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1. 发明申请

WO2013086008A1 METHODS AND PRODUCTS FOR TRANSFECTING CELLS 审中-公开
标题翻译：转染细胞的方法和产品
公开(公告)号：WO2013086008A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/067966
申请日：2012-12-05
申请人： FACTOR BIOSCIENCE INC. , ANGEL, Matthew , ROHDE, Christopher
发明人： ANGEL, Matthew , ROHDE, Christopher
IPC分类号： A61K48/00 , C07H21/02 , C12N15/00
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
摘要： The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non- canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
摘要翻译：本发明部分涉及编码蛋白质的核酸，含有非典型核苷酸的核酸，包含核酸的治疗剂，用于诱导细胞表达蛋白质的方法，试剂盒和装置，用于转染，基因编辑的方法，试剂盒和装置，并使用这些方法，试剂盒和装置重新编程细胞，细胞，生物体和治疗剂。公开了诱导细胞表达蛋白质并使用RNA重编程和基因编辑细胞的方法。还公开了从患者样品中产生细胞的方法，使用这些方法产生的细胞，以及包含使用这些方法产生的细胞的治疗剂。

2. 发明申请

WO2012015536A1 CARTRIDGE ASSEMBLY WITH RIBBON LOCK 审中-公开
标题翻译：带盒子的卡座组件
公开(公告)号：WO2012015536A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/039787
申请日：2011-06-09
申请人： BRADY WORLDWIDE, INC. , SUVA, Alan, J. , EDWARDS, Thomas, J. , ROHDE, Christopher, J.
发明人： SUVA, Alan, J. , EDWARDS, Thomas, J. , ROHDE, Christopher, J.
IPC分类号： B41J17/32 , B41J33/52 , B41J15/04
CPC分类号： B41J33/52 , B41J15/044 , B41J17/32
摘要： A cartridge assembly is disclosed. The cartridge assembly includes a cartridge housing defining an internal chamber. At least one rotatable spool is housed in the internal chamber. In the wall of the cartridge housing, a ribbon lock is formed. The ribbon lock has an engaged position and a disengaged position. In the engaged position, the ribbon lock is biased into engagement with the rotatable spool (s) to inhibit rotation of the rotatable spool (s). In the disengaged position, the ribbon lock is urged away from the rotatable spool (s) to disengage the ribbon lock from the rotatable spool (s) to permit rotation of the spool (s).
摘要翻译：公开了一种盒组件。盒组件包括限定内部室的盒壳体。至少一个可旋转的卷轴容纳在内部室中。在盒壳体的壁上形成色带锁。色带锁具有接合位置和脱离位置。在接合位置，色带锁被偏置成与可旋转的卷轴接合以阻止可旋转卷轴的旋转。在脱离位置时，色带锁被推离远离可旋转的卷轴，以使色带锁与可旋转的卷轴脱离，以允许卷轴旋转。

3. 发明申请

WO2010053913A1 SYSTEM AND METHOD FOR RESTRICTING ACCESS TO A VALVE 审中-公开
标题翻译：限制进入阀门的系统和方法
公开(公告)号：WO2010053913A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063110
申请日：2009-11-03
申请人： BRADY WORLDWIDE, INC. , MILBECK, Katherine, T. , EDWARDS, Thomas, J. , ROHDE, Christopher, J. , PHILLIPS, Kenneth, W. , LOCKWOOD, Steven, J.
发明人： MILBECK, Katherine, T. , EDWARDS, Thomas, J. , ROHDE, Christopher, J. , PHILLIPS, Kenneth, W. , LOCKWOOD, Steven, J.
IPC分类号： F16K35/10
CPC分类号： F16K35/10 , Y10T70/5628
摘要： A method and system for restricting access to a valve stem (116) of a valve (114) by employing a valve locking assembly (104) is disclosed. The locking assembly comprises a first means (124) for receiving a valve stem of a valve and an engaging member (140). The locking assembly additionally comprises a second means (120) for receiving the valve stem of the valve and comprising a slide (128) for engaging the engaging member of the first means, the slide having a first length (132) along an outer periphery of the second means and a second length (134) intersecting the first length such that the second length is shorter than the first length. The locking assembly additionally comprises a third means (122) for releasably securing the second means in position about the valve stem of the valve, wherein the first means is capable of being positioned over the second and the third means about the valve stem.
摘要翻译：公开了一种通过采用阀门锁定组件（104）来限制进入阀门（114）的阀杆（116）的方法和系统。锁定组件包括用于接收阀的阀杆和接合构件（140）的第一装置（124）。锁定组件还包括用于接收阀的阀杆的第二装置（120），并且包括用于接合第一装置的接合构件的滑动件（128），滑块具有沿着第一装置的外周的第一长度（132）所述第二装置和与所述第一长度相交的第二长度（134）使得所述第二长度短于所述第一长度。锁定组件还包括第三装置（122），用于将第二装置可释放地固定在阀的阀杆周围的适当位置，其中第一装置能够围绕阀杆定位在第二和第三装置的上方。

