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1. 发明申请

WO2010106507A3 HALLUX ABDUCTO VALGUS ASSEMBLIES 审中-公开
公开(公告)号：WO2010106507A3
公开(公告)日：2010-11-18
申请号：PCT/IB2010051155
申请日：2010-03-17
申请人： MOR RESEARCH APPLIC LTD , ROBINSON DROR
发明人： ROBINSON DROR
IPC分类号： A61B17/17 , A61B17/68 , A61B17/80
CPC分类号： A61B17/68 , A61B17/8085 , A61B17/842 , A61B17/864 , A61B2017/565
摘要： Disclosed is an assembly for in vivo alignment of two or more bones in a living body. The assembly comprises a cannulated sleeve (132) configured to secure in a bore (133) in a first bone, a mesh body (136) having a proximal arm configured to be engaged by the cannulated sleeve, and a distal arm configured to be secured to a portion of a second bone. The assembly further includes a fastener (138) configured to secure the distal arm to the portion of the second bone.
摘要翻译：公开了一种用于活体内两个或多个骨的体内对准的组件。组件包括构造成固定在第一骨中的孔（133）中的套管套管（132），具有被套管套筒接合的近端臂的网状体（136）和被构造成被固定的远侧臂到第二骨的一部分。组件还包括紧固件（138），其被构造成将远端臂固定到第二骨的部分。

2. 发明申请

WO2010106507A2 HALLUX ABDUCTO VALGUS ASSEMBLIES 审中-公开
公开(公告)号：WO2010106507A2
公开(公告)日：2010-09-23
申请号：PCT/IB2010/051155
申请日：2010-03-17
申请人： MOR RESEARCH APPLICATIONS LTD , ROBINSON, Dror
发明人： ROBINSON, Dror
IPC分类号： A61B17/17 , A61B17/80 , A61B17/68
CPC分类号： A61B17/68 , A61B17/8085 , A61B17/842 , A61B17/864 , A61B2017/565
摘要： Disclosed is an assembly for in vivo alignment of two or more bones in a living body. The assembly comprises a cannulated sleeve configured to secure in a bore in a first bone, a mesh body having a proximal arm configured to be engaged by the cannulated sleeve, and a distal arm configured to be secured to a portion of a second bone. The assembly further includes a fastener configured to secure the distal arm to the portion of the second bone.
摘要翻译：公开了一种用于活体内两个或多个骨的体内对准的组件。组件包括被配置成固定在第一骨中的孔中的插管套筒，具有构造成与套管套接合的近端臂的网状体，以及构造成固定到第二骨的一部分的远侧臂。组件还包括紧固件，其被构造成将远端臂固定到第二骨的部分。

3. 发明申请

WO2007013078A3 INHIBITION OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF RENAL, VASCULAR AND CARTILAGE PATHOLOGY 审中-公开
标题翻译：用于治疗肾脏，血管和软组织病理学的瑞恩 - 血管紧张素系统的抑制
公开(公告)号：WO2007013078A3
公开(公告)日：2007-03-15
申请号：PCT/IL2006000871
申请日：2006-07-27
申请人： MOR RESEARCH APPLIC LTD , WEINSTEIN TALIA , GAFTER UZI , NEVO ZVI , ROBINSON DROR , EVRON ZOHARIA
发明人： WEINSTEIN TALIA , GAFTER UZI , NEVO ZVI , ROBINSON DROR , EVRON ZOHARIA
IPC分类号： A61K31/401 , A61K31/4184 , A61P9/00 , A61P13/12 , A61P17/00 , A61P19/02
CPC分类号： A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/473 , A61K31/5025 , A61K31/519 , A61K31/713 , A61K38/05 , A61K38/085 , Y10T436/143333
摘要： A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.
摘要翻译：公开了治疗上调GAGs治疗有益的疾病或病症的方法，特别是骨关节炎和皮肤疾病。该方法包括向受试者局部施用治疗有效量的能够下调肾素 - 血管紧张素系统组分的活性或表达的试剂。

