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1. 发明申请

WO2015073438A1 DIRECTIONAL BACKLIGHTS WITH LIGHT EMITTING ELEMENT PACKAGES 审中-公开
标题翻译：具有发光元件包的方向背光
公开(公告)号：WO2015073438A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065020
申请日：2014-11-11
申请人： REALD INC. , WOODGATE, Graham J. , HARROLD, Jonathan , ROBINSON, Michael G.
发明人： WOODGATE, Graham J. , HARROLD, Jonathan , ROBINSON, Michael G.
IPC分类号： F21S2/00
CPC分类号： G02B6/0073 , G02B6/0046 , G02B6/0048 , G02B6/0055 , G02B6/0068 , G02B27/2214 , G02B27/225 , H01L24/48 , H01L24/49 , H01L25/0753 , H01L25/167 , H01L27/15 , H01L29/866 , H01L33/486 , H01L33/505 , H01L33/62 , H01L33/642 , H01L33/647 , H01L2224/48091 , H01L2224/48137 , H01L2224/48247 , H01L2224/48257 , H01L2224/49113 , H01L2924/00014 , H01L2933/0066 , H01L2933/0075 , H01L2224/05599 , H01L2224/45099 , H01L2224/85399
摘要： A light emitting diode package for a directional display may comprise light emitting diodes and a protection diode. The protection diode may be arranged in a well that is at a different location to the well that the light emitting diodes are arranged. The directional display may include a waveguide. The waveguide may include light extraction features arranged to direct light from an array of light sources by total internal reflection to an array of viewing windows and a reflector arranged to direct light from the waveguide by transmission through extraction features of the waveguide to the same array of viewing windows. The brightness of the directional display can be increased. An efficient and bright directional display system can be achieved. Efficient light baffling for light escaping from the edge of the waveguide is achieved through light deflecting extraction films.
摘要翻译：用于定向显示器的发光二极管封装可以包括发光二极管和保护二极管。保护二极管可以布置在与发光二极管布置的阱不同的位置的阱中。方向显示器可以包括波导。波导可以包括光提取特征，其布置成将来自光源阵列的光通过全内反射引导到观察窗阵列，以及反射器，布置成通过将波导的提取特征透射通过波导的提取特征来引导来自波导的光，查看窗口。可以提高定向显示的亮度。可以实现高效明亮的方向显示系统。通过光偏转提取膜实现了从波导边缘逸出的光的高效光阻挡。

2. 发明申请

WO2013101954A1 3-PHENYL-5-UREIDOISOTHIAZOLE-4-CARBOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂的3-苯基-5-尿嘧啶-4-氧羰酰胺和3-氨基-5-苯并噻唑衍生物
公开(公告)号：WO2013101954A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/071855
申请日：2012-12-27
申请人： ALLERGAN, INC. , MALONE, Thomas C. , HULL, Clarence, E., III , BORAL, Sougato , WURSTER, Julie A. , EDELMAN, Jeffrey L. , ROBINSON, Michael R.
发明人： MALONE, Thomas C. , HULL, Clarence, E., III , BORAL, Sougato , WURSTER, Julie A. , EDELMAN, Jeffrey L. , ROBINSON, Michael R.
IPC分类号： C07D417/12 , C07D295/13 , C07D275/03 , A61K31/425 , A61K31/427 , A61P35/00 , A61P3/00
CPC分类号： C07D417/12 , C07D275/03 , C07D295/13
摘要： This invention is directed to a compound of Formula I Formula I or a pharmaceutically acceptable salt thereof, wherein R, R 1 , R 2 , R 3 , n, X 1 , X 2 , L 1 , and L 2 are as defined herein. The compounds of Formula I are useful as receptor tyrosine kinase (RTK) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders and metabolic diseases.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R，R 1，R 2，R 3，n，X 1，X 2，L 1和L 2如本文所定义。式I化合物可用作受体酪氨酸激酶（RTK）抑制剂，可用于治疗癌症，血管增生性疾病，纤维化病症，肾小球膜细胞增殖性疾病和代谢疾病等疾病。

