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1. 发明申请

WO2005092924A2 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译： RAB9A，RAB11A及其与感染性疾病相关的调节剂
公开(公告)号：WO2005092924A2
公开(公告)日：2005-10-06
申请号：PCT/US2005006396
申请日：2005-02-24
申请人： US GOV HEALTH & HUMAN SERV , UNIV VANDERBILT , HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
发明人： HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
IPC分类号： A61K48/00 , C07K14/82 , C12N15/113
CPC分类号： C07K14/82 , A01K2217/075 , A01K2267/0337 , A61K48/00 , C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/121 , C12N2310/14 , G01N33/569 , G01N33/56983 , G01N2500/00 , G01N2800/26
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.
摘要翻译：本文公开的是减少病原体感染细胞的方法，例如治疗或预防病原体感染。示例性病原体包括使用脂筏的病原体。本公开还涉及鉴定参与病原体感染的药物的方法，例如Rab9A和Rab11A的调节剂。

2. 发明申请

WO2004070002A2 CELL LINES AND HOST NUCLEIC ACID SEQUENCES RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译：细胞系和宿主细胞核酸序列与感染性疾病相关
公开(公告)号：WO2004070002A2
公开(公告)日：2004-08-19
申请号：PCT/US2003/037143
申请日：2003-11-18
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , HODGE, Thomas, W. , MOREY, Natalie, J. , RUBIN, Don , SHAW, Michael, W. , SANCHEZ, Anthony
发明人： HODGE, Thomas, W. , MOREY, Natalie, J. , RUBIN, Don , SHAW, Michael, W. , SANCHEZ, Anthony
IPC分类号： C12N
CPC分类号： C07K14/47 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/18 , G01N33/56983 , G01N2500/02
摘要： Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.
摘要翻译：已经鉴定了参与病毒感染的宿主核酸和宿主蛋白，例如人类免疫缺陷病毒（HIV），甲型流感和埃博拉病毒。干扰或破坏宿主核酸或宿主蛋白与病毒或病毒蛋白质之间的相互作用赋予对感染的抑制或抗性。因此，干扰宿主受试者中的这种相互作用可以赋予针对病毒的治疗或预防效果。鉴定的序列可用于鉴定减少或抑制病毒感染的试剂。

3. 发明申请

WO2003028632A3 DEVELOPMENT OF A PREVENTIVE VACCINE FOR FILOVIRUS INFECTION IN PRIMATES 审中-公开
公开(公告)号：WO2003028632A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/030251
申请日：2002-09-24
申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE , NABEL, Gary, J. , YANG, Zhi-yong , SULLIVAN, Nancy , SANCHEZ, Anthony
发明人： NABEL, Gary, J. , YANG, Zhi-yong , SULLIVAN, Nancy , SANCHEZ, Anthony
IPC分类号： C12P21/06
摘要： The present invention relates generally to viral vaccines and, more particularly, to filovirus vaccines and methods of eliciting an immune response against a filovirus or disease caused by infection with filovirus.

4. 发明申请

WO2003102219A2 IMPROVED PSEUDOTYPED RETROVIRUSES 审中-公开
标题翻译：改进的PSEUDOTYPED RETROVIRUSUS
公开(公告)号：WO2003102219A2
公开(公告)日：2003-12-11
申请号：PCT/US2003/017577
申请日：2003-06-04
申请人： PURDUE RESEARCH FOUNDATION , CENTERS FOR DISEASE CONTROL AND PREVENTION , SANDERS, David, A. , JEFFERS, Scott, A. , SANCHEZ, Anthony
发明人： SANDERS, David, A. , JEFFERS, Scott, A. , SANCHEZ, Anthony
IPC分类号： C12Q
CPC分类号： C12N15/86 , A61K35/13 , C12N2740/15043 , C12N2740/15045 , C12N2760/14122 , C12N2810/60 , C12N2810/6072 , Y10S977/802 , Y10S977/803
摘要： Pseudotyped retroviruses having viral glycoproteins with modified O glycosylation regions are provided. Also provided are methods for making the pseudotyped retroviruses of the present invention and for using the pseudotyped retroviruses for transduction of target cells. Cells for stably producing the pseudotyped retroviruses or the present invention are also provided.
摘要翻译：提供具有修饰的O糖基化区域的具有病毒糖蛋白的假型逆转录病毒。还提供了制备本发明的假型逆转录病毒和使用假型逆转录病毒用于转导靶细胞的方法。还提供了用于稳定产生假型逆转录病毒或本发明的细胞。