4. 发明申请

WO2007013078A2 INHIBITION OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF RENAL, VASCULAR AND CARTILAGE PATHOLOGY 审中-公开
标题翻译：用于治疗肾脏，血管和软组织病理学的瑞恩 - 血管紧张素系统的抑制
公开(公告)号：WO2007013078A2
公开(公告)日：2007-02-01
申请号：PCT/IL2006/000871
申请日：2006-07-27
申请人： MOR RESEARCH APPLICATIONS LTD. , WEINSTEIN, Talia , GAFTER, Uzi , NEVO, Zvi , ROBINSON, Dror , EVRON, Zoharia
发明人： WEINSTEIN, Talia , GAFTER, Uzi , NEVO, Zvi , ROBINSON, Dror , EVRON, Zoharia
IPC分类号： A61K31/401 , A61K31/4184 , A61P19/02 , A61P13/12 , A61P17/00 , A61P9/00
CPC分类号： A61K31/401 , A61K31/4178 , A61K31/4184 , A61K31/422 , A61K31/473 , A61K31/5025 , A61K31/519 , A61K31/713 , A61K38/05 , A61K38/085 , Y10T436/143333
摘要： A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.
摘要翻译：公开了治疗上调GAGs治疗有益的疾病或病症的方法。该方法包括向受试者局部施用治疗有效量的能够下调肾素 - 血管紧张素系统组分的活性或表达的试剂。

5. 发明申请

WO2002080995A1 SCAFFOLD MATRIX AND TISSUE MAINTAINING SYSTEMS 审中-公开
标题翻译： SCAFFOLD矩阵和组织维护系统
公开(公告)号：WO2002080995A1
公开(公告)日：2002-10-17
申请号：PCT/IL2002/000280
申请日：2002-04-04
申请人： RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. , NEVO, Zvi , ROBINSON, Dror
发明人： NEVO, Zvi , ROBINSON, Dror
IPC分类号： A61L27/36
CPC分类号： A61L27/3691 , A61F2/3094 , A61F2002/30762 , A61F2002/30766 , A61K35/12 , A61L27/3604 , A61L27/3608 , A61L27/3612 , A61L27/3629 , A61L27/3683 , A61L27/3687 , A61L27/56 , C12M21/08 , C12M25/14 , C12N5/0062 , C12N5/0068 , C12N5/0655 , C12N2533/90 , C12N2533/92
摘要： The invention concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three-dimensional tissues. The scaffold may comprise naturally derived connective or skeletal tissue in the form of attached flakes having a very high porosity. Alternatively the scaffold may be composed of fused epiphyses.
摘要翻译：本发明涉及用作来自三维组织的各种细胞和组织移植物的生长支持基质的支架。支架可以包括具有非常高孔隙率的附着薄片形式的天然衍生的结缔组织或骨骼组织。或者，支架可以由融合的骨be构成。

6. 发明申请

WO2010109460A1 RESTORATIVE DEVICE FOR INTERVERTEBRAL DISCS 审中-公开
标题翻译：椎间盘的复原装置
公开(公告)号：WO2010109460A1
公开(公告)日：2010-09-30
申请号：PCT/IL2010000243
申请日：2010-03-23
申请人： CHI 2 GEL LTD , ROBINSON DROR
发明人： ROBINSON DROR
IPC分类号： A61F2/44 , A61B17/88
CPC分类号： A61B17/8855 , A61B17/025 , A61B17/7098 , A61B2017/0256 , A61F2/441 , A61F2/442 , A61F2002/30062 , A61F2002/30075 , A61F2002/30291 , A61F2002/30583 , A61F2002/30677 , A61F2002/444 , A61F2210/0004 , A61F2210/0061 , A61F2210/0085 , A61F2230/0091
摘要： The present invention provides a disc restoration system for relieving symptoms of a degenerative disc, comprising: a) a percutaneously insertable expandable element (88) adapted to be (i) inserted in between two adjacent vertebraes of the spinal cord; and, (ii) expanded to form a scaffold; said scaffold provides mechanical support to said two adjacent vertebraes so as to restore said degenerative disc to approximately the dimensions of a normal disc; b) an injectable filler having a first flowable state, and a second non-flowable set state; the filler is configured for being introduced, in said first flowable state, into a confined volume formed by the expandable element and the tissues, following the full expansion of said expandable element in said disc; and, following introduction of said filler, said filler is adapted to set into said second non-flowable state; such that following setting of said filler into said second state said disc is internally supported by said set filler.
摘要翻译：本发明提供了一种用于缓解退行性椎间盘症状的椎间盘修复系统，包括：a）经皮插入的可膨胀元件（88），其适于（i）插入脊髓的两个相邻椎骨之间; 和（ii）扩大以形成支架; 所述支架为所述两个相邻椎骨提供机械支撑，以便将所述退化椎间盘恢复到大致正常椎间盘的尺寸; b）具有第一可流动状态和第二不可流动设定状态的可注射填充物; 所述填充物被配置用于在所述可扩张元件在所述盘中完全膨胀之后以所述第一可流动状态被引入由所述可扩张元件和所述组织形成的限定容积中; 并且在引入所述填充物之后，所述填充物适于设定为所述第二不可流动状态; 使得在将所述填充物设置成所述第二状态之后，所述盘由所述设定的填充物在内部支撑。

