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1. 发明申请

WO2006032441A3 STOICHIOMETRICALLY DEFINED DYE-LABELED SUBSTANCES FOR MEASURING GLOMERULAR FILTRATION RATE 审中-公开
标题翻译：化学计量DEFINED染料标记的物质用于测量肾小球滤过率
公开(公告)号：WO2006032441A3
公开(公告)日：2007-02-01
申请号：PCT/EP2005010093
申请日：2005-09-20
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
发明人： PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
IPC分类号： A61K49/00 , A61K47/48
CPC分类号： A61K49/0052 , A61K49/0043
摘要： The invention relates to novel chemical compounds that can be used as tracers in renal diagnosis, to the production and use thereof, and to renal diagnostic reagent containing them.
摘要翻译：本发明涉及一种可以用作肾诊断含有它们的肾诊断标记物的物质，其制备和用途，和组合物的新化合物。

2. 发明申请

WO1992005782A1 USE OF THROMBOXANE A2-RECEPTOR ANTAGONISTS AGAINST PROLIFERATIVE ALTERATIONS OF THE BLOOD VESSEL WALLS 审中-公开
标题翻译：使用血栓A2-受体拮抗剂对血管壁增生改变的反应
公开(公告)号：WO1992005782A1
公开(公告)日：1992-04-16
申请号：PCT/EP1991001874
申请日：1991-10-01
申请人： BOEHRINGER MANNHEIM GMBH , PILL, Johannes
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K31/19
CPC分类号： A61K31/41 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/405 , A61K31/445
摘要： The use is disclosed of thromboxane (TX) A2-receptor antagonists for producing medicaments that prevent proliferative processes in occlusive vascular diseases.

3. 发明申请

WO2006032441A2 STÖCHIOMETRISCH DEFINIERTE FARBSTOFFMARKIERTE SUBSTANZEN ZUR MESSUNG DER GLOMERULÄREN FILTRATIONSRATE, IHRE HERSTELLUNG UND VERWENDUNG 审中-公开
标题翻译：化学计量DEFINED染料标记的物质用于测量肾小球滤过率，生产和使用
公开(公告)号：WO2006032441A2
公开(公告)日：2006-03-30
申请号：PCT/EP2005/010093
申请日：2005-09-20
申请人： ROCHE DIAGNOSTICS GMBH , F.HOFFMANN-LA ROCHE AG , PILL, Johannes , KRAEMER, Uwe , GRETZ, Norbert , DEUS, Carsten , HAGENBRUCH, Bernd , KLOETZER, Hans-Martin
发明人： PILL, Johannes , KRAEMER, Uwe , GRETZ, Norbert , DEUS, Carsten , HAGENBRUCH, Bernd , KLOETZER, Hans-Martin
IPC分类号： A61K49/00
CPC分类号： A61K49/0052 , A61K49/0043
摘要： Die Erfindung betrifft neue chemische Verbindungen, die als Markersubstanzen in der Nierendiagnostik eingesetzt werden können, ihre Herstellung und Verwendung sowie sie enthaltende Nierendiagnostika.
摘要翻译：本发明涉及一种可以用作肾诊断含有它们的肾诊断标记物的物质，其制备和用途，和组合物的新化合物。