5. 发明申请

WO1994003791A1 METABOLIC MONITORING OF CELLS IN A MICROPLATE READER 审中-公开
标题翻译：微量读数器中细胞的代谢监测
公开(公告)号：WO1994003791A1
公开(公告)日：1994-02-17
申请号：PCT/US1993007177
申请日：1993-07-30
申请人： MOLECULAR DEVICES CORPORATION , HAFEMAN, Dean, G. , CRAWFORD, Kimberly, L. , SANCHEZ, Anthony, J. , WADA, Henry, Garrett
发明人： MOLECULAR DEVICES CORPORATION
IPC分类号： G01N21/31
CPC分类号： C12M41/46 , C12M41/26 , G01N21/253
摘要： The invention disclosed is a method for monitoring the metabolism of cells retained in individual wells of a multiassay plate by measuring the rates of extracellular acidification comprising the steps of: placing the cells in a solution containing a pH buffer and an acid/base indicator (the acidic form having optimum absorbance in a first wavelength region and the basic form having optimum absorbance in a second wavelength region), heating the solution in the individual wells to a substantially uniform temperature, mixing the solution in each well, measuring the optical densities of light passing vertically through the wells at a first wavelength in the first wavelength region and a second wavelength in the second wavelength region, determining a ratio of the optical density at the first and second wavelengths in each of two, or more wells, and repeating the mixing, measuring, and determining steps to monitor kinetically a rate of change in extracellular pH caused by the cells. The use of selected buffering system-acid/base indicator pairs, which provide little or no optically-apparent change in pH with change in temperature, was found to be highly desirable for carrying out the method. Methods for composing such buffering system-acid/base indicator pairs are disclosed, together with examples of such pairs.
摘要翻译：本发明公开了一种通过测量细胞外酸化速率来监测多分析板单个孔中保留细胞代谢的方法，包括以下步骤：将细胞置于含有pH缓冲液和酸/碱指示剂的溶液中在第一波长区域具有最佳吸光度的酸性形式和在第二波长区域中具有最佳吸光度的碱性形式），将各孔中的溶液加热至基本均匀的温度，将溶液混合在每个孔中，测量光的光密度在第一波长区域中以第一波长垂直穿过阱并且在第二波长区域中穿过第二波长，确定两个或更多个孔中的每一个中的第一和第二波长处的光密度的比率，并重复混合，测量和确定动态监测由细胞引起的细胞外pH变化速率的步骤。发现使用选择的缓冲系统 - 酸/碱指示器对，其提供很少或没有光学上明显的pH随温度变化的变化，对于进行该方法是非常需要的。公开了组合这种缓冲系统酸/碱指示剂对的方法以及这些对的实例。

6. 发明申请

WO2013066442A3 MAMMALIAN GENES AND GENE PRODUCTS INVOLVED IN INFECTION 审中-公开
标题翻译：涉及感染的MAMMALIAN基因和基因产物
公开(公告)号：WO2013066442A3
公开(公告)日：2013-07-18
申请号：PCT/US2012048507
申请日：2012-07-27
申请人： HODGE THOMAS W , MCDONALD NATALIE J , MURRAY JAMES L , SHAW MICHAEL W , RUBIN DONALD H , SANCHEZ ANTHONY
发明人： HODGE THOMAS W , MCDONALD NATALIE J , MURRAY JAMES L , SHAW MICHAEL W , RUBIN DONALD H , SANCHEZ ANTHONY
IPC分类号： A61K31/00 , A61K31/7088 , C12N15/113
CPC分类号： C07K14/47 , A61K48/005 , C12N2740/16011 , C12N2760/14111 , C12N2760/16111 , C12N2999/005 , C12Q1/18 , C12Q1/6883 , C12Q2600/156
摘要： The present disclosure relates to mammalian genes and gene products that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include HIV-1, HIV-2, influenza A, Marburg virus and Ebola virus. The disclosure also relates to methods of identifying agents involved in pathogen infection.
摘要翻译：本公开涉及涉及感染或以其他方式与一种或多种病原体的生命周期相关的哺乳动物基因和基因产物。本文公开了减少病原体感染细胞的方法，例如治疗或预防病原体感染。示例性病原体包括HIV-1，HIV-2，甲型流感病毒，马尔堡病毒和埃博拉病毒。本公开还涉及鉴定涉及病原体感染的药剂的方法。

