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1. 发明申请

WO2011047013A1 NITRIC OXIDE-RELEASING COATINGS 审中-公开
标题翻译：硝酸氧化物涂层
公开(公告)号：WO2011047013A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052460
申请日：2010-10-13
申请人： NOVAN, INC. , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , STASKO, Nathan , SCHOENFISCH, Mark , PRIVETT, Benjamin , SHIN, Jae Ho , STORM, Wesley
发明人： STASKO, Nathan , SCHOENFISCH, Mark , PRIVETT, Benjamin , SHIN, Jae Ho , STORM, Wesley
IPC分类号： C09D5/00
CPC分类号： A61K33/00 , C09D5/08 , C09D183/08 , Y10T428/31663
摘要： Provided according to embodiments of the invention are NO-releasing sol-gel coating formed from a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane. Further provided are methods of producing NO-releasing sol-gel coatings. Such methods may include (a) co-condensing a sol precursor solution comprising a backbone alkoxysilane and a diazeniumdiolate-modified alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; and (c) drying the sol to form the NO-releasing sol-gel coating.
摘要翻译：根据本发明的实施方案提供的是由包含骨架烷氧基硅烷和二氮烯鎓二硫醇盐改性的烷氧基硅烷的溶胶前体溶液形成的释放NO的溶胶 - 凝胶涂层。还提供了生产释放NO的溶胶 - 凝胶涂层的方法。这样的方法可以包括（a）在溶剂中将包含骨架烷氧基硅烷和二氮烯鎓二硫醇盐改性的烷氧基硅烷的溶胶前体溶液共聚以形成溶胶; （b）用溶胶涂布基材; 和（c）干燥溶胶以形成释放NO的溶胶 - 凝胶涂层。

2. 发明申请

WO2009049208A1 USE OF NITRIC OXIDE TO ENHANCE THE EFFICACY OF SILVER AND OTHER TOPICAL WOUND CARE AGENTS 审中-公开
标题翻译：使用氮氧化物以提高银和其他局部保护剂的效率
公开(公告)号：WO2009049208A1
公开(公告)日：2009-04-16
申请号：PCT/US2008/079582
申请日：2008-10-10
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SCHOENFISCH, Mark, H. , HETRICK, Evan, M. , STASKO, Nathan, A. , JOHNSON, C., Bryce
发明人： SCHOENFISCH, Mark, H. , HETRICK, Evan, M. , STASKO, Nathan, A. , JOHNSON, C., Bryce
IPC分类号： A61K31/33 , A61K33/38 , A61K45/06 , A61P31/00 , A61P31/12 , A61P17/02
CPC分类号： A61K31/695 , A61K31/33 , A61K33/00 , A61K33/38 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to compositions comprising at least one nitric oxide donor and at least one second therapeutically active agent with antimicrobial or wound healing capability. In one embodiment, the nitric oxide donor is a nanoparticle which is designed to control for the amount and duration of release of nitric oxide. The nanoparticle may further comprise the additional therapeutically active agent. The composition is useful for enhancing wound healing and for treating and preventing microbial infection. In one embodiment, the composition is directed toward reducing oral bacteria or dental plaque. The combination of one or more nitric oxide donors and one or more additional therapeutically active agent results in unexpected synergistic effects, wherein both the antimicrobial efficacy of the nitric oxide and the antimicrobial or wound healing efficacy of the second therapeutically active agent are enhanced. As a result, a patient may benefit from reduced dosage requirements and a reduced likelihood of antimicrobial resistance. The composition may be formulated for local or systemic administration, for topical applications as well as for use in coatings for medical supplies and devices.
摘要翻译：本发明涉及包含至少一种一氧化氮供体和至少一种具有抗微生物或伤口愈合能力的第二治疗活性剂的组合物。在一个实施方案中，一氧化氮供体是纳米颗粒，其被设计成控制一氧化氮释放的量和持续时间。纳米颗粒可以进一步包含另外的治疗活性剂。该组合物可用于增强伤口愈合和治疗和预防微生物感染。在一个实施方案中，组合物针对减少口腔细菌或牙菌斑。一种或多种一氧化氮供体和一种或多种另外的治疗活性剂的组合导致意想不到的协同效应，其中增强了一氧化氮的抗微生物功效和第二种治疗活性剂的抗微生物或伤口愈合功效。结果，患者可以从减少的剂量要求和降低的抗微生物耐药性的可能性中受益。组合物可以配制用于局部或全身给药，用于局部应用以及用于医疗用品和装置的涂层。