7. 发明申请

WO2002094113A1 MAGNETICALLY-ACTUABLE INTRAMEDULLARY DEVICE 审中-公开
标题翻译：可激活的内置装置
公开(公告)号：WO2002094113A1
公开(公告)日：2002-11-28
申请号：PCT/IL2002/000401
申请日：2002-05-22
申请人： KOSASHVILI, Yona , ROBINSON, Dror
发明人： KOSASHVILI, Yona , ROBINSON, Dror
IPC分类号： A61B17/66
CPC分类号： A61B17/7216
摘要： The present invention provides a two-part telescopic intramedullary orthopedic device capable of connecting two adjacent fractured or severed bone ends, characterized in that said device comprises a first section (12) inserted into the medullary cavity of one of the fractured or severed bone ends, and secured thereto, and a second section (13) inserted into the medullary cavity of the other fractured or severed bone end and secured thereto, wherein said second section (13) comprises an internal space communicating with an external opening, and wherein said first section (12) is more or less telescoped within said internal space of said second section (13), and wherein one of said sections comprises a ferromagnetic material and the other section is either constructed entirely of a non-magnetic material or comprises a ferromagnetic material, wherein the ferromagnetic section(s) are actuable by an external magnetic field, such that one section may be caused to move axially in relation to the other section, and wherein said axial movement may be either bidirectional or essentially unidirectional. In addition, the invention encompasses a method for changing bone length as well as a method for enhancing bone fracture healing.
摘要翻译：本发明提供了一种能够连接两个相邻的断裂或切断的骨端的两部分伸缩髓内矫形装置，其特征在于，所述装置包括插入到断裂或切断的骨端之一的髓腔中的第一部分（12）并固定到其上，以及第二部分（13），其插入到另一个断裂或切断的骨端的髓腔中并固定到其上，其中所述第二部分（13）包括与外部开口连通的内部空间，并且其中所述第一部分（12）或多或少在所述第二部分（13）的所述内部空间内伸缩，并且其中所述部分中的一个包括铁磁材料，另一部分全部由非磁性材料构成或包括铁磁材料，其中所述铁磁部分可由外部磁场致动，使得一个部分可以相对于另一部分，并且其中所述轴向运动可以是双向的或基本上单向的。此外，本发明还包括骨长度变化的方法以及增强骨折愈合的方法。

8. 发明申请

WO0102030A2 SCAFFOLD MATRIX AND TISSUE MAINTAINING SYSTEMS 审中-公开
标题翻译： SCAFFOLD矩阵和组织维护系统
公开(公告)号：WO0102030A2
公开(公告)日：2001-01-11
申请号：PCT/IL0000386
申请日：2000-07-04
申请人： UNIV RAMOT , NEVO ZVI , ROBINSON DROR
发明人： NEVO ZVI , ROBINSON DROR
IPC分类号： A61L27/00 , A61F2/30 , A61K35/12 , A61L27/36 , C12M3/02 , C12N5/00 , C12N5/077
CPC分类号： A61L27/3691 , A61F2/3094 , A61F2002/30762 , A61F2002/30766 , A61K35/12 , A61L27/3608 , A61L27/3612 , A61L27/3629 , A61L27/3687 , C12M21/08 , C12M25/14 , C12N5/0062 , C12N5/0655 , C12N2533/90 , C12N2533/92
摘要： The invention concerns a device with a constant perfusion system for maintenance of viable cells, tissues and composite implants, which involves a pressure generator for producing rhythmic pulses of pressure on the biological specimen. All the operative parameters of the system are controllable, easily manipulated. The invention further concerns a scaffold which is used as a growth supportive base for various cells and tissue explants from three-dimensional tissue comprising naturally derived connective or skeletal tissue cross-linked with one of the following: hyaluronic acid, proteoglycans, glycosaminolycans, chondroitin sulfates, heparan sulfates, heparins and dextran sulfates.
摘要翻译：本发明涉及一种具有用于维持活细胞，组织和复合植入物的恒定灌注系统的装置，其包括用于在生物样本上产生节奏脉冲压力的压力发生器。系统的所有操作参数都是可控的，易于操作。本发明还涉及一种支架，其用作来自三维组织的各种细胞和组织移植物的生长支持基质，其包含与以下之一交联的天然衍生的结缔组织或骨骼组织：透明质酸，蛋白聚糖，糖胺聚糖，硫酸软骨素，硫酸乙酰肝素，肝素和硫酸葡聚糖。

