专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012025251A1 NUCLEIC ACIDS FOR TREATMENT OF CHRONIC COMPLICATIONS OF DIABETES 审中-公开
标题翻译：用于治疗糖尿病慢性并发症的核酸
公开(公告)号：WO2012025251A1
公开(公告)日：2012-03-01
申请号：PCT/EP2011/004331
申请日：2011-08-29
申请人： NOXXON PHARMA AG , PURSCHKE, Werner , JAROSCH, Florian , EULBERG, Dirk , KLUSSMANN, Sven , BUCHNER, Klaus , MAASCH, Christian , DINSE, Nicole
发明人： PURSCHKE, Werner , JAROSCH, Florian , EULBERG, Dirk , KLUSSMANN, Sven , BUCHNER, Klaus , MAASCH, Christian , DINSE, Nicole
IPC分类号： A61K31/7088 , C12N15/115
CPC分类号： A61K31/7088 , A61K31/7105 , A61K31/7115 , C12N15/115 , C12N2310/16 , Y02A50/414
摘要： The present invention is related to a nucleic acid molecule capable of binding to MCP-1, preferably capable of inhibiting MCP-1, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of a disease or disorder, or for use as a medicament for the treatment and/or prevention of a disease or disorder, wherein the disease or disorder is selected from the group of diabetes, diabetic complication, diabetic condition, inflammatory joint disease, eye disease, asthma, autoimmune disease, neuroinflammatory disease, tissue disease, cardiovascular disease, renal disease, ischemia injury, reperfusion injury, lung disease, transplantation, gynecological disease and conditions with elevated MCP-1 level.
摘要翻译：本发明涉及能够结合MCP-1的核酸分子，优选能够抑制MCP-1，由此核酸分子用于治疗和/或预防疾病或病症的方法，或用作治疗和/或预防疾病或病症的药物，其中所述疾病或病症选自糖尿病，糖尿病并发症，糖尿病，炎性关节疾病，眼病，哮喘，自身免疫性疾病，神经炎症，组织疾病，心血管疾病，肾脏疾病，缺血损伤，再灌注损伤，肺部疾病，移植，妇科疾病和升高的MCP-1水平的病症。

2. 发明申请

WO2012031773A1 SDF-1 BINDING NUCLEIC ACIDS AND THE USE THEREOF IN CANCER TREATMENT 审中-公开
标题翻译： SDF-1结合核酸及其在癌症治疗中的应用
公开(公告)号：WO2012031773A1
公开(公告)日：2012-03-15
申请号：PCT/EP2011/004554
申请日：2011-09-09
申请人： NOXXON PHARMA AG , PURSCHKE, Werner , JAROSCH, Florian , EULBERG, Dirk , KLUSSMANN, Sven , BUCHNER, Klaus , MAASCH, Christian , DINSE, Nicole , ZBORALSKI, Dirk
发明人： PURSCHKE, Werner , JAROSCH, Florian , EULBERG, Dirk , KLUSSMANN, Sven , BUCHNER, Klaus , MAASCH, Christian , DINSE, Nicole , ZBORALSKI, Dirk
IPC分类号： A61K31/7088 , C12N15/115 , A61P35/00
CPC分类号： C12N15/115 , A61K31/69 , A61K31/7076 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K35/12 , A61K45/06 , C12N2310/16 , C12N2310/30 , C12N2310/351 , C12N2320/30 , C12N2320/31 , A61K2300/00
摘要： The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of a disease or disorder, for use in a method for the treatment of a subject suffering from a disease or disorder or being at risk of developing a disease or disorder as an adjunct therapy, or for use as a medicament for the treatment and/or prevention of a disease or disorder, whereby the disease or disorder is cancer.
摘要翻译：本发明涉及能够结合SDF-1，优选能够抑制SDF-1的核酸分子，其中核酸分子用于治疗和/或预防疾病或病症的方法，用于治疗患有疾病或障碍或患有作为辅助治疗的疾病或病症发生风险的受试者的方法，或用作治疗和/或预防疾病或病症的药物，其中疾病或病症是癌症。

