACKI, Lisa, Guise , HOBBS, Douglas, W. , BALDWIN, John, J. , SHAO, Yuefei
发明人： ROSENBLUM, Stuart, B. , KIM, Seong, Heon , ZENG, Qingbei , WONG, Michael, K.C. , ANILKUMAR, Gopinadhan, N. , JIANG, Yueheng , YU, Wensheng , KOZLOWSKI, Joseph, A. , SHIH, Neng-Yang , SHANKAR, Bandarpalle, B. , MCGUINNESS, Brian, F. , DONG, Guizhen , ZAWACKI, Lisa, Guise , HOBBS, Douglas, W. , BALDWIN, John, J. , SHAO, Yuefei
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , A61K31/445 , A61K31/495
CPC分类号： C07D405/14 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula (1): Chemical formula should be inserted here as it appears on the abstract in paper form. and the pharmaceutically acceptable salts, solvates and esters thereof. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases ( e.g. , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula (1).
摘要翻译：本申请公开了所述化合物的一种或多种对映异构体，立体异构体，旋转异构体，互变异构体，外消旋体或前药，或所述化合物或所述前药的可药用盐，溶剂合物或酯，所述化合物具有式（1）所示的一般结构：化学式应插入此处，因为它以摘要形式出现在纸上。及其药学上可接受的盐，溶剂化物和酯。还公开了治疗趋化因子介导的疾病的方法，例如姑息性治疗，治愈性治疗，某些疾病和病症的预防性治疗，例如炎性疾病（非限制性实例包括牛皮癣），自身免疫性疾病（非限制性实例（包括类风湿性关节炎，多发性硬化），移植排斥（非限制性实例包括同种异体移植排斥，异种移植排斥），感染性疾病（例如结核性麻风），固定药疹，皮肤迟发型超敏反应，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式（1）化合物的肿瘤。

6. 发明申请

WO2012018534A2 SUBSTITUTED BIPHENYLENE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：替代联苯胺化合物及其用于治疗病毒性疾病的方法
公开(公告)号：WO2012018534A2
公开(公告)日：2012-02-09
申请号：PCT/US2011044769
申请日：2011-07-21
申请人： SCHERING CORP , KOZLOWSKI JOSEPH A , SHANKAR BANDARPALLE B
发明人： KOZLOWSKI JOSEPH A , SHANKAR BANDARPALLE B
IPC分类号： A61K31/695
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/439 , A61K31/695 , A61K45/06 , C07D401/14 , C07D403/04 , C07F7/0816
摘要： The present invention relates to novel Substituted Biphenylene Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein Y1, Y2, R1, R2, R4, Ra and Rb are as defined herein. The present invention also relates to compositions comprising at least one Substituted Biphenylene Compound, and methods of using the Substituted Biphenylene Compounds for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的新型取代的联苯化合物：（I）及其药学上可接受的盐，其中Y1，Y2，R1，R2，R4，Ra和Rb如本文所定义。本发明还涉及包含至少一种取代的联苯化合物的组合物，以及使用所述取代的联苯化合物治疗或预防患者HCV感染的方法。

7. 发明申请

WO2010036640A2 COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
标题翻译：治疗炎性疾病的化合物
公开(公告)号：WO2010036640A2
公开(公告)日：2010-04-01
申请号：PCT/US2009/057805
申请日：2009-09-22
申请人： SCHERING CORPORATION , WONG, Michael, K., C. , YU, Wensheng , TONG, Ling , LAVEY, Brian, J. , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , KIM, Seong, Heon , ZHOU, Guowei , YANG, De-Yi , RIZVI, Razia, K. , CHEN, Lei , KOSINSKI, Aneta, Maria , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
发明人： WONG, Michael, K., C. , YU, Wensheng , TONG, Ling , LAVEY, Brian, J. , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , KIM, Seong, Heon , ZHOU, Guowei , YANG, De-Yi , RIZVI, Razia, K. , CHEN, Lei , KOSINSKI, Aneta, Maria , ROSNER, Kristen, E. , FIRE, Luke , RICHARD, Judson, E. , LI, Dansu
IPC分类号： A61K31/4725
CPC分类号： C07D405/14 , C07D403/06 , C07D403/14 , C07D491/048
摘要： This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- α combinations thereof.
摘要翻译：本发明涉及如本文所定义的式（I） - （IX）的化合物或其药学上可接受的盐，溶剂化物或酯，其可用于治疗疾病或由MMPs，ADAMs，TACE，聚集蛋白聚糖酶，TNF-α组合介导的病症。