3. 发明申请

WO2006128121A3 NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS 审中-公开
公开(公告)号：WO2006128121A3
公开(公告)日：2006-11-30
申请号：PCT/US2006/020781
申请日：2006-05-30
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SCHOENFISCH, Mark, H. , HO SHIN, Jae , STASKO, Nathan
发明人： SCHOENFISCH, Mark, H. , HO SHIN, Jae , STASKO, Nathan
IPC分类号： C07C239/00 , C07C259/00
摘要： The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.

4. 发明申请

WO2012118819A3 NITRIC OXIDE-RELEASING S-NITROSOTHIOL-MODIFIED SILICA PARTICLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：氮氧化物释放S-硝基硅烷改性二氧化硅颗粒及其制备方法
公开(公告)号：WO2012118819A3
公开(公告)日：2014-04-17
申请号：PCT/US2012026960
申请日：2012-02-28
申请人： NOVAN INC , UNIV NORTH CAROLINA , SCHOENFISCH MARK , RICCIO DANIEL , NUGENT JULIA , STASKO NATHAN
发明人： SCHOENFISCH MARK , RICCIO DANIEL , NUGENT JULIA , STASKO NATHAN
IPC分类号： A01N59/00
CPC分类号： A61L2/18 , C07F7/0874 , C07F7/10 , C07F7/1836 , C08G77/26 , C08G77/28 , C08K3/28 , C08K3/30 , C08K2003/023 , Y10T428/2982
摘要： Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.
摘要翻译：根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

5. 发明申请

WO2012125723A2 MICROFLUIDIC NITRIC OXIDE SENSOR 审中-公开
标题翻译：微流体一氧化氮传感器
公开(公告)号：WO2012125723A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029076
申请日：2012-03-14
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SCHOENFISCH, Mark , PRIVETT, Benjamin , RAMSEY, John , HENLEY, William
发明人： SCHOENFISCH, Mark , PRIVETT, Benjamin , RAMSEY, John , HENLEY, William
IPC分类号： G01N27/333 , G01N35/00 , G01N27/12
CPC分类号： G01N27/28 , B01L3/5027 , G01N27/4045 , G01N33/4915 , Y10T29/49117
摘要： The presently disclosed subject matter relates to a microfluidic device for measuring an amount of a molecular species in a sample. The device comprises a body and an electrode assembly, the electrode assembly comprising at least one electrode coupled to the body. The device also includes a gas permeable membrane disposed on at least one electrode and a detector for measuring a current at each of the electrodes. Further, the device comprises a channel defined between a substantially planar substrate and planar cover glass. The presently disclosed subject matter also relates to methods of making the microfluidic device.
摘要翻译：目前公开的主题涉及用于测量样品中的分子种类的量的微流体装置。该装置包括主体和电极组件，电极组件包括耦合到主体的至少一个电极。该装置还包括设置在至少一个电极上的气体可渗透膜和用于测量每个电极处的电流的检测器。此外，该装置包括限定在基本上平面的基底和平面覆盖玻璃之间的通道。目前公开的主题还涉及制造微流体装置的方法。