3. 发明申请

WO2012158574A1 EFFICIENT POLARIZED DIRECTIONAL BACKLIGHT 审中-公开
标题翻译：有效的极化方向背光
公开(公告)号：WO2012158574A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/037677
申请日：2012-05-12
申请人： REALD INC. , ROBINSON, Michael, G.
发明人： ROBINSON, Michael, G.
IPC分类号： G02B27/26 , G02F1/1335 , G02F1/13357
CPC分类号： G02B27/26 , G02B5/3041 , G02B6/0048 , G02B6/0055 , G02B6/0056 , G02F1/13362 , H04N13/32
摘要： By introducing a stack of alternating high and low index dichroic material layers on the exit surface of a waveguide for a wedge type directional backlight, natural reflectivity differences between polarized components can be increased, effectively reflecting the vast proportion of S-polarized light rays, while at the same time transmitting the P-polarized light rays, of light impacting the exit surface of the waveguide at an angle sufficient to exit the waveguide. This recovers polarization in wedge type backlight systems, increasing illumination exiting the waveguide. Also, on the back reflecting surface of the waveguide, a birefringent material can be added to efficiently transform S-polarized reflected light from the dichroic stack, into returning P-polarized light. Because returning rays that are now P-polarized by the birefringent material have already achieved the critical angle for exiting the waveguide, the rays transformed to P-polarization can now also exit the waveguide, increasing waveguide illumination.
摘要翻译：通过在波导的出口表面上引入一叠交替的高折射率和低折射率的二向色性材料层用于楔形定向背光源，可以增加偏振分量之间的自然反射率差异，有效地反映了大部分的S偏振光线，同时同时透射P偏振光，其以足以离开波导的角度冲击波导的出射表面。这恢复了楔形背光系统中的极化，增加了离开波导的照明。此外，在波导的背反射面上，可以添加双折射材料，以有效地将来自二向色层的S偏振反射光变换为返回的P偏振光。因为现在由双折射材料P偏振的返回光线已经达到了用于离开波导的临界角，所以变换为P偏振的光线现在也可以离开波导，增加波导照明。

4. 发明申请

WO2012145069A2 MATERIALS AND METHODS USEFUL TO INDUCE CELL DEATH VIA METHUOSIS 审中-公开
标题翻译：用于通过甲状腺诱导细胞死亡的材料和方法
公开(公告)号：WO2012145069A2
公开(公告)日：2012-10-26
申请号：PCT/US2012/026609
申请日：2012-02-24
申请人： THE UNIVERSITY OF TOLEDO , MALTESE, William, A. , ERHARDT, Paul, W. , ROBINSON, Michael, W. , OVERMEYER, Jean, H.
发明人： MALTESE, William, A. , ERHARDT, Paul, W. , ROBINSON, Michael, W. , OVERMEYER, Jean, H.
IPC分类号： A61K31/4439
CPC分类号： A61K31/404 , A61K31/4439 , A61K45/06 , C07D209/08 , C07D209/12 , C07D401/06 , C07D403/06 , C40B40/04 , A61K2300/00
摘要： The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
摘要翻译：本发明提供了通过无细胞凋亡机制诱导细胞死亡的材料和方法。本文中的小分子可用于治疗细胞增殖障碍或异常，特别是但不排他地是癌症。本文还提供了与小分子的研究和药物应用相关的方法。

5. 发明申请

WO2012125881A2 LIQUID CRYSTAL DEVICES HAVING REDUCED ELECTRODE-GAP VISIBILITY 审中-公开
标题翻译：具有减少电极 - 气隙可见性的液晶装置
公开(公告)号：WO2012125881A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029313
申请日：2012-03-15
申请人： REALD INC. , McKNIGHT, Douglas, J. , ROBINSON, Michael, G.
发明人： McKNIGHT, Douglas, J. , ROBINSON, Michael, G.
IPC分类号： G02F1/1333 , G02F1/1343
CPC分类号： B32B38/06 , B32B37/24 , B32B2037/243 , B32B2309/105 , B32B2457/202 , G02F1/133707 , G02F1/134309 , Y10T156/10
摘要： Liquid crystal devices may include electrode segments that are spaced apart and have a gap therebetween. A bridge layer may be disposed in the gap and configured to have a resistance that is operable provide a substantially equipotential region proximate to the gap portion while still allowing the electrode segments to be substantially isolated electrically. The disclosed liquid crystal devices may have reduced visual artifacts and may be configured to be a liquid crystal display, a polarization control panel, or a switch having liquid crystal cells.
摘要翻译：液晶装置可以包括间隔开并且在它们之间具有间隙的电极段。桥接层可以设置在间隙中并且被配置为具有可操作的电阻，其提供靠近间隙部分的基本上等电位的区域，同时仍允许电极段基本上是电隔离的。所公开的液晶装置可以具有减少的视觉瑕疵，并且可以被配置为液晶显示器，偏振控制面板或具有液晶单元的开关。