4. 发明申请

WO2015059083A1 IMPROVED TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 审中-公开
标题翻译：改进的交叉机构功能测量
公开(公告)号：WO2015059083A1
公开(公告)日：2015-04-30
申请号：PCT/EP2014/072420
申请日：2014-10-20
申请人： HEINRICH, Ralf , GRETZ, Norbert , PILL, Johannes , NEUDECKER, Sabine , SCHOCK-KUSCH, Daniel , GÜNTHER, Jürgen , KÖNIG, Stefan , FRIEDEMANN, Jochen
发明人： HEINRICH, Ralf , GRETZ, Norbert , PILL, Johannes , NEUDECKER, Sabine , SCHOCK-KUSCH, Daniel , GÜNTHER, Jürgen , KÖNIG, Stefan , FRIEDEMANN, Jochen
IPC分类号： A61B5/00 , A61B5/20
CPC分类号： A61B5/0071 , A61B5/1455 , A61B5/201
摘要： The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject. The invention further relates to a device for determining an organ function according to the method of the present invention, said device comprising a first sensor for transcutaneously measuring fluorescence of an indicator at a first position, a second sensor for transcutaneously measuring fluorescence of an indicator at a second position; and a data processing unit for fitting the values obtained by the sensors into a kinetic model of one of the preceding claims. The present invention also relates to a kit comprising a device of the present invention and an indicator compound, as well as to a computer or computer network comprising at least one processor, wherein the computer or computer network is adapted to perform the method according to the present invention.
摘要翻译：本发明涉及一种用于确定受试者的器官功能的方法，包括以下步骤：提供通过在至少一个第一时间点的第一位置背景荧光的体液中经皮测量而获得的第一浓度 - 时间曲线，以及在至少第二，第三，第四，第五和第六时间点的指示剂化合物的荧光; 提供通过在至少八分之一，九分之一，十分之一，十一分之一和十二分之一的至少七个时间点内的第二位置背景荧光体液测量和指示剂化合物的荧光获得的第二浓度曲线时间点; 将第一和第二浓度曲线拟合成代表至少四个扩散室的动力学模型; 从而确定受试者的器官功能。本发明还涉及根据本发明的方法确定器官功能的装置，所述装置包括用于经皮测量第一位置上的指示器的荧光的第一传感器，用于经皮测量指示器的荧光的第二传感器第二个位置以及数据处理单元，用于将由所述传感器获得的值拟合到前述权利要求之一的动力学模型中。本发明还涉及包括本发明的装置和指示剂化合物的试剂盒以及包括至少一种处理器的计算机或计算机网络，其中计算机或计算机网络适于执行根据本发明的方法本发明。

5. 发明申请

WO9615784A3 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE 审中-公开
标题翻译： 2,2-DICHLORALKANCARBONSÄUREN，制造含药物的方法，及其用途用于胰岛素抵抗的治疗
公开(公告)号：WO9615784A3
公开(公告)日：1996-05-30
申请号：PCT/EP9504413
申请日：1995-11-09
申请人： BOEHRINGER MANNHEIM GMBH , VOSS EDGAR , PILL JOHANNES , FREUND PETER
发明人： VOSS EDGAR , PILL JOHANNES , FREUND PETER
IPC分类号： A61K31/19 , A61K31/195 , A61K31/20 , A61K31/23 , A61P3/06 , A61P3/08 , A61P3/10 , C07C17/26 , C07C17/266 , C07C51/29 , C07C53/16 , C07C53/19 , C07C53/23 , C07C57/58 , C07C57/60 , C07C59/215 , C07C59/64 , C07C59/68 , C07C69/63 , C07C69/65 , C07C233/05 , C07C255/19 , C07C311/19 , C07C317/44 , C07C323/52
CPC分类号： A61K31/23 , A61K31/20 , C07C17/2632 , C07C17/2635 , C07C17/266 , C07C53/19 , C07C53/23 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/68 , C07C69/63 , C07C233/05 , C07C255/19 , C07C317/44 , C07C323/52 , Y10S514/866 , C07C22/04 , C07C25/02 , C07C22/00
摘要： A medicament for the treatment of diabetes mellitus contains as active substance a compound having the formula (I), in which A, B, A' and W have the meanings given in the description. Also disclosed are new compounds having the formula (I) and a process for preparing the same. 00000
摘要翻译： 00000

6. 发明申请

WO1996015784A2 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE 审中-公开
标题翻译： 2,2-DICHLORALKANCARBONSÄUREN，制造含药物的方法，及其用途用于胰岛素抵抗的治疗
公开(公告)号：WO1996015784A2
公开(公告)日：1996-05-30
申请号：PCT/EP1995004413
申请日：1995-11-09
申请人： BOEHRINGER MANNHEIM GMBH , VOSS, Edgar , PILL, Johannes , FREUND, Peter
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K31/20
CPC分类号： A61K31/23 , A61K31/20 , C07C17/2632 , C07C17/2635 , C07C17/266 , C07C53/19 , C07C53/23 , C07C57/58 , C07C57/60 , C07C59/64 , C07C59/68 , C07C69/63 , C07C233/05 , C07C255/19 , C07C317/44 , C07C323/52 , Y10S514/866 , C07C22/04 , C07C25/02 , C07C22/00
摘要： A medicament for the treatment of diabetes mellitus contains as active substance a compound having the formula (I), in which A, B, A' and W have the meanings given in the description. Also disclosed are new compounds having the formula (I) and a process for preparing the same.
摘要翻译：含有作为活性成分的式（I）的化合物对糖尿病的治疗药，其中A，B，A“和W具有权利要求中给出的含义，它们的制备方法式（I）的新化合物和。