7. 发明申请

WO2005092924A8 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译： RAB9A，RAB11A及其与感染性疾病相关的调节剂
公开(公告)号：WO2005092924A8
公开(公告)日：2006-10-19
申请号：PCT/US2005006396
申请日：2005-02-24
申请人： US GOV HEALTH & HUMAN SERV , UNIV VANDERBILT , HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
发明人： HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
IPC分类号： A61K48/00 , C07K14/82 , C12N5/10 , C12N15/113 , C12N15/63
CPC分类号： C07K14/82 , A01K2217/075 , A01K2267/0337 , A61K48/00 , C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/121 , C12N2310/14 , G01N33/569 , G01N33/56983 , G01N2500/00 , G01N2800/26
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, comprising decreasing activity of Rab9A or Rab11A in the cell, for example to treat or prevent a pathogen infection. Exemplary pathogens are those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.
摘要翻译：本文公开了减少病原体感染细胞的方法，包括降低细胞中Rab9A或Rab11A的活性，例如治疗或预防病原体感染。示例性病原体是使用脂筏的病原体。本公开还涉及鉴定涉及病原体感染的药物的方法，例如Rab9A和Rab11A的调节剂。

8. 发明申请

WO2004070002A3 CELL LINES AND HOST NUCLEIC ACID SEQUENCES RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译：细胞系和宿主细胞核酸序列与感染性疾病相关
公开(公告)号：WO2004070002A3
公开(公告)日：2009-06-18
申请号：PCT/US0337143
申请日：2003-11-18
申请人： US GOV HEALTH & HUMAN SERV , UNIV VANDERBILT , HODGE THOMAS W , MOREY NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY
发明人： HODGE THOMAS W , MOREY NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY
IPC分类号： C07H21/04 , A01K67/027 , A61K31/7105 , A61K38/00 , A61K48/00 , A61P31/12 , A61P31/18 , C12N20060101 , C12N5/00 , C12N7/00 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/47 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12Q1/18 , G01N33/56983 , G01N2500/02
摘要： Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.
摘要翻译：已经鉴定了参与病毒感染的宿主核酸和宿主蛋白，例如人类免疫缺陷病毒（HIV），甲型流感和埃博拉病毒。干扰或破坏宿主核酸或宿主蛋白与病毒或病毒蛋白质之间的相互作用赋予对感染的抑制或抗性。因此，干扰宿主受试者中的这种相互作用可以赋予针对病毒的治疗或预防效果。鉴定的序列可用于鉴定减少或抑制病毒感染的试剂。

9. 发明申请

WO2005092924A3 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
公开(公告)号：WO2005092924A3
公开(公告)日：2005-10-06
申请号：PCT/US2005/006396
申请日：2005-02-24
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , VANDERBILT UNIVERSITY , HODGE, Thomas, W. , MCDONALD, Natalie, J. , RUBIN, Donald , SHAW, Michael, W. , SANCHEZ, Anthony , MURRAY, James, L.
发明人： HODGE, Thomas, W. , MCDONALD, Natalie, J. , RUBIN, Donald , SHAW, Michael, W. , SANCHEZ, Anthony , MURRAY, James, L.
IPC分类号： A61K48/00 , C07K14/82 , C12N15/11 , C12N15/63 , C12N5/10
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, comprising decreasing activity of Rab9A or Rab11A in the cell, for example to treat or prevent a pathogen infection. Exemplary pathogens are those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.

10. 发明申请

WO03102219A9 IMPROVED PSEUDOTYPED RETROVIRUSES 审中-公开
标题翻译：改进的PSEUDOTYPED RETROVIRUSUS
公开(公告)号：WO03102219A9
公开(公告)日：2004-04-01
申请号：PCT/US0317577
申请日：2003-06-04
申请人： PURDUE RESEARCH FOUNDATION , CT S FOR DISEASE CONTROL AND P , SANDERS DAVID A , JEFFERS SCOTT A , SANCHEZ ANTHONY
发明人： SANDERS DAVID A , JEFFERS SCOTT A , SANCHEZ ANTHONY
IPC分类号： A61K39/12 , C12N15/867 , C12Q20060101 , C12Q
CPC分类号： C12N15/86 , A61K35/13 , C12N2740/15043 , C12N2740/15045 , C12N2760/14122 , C12N2810/60 , C12N2810/6072 , Y10S977/802 , Y10S977/803
摘要： Pseudotyped retroviruses having viral glycoproteins with modified O glycosylation regions are provided. Also provided are methods for making the pseudotyped retroviruses of the present invention and for using the pseudotyped retroviruses for transduction of target cells. Cells for stably producing the pseudotyped retroviruses or the present invention are also provided.
摘要翻译：提供具有修饰的O糖基化区域的具有病毒糖蛋白的假型逆转录病毒。还提供了制备本发明的假型逆转录病毒和使用假型逆转录病毒用于转导靶细胞的方法。还提供了用于稳定产生假型逆转录病毒或本发明的细胞。

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