4. 发明申请

WO2008076871A3 KEYWAY COVER FOR A LOCK 审中-公开
标题翻译： KEYWAY盖上一个锁
公开(公告)号：WO2008076871A3
公开(公告)日：2008-12-11
申请号：PCT/US2007087547
申请日：2007-12-14
申请人： MASTER LOCK CO , ROHDE CHRISTOPHER , BLOMSTROM JOHN
发明人： ROHDE CHRISTOPHER , BLOMSTROM JOHN
IPC分类号： E05B17/18 , E05B67/36
CPC分类号： E05B67/383 , E05B17/18 , E05B67/38 , Y10T70/443 , Y10T70/498 , Y10T70/8649
摘要： A lock assembly includes a lock body and a keyway covering member. The lock body includes a keyway disposed on an outer surface. The keyway covering member is assembled with the outer surface of the lock body, and is slideable between a covering orientation and an uncovering orientation. When the keyway covering member is in the covering orientation, a covering portion of the keyway covering member aligns with the keyway to cover the keyway. When the keyway covering member is in the uncovering orientation, an opening in the keyway covering member aligns with the keyway to permit insertion of a key in the keyway.
摘要翻译：锁组件包括锁体和键槽覆盖构件。锁体包括设置在外表面上的键槽。键槽盖构件与锁体的外表面组装在一起，并且可在覆盖取向和展开取向之间滑动。当键槽覆盖构件处于覆盖方位时，键槽覆盖构件的覆盖部分与键槽对齐以覆盖键槽。当键槽覆盖构件处于揭开取向时，键槽覆盖构件中的开口与键槽对准以允许键槽插入键槽中。

5. 发明申请

WO2008076871A2 KEYWAY COVER FOR A LOCK 审中-公开
标题翻译：钥匙钥匙锁
公开(公告)号：WO2008076871A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/087547
申请日：2007-12-14
申请人： MASTER LOCK COMPANY LLC , ROHDE, Christopher , BLOMSTROM, John
发明人： ROHDE, Christopher , BLOMSTROM, John
IPC分类号： E05B17/18
CPC分类号： E05B67/383 , E05B17/18 , E05B67/38 , Y10T70/443 , Y10T70/498 , Y10T70/8649
摘要： A lock assembly includes a lock body and a keyway covering member. The lock body includes a keyway disposed on an outer surface. The keyway covering member is assembled with the outer surface of the lock body, and is slideable between a covering orientation and an uncovering orientation. When the keyway covering member is in the covering orientation, a covering portion of the keyway covering member aligns with the keyway to cover the keyway. When the keyway covering member is in the uncovering orientation, an opening in the keyway covering member aligns with the keyway to permit insertion of a key in the keyway.
摘要翻译：锁组件包括锁体和键槽覆盖件。锁体包括设置在外表面上的键槽。键槽覆盖构件与锁体的外表面组装，并且可在覆盖方向和露出方向之间滑动。当键槽覆盖构件处于覆盖方向时，键槽覆盖构件的覆盖部分与键槽对准以覆盖键槽。当键槽覆盖构件处于露出方向时，键槽覆盖构件中的开口与键槽对齐以允许将键插入键槽。