3. 发明申请

WO2010108657A3 C5A BINDING NUCLEIC ACIDS AND THE USE THEREOF 审中-公开
标题翻译： C5A结合核酸及其用途
公开(公告)号：WO2010108657A3
公开(公告)日：2011-03-10
申请号：PCT/EP2010001813
申请日：2010-03-23
申请人： NOXXON PHARMA AG , JAROSCH FLORIAN , PURSCHKE WERNER , EULBERG DIRK , MAASCH CHRISTIAN , BUCHNER KLAUS , KLUSSMANN SVEN
发明人： JAROSCH FLORIAN , PURSCHKE WERNER , EULBERG DIRK , MAASCH CHRISTIAN , BUCHNER KLAUS , KLUSSMANN SVEN
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00 , A61P11/00 , A61P25/00 , A61P35/00
CPC分类号： C12N15/115 , C12N2310/16
摘要： The present invention is related to a nucleic acid molecule, capable of binding to C5a, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of tumors, the treatment and/or prevention of a respiratory disease, the treatment and/or prevention of pain and/or the treatment and/or prevention of a neurodegenerative disorder.
摘要翻译：本发明涉及能够结合C5a的核酸分子，其中核酸分子用于治疗和/或预防肿瘤的方法，治疗和/或预防呼吸系统疾病，治疗和/或预防疼痛和/或治疗和/或预防神经变性疾病。

4. 发明申请

WO2010108657A2 C5A BINDING NUCLEIC ACIDS AND THE USE THEREOF 审中-公开
标题翻译： C5A结合核酸及其用途
公开(公告)号：WO2010108657A2
公开(公告)日：2010-09-30
申请号：PCT/EP2010/001813
申请日：2010-03-23
申请人： NOXXON PHARMA AG , JAROSCH, Florian , PURSCHKE, Werner , EULBERG, Dirk , MAASCH, Christian , BUCHNER, Klaus , KLUSSMANN, Sven
发明人： JAROSCH, Florian , PURSCHKE, Werner , EULBERG, Dirk , MAASCH, Christian , BUCHNER, Klaus , KLUSSMANN, Sven
IPC分类号： C12N15/113
CPC分类号： C12N15/115 , C12N2310/16
摘要： The present invention is related to a nucleic acid molecule, capable of binding to C5a, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of tumors, the treatment and/or prevention of a respiratory disease, the treatment and/or prevention of pain and/or the treatment and/or prevention of a neurodegenerative disorder.
摘要翻译：本发明涉及能够结合C5a的核酸分子，其中核酸分子用于治疗和/或预防肿瘤的方法，治疗和/或预防呼吸系统疾病，治疗和/或预防疼痛和/或治疗和/或预防神经变性疾病。

5. 发明申请

WO2009019007A3 SDF-1 BINDING NUCLEIC ACIDS AND THE USE THEREOF 审中-公开
标题翻译： SDF-1结合核酸及其用途
公开(公告)号：WO2009019007A3
公开(公告)日：2009-04-16
申请号：PCT/EP2008006473
申请日：2008-08-06
申请人： NOXXON PHARMA AG , PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN , DINSE NICOLE
发明人： PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN , DINSE NICOLE
IPC分类号： A61K31/713 , C12N15/115
CPC分类号： C12N15/115 , A61K31/7105 , A61K31/713 , A61K47/60 , C07K14/521 , C07K16/24 , C12N2310/16 , C12N2310/351 , C12N2320/30
摘要： The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells.
摘要翻译：本发明涉及与SDF-1结合的核酸分子，由此核酸分子影响细胞的迁移。

6. 发明申请

WO2008009437A3 SDF-I BINDING NUCLEIC ACIDS 审中-公开
标题翻译： SDF-I结合核酸
公开(公告)号：WO2008009437A3
公开(公告)日：2008-03-27
申请号：PCT/EP2007006387
申请日：2007-07-18
申请人： NOXXON PHARMA AG , PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN , DINSE NICOLE
发明人： PURSCHKE WERNER , JAROSCH FLORIAN , EULBERG DIRK , KLUSSMANN SVEN , BUCHNER KLAUS , MAASCH CHRISTIAN , DINSE NICOLE
IPC分类号： A61K38/00 , C12N15/115 , C12Q1/68
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/30
摘要： The present invention is related to a nucleic acid molecule, preferably binding to SDF-I, selected from the group comprising type A nucleic acid molecules, type B nucleic acid molecules, type C nucleic acid molecules and nucleic acid molecules having a nucleic acid sequence according to any of SEQ.ID.No. 142, SEQ.ID.No. 143 and SEQ.ID.No. 144.
摘要翻译：本发明涉及选自A型核酸分子，B型核酸分子，C型核酸分子和具有根据本发明的核酸序列的核酸分子的核酸分子，优选与SDF-1结合的核酸分子，到SEQ.ID.No. 142，SEQ.ID.No. 143和SEQ.ID.No. 144。