6. 发明申请

WO2011091205A3 INTRACAMERAL SUSTAINED RELEASE THERAPEUTIC AGENT IMPLANTS 审中-公开
标题翻译：内镜持续释放治疗代理植入物
公开(公告)号：WO2011091205A3
公开(公告)日：2012-04-19
申请号：PCT/US2011021971
申请日：2011-01-21
申请人： ALLERGAN INC , ROBINSON MICHAEL R , BURKE JAMES , SCHIFFMAN RHETT
发明人： ROBINSON MICHAEL R , BURKE JAMES , SCHIFFMAN RHETT
IPC分类号： A61K9/00 , A61K31/5575 , A61K47/34
CPC分类号： A61K9/0051 , A61K9/0024 , A61K9/1647 , A61K31/5575 , A61K47/10 , A61K47/34 , A61L27/18 , A61L27/54 , A61L27/58
摘要： Described herein are intracameral implants including at least one therapeutic agent for treatment of at least one ocular condition. The implants described herein are not anchored to the ocular tissue, but rather are held in place by currents and gravity present in the anterior chamber of an eye. The implants are preferably polymeric, biodegradable and provide sustained release of at least one therapeutic agent to both the trabecular meshwork and associated ocular tissue and the fluids within the anterior chamber of an eye.
摘要翻译：本文描述的是包括用于治疗至少一种眼部病症的至少一种治疗剂的植入物植入物。本文所述的植入物不固定在眼组织上，而是通过存在于眼前房中的电流和重力保持在适当位置。植入物优选是聚合的，可生物降解的并且提供至少一种治疗剂持续释放到小梁网和相关联的眼组织和眼睛前房内的流体。

7. 发明申请

WO2011130462A3 INTRAOCULAR PRESSURE REDUCTION WITH INTRACAMERAL BIMATOPROST IMPLANTS 审中-公开
公开(公告)号：WO2011130462A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/032393
申请日：2011-04-14
申请人： ALLERGAN, INC. , HUGHES, Patrick, M. , ROBINSON, Michael, R. , BURKE, James, A.
发明人： HUGHES, Patrick, M. , ROBINSON, Michael, R. , BURKE, James, A.
IPC分类号： A61K9/70 , A61K47/34 , A61K31/557 , A61P27/02
摘要： The present invention provides a method of treating an ocular condition in an eye of a patient, comprising the step of placing a biodegradable intraocular implant in an eye of the patient, the implant comprising a prostamide and a biodegradable polymer matrix that releases drug at a rate effective to sustain release of an amount of the prostamide from the implant to provide an amount of the prostamide effective to prevent or reduce a symptom of an ocular condition of the eye, wherein said ocular condition is elevated IOP and said implant is placed in an intracameral location to dilate the outflow channels of the eye emanating from Schlemm's Canal.

8. 发明申请

WO2011103581A2 BENDABLE LIQUID CRYSTAL POLARIZATION SWITCH FOR DIRECT VIEW STEREOSCOPIC DISPLAY 审中-公开
标题翻译：可弯曲的液晶偏振开关，用于直视立体显示
公开(公告)号：WO2011103581A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025742
申请日：2011-02-22
申请人： REALD INC. , SHARP, Gary, D. , ROBINSON, Michael, G.
发明人： SHARP, Gary, D. , ROBINSON, Michael, G.
IPC分类号： G02B27/26 , H04N13/00 , G02F1/1335
CPC分类号： G02B27/26 , G02B27/2264 , H04N13/337
摘要： A system for stereoscopic display and a bendable polarization switch for use with a system for stereoscopic display provide alternately polarized left and right eye images. Viewers then wear polarization analyzing eyewear to correctly see the different images. More specifically, a bendable polarization switch may be laminated to the front of a system for stereoscopic display. The bendable polarization switch may be used with a modulator configuration that is compatible with various performance requirements in a manner that is a low-cost manufacturing friendly solution. Further, the bendable polarization switch is a robust polarization switch technology that is reliable in an environment where mechanical stresses are inevitably applied during product lifetime.
摘要翻译：用于立体显示的系统和用于立体显示系统的可弯曲偏振开关提供交替极化的左眼图像和右眼图像。观众然后穿戴偏光分析眼镜正确地看见不同的图象。更具体地说，可弯曲的偏振开关可以被层压到用于立体显示的系统的前部。可弯曲偏振开关可以与低成本制造友好型解决方案的方式兼容的各种性能要求的调制器配置一起使用。此外，可弯曲的偏振开关是一种鲁棒的偏振开关技术，在产品寿命期间不可避免地施加机械应力的环境中是可靠的。