6. 发明申请

WO2007109159A2 PADLOCK 审中-公开
标题翻译：挂锁
公开(公告)号：WO2007109159A2
公开(公告)日：2007-09-27
申请号：PCT/US2007/006683
申请日：2007-03-16
申请人： MASTER LOCK COMPANY LLC , ROHDE, Christopher , BLOMSTROM, John , WEBER, John , RICE, Robert
发明人： ROHDE, Christopher , BLOMSTROM, John , WEBER, John , RICE, Robert
IPC分类号： E05B67/02
CPC分类号： E05B67/02 , E05B67/24 , Y10T29/49 , Y10T29/49789 , Y10T29/49792 , Y10T29/49794 , Y10T29/49798 , Y10T70/461 , Y10T70/489 , Y10T70/496 , Y10T70/498
摘要： A padlock includes a lock body, a shackle, and a sleeve. The lock body includes opposed front and rear longitudinally extending side walls terminating at first and second end portions. The shackle extends from the first end portion of the lock body. The sleeve covers at least a portion of each of the longitudinally extending side walls, and an internal surface of the sleeve includes at least one longitudinally extending rib contacting at least one of the front and rear longitudinally extending side walls to define a gap between the sleeve and the lock body.
摘要翻译：挂锁包括锁体，钩环和套筒。锁体包括终止在第一和第二端部处的相对的前后纵向延伸的侧壁。钩环从锁体的第一端部延伸。套筒覆盖每个纵向延伸的侧壁的至少一部分，并且套筒的内表面包括至少一个纵向延伸的肋，其接触前后纵向延伸的侧壁中的至少一个，以限定套筒和锁体。

7. 发明申请

WO2014071219A1 METHODS AND PRODUCTS FOR EXPRESSING PROTEINS IN CELLS 审中-公开
标题翻译：在细胞中表达蛋白质的方法和产品
公开(公告)号：WO2014071219A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/068118
申请日：2013-11-01
申请人： FACTOR BIOSCIENCE INC. , ANGEL, Matthew , ROHDE, Christopher
发明人： ANGEL, Matthew , ROHDE, Christopher
IPC分类号： C12N15/31 , C12N5/10 , C12N9/22 , C12Q1/68 , C12N15/63 , A61K38/46 , A61K31/7115 , A61K48/00 , A61P35/00 , A61P25/28 , A61P25/14
CPC分类号： C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
摘要翻译：本发明部分涉及编码蛋白质的核酸，包含编码蛋白质的核酸的治疗剂，使用核酸诱导细胞表达蛋白质的方法，用于转染，基因编辑和重编程细胞，细胞，生物体的方法，试剂盒和装置，以及使用这些方法，试剂盒和装置制备的治疗剂。描述了用于改变细胞DNA序列的方法和产物，以及用合成RNA分子诱导细胞表达蛋白质的方法和产物。还描述了包含编码基因编辑蛋白的核酸的治疗剂。

8. 发明申请

WO2014022493A1 VALVE LOCKOUT DEVICE 审中-公开
标题翻译：阀门锁定装置
公开(公告)号：WO2014022493A1
公开(公告)日：2014-02-06
申请号：PCT/US2013/052898
申请日：2013-07-31
申请人： BRADY WORLDWIDE, INC. , GRADE, Paul , ROHDE, Christopher, J.
发明人： GRADE, Paul , ROHDE, Christopher, J.
IPC分类号： F16K35/10
CPC分类号： F16K35/10 , Y10T137/7256
摘要： A valve lockout device (10) includes a body (18) having a mount portion (20) that defines a passageway. A cover (46) positioned adjacent to the body defines a cover portion (66) adjacent the mount portion thereby inhibiting access to the passageway in the mount portion. A position control arm (102) extends through at least one of the body and cover, the position control arm defines a valve engagement portion (104) and an adjustment portion (108). A lock aperture is formed in at least the other of the body and cover through which the position control arm extends. An adjustment member is positioned adjacent at least one of the body and the cover, the adjustment member defines an adjustment member aperture aligned with the lock aperture and is configured to engage the adjustment portion of the position control arm. Coupling the lock aperture and the adjustment member aperture inhibits relative movement of the body, cover, and adjustment member.
摘要翻译：阀门锁定装置（10）包括具有限定通道的安装部分（20）的主体（18）。靠近主体定位的盖（46）限定了邻近安装部分的盖部分（66），从而阻止了进入安装部分中的通道。位置控制臂（102）延伸穿过主体和盖子中的至少一个，位置控制臂限定阀接合部分（104）和调节部分（108）。锁定孔形成在主体和盖中的至少另一个中，位置控制臂通过该盖延伸。调节构件邻近主体和盖中的至少一个定位，调节构件限定与锁定孔对准的调节构件孔，并且构造成接合位置控制臂的调节部。耦合锁定孔和调节构件孔禁止身体，盖和调节构件的相对运动。