7. 发明申请

WO2006117217A2 NEUE VERWENDUNG VON SPIEGELMEREN 审中-公开
标题翻译： Spiegelmers®的新用途
公开(公告)号：WO2006117217A2
公开(公告)日：2006-11-09
申请号：PCT/EP2006/004180
申请日：2006-05-04
申请人： NOXXON PHARMA AG , JAROSCH, Florian , MAASCH, Christian , KLUSSMANN, Sven , VATER, Axel , EULBERG, Dirk , PURSCHKE, Werner , BUCHNER, Klaus
发明人： JAROSCH, Florian , MAASCH, Christian , KLUSSMANN, Sven , VATER, Axel , EULBERG, Dirk , PURSCHKE, Werner , BUCHNER, Klaus
IPC分类号： A61K31/7088 , G01N33/50 , A61P35/00 , A61P31/00 , A61P19/02 , C12N15/11
CPC分类号： C12N15/115 , C12N2310/16 , G01N2500/04
摘要： Die vorliegende Erfindung betrifft die Verwendung einer L-Nukleinsäure als intrazellulär aktives Agens.
摘要翻译：本发明涉及使用一个L核酸作为细胞内的活性剂。

8. 发明申请

WO2012095303A1 NUCLEIC ACID MOLECULE HAVING BINDING AFFINITY TO A TARGET MOLECULE AND A METHOD FOR GENERATING THE SAME 审中-公开
标题翻译：具有结合亲和性的目标分子的核酸分子及其产生方法
公开(公告)号：WO2012095303A1
公开(公告)日：2012-07-19
申请号：PCT/EP2012/000089
申请日：2012-01-10
申请人： NOXXON PHARMA AG , JAROSCH, Florian , KLUSSMANN, Sven , SELL, Simone , PURSCHKE, Werner , MAASCH, Christian , VATER, Axel , HÖHLIG, Kai
发明人： JAROSCH, Florian , KLUSSMANN, Sven , SELL, Simone , PURSCHKE, Werner , MAASCH, Christian , VATER, Axel , HÖHLIG, Kai
IPC分类号： C12N15/11 , C12N15/115
CPC分类号： C12N15/115 , C12N15/102 , C12N15/111 , C12N2310/16 , C12N2310/32 , C12N2320/13 , C12N2330/31 , G01N33/5308 , G01N2400/10 , G01N2500/04
摘要： The present invention is related to a method for generating a nucleic acid molecule capable of binding to a target molecule comprising the following steps: a) providing a reference nucleic acid molecule, wherein the reference nucleic acid molecule is capable of binding to the target molecule and wherein the reference nucleic acid molecule comprises a sequence of nucleotides, wherein the sequence of nucleotides comprises n nucleotides; b) preparing a first level derivative of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule differs from the reference nucleic acid molecule at one nucleotide position, wherein the first level derivative is prepared by replacing the ribonucleotide at the one nucleotide position by a 2'-deoxyribonucleotide in case the reference nucleic acid has a ribonucleotide at the nucleotide position and wherein the first level derivative is prepared by replacing the 2'-deoxyribonucleotide at the one nucleotide position by a ribonucleotide in case the reference nucleic acid has a 2'-deoxyribonucleotide at the nucleotide position and wherein the nucleotide position at which the replacement is made is the modified nucleotide position; and c) repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the group of first level derivatives of the reference nucleic acid molecule consists of n first level derivatives, wherein each of the first level derivatives of the reference nucleic acid molecule differs from the reference nucleic acid molecule by a single nucleotide replacement and wherein each of the first level derivatives of the reference nucleic acid molecule has a single modified nucleotide position which is different from the single modified nucleotide of all of the single modified nucleotide positions of the other first level derivatives of the group of first level derivatives of the reference nucleic acid molecule.
摘要翻译：本发明涉及产生能够结合靶分子的核酸分子的方法，该方法包括以下步骤：a）提供参照核酸分子，其中参考核酸分子能够结合靶分子和其中所述参考核酸分子包含核苷酸序列，其中所述核苷酸序列包含n个核苷酸; b）制备参考核酸分子的一级衍生物，其中参考核酸分子的第一级衍生物在一个核苷酸位置与参考核酸分子不同，其中第一级衍生物通过将核糖核酸在参考核酸在核苷酸位置具有核糖核苷酸的情况下，通过2'-脱氧核糖核苷酸的一个核苷酸位置，并且其中第一级衍生物是通过核糖核苷酸替换核糖核苷酸的2'-脱氧核糖核苷酸而制备的，酸在核苷酸位置具有2'-脱氧核糖核苷酸，其中进行置换的核苷酸位置是修饰的核苷酸位置; 和c）对参考核酸分子的每个核苷酸位置重复步骤b），从而制备参考核酸分子的一级第一级衍生物，其中参考核酸分子的一级衍生物组由n个第一其中参考核酸分子的每个第一级衍生物通过单核苷酸替换与参考核酸分子不同，并且其中参考核酸分子的每个第一级衍生物具有单个修饰的核苷酸位置，其为与参考核酸分子的第一级衍生物组的其他第一级衍生物的所有单一修饰的核苷酸位置的单个修饰的核苷酸不同。