6. 发明申请

WO2006128121A2 NITRIC OXIDE-RELEASING PARTICLES FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS 审中-公开
标题翻译：用于氧化氮治疗和生物医学应用的氮氧化物释放颗粒
公开(公告)号：WO2006128121A2
公开(公告)日：2006-11-30
申请号：PCT/US2006020781
申请日：2006-05-30
申请人： UNIV NORTH CAROLINA , SCHOENFISCH MARK H , HO SHIN JAE , STASKO NATHAN
发明人： SCHOENFISCH MARK H , HO SHIN JAE , STASKO NATHAN
IPC分类号： A61K31/198
CPC分类号： C07F7/10 , A61K9/14 , A61K9/167 , A61K9/5115 , A61K31/695 , A61K41/0042 , A61K47/59 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07F7/18
摘要： The presently disclosed subject matter relates to nitric oxide-releasing particles for delivering nitric oxide, and their use in biomedical and pharmaceutical applications.
摘要翻译：目前公开的主题涉及用于输送一氧化氮的一氧化氮释放颗粒及其在生物医学和药物应用中的用途。

7. 发明申请

WO2012118829A3 TERTIARY S-NITROSOTHIOL-MODIFIED NITRICOXIDE-RELEASING XEROGELS AND METHODS OF USING THE SAME 审中-公开
标题翻译：新型硝基萘酚改性硝基氧化物释放XEROGELS及其使用方法
公开(公告)号：WO2012118829A3
公开(公告)日：2014-04-17
申请号：PCT/US2012026972
申请日：2012-02-28
申请人： NOVAN INC , UNIV NORTH CAROLINA , SCHOENFISCH MARK , RICCIO DANIEL
发明人： SCHOENFISCH MARK , RICCIO DANIEL
IPC分类号： A01N59/00
CPC分类号： A61L2/18 , C07F7/0874 , C07F7/10 , C07F7/1836 , C08G77/26 , C08G77/28 , C08K3/28 , C08K3/30 , C08K2003/023 , Y10T428/2982
摘要： Provided according to embodiments of the invention are novel tertiary alkyl thiol compounds and novel tertiary alkyl nitrosothiol compounds. Further provided according to embodiments of the invention are methods of forming a nitric oxide (NO)-releasing xerogel coating that include (a) co-condensing a sol precursor solution comprising at least one backbone alkoxysilane and at least one tertiary thiol alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; (c) optionally, drying the sol to form the xerogel coating; and (d) contacting the xerogel coating with a nitrosating agent. Methods of using xerogel coatings are also included.
摘要翻译：根据本发明的实施方案提供的是新的叔烷基硫醇化合物和新的叔烷基亚硝基硫醇化合物。根据本发明的实施方案还提供了形成一氧化氮（NO）释放干凝胶涂层的方法，其包括（a）将包含至少一种骨架烷氧基硅烷和至少一种叔硫醇烷氧基硅烷的溶胶前体溶液在溶剂中共缩合形成溶胶; （b）用溶胶涂布基材; （c）任选地，干燥溶胶以形成干凝胶涂层; 和（d）将干凝胶涂层与亚硝化剂接触。还包括使用干凝胶涂层的方法。

8. 发明申请

WO2012125723A3 MICROFLUIDIC NITRIC OXIDE SENSOR 审中-公开
标题翻译：微氧化氮氧化物传感器
公开(公告)号：WO2012125723A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029076
申请日：2012-03-14
申请人： UNIV NORTH CAROLINA , SCHOENFISCH MARK , PRIVETT BENJAMIN , RAMSEY JOHN , HENLEY WILLIAM
发明人： SCHOENFISCH MARK , PRIVETT BENJAMIN , RAMSEY JOHN , HENLEY WILLIAM
IPC分类号： G01N27/333 , G01N27/12 , G01N35/00
CPC分类号： G01N27/28 , B01L3/5027 , G01N27/4045 , G01N33/4915 , Y10T29/49117
摘要： The presently disclosed subject matter relates to a microfluidic device for measuring an amount of a molecular species in a sample. The device comprises a body and an electrode assembly, the electrode assembly comprising at least one electrode coupled to the body. The device also includes a gas permeable membrane disposed on at least one electrode and a detector for measuring a current at each of the electrodes. Further, the device comprises a channel defined between a substantially planar substrate and planar cover glass. The presently disclosed subject matter also relates to methods of making the microfluidic device.
摘要翻译：目前公开的主题涉及用于测量样品中分子种类的量的微流体装置。该装置包括主体和电极组件，电极组件包括耦合到主体的至少一个电极。该装置还包括设置在至少一个电极上的透气膜和用于测量每个电极处的电流的检测器。此外，该装置包括限定在基本平坦的基板和平面盖玻璃之间的通道。目前公开的主题还涉及制造微流体装置的方法。

