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1. 发明申请

WO2016063269A1 USE OF ANTAGONISTS TO THE NUCLEAR STEROID RECEPTOR ALONE OR IN COMBINATION AS DIRECT ANTIVIRAL AGENTS TO INHIBIT ALPHAVIRUS, TOGAVIRIDAE, ARENAVIRIDAE, FILOVIRIDAE, BUNYAVIRIDAE, FLAVIVIRIDAE AND RHABDOVIRIDAE 审中-公开
标题翻译：将拮抗剂用于核苷类似物受体，或作为直接抗病毒药物抑制ALPHAVIRUS，TOGAVIRIDAE，ARENAVIRIDAE，FILOVIRIDAE，BUNYAVIRIDAE，FLAVIVIRIDAE和RHABDOVIRIDAE的组合
公开(公告)号：WO2016063269A1
公开(公告)日：2016-04-28
申请号：PCT/IE2015/000016
申请日：2015-10-20
申请人： PRENDERGAST, Patrick T.
发明人： PRENDERGAST, Patrick T.
IPC分类号： A61K31/4422 , A61K31/56 , A61P31/12
CPC分类号： A61K31/56 , A61K31/4422
摘要： The present invention is directed to therapeutic use of antagonists of the mineralocorticoid / aldosterone receptor for their previously unappreciated, prophylactic and therapeutic properties in preventing damage to the endothelial barrier that causes loss of vascular integrity resultant from filoviral infection of a patient and the effect of the Ebola viral coat glycoproteins GP1 / 2 attaching to the aldosterone receptor and causing the loss of endothelial cell attachment leading to characteristic haemorrhaging which results in hypovolemic shock to the patient. The invention also relates to compositions that comprise antagonist of the mineralocorticoid / aldosterone receptor and an excipient.
摘要翻译：本发明涉及盐皮质激素/醛固酮受体的拮抗剂在治疗中的用途，以防止其预防和预防和治疗性质，以防止损害内皮屏障，导致患者的病毒感染导致的血管完整性丧失和埃博拉病毒外壳糖蛋白GP1 / 2附着于醛固酮受体并导致内皮细胞附着丧失，导致特征性出血，导致患者血容量不足的休克。本发明还涉及包含盐皮质激素/醛固酮受体的拮抗剂和赋形剂的组合物。

2. 发明申请

WO2012095731A1 COMPOSITIONS FOR ALLEVIATING: STRESS, ANXIETY, DEPRESSION AND AIDING WITH WIGHT LOSS 审中-公开
标题翻译：用于表达的组合物：应力，放矢，缓解和援助与轻度损失
公开(公告)号：WO2012095731A1
公开(公告)日：2012-07-19
申请号：PCT/IB2012/000031
申请日：2012-01-11
申请人： PRENDERGAST, Patrick, T.
发明人： PRENDERGAST, Patrick, T.
IPC分类号： A61K31/355 , A61K31/685 , A61K36/63 , A61K36/575
CPC分类号： A61K36/575 , A61K33/26 , A61K33/34 , A61K36/63 , A61K45/06 , A61K2300/00
摘要： The present invention provides specific formula for producing compositions for nutritional support to enhance alertness and reduce the symptoms of stress, anxiety and depression. The compositions of this invention consist primarily of the following ingredients olive oil supplemented with extra hydroxytyrosol, phosphatidylserine (PS), lecithin (from soya), as well as the herbal extract from Magnolia bark. The present invention also relates to the administration of these specific formulated compounds to persons for weight loss.
摘要翻译：本发明提供了用于生产营养支持组合物以提高警觉性并减轻压力，焦虑和抑郁症状的具体配方。本发明的组合物主要由以下成分组成，补充有额外的羟基酪醇，磷脂酰丝氨酸（PS），卵磷脂（大豆）以及来自木兰树皮的草药提取物的橄榄油。本发明还涉及将这些具体配制的化合物给予减肥者。

3. 发明申请

WO2011023830A3 ANTI-BACTERIAL COMPOSITIONS COMPRISING EXTRACTS OF EREMOPHILA LONGIFOLIA AND METHODS FOR USE OF SAME 审中-公开
公开(公告)号：WO2011023830A3
公开(公告)日：2011-03-03
申请号：PCT/EP2010/062774
申请日：2010-08-31
申请人： PRENDERGAST, Patrick T.
发明人： PRENDERGAST, Patrick T.
IPC分类号： A61K36/185 , A61P31/04
摘要： A method for inhibiting growth of bacteria is provided wherein the method comprises the step of administering to a region in need of bacterial growth inhibition an anti-bacterially effective amount of a composition comprising an extract from the plant Eremophila longifolia . The method has utility in the treatment of a number of conditions, including cariogenesis, halitosis, gingivitis and/or periodontitis. The method of the invention may also be used ex vivo to prevent growth of bacterial biofilms on the surfaces of medical devices and other surfaces, such as those found in water systems, ventilation systems, plumbing systems, air conditioners, humidifiers and hot tubs.

