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1. 发明申请

WO2012119727A1 AQUEOUS PHARMACEUTICAL FORMULATION OF TAPENTADOL FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口服给药的TAPENTADOL的水性药物制剂
公开(公告)号：WO2012119727A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/000904
申请日：2012-03-02
申请人： GRÜNENTHAL GMBH , REINHOLD, Ulrich , SCHILLER, Marc , WULSTEN, Eva , INGHELBRECHT, Sabine, Karine, Katrien , EMBRECHTS, Roger, Carolus, Augusta
发明人： REINHOLD, Ulrich , SCHILLER, Marc , WULSTEN, Eva , INGHELBRECHT, Sabine, Karine, Katrien , EMBRECHTS, Roger, Carolus, Augusta
IPC分类号： A61K31/137 , A61K9/00
CPC分类号： A61K31/137 , A61K9/0053 , A61K9/0095 , A61K9/08 , A61K47/02 , A61K47/12
摘要： The invention relates to an aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof and being adapted for oral administration. The composition has excellent storage stability without relying on the presence of high amounts of preservatives.
摘要翻译：本发明涉及含有他喷他多或其生理上可接受的盐并适于口服给药的水性药物组合物。该组合物具有优异的储存稳定性，而不依赖于大量防腐剂的存在。

2. 发明申请

WO2006091529A3 A SOLID PHARMACEUTICAL DOSAGE FORMULATION 审中-公开
标题翻译：固体药物制剂
公开(公告)号：WO2006091529A3
公开(公告)日：2007-02-08
申请号：PCT/US2006005944
申请日：2006-02-21
申请人： ABBOTT LAB , ROSENBERG JOEERG , REINHOLD ULRICH , LIEPOLD BERND , BERNDL GUNTHER , BREITENBACH JOERG , ALANI LAMAN , GHOSH SOUMOJEET
发明人： ROSENBERG JOEERG , REINHOLD ULRICH , LIEPOLD BERND , BERNDL GUNTHER , BREITENBACH JOERG , ALANI LAMAN , GHOSH SOUMOJEET
IPC分类号： A61K31/513 , A61K9/16 , A61K9/20 , A61K9/28 , A61K31/426 , A61K31/427
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/204 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/00 , A61K31/426 , A61K31/427 , A61K31/513 , A61K47/32 , A61K2300/00
摘要： The present invention provides a pharmaceutical dosage formulation, and more particularly, to a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
摘要翻译：本发明提供药物剂型制剂，更具体地，涉及包含HIV蛋白酶抑制剂的药物剂型。

3. 发明申请

WO0032169A2 METHOD FOR PRODUCING SOLID FORMS OF ADMINISTRATION BY MELT EXTRUSION 审中-公开
标题翻译：法生产固体剂型通过熔体挤出
公开(公告)号：WO0032169A2
公开(公告)日：2000-06-08
申请号：PCT/EP9909309
申请日：1999-11-30
申请人： BASF AG , BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
发明人： BERNDL GUNTHER , KOTHRADE STEPHAN , KESSLER THOMAS , LANGE ARMIN , HOFMANN JUERGEN , REINHOLD ULRICH
IPC分类号： A61J3/10 , A61K9/16 , A61K9/20 , B29C47/42
CPC分类号： B29C47/42 , A61J3/10 , A61J2200/20 , A61K9/1694 , A61K9/2095 , B29C47/0021
摘要： The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).
摘要翻译：本发明涉及一种通过熔体挤出制备固体剂型的方法。在这种情况下，混合的聚合物粘合剂，至少一种药物活性成分和任选的其它添加剂，将混合物熔化到挤出机中并挤出它然后在连续塑料产物链的形式。使用本发明的方法的特征在于，作为挤出机具有一个行星辊挤出机（10），其优选地具有一个中心轴（13）和6个行星主轴（14）。

4. 发明申请

WO2006091529A2 A SOLID PHARMACEUTICAL DOSAGE FORMULATION 审中-公开
标题翻译：固体药物制剂
公开(公告)号：WO2006091529A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005944
申请日：2006-02-21
申请人： ABBOTT LABORATORIES , ROSENBERG, Jöerg , REINHOLD, Ulrich , LIEPOLD, Bernd , BERNDL, Gunther , BREITENBACH, Jörg , ALANI, Laman , GHOSH, Soumojeet
发明人： ROSENBERG, Jöerg , REINHOLD, Ulrich , LIEPOLD, Bernd , BERNDL, Gunther , BREITENBACH, Jörg , ALANI, Laman , GHOSH, Soumojeet
IPC分类号： A61K31/513 , A61K31/426 , A61K9/20 , A61K9/28
CPC分类号： A61K9/1694 , A61K9/1617 , A61K9/1635 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/204 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/00 , A61K31/426 , A61K31/427 , A61K31/513 , A61K47/32 , A61K2300/00
摘要： The present invention provides a pharmaceutical dosage formulation, and more particularly, to a pharmaceutical dosage formulation comprising an HIV protease inhibitor.
摘要翻译：本发明提供药物剂型制剂，更具体地说，涉及包含HIV蛋白酶抑制剂的药物剂型。