9. 发明申请

WO2012029008A1 ORTHOPEDIC IMPLANT FOR TREATMENT OF BONE DEFORMITIES 审中-公开
标题翻译：用于治疗骨质疏松的手术植入物
公开(公告)号：WO2012029008A1
公开(公告)日：2012-03-08
申请号：PCT/IB2011/053763
申请日：2011-08-28
申请人： BONFIX LTD. , HERZOG, Rafi , BARKAI, Nir , SHAHAR, Mark , ROBINSON, Dror , SCHON, Lew
发明人： HERZOG, Rafi , BARKAI, Nir , SHAHAR, Mark , ROBINSON, Dror , SCHON, Lew
IPC分类号： A61B17/68
CPC分类号： A61B17/683 , A61B17/68 , A61B17/7291 , A61B17/842 , A61B17/844 , A61B2017/565 , A61B2017/681
摘要： An implantable device (20) includes a first anchor (22), configured to be implanted inside a first bone (24), and a second anchor (26), configured to be implanted inside a second bone (28), adjacent to the first bone. A cord (30) connects the first and second anchors. A shock absorber (42) contained within at least one of the first and second anchors is coupled to the cord so as to deform in response to a force exerted on the cord. The shock absorber may also include a force adjuster (48). The device may include an adjustment mechanism (44), which is operable, after implantation of the first and second anchors in the first and second bones, to adjust a length of the cord extending between the first and second anchors.
摘要翻译：可植入装置（20）包括构造成植入在第一骨骼（24）内的第一锚固件（22）和构造成植入第二骨骼（28）内部的第二锚固件（26），邻近第一骨。线（30）连接第一和第二锚。包含在第一和第二锚定件中的至少一个中的减震器（42）联接到绳索，以便响应于施加在绳索上的力而变形。减震器还可以包括力调节器（48）。该装置可以包括调节机构（44），其可以在将第一和第二锚固件植入第一和第二骨中之后调节在第一和第二锚定件之间延伸的绳索的长度。

10. 发明申请

WO2009150651A4 INJECTABLE HYDROGEL FORMING CHITOSAN MIXTURES 审中-公开
标题翻译：可注射的水凝胶形成CHITOSAN混合物
公开(公告)号：WO2009150651A4
公开(公告)日：2010-02-18
申请号：PCT/IL2009000582
申请日：2009-06-11
申请人： CHI2GEL LTD , BEN-SHALOM NOAH , NEVO ZVI , PATCHORNIK AVRAHAM , ROBINSON DROR
发明人： BEN-SHALOM NOAH , NEVO ZVI , PATCHORNIK AVRAHAM , ROBINSON DROR
IPC分类号： C08L5/08 , A61K47/36 , A61L27/52
CPC分类号： C08J3/075 , A23L29/275 , A61K8/042 , A61K8/736 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/06 , A61K9/19 , A61K47/36 , A61K2800/91 , A61L27/20 , A61L27/3804 , A61L27/52 , A61Q19/00 , C08J2305/08 , C08L5/08 , C08L2666/26
摘要： The present invention relates to combinations of chitosans that form hydrogels in a pH-dependant and thermo-sensitive manner, aqueous solutions used to form such hydrogels, and methods of use thereof.
摘要翻译：本发明涉及以pH依赖性和热敏感形式形成水凝胶的壳聚糖的组合，用于形成这种水凝胶的水溶液及其使用方法。

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