9. 发明申请

WO2011097572A1 TRANSCRIPTIONAL PROFILING AND BIOMARKER-BASED METHODS FOR IDENTIFYING AND EVALUATING AGENTS FOR ANTIOXIDANT EFFICACY IN COSMETIC SKIN CARE FORMULATIONS 审中-公开
标题翻译：用于识别和评估化妆品护肤产品中抗氧化剂效力的代谢分析和基于生物标记的方法
公开(公告)号：WO2011097572A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023918
申请日：2011-02-07
申请人： THE PROCTER & GAMBLE COMPANY , FINLAY, Deborah, Ruth , BINDER, Robert, Lloyd , ROBINSON, Michael, Keith , OSBORNE, Rosemarie , MULLINS, Lisa, Ann
发明人： FINLAY, Deborah, Ruth , BINDER, Robert, Lloyd , ROBINSON, Michael, Keith , OSBORNE, Rosemarie , MULLINS, Lisa, Ann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/148 , C12Q2600/158 , C12Q2600/16 , G01N33/5044 , G01N2333/90245 , G01N2500/04 , G01N2500/10
摘要： Gene panels, microarrays and biomarker panels relating to genes and gene products associated with age-related oxidative damage to skin, and transcriptional profiling-based methods for identification and evaluation of cosmetic agents for prevention, reversal, or reduction of oxidative damage to skin. Cosmetic agents and compositions comprising the cosmetic agents, capable of inducing nrf2-mediated activation of the antioxidant response element to increase expression of Phase 2 enzymes, methods for restoring optimal redox status to skin employing the agents, and methods for identifying and evaluating cosmetic agents acting via the nrf2-mediated mechanism.
摘要翻译：与与年龄相关的对皮肤的氧化损伤相关的基因和基因产物的基因组，微阵列和生物标记面板以及用于鉴定和评价化妆品以预防，逆转或减少对皮肤的氧化损伤的基于转录谱的方法。包含化妆品的化妆品和组合物，其能够诱导nrf2介导的抗氧化反应元件的活化以增加阶段2酶的表达，使用该试剂恢复对皮肤的最佳氧化还原状态的方法，以及用于鉴定和评估作用的化妆品的方法通过nrf2介导的机制。

10. 发明申请

WO2011085044A3 CROSSTALK SUPPRESSION IN TIME SEQUENTIAL LIQUID CRYSTAL STEREOSCOPIC DISPLAY SYSTEMS 审中-公开
公开(公告)号：WO2011085044A3
公开(公告)日：2011-07-14
申请号：PCT/US2011/020277
申请日：2011-01-05
申请人： REALD INC. , ROBINSON, Michael, G. , MCKNIGHT, Douglas, J.
发明人： ROBINSON, Michael, G. , MCKNIGHT, Douglas, J.
IPC分类号： G09G3/36 , H04N13/04
摘要： This disclosure primarily concerns 3D stereoscopic displays that provide alternately polarized left and right eye images encoded with a modulating LC polarization control panel (PCP) attached to the front of the display. Viewers then wear polarization analyzing eyewear to correctly see the different images. More specifically, the disclosure introduces global LC electrical reset during the addressing of liquid crystal time- sequential stereoscopic displays in order to reduce left/right eye contamination. LC materials in general do not respond fast enough with conventional addressing schemes to provide independent left and right eye images at the desired flicker-free, rate of sixty frames per second per eye. This disclosure and its embodiments may overcome this limitation, and also may address motion blur limitations, by driving pixels to a common LC state as part of the addressing cycle.

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