4. 发明申请

WO2009037362A9 COMPOSITIONS COMPRISING SIRAITIA GROSVENORI EXTRACTS AND METHODS FOR THE TREATMENT OF INFECTION 审中-公开
公开(公告)号：WO2009037362A9
公开(公告)日：2009-03-26
申请号：PCT/EP2008/062645
申请日：2008-09-22
申请人： PRENDERGAST, Patrick T.
发明人： PRENDERGAST, Patrick T.
IPC分类号： A61K36/42 , A61P31/12 , A61P31/18 , A61P31/16
摘要： A method for the treatment and/or prophylaxis of a viral infection in a subject is provided wherein the method comprises the steps of providing a therapeutically effective amount of a composition comprising an extract of the fruit of Siraitia grosvenori Swingle and administering the composition to the subject. The fruit from which the extract is derived is Luo Han Guo. The extract comprises at least one thterpene glycoside, which may be in the form of a mogroside compound. The extract has been shown to be effective in the treatment of viral infections such as hepatitis C and HIV. Also provided are pharmaceutical compositions comprising at least one triterpene glycoside, or an analogue, metabolite, precursor, derivative, pharmaceutically active salt or pro-drug thereof.

5. 发明申请

WO2007131973A3 COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM 审中-公开
标题翻译：用于调节免疫系统的组合物和方法
公开(公告)号：WO2007131973A3
公开(公告)日：2008-04-03
申请号：PCT/EP2007054605
申请日：2007-05-11
申请人： PRENDERGAST PATRICK T
发明人： PRENDERGAST PATRICK T
IPC分类号： A61K31/497 , A61K31/52 , A61P7/00
CPC分类号： A61K31/497 , A61K31/52
摘要： The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
摘要翻译：本发明提供了用于预防血细胞病症如嗜中性白细胞减少症，血小板减少症，淋巴细胞减少症和贫血症的方法和组合物。本发明提供了其中包含至少一种细胞分裂素化合物的组合物以治疗或预防性施用的方法。本发明还可用于DNA修复方法。

6. 发明申请

WO2007052242A1 COMPOSITION AND METHOD FOR THE TREATMENT OF VIRAL INFECTION USING CAMELID HEAVY CHAIN ANTIBODIES 审中-公开
标题翻译：使用CAMELID重链抗体治疗病毒感染的组合物和方法
公开(公告)号：WO2007052242A1
公开(公告)日：2007-05-10
申请号：PCT/IE2006/000126
申请日：2006-11-03
申请人： PRENDERGAST, Patrick, T.
发明人： PRENDERGAST, Patrick, T.
IPC分类号： C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/22 , C07K2317/76
摘要： The present invention provides a method of treating or preventing human infection with type A Influenza comprising the step of administering a therapeutically useful amount of an isolated heavy chain Camelid antibody, or an antigen binding portion thereof, to a subject in need of treatment. The invention also extends to an isolated heavy chain Camelid antibody, or an antigen binding portion thereof, for use in the prophylaxis or treatment of human infection with type A influenza. Also provided is a method of producing a polyclonal Camelid heavy chain immunoglobulin preparation which specifically binds Neuraminidase and a method of treating influenza A viral infection comprising the step of administering said immunoglobulin preparation, or an antigen-binding portion thereof, to a subject in need of therapy.
摘要翻译：本发明提供一种治疗或预防甲型流感的人感染的方法，包括向需要治疗的受试者施用治疗有用量的分离的重链骆驼科抗体或其抗原结合部分的步骤。本发明还延伸到用于预防或治疗人类A型流感感染的分离的重链骆驼科动物抗体或其抗原结合部分。还提供了一种制备特异性结合神经氨酸酶的多克隆骆驼重链免疫球蛋白制剂的方法和一种治疗甲型流感病毒感染的方法，包括将所述免疫球蛋白制剂或其抗原结合部分施用于需要治疗。

7. 发明申请

WO2008110585A2 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING MUCOSITIS AND WEIGHT LOSS 审中-公开
标题翻译：用于预防和治疗肌瘤和重量损失的组合物和方法
公开(公告)号：WO2008110585A2
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052969
申请日：2008-03-12
申请人： PRENDERGAST, Patrick T.
发明人： PRENDERGAST, Patrick T.
IPC分类号： A61K31/497 , A61K31/7076 , A61P1/04
CPC分类号： A61K31/497 , A61K31/4985 , A61K31/7076 , A61K45/06
摘要： A method for prophylaxis and/or treatment of mucositis comprising the steps of providing a therapeutically effective amount of a composition comprising either (1) at least one compound selected from the group consisting of 5-[2-pyrazinyl]-4-methyl-1,2-3-thione or an analogue, derivative, metabolite, prodrug, solvate or a pharmaceutically acceptable salt thereof; or (2) a cytokinin compound; and administering the composition to a subject in need of such treatment. Also provided are pharmaceutical compositions comprising 5-[2-pyrazinyl]-4-methyl-1,2-3- thione and/or a cytokinin compound and use of these compositions in the preparation of a medicament for the treatment and/or prophylaxis of mucositis. The cytokinin compound may be selected from, but is not limited to N 6 -isopentenyl adenosine and N 6 -benzyl adenosine. The compositions may further comprise a chemotherapeutic agent, such as cisplatin. Further provided are methods and compositions for reducing and/or preventing weight loss in subjects undergoing cancer treatment.
摘要翻译：一种预防和/或治疗粘膜炎的方法，包括以下步骤：提供治疗有效量的组合物，所述组合物包含（1）至少一种选自5- [2-吡嗪基] -4-甲基-1 2-3-硫酮或类似物，衍生物，代谢物，前药，溶剂合物或其药学上可接受的盐; 或（2）细胞分裂素化合物; 并将该组合物施用于需要这种治疗的受试者。还提供了包含5- [2-吡嗪基] -4-甲基-1,2-3-硫酮和/或细胞分裂素化合物的药物组合物，以及这些组合物在制备用于治疗和/或预防粘膜炎。细胞分裂素化合物可以选自但不限于N 6 - 异戊烯基腺苷和N 6 - 苄基腺苷。组合物还可以包含化学治疗剂，例如顺铂。还提供了用于减少和/或预防经受癌症治疗的受试者体重减轻的方法和组合物。