5. 发明申请

WO9927891A3 METHOD FOR PRODUCING SOLVENT-FREE NON-CRYSTALLINE BIOLOGICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：制备无溶剂非结晶生物活性物质的方法
公开(公告)号：WO9927891A3
公开(公告)日：1999-08-12
申请号：PCT/EP9807141
申请日：1998-11-09
申请人： KNOLL AG , BREITENBACH JOERG , REINHOLD ULRICH , ZEIDLER JUERGEN , ROSENBERG JOERG
发明人： BREITENBACH JOERG , REINHOLD ULRICH , ZEIDLER JUERGEN , ROSENBERG JOERG
IPC分类号： A61K9/14 , A61K9/16
CPC分类号： A61K9/14 , A61K9/1688
摘要： A method for producing solvent-free non-crystalline biologically active substances from corresponding crystalline biologically active substances in an extruder, characterised in that said substances are melted in an extruder in a vacuum without the presence of adjuvants and are cooled and ground.
摘要翻译：用于在挤出机中由相应的结晶生物活性物质制备无溶剂非结晶生物活性物质的方法，其特征在于将物质熔融，冷却并在真空下和不存在助剂的情况下在挤出机中粉碎。

6. 发明申请

WO1990010785A1 OPERATION OF A COMBINED GAS TURBINE/STEAM TURBINE PROCESS 审中-公开
标题翻译：组合式涡轮机/蒸汽涡轮机工艺的运行
公开(公告)号：WO1990010785A1
公开(公告)日：1990-09-20
申请号：PCT/EP1990000367
申请日：1990-03-06
申请人： L. & C. STEINMÜLLER GMBH , CROONENBROCK, Raimund , STEVEN, Hubert , PITT, Reinhold, Ulrich
发明人： L. & C. STEINMÜLLER GMBH
IPC分类号： F01K23/06
CPC分类号： F02C3/205 , F01K23/062 , F02C6/003
摘要： Operation of a combined gas turbine/steam turbine process. The boosted primary high-pressure gas turbine process is operated by means of compressed air and a combustible fluid and the steam turbine process is operated with a fluidized bed combustor fed with a carbonaceous solid fuel. The combustion in the fluidized bed combustor is carried out with the oxygen-laden waste gases from the primary high-pressure gas turbine process and electrical energy can be produced by both turbine processes. To increase the efficiency, the pressure of the exhaust gases from the primary high-pressure gas turbine process (13) is reduced only until the fluidized bed combustor can be operated as a pressurized fluidized bed (6) and the pressure of the exhaust gases of the pressurized fluidized bed combustor is reduced after dust removal (14) in a second gas turbine process (2). These exhaust gases undergo heat exchange (10) with the compressed air of the primary high-pressure gas turbine process (13). The air for the primary high-pressure gas turbine process undergoes a two-stage compression (19) with recooling (8). The compression energy for the first stage (1) is derived from the second gas turbine process (2) and the energy for the second stage (9) from the primary high-pressure gas turbine process (13).
摘要翻译：组合燃气轮机/汽轮机过程的运行。增压的初级高压燃气轮机过程通过压缩空气和可燃液体进行操作，并且蒸汽轮机过程与供给有碳质固体燃料的流化床燃烧器一起操作。流化床燃烧器中的燃烧是用来自初级高压燃气轮机过程的含氧废气进行的，并且可以通过两个涡轮机过程产生电能。为了提高效率，来自初级高压燃气轮机工艺（13）的废气的压力仅在流化床燃烧器可以作为加压流化床（6）运行并且废气的压力在第二燃气轮机过程（2）中除尘（14）之后减压加压流化床燃烧器。这些废气与主要高压燃气轮机过程（13）的压缩空气进行热交换（10）。用于初级高压燃气轮机过程的空气经过二级压缩（19），具有再冷凝（8）。第一级（1）的压缩能量源自第二燃气轮机过程（2）和来自初级高压燃气轮机过程（13）的第二级（9）的能量。