8. 发明申请

WO2007047202A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CXCR3拮抗剂活性的取代的杂环化合物
公开(公告)号：WO2007047202A1
公开(公告)日：2007-04-26
申请号：PCT/US2006/039404
申请日：2006-10-10
申请人： SCHERING CORPORATION , KIM, Seong, Heon , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang
发明人： KIM, Seong, Heon , SHANKAR, Bandarpalle, B. , KOZLOWSKI, Joseph, A. , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang
IPC分类号： C07D401/14 , C07D413/14 , A61K31/497 , A61P29/00
CPC分类号： C07D401/14 , C07D401/08 , C07D413/14
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula (1) , or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non-limiting example(s) include, psoriasis), autoimmune diseases (non-limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non-limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed-type hypersensitivity responses, type I diabetes, viral meningitis and tumors using a compound of Formula (1).
摘要翻译：本申请公开了所述化合物或所述前体药物的所述化合物或其药学上可接受的盐，溶剂合物或酯的化合物或对映体，立体异构体，旋转异构体，互变异构体，前体药物，所述化合物具有式 1）或其药学上可接受的盐，溶剂合物或酯，其中各种部分在本文中定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息治疗，疗效治疗，某些疾病和疾病如炎性疾病的预防性治疗（非限制性实例，牛皮癣），自身免疫性疾病（非限制性的例如，类风湿性关节炎，多发性硬化症），移植排斥反应（非限制性实例包括，同种异体移植排斥反应，异种移植物排斥），感染性疾病（例如结核性麻风病），固定药物爆发，皮肤迟发型超敏反应应答，I型糖尿病，病毒性脑膜炎和使用式（1）的化合物的肿瘤。

9. 发明申请

WO2006088836A2 PIPERAZINE-PIPERIDINES WITH CXCR3 ANTAGONIST ACTIVITY 审中-公开
标题翻译：具有CXCR3拮抗剂活性的哌嗪哌啶
公开(公告)号：WO2006088836A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005121
申请日：2006-02-14
申请人： SCHERING CORPORATION , PHARMACOPEIA DRUG DISCOVERY, INC. , YU, Wensheng , KIM, Seong, Heon , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , SHANKAR, Bandarpalle, B. , MCGUINNESS, Brian, F. , HOBBS, Douglas, W. , SHAO, Yuefei
发明人： YU, Wensheng , KIM, Seong, Heon , ANILKUMAR, Gopinadhan, N. , ROSENBLUM, Stuart, B. , SHANKAR, Bandarpalle, B. , MCGUINNESS, Brian, F. , HOBBS, Douglas, W. , SHAO, Yuefei
IPC分类号： C07D487/04 , C07D401/12 , A61K31/445 , A61K31/495
CPC分类号： C07D487/04 , C07D401/12
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1 or a pharmaceutically acceptable salt, solvate or ester thereof, wherein the various moieties are defined herein. Also disclosed is a method of treating chemokine mediated diseases, such as, palliative therapy, curative therapy, prophylactic therapy of certain diseases and conditions such as inflammatory diseases (non limiting example(s) include, psoriasis), autoimmune diseases (non limiting example(s) include, rheumatoid arthritis, multiple sclerosis), graft rejection (non limiting example(s) include, allograft rejection, xenograft rejection), infectious diseases (e.g , tuberculoid leprosy), fixed drug eruptions, cutaneous delayed type hypersensitivity responses, ophthalmic inflammation, type I diabetes, viral meningitis and tumors using a compound of Formula 1.
摘要翻译：本申请公开了所述化合物的一种或多种对映异构体，立体异构体，旋转异构体，互变异构体，外消旋体或前药，或所述化合物或所述前药的可药用盐，溶剂合物或酯，所述化合物具有式1所示的一般结构或其药学上可接受的盐，溶剂化物或酯，其中各种部分如本文所定义。还公开了治疗趋化因子介导的疾病的方法，例如姑息性治疗，治愈性治疗，某些疾病和病症的预防性治疗，例如炎性疾病（非限制性实例包括牛皮癣），自身免疫性疾病（非限制性实例（包括类风湿性关节炎，多发性硬化症），移植排斥（非限制性实例包括同种异体移植排斥，异种移植排斥），感染性疾病（例如结核性麻风），固定药物疹，皮肤迟发型超敏反应，眼部炎症，I型糖尿病，病毒性脑膜炎和使用式1化合物的肿瘤。

10. 发明申请

WO2004085385A2 CANNABINOID RECEPTOR LIGANDS 审中-公开
标题翻译： CANNABINOID受体配体
公开(公告)号：WO2004085385A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008333
申请日：2004-03-18
申请人： SCHERING CORPORATION , SHANKAR, Bandarpalle, B. , RIZVI, Razia, K. , KOZLOWSKI, Joseph, A. , SHIH, Neng-Yang
发明人： SHANKAR, Bandarpalle, B. , RIZVI, Razia, K. , KOZLOWSKI, Joseph, A. , SHIH, Neng-Yang
IPC分类号： C07C317/00
CPC分类号： C07D213/80 , C07C317/14 , C07C317/22 , C07C317/36 , C07C2601/02 , C07D209/30 , C07D211/54 , C07D213/71 , C07D213/89 , C07D239/38 , C07D295/205 , C07D307/64 , C07D333/34 , C07D401/12 , C07D405/12 , C07D493/08
摘要： There are disclosed compounds of the formula (I) a pharmaceutically acceptable salt or solvate of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.
摘要翻译：公开了具有抗炎和免疫调节活性的化合物的药学上可接受的盐或溶剂合物的式（I）化合物。还公开了含有所述化合物的药物组合物。

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