8. 发明申请

WO2008074896A1 COMPOSITIONS AND METHODS FOR TREATMENT OF CHRONIC NEUROLOGICAL DISORDERS 审中-公开
标题翻译：用于治疗慢性神经疾病的组合物和方法
公开(公告)号：WO2008074896A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064523
申请日：2007-12-21
申请人： PRENDERGAST, Patrick T.
发明人： PRENDERGAST, Patrick T.
IPC分类号： A61K36/185 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/30
CPC分类号： A61K36/575 , A61K31/05 , A61K31/366 , A61K31/473
摘要： The present invention provides a composition comprising at least one extract of magnolia,or an analogue, derivative, metabolite or pro-drug thereof, and lecithin. The extract of magnolia may be selected from the group consisting of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1), honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), taspine and asimilobine. The invention further provides a method of treatment of a chronic neurological disorder using the composition of the invention. The chronic neurological disorder for treatment may be selected from, but is not limited to, drug dependence, in particular drug cravings, Alzheimer's disease and Parkinson's disease.
摘要翻译：本发明提供了包含至少一种木兰提取物或其类似物，衍生物，代谢物或前药以及卵磷脂的组合物。木兰提取物可以选自厚朴酚（5,5'-二烯丙基-2,2'-二羟基联苯，1），和厚朴酚（5,5'-二烯丙基-2,4'-二羟基联苯，2），莨菪碱和亚叶酸。本发明还提供使用本发明的组合物治疗慢性神经障碍的方法。用于治疗的慢性神经障碍可以选自但不限于药物依赖性，特别是药物渴求，阿尔茨海默病和帕金森病。

9. 发明申请

WO2007049265A3 ANTI MINERALOCORTICOID THERAPY OF INFECTION 审中-公开
标题翻译：抗感染的矿物质治疗
公开(公告)号：WO2007049265A3
公开(公告)日：2008-01-24
申请号：PCT/IE2006000124
申请日：2006-10-31
申请人： PRENDERGAST PATRICK T
发明人： PRENDERGAST PATRICK T
IPC分类号： A61K31/565 , A61K9/00 , A61K9/02 , A61K9/127 , A61K9/28 , A61K31/567 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/585 , A61K39/395 , A61K45/06 , A61K47/10 , A61K47/48 , C12N7/04
CPC分类号： A61K31/585 , A61K9/0019 , A61K9/02 , A61K9/127 , A61K9/4891 , A61K31/565 , A61K31/567 , A61K31/57 , A61K31/573 , A61K31/58 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/6913 , A61K47/6951 , B82Y5/00 , A61K2300/00
摘要： Antimineralocorticoid compounds are disclosed for use in the prophylaxis and therapy of viral infections, especially the retroviral infection by HlV. These compounds can be administered alone or in combination with conventional anti-viral agents or anti-sense mineralocorticoid Steroid ReceptorNA or DNA mutants of heat shock proteins.
摘要翻译：公开了抗皮质激素化合物用于预防和治疗病毒感染，特别是H1V的逆转录病毒感染。这些化合物可以单独施用或与常规抗病毒剂或反义盐皮质激素类固醇受体NA或热休克蛋白的DNA突变体组合施用。

10. 发明申请

WO2007131973A2 COMPOSITIONS AND METHODS FOR MODULATING THE IMMUNE SYSTEM 审中-公开
标题翻译：用于调节免疫系统的组合物和方法
公开(公告)号：WO2007131973A2
公开(公告)日：2007-11-22
申请号：PCT/EP2007/054605
申请日：2007-05-11
申请人： PRENDERGAST, Patrick, T.
发明人： PRENDERGAST, Patrick, T.
IPC分类号： A61K31/497 , A61K31/52 , A61P7/00
CPC分类号： A61K31/497 , A61K31/52
摘要： The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.
摘要翻译：本发明提供了用于预防血细胞病症如嗜中性白细胞减少症，血小板减少症，淋巴细胞减少症和贫血症的方法和组合物。本发明提供了其中包含至少一种细胞分裂素化合物的组合物以治疗或预防性施用的方法。本发明还可用于DNA修复方法。

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