9. 发明申请

WO2009021232A3 HIGH-THROUGHPUT, WHOLE-ANIMAL SCREENING SYSTEM 审中-公开
标题翻译：高通量，全动物筛选系统
公开(公告)号：WO2009021232A3
公开(公告)日：2009-03-26
申请号：PCT/US2008072768
申请日：2008-08-11
申请人： MASSACHUSETTS INST TECHNOLOGY , YANIK MEHMET FATIH , ROHDE CHRISTOPHER , ANGEL MATTHEW , GILLELAND CODY , ZENG FEI
发明人： YANIK MEHMET FATIH , ROHDE CHRISTOPHER , ANGEL MATTHEW , GILLELAND CODY , ZENG FEI
IPC分类号： A01K67/00
CPC分类号： G01N33/5082 , A61K49/0008 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2400/0406 , B01L2400/0439 , B01L2400/0487 , B01L2400/0655
摘要： Distinctive components that enable high-throughput, whole-animal screening are described. These components can be used individually or in various combinations. A staging chip strains off the excess fluid that the input animals are immersed in, increasing their density (number of animals in a given volume) and rapidly bringing them close to other fluidic components. A microfluidic sorter is adapted to isolate and immobilize a single, physiologically active animal in a selected geometry. A multiplexed micro-chamber chip receives single animals and the microchamber chip includes individually addressable screening chambers for imaging, incubation and exposure of individual animals to selected chemical compounds. An imaging structure generates sub-cellular, high-resolution images of the physiologically active animals. A well-plate interface chip is used to deliver elements from a compound library to a single output of the chip.
摘要翻译：描述了能够实现高通量，全动物筛选的独特成分。这些组分可以单独使用或以各种组合使用。分级芯片使输入动物浸入的过量液体变得紧张，增加它们的密度（给定体积中的动物数量）并迅速使它们接近其它流体组分。微流体分选器适于在选定的几何形状中分离和固定单个生理活性动物。复合的微室芯片接收单个动物，并且微型仓芯片包括用于成像，孵育和暴露于所选化学化合物的各个动物的单独可寻址的筛选室。成像结构产生生理活性动物的亚细胞，高分辨率图像。使用阱板接口芯片将元件从复合库传送到芯片的单个输出。

10. 发明申请

WO2003018941A3 CABLE LOCKING MECHANISM 审中-公开
公开(公告)号：WO2003018941A3
公开(公告)日：2003-03-06
申请号：PCT/US2002/027997
申请日：2002-09-03
申请人： MASTER LOCK COMPANY , BURMESCH, Gary , ROHDE, Christopher , SCHNEIDER, Suzanne , GRANDY, Kenneth, N. , MEEKMA, Glenn , ZAPUSHEK, John
发明人： BURMESCH, Gary , ROHDE, Christopher , SCHNEIDER, Suzanne , GRANDY, Kenneth, N. , MEEKMA, Glenn , ZAPUSHEK, John
IPC分类号： E05B67/00
摘要： A cable locking mechanism for use in a variety of cable locks that includes one or more locking clamps, a lever arm, a spring that biases the locking clamps, and an actuation means that engages the lever arm. When a cable is inserted into a cable passageway of a cable lock, the locking clamps secure the cable and prevent it withdrawal from the lock body. To remove the cable, the actuation means is deployed to move the lever arm, which engages and displaces the locking clamps along a sloped surface. The displacement of the locking clamps widens the cable passageway, thereby allowing the cable to move freely in and out of the lock body.

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