7. 发明申请

WO1996011901A1 NOVEL 'alpha','alpha','alpha'','alpha''-TETRACHLOROBICARBOXYLIC ACIDS, PROCESS FOR PRODUCING THEM AND MEDICAMENTS CONTAINING THEM 审中-公开
标题翻译： NEWα，α，α“α-”-TETRACHLORDICARBONSÄUREN，制造方法相同，并且含药物
公开(公告)号：WO1996011901A1
公开(公告)日：1996-04-25
申请号：PCT/EP1995003980
申请日：1995-10-10
申请人： BOEHRINGER MANNHEIM GMBH , VOSS, Edgar , PILL, Johannes , FREUND, Peter
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C07C57/58
CPC分类号： C07C317/44 , C07C57/58 , C07C323/52
摘要： Compound of formula (I) in which A and A' are mutually independently a straight or branched alkylene chain with 1-10 carbon atoms, B is ortho, meta or para-phenylene, 1,2, 1,3 or 1,4-cyclohexylidene, sulphur, oxygen or NR1 in which R1 may be hydrogen, benzyl, phenyl or a C1-C4 alkyl radical, a carbonyl, sulphoxide or sulphone group, an E or Z-vinylene or an acetylene group, a CR2-R3 group, R2 is hydrogen, a C1-C4 alkyl radical or phenyl, R3 is a C1-C4 alkyl radical, benzyl, phenyl, hydroxy or a NR4R5 group, R4 is hydrogen, benzyl, phenyl or a C1-C4 alkyl radical, and R5 may be a hydrogen or a C1-C4 alkyl radical, a Y-W-Y group, Y is sulphur or oxygen and W is an alkylene chain (CH2)n, and n may be 1-15, their optical isomers and their physiologically compatible salts and esters, process for producing them and medicaments containing these compounds for the treatment of metabolic syndrome.
摘要翻译：式（I）的化合物，其中A和A“独立地具有1-10个碳原子，B彼此的直链或支链的亚烷基链的邻 - ，间 - 或对 - 亚苯基，1,2-，1,3-或1， 4-亚环己基，硫，氧或NR 1，其中R 1是氢，苄基，苯基或C1-C4烷基可以是羰基，亚砜或砜基，E-或Z-亚乙烯基或亚乙炔基，CR2 -R 3基团，R2是氢，C1-C4烷基或苯基，R3是C1-C4烷基，苄基，苯基，羟基或基团NR 4 R 5，R 4是氢，苄基，苯基或C1-C4烷基和R5 可以是氢或C1-C4烷基，基团YWY，Y是硫或氧，W是亚烷基链 - （CH 2）n和n为1-5可以是装置，它们的光学异构体，和它们的生理学上可接受的盐和酯，到流程其制备方法和含有这些化合物，代谢综合征的治疗药物组合物。

8. 发明申请

WO1986000298A1 ALPHA-, OMEGA-DICARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICINES COMPOSED THEREOF 审中-公开
标题翻译： ALPHA-，OMEGA-DICARBOXYLIC ACIDS，其制备方法和药物组合物
公开(公告)号：WO1986000298A1
公开(公告)日：1986-01-16
申请号：PCT/EP1985000288
申请日：1985-06-15
申请人： EPIS S.A. , BAR-TANA, Jacob , WITTE, Ernst-Christian , HAGENBRUCH, Bernd , PILL, Johannes , STEGMEIER, Karlheinz
发明人： EPIS S.A.
IPC分类号： C07C50/02
CPC分类号： C07C57/42 , C07C55/28 , C07C55/32 , C07C57/13 , C07C57/34 , C07C57/38 , C07C59/245 , C07C59/305 , C07C59/84
摘要： alpha , omega -dicarboxylic acids having the general formula (I') in which: R1 and R2, which may be different or the same, represent a lower alkyl group which can be substituted by hydroxy, lower alkoxy, halogen or phenyl, the phenyl being capable of substitution one or several times by hydroxy, lower alkoxy, lower alkyl or halogen; a lower alkenyl or alkinyl group; a C3-C7-cyclo-alkyl group or a phenyl group possibly substituted by hydroxy, halogen, lower alkyl or lower alkoxy, and X and Y, which may be different or the same, represent hydrogen, lower alkyl, lower alkoxy, hydroxy, cyano, halogen, carboxyl, lower alkoxycarbonyl or carbamoyl, and Q represents non-ramified, saturated or unsaturated alkyl chain with 8-14 C atoms, which can be substituted, interrupted by hetero-atoms, and form part of a cyclic system, as well as their carboxylic acid derivatives in vivo, provided that when Q represents an unramified, saturated alkyl chain with 8-14 C atoms, and R1 and R2 represent methyl and Y represents hydrogen, X may not represent hydrogen, ethoxy-carbonyl, bromine, cyano or methyl, and if R1 and R2 represent methyl and X and Y hydrogen, then Q may not represent any formula (II) group. Process for their preparation and medicines containing these compounds, which have an anti-diabetic action and lower the level of lipids.
摘要翻译：具有通式（I'）的α，ω-二羧酸，其中：R 1和R 2可以不同或相同，表示可被羟基，低级烷氧基，卤素或苯基取代的低级烷基，苯基能够被羟基，低级烷氧基，低级烷基或卤素取代一次或几次; 低级烯基或炔基; 可以被羟基，卤素，低级烷基或低级烷氧基取代的C 3 -C 7 - 环烷基或苯基，X和Y可以不同或相同，表示氢，低级烷基，低级烷氧基，羟基，氰基，卤素，羧基，低级烷氧基羰基或氨基甲酰基，Q表示具有8-14个C原子的非分支，饱和或不饱和的烷基链，其可被取代，被杂原子间隔并形成环系的一部分，如以及它们的羧酸衍生物在体内，条件是当Q表示具有8-14个C原子的未饱和的饱和烷基链时，R 1和R 2表示甲基，Y代表氢，X可以不表示氢，乙氧羰基，溴，氰基或甲基，并且如果R 1和R 2表示甲基且X和Y氢，则Q可以不表示任何式（II）基团。其制备方法和含有这些化合物的药物，其具有抗糖尿病作用并降低脂质水平。