7. 发明申请

WO2005039551A3 SOLID PHARMACEUTICAL DOSAGE FORM COMPRISING AN HIV PROTEASE INHIBITOR SOLID DISPERSION 审中-公开
标题翻译：包含HIV蛋白酶抑制剂固体分散体的固体药物剂型
公开(公告)号：WO2005039551A3
公开(公告)日：2006-08-03
申请号：PCT/US2004027401
申请日：2004-08-23
申请人： ABBOTT LAB , ROSENBERG JOEERG , REINHOLD ULRICH , LIEPOLD BERND , DERNDL GUNTHER , BREITENBACH JOERG , ALANI LAMAN , GHOSH SOUMOJEET
发明人： ROSENBERG JOEERG , REINHOLD ULRICH , LIEPOLD BERND , DERNDL GUNTHER , BREITENBACH JOERG , ALANI LAMAN , GHOSH SOUMOJEET
IPC分类号： A61K9/14 , A61K9/20 , A61K9/28 , A61K31/425
CPC分类号： A61K31/425 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2866
摘要： A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
摘要翻译：公开了提供改善的口服生物利用度的固体药物剂型，用于HIV蛋白酶的抑制剂。特别地，剂型包含至少一种HIV蛋白酶抑制剂和至少一种药学上可接受的水溶性聚合物和至少一种药学上可接受的表面活性剂的固体分散体，所述药学上可接受的水溶性聚合物的Tg至少为约50 C。优选地，药学上可接受的表面活性剂的HLB值为约4至约10。

8. 发明申请

WO2012119729A1 SEMISOLID AQUEOUS PHARMACEUTICAL COMPOSITION CONTAINING TAPENTADOL 审中-公开
标题翻译：含有TAPENTADOL的SEMISOLID水性药物组合物
公开(公告)号：WO2012119729A1
公开(公告)日：2012-09-13
申请号：PCT/EP2012/000906
申请日：2012-03-02
申请人： GRÜNENTHAL GMBH , REINHOLD, Ulrich , SCHILLER, Marc , WULSTEN, Eva , INGHELBRECHT, Sabine, Karine , EMBRECHTS, Roger, Carolus, Augusta
发明人： REINHOLD, Ulrich , SCHILLER, Marc , WULSTEN, Eva , INGHELBRECHT, Sabine, Karine , EMBRECHTS, Roger, Carolus, Augusta
IPC分类号： A61K31/137 , A61K9/00
CPC分类号： A61K31/137 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K47/06 , A61K47/10 , A61K47/14 , Y02A50/473 , Y02A50/481
摘要： The invention relates to a semisolid aqueous pharmaceutical composition containing tapentadol or a physiologically acceptable salt thereof.
摘要翻译：本发明涉及含有他喷他多或其生理上可接受的盐的半固体含水药物组合物。

9. 发明申请

WO2005039551A2 SOLID PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：固体药物剂型
公开(公告)号：WO2005039551A2
公开(公告)日：2005-05-06
申请号：PCT/US2004/027401
申请日：2004-08-23
申请人： ABBOTT LABORATORIES , ROSENBERG, Jöerg , REINHOLD, Ulrich , LIEPOLD, Bernd , DERNDL, Gunther , BREITENBACH, Jörg , ALANI, Laman , GHOSH, Soumojeet
发明人： ROSENBERG, Jöerg , REINHOLD, Ulrich , LIEPOLD, Bernd , DERNDL, Gunther , BREITENBACH, Jörg , ALANI, Laman , GHOSH, Soumojeet
IPC分类号： A61K31/00
CPC分类号： A61K31/425 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2866
摘要： A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
摘要翻译：公开了提供改善的口服生物利用度的固体药物剂型，用于HIV蛋白酶的抑制剂。特别地，剂型包含至少一种HIV蛋白酶抑制剂和至少一种药学上可接受的水溶性聚合物和至少一种药学上可接受的表面活性剂的固体分散体，所述药学上可接受的水溶性聚合物的Tg至少为约50 C。优选地，药学上可接受的表面活性剂具有约4至约10的HLB值。

10. 发明申请

WO0041481A2 MEDICAMENT FORMS HAVING CONTROLLED RELEASE AND CONTAINING ACTIVE SUBSTANCES WHICH EASILY DISSOLVE IN WATER 审中-公开
标题翻译：与控释药物形成含有水溶性好ACTIVE
公开(公告)号：WO0041481A2
公开(公告)日：2000-07-20
申请号：PCT/EP0000053
申请日：2000-01-07
申请人： KNOLL AG , ROSENBERG JOERG , NEUMANN JOERG , VOLLGRAF CHRISTIANE , REINHOLD ULRICH
发明人： ROSENBERG JOERG , NEUMANN JOERG , VOLLGRAF CHRISTIANE , REINHOLD ULRICH
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/28 , A61K31/138 , A61K47/32 , A61P9/12
CPC分类号： A61K31/138 , A61K9/2027 , A61K9/2054 , A61K9/2095 , A61K9/2866
摘要： The invention relates to a medicament form containing an active substance with a water-solubility, according to USP, ranging from 23 to 30 in a matrix that is based on acrylate polymers, whereby the medicament form can be obtained by melt extrusion.
摘要翻译：含有根据USP 23在水中的溶解度的活性成分的剂型最多30在基于丙烯酸酯聚合物的基体，其中所述剂型是通过熔融挤出而获得。

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