9. 发明申请

WO2012167017A2 SUPERHYDROPHOBIC COATINGS AND METHODS FOR THEIR PREPARATION 审中-公开
标题翻译：超级涂料及其制备方法
公开(公告)号：WO2012167017A2
公开(公告)日：2012-12-06
申请号：PCT/US2012/040374
申请日：2012-06-01
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , PRIVETT, Ben , SCHOENFISCH, Mark, H. , SHIN, Jae, Ho , YOUN, Jonghae
发明人： PRIVETT, Ben , SCHOENFISCH, Mark, H. , SHIN, Jae, Ho , YOUN, Jonghae
IPC分类号： C01B33/149 , C01B33/14 , C07F7/04
CPC分类号： B05D1/02 , C01B33/128 , C01B33/142 , C01B33/143 , C09D1/00
摘要： Superhydrophobic coatings and compositions and methods for preparing superhydrophobic coatings and compositions are described herein whereby the coatings and compositions are prepared under mild conditions, yet the methods are amenable to chemical functionalization of the coatings and components therein. The methods are useful for tuning and optimizing the physical properties of the coatings. In an embodiment, the coatings comprise nanostructured fluorinated silica colloids.
摘要翻译：超疏水涂料以及用于制备超疏水涂料和组合物的组合物和方法在本文中描述，其中涂层和组合物在温和条件下制备，但是该方法适用于其中的涂料和组分的化学官能化。这些方法可用于调整和优化涂层的物理性能。在一个实施方案中，涂层包含纳米结构的氟化二氧化硅胶体。

10. 发明申请

WO2012118819A2 NITRIC OXIDE-RELEASING S-NITROSOTHIOL-MODIFIED SILICA PARTICLES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：氮氧化物释放S-硝基硅烷改性二氧化硅颗粒及其制备方法
公开(公告)号：WO2012118819A2
公开(公告)日：2012-09-07
申请号：PCT/US2012/026960
申请日：2012-02-28
申请人： NOVAN, INC. , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , SCHOENFISCH, Mark , RICCIO, Daniel , NUGENT, Julia , STASKO, Nathan
发明人： SCHOENFISCH, Mark , RICCIO, Daniel , NUGENT, Julia , STASKO, Nathan
IPC分类号： C09D183/08 , C07F7/10
CPC分类号： A61L2/18 , C07F7/0874 , C07F7/10 , C07F7/1836 , C08G77/26 , C08G77/28 , C08K3/28 , C08K3/30 , C08K2003/023 , Y10T428/2982
摘要： Provided according to some embodiments of the invention are methods of forming co-condensed silica particles. In some embodiments, the methods include reacting a thiol-containing silane and a backbone alkoxysilane in a reaction solution that comprises water to form thiol-functionalized co-condensed silica particles, wherein the thiol-functionalized co-condensed silica particles include a polysiloxane matrix and at least some of thiol groups are present within the polysiloxane matrix; and reacting the thiol-functionalized co-condensed silica particles with a nitrosating agent to provide the S-nitrosothiol-functionalized co-condensed silica particles. In some embodiments, provided are S-nitrosothiol-functionalized co-condensed silica particles.
摘要翻译：根据本发明的一些实施方案提供了形成共缩合二氧化硅颗粒的方法。在一些实施方案中，所述方法包括在包含水以形成硫醇官能化的共缩合二氧化硅颗粒的反应溶液中使含硫醇的硅烷和骨架烷氧基硅烷反应，其中硫醇官能化的共缩合二氧化硅颗粒包括聚硅氧烷基质和至少一些硫醇基团存在于聚硅氧烷基质内; 并使硫醇官能化的共缩合二氧化硅颗粒与亚硝化剂反应以提供S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。在一些实施方案中，提供了S-亚硝基硫醇官能化的共缩合二氧化硅颗粒。

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