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1. 发明申请

WO2011163370A2 ANALYSIS OF MICRONEUTRALIZATION ASSAY USING CURVE-FITTING CONSTRAINTS 审中-公开
标题翻译：使用曲线拟合约束进行微分方程分析
公开(公告)号：WO2011163370A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041459
申请日：2011-06-22
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , SCHIFFER, Jarad , HANCOCK, Kathy
发明人： SCHIFFER, Jarad , HANCOCK, Kathy
IPC分类号： G01N33/52 , G01N21/84 , C12Q1/02
CPC分类号： G06F19/10 , G01N21/5907
摘要： A method and apparatus are disclosed for analyzing a microneutralization assay. Specifically, an automated process can be used to read the optical density of multiple samples in a microneutralization assay and plot the results using one or more constraints. A particular constraint that can be used is a maximum optical density that is read from a sample. Using the plotted curve, a neutralization titer is determined, which is the highest dilution at which a virus is effectively blocked. Other constraints can also be used. For example, a constraint can be based on using a cell control optical density as a lower asymptote and a virus control optical density as an upper asymptote. When multiple constraints are used, analysis is performed to determine which constraint provided the most accurate curve fit.
摘要翻译：公开了一种用于分析微中和测定的方法和装置。具体地，可以使用自动化过程来在微中和测定中读取多个样品的光密度，并使用一个或多个约束绘制结果。可以使用的特定约束是从样品读取的最大光密度。使用绘制的曲线，确定中和滴度，其是病毒有效阻断的最高稀释度。也可以使用其他约束。例如，约束可以基于使用细胞控制光密度作为较低渐进线，病毒控制光密度作为上渐近线。当使用多个约束时，执行分析以确定提供最准确的曲线拟合的约束。

2. 发明申请

WO0059373A9 ASSAY DEVICE FOR MEASURING CHARACTERISTICS OF A FLUID ON A CONTINUAL BASIS 审中-公开
标题翻译：用于测量流体在连续基础上的特性的测定装置
公开(公告)号：WO0059373A9
公开(公告)日：2002-02-07
申请号：PCT/US0009393
申请日：2000-04-07
申请人： SPECTRX INC , KUMAR KRISHNA S , PAPP JOSEPH , FARQUHAR J DAVID , TAYLOR LANCE , SMITH ALAN M , VREEKE MARK S , HATCH MICHAEL R , SCHIFFER JARAD , FAUPEL MARK L , CONNOLLY JAMES
发明人： KUMAR KRISHNA S , PAPP JOSEPH , FARQUHAR J DAVID , TAYLOR LANCE , SMITH ALAN M , VREEKE MARK S , HATCH MICHAEL R , SCHIFFER JARAD , FAUPEL MARK L , CONNOLLY JAMES
IPC分类号： G01N33/66 , A61B5/00 , G01N27/28 , G01N27/416
CPC分类号： A61B5/1486 , A61B5/1495
摘要： The present invention is directed at an assay device for detecting and enabling measurement of an analyte in a fluid. The assay device contains: a) an inlet port to receive fluid; b) a well in fluid communication with the inlet port; c) an outlet port in fluid communication with the well, wherein the outlet port is designed to allow discharge of the fluid; d) at least one first working electrode and at least one reference electrode disposed within the well; e) a quantity of reactant that reacts with the analyte to form a reaction product, wherein the reaction product is in fluid communication with the at least one first working electrode; and f) at least one membrane disposed over or around the reactant to regulate contact of the analyte in the fluid with the reactant.
摘要翻译：本发明涉及用于检测和测量流体中分析物的测定装置。测定装置包含：a）用于接收流体的入口; b）与入口流体连通的井; c）与所述井流体连通的出口，其中所述出口被设计成允许流体排放; d）至少一个第一工作电极和设置在所述阱内的至少一个参考电极; e）一定量的与分析物反应以形成反应产物的反应物，其中反应产物与至少一个第一工作电极流体连通; 和f）设置在反应物上方或周围的至少一个膜，以调节流体中分析物与反应物的接触。

3. 发明申请

WO2011163370A3 ANALYSIS OF MICRONEUTRALIZATION ASSAY USING CURVE-FITTING CONSTRAINTS 审中-公开
标题翻译：使用曲线拟合约束进行微分方程分析
公开(公告)号：WO2011163370A3
公开(公告)日：2012-04-19
申请号：PCT/US2011041459
申请日：2011-06-22
申请人： US GOV HEALTH & HUMAN SERV , SCHIFFER JARAD , HANCOCK KATHY
发明人： SCHIFFER JARAD , HANCOCK KATHY
IPC分类号： G01N33/52 , C12Q1/02 , G01N21/84
CPC分类号： G06F19/10 , G01N21/5907
摘要： A method and apparatus are disclosed for analyzing a microneutralization assay. Specifically, an automated process can be used to read the optical density of multiple samples in a microneutralization assay and plot the results using one or more constraints. A particular constraint that can be used is a maximum optical density that is read from a sample. Using the plotted curve, a neutralization titer is determined, which is the highest dilution at which a virus is effectively blocked. Other constraints can also be used. For example, a constraint can be based on using a cell control optical density as a lower asymptote and a virus control optical density as an upper asymptote. When multiple constraints are used, analysis is performed to determine which constraint provided the most accurate curve fit.
摘要翻译：公开了一种用于分析微中和测定的方法和装置。具体地，可以使用自动化过程来在微中和测定中读取多个样品的光密度，并使用一个或多个约束绘制结果。可以使用的特定约束是从样品读取的最大光密度。使用绘制的曲线，确定中和滴度，其是病毒有效阻断的最高稀释度。也可以使用其他约束。例如，约束可以基于使用细胞控制光密度作为较低渐进线，病毒控制光密度作为上渐近线。当使用多个约束时，执行分析以确定提供最准确的曲线拟合的约束。

4. 发明申请

WO0157241A3 Cast analyte diffusion-limiting membranes using photopolymerizable hydrophylic monomers 审中-公开
标题翻译：使用可光聚合的亲水单体浇注分析物扩散限制膜
公开(公告)号：WO0157241A3
公开(公告)日：2002-04-25
申请号：PCT/US0103304
申请日：2001-02-01
申请人： KELLY PATRICK , SCHIFFER JARAD , SPECTRX INC
发明人： KELLY PATRICK , SCHIFFER JARAD
IPC分类号： G01N33/66 , C12M1/34 , C12Q1/00 , G01N27/327
CPC分类号： C12Q1/002 , C12Q1/006
摘要： The present ivention provides a diffusion limiting membrane system for filtering an analyte from a fluid, comprising: a) a first layer comprising an analyte responsive enzyme; and b) a second layer comprising a water-soluble monomer composition, wherein the first layer is in direct contact with one or more sensor electrodes and the second layer is in direct contact with the first layer.

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