9. 发明申请

WO2011131371A1 LIPID BINDING NUCLEIC ACIDS 审中-公开
标题翻译：脂肪结合核酸
公开(公告)号：WO2011131371A1
公开(公告)日：2011-10-27
申请号：PCT/EP2011/002068
申请日：2011-04-21
申请人： NOXXON PHARMA AG , PURSCHKE, Werner , KLUSSMANN, Sven , BUCHNER, Klaus , SCHWÖBEL, Frank , HÖHLIG, Kai
发明人： PURSCHKE, Werner , KLUSSMANN, Sven , BUCHNER, Klaus , SCHWÖBEL, Frank , HÖHLIG, Kai
IPC分类号： C12N15/115 , A61K31/7088
CPC分类号： C12N15/115 , C12N2310/16 , G01N33/92
摘要： The present invention is related to a nucleic acid molecule capable of binding to a lipid.
摘要翻译：本发明涉及能够结合脂质的核酸分子。

10. 发明申请

WO2006058705A1 VASOPRESSIN BINDENDE L-NUKLEINSÄURE 审中-公开
标题翻译：加压素约束力L-核酸
公开(公告)号：WO2006058705A1
公开(公告)日：2006-06-08
申请号：PCT/EP2005/012744
申请日：2005-11-29
申请人： NOXXON PHARMA AG , PURSCHKE, Werner , EULBERG, Dirk , KLUSSMANN, Sven , RÖHL, Ingo , VATER, Axel
发明人： PURSCHKE, Werner , EULBERG, Dirk , KLUSSMANN, Sven , RÖHL, Ingo , VATER, Axel
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/351
摘要： Die vorliegende Erfindung betrifft Vasopressin bindende Nukleinsäure, dadurch gekennzeichnet, dass die Nukleinsäure einen Abschnitt Box l und einen Abschnitt Box2 umfasst, wobei Box1 die Sequenz GUGGW aufweist und W = A oder U ist, bevorzugterweise W = U ist und wobei Box2 eine Sequenz aus etwa 18 bis 24 Nukleotiden aufweist, bevorzugterweise 21 Nukleotiden aufweist, und eine Gruppe (G) n in der Sequenz viermal enthalten ist, wobei n = 2, 3 oder 4 ist.
摘要翻译：本发明涉及一种加压素结合核酸，其特征在于所述核酸的部分盒升，并包括一个部BOX2，其中BOX1具有序列GUGGW和W = A或U，优选W = U和其中BOX2的大约一个序列包括18至24个核苷酸，优选具有21个核苷酸，和的基团（G）_{名词被包括在序列，其中n = 2，3或四倍。4}

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式