9. 发明申请

WO1997030018A1 2,2-DIFLUOROALKANE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THE SAME 审中-公开
标题翻译： 2,2-DIFLUORALKANCARBONSÄUREN，其制造方法相同，含药物
公开(公告)号：WO1997030018A1
公开(公告)日：1997-08-21
申请号：PCT/EP1997000725
申请日：1997-02-15
申请人： BOEHRINGER MANNHEIM GMBH , VOSS, Edgar , PILL, Johannes
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： C07C57/56
CPC分类号： C07C69/65 , C07C57/58
摘要： The invention concerns medicaments for treating diabetes mellitus which contain as active substance a compound of formula (I), in which A, B, A' and W have the meanings given in the claims. The invention further concerns novel compounds of formula (I) and a process for their preparation.
摘要翻译：含有作为活性成分的式（I）的化合物对糖尿病的治疗药，其中A，B，A“和W具有权利要求中给出的含义，它们的制备方法式（I）的新化合物和。

10. 发明申请

WO2012160091A3 SENSOR DEVICE FOR DETECTING AN ANALYTE 审中-公开
标题翻译：传感器设备中，用于分析物的检测
公开(公告)号：WO2012160091A3
公开(公告)日：2013-06-27
申请号：PCT/EP2012059593
申请日：2012-05-23
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , FUERST OTTO , PILL JOHANNES , ROESICKE BERND
发明人： FUERST OTTO , PILL JOHANNES , ROESICKE BERND
IPC分类号： A61B5/145 , A61B5/1473 , C12Q1/00 , G01N33/487 , G01N33/543
CPC分类号： G01N27/3271 , A61B5/14532 , A61B5/14546 , A61B5/14735 , G01N27/3276 , G01N27/403 , G01N27/404 , G01N27/4145 , G01N33/54366
摘要： The invention relates to a sensor device (110) for detecting at least one analyte (144) in a fluid, in particular in a body fluid. The sensor device (110) comprises at least one closed detector chamber (140) and at least one electric sensor (112) having at least one sensor electrode (162). The detector chamber (140) can be connected to the fluid (146) such that the analyte (144) can penetrate into the detector chamber (140). The detector chamber (140) comprises at least one detector substance (150). The detector substance (150) is designed to influence at least one electric property of the electric sensor (112), in particular at least one electric property of the sensor electrode (162), depending on a concentration of the analyte (144) in the detector chamber (140).
摘要翻译：它提出了一种在体液中的流体（146）检测至少一种分析物（144），尤其是传感器设备（110）。所述的传感器装置（110）包括至少一个封闭室检测器（140）和至少一个电传感器（112）与至少一个传感器电极（162）。检测器室（140）与在连接所述流体（146）这样的方式接合，即分析物（144）可以渗透到检测室（140）。检测器室（140）包括至少一个检测器的物质（150）。探测器物质（150）被配置为影响所述电传感器（112）的至少一个电特性，特别是至少一个传感器电极（162）的电特性，取决于在检测器室（140）的分析物（144）的浓度。

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