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1. 发明申请

WO2012128696A1 APPARATUS FOR MAINTAINING A HARVESTED ORGAN VIABLE AND TRANSPORTABLE 审中-公开
标题翻译：维护受影响的有机体和运输的装置
公开(公告)号：WO2012128696A1
公开(公告)日：2012-09-27
申请号：PCT/SE2012/000045
申请日：2012-03-23
申请人： VIVOLINE MEDICAL AB , STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin
发明人： STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin
IPC分类号： A61J1/00 , A01N1/02
CPC分类号： A01N1/0289 , A01N1/0247 , Y10T137/86035
摘要： An apparatus for enclosing an organ after harvesting and before implantation, comprising: a vessel (2) enclosing a fluid (3); a connection tube (31) for connecting a fluid flow hose (35) to the organ for passing a fluid to the organ by means of a pump (41). A degassing hose (46) extending from the connection tube (31) from a position adjacent the connection of the tube (31) with an inlet part of the organ and to said vessel (2). A pinch valve (48) is arranged in the degassing hose. During a degassing phase, the pinch valve (48) is opened to allow fluid flow from the pump, via the fluid flow hose to the connection tube (31) and via the degassing hose (46) to the vessel (2) for expelling air entrapped in the fluid flow system. A balloon (49) is arranged to prevent fluid flow via the connection tube (31) to the organ during the degassing phase. A sterility arrangement (70) closes the vessel at the top thereof and may be replaced by a second, third etc sterility arrangement (77) without compromising the sterility.
摘要翻译：一种用于在收获后和植入前封闭器官的装置，包括：封闭流体（3）的容器（2）; 连接管（31），用于将流体软管（35）连接到器官，用于通过泵（41）将流体传递到器官。从连接管（31）从邻近管（31）的连接的位置与器官的入口部分延伸到所述容器（2）的脱气软管（46）。夹管阀（48）布置在脱气软管中。在脱气阶段期间，夹管阀（48）被打开以允许流体从泵流经流体流动软管流到连接管（31）并且经由脱气软管（46）流到容器（2）以排出空气夹在流体流动系统中。气囊（49）布置成在脱气阶段期间防止流体经由连接管（31）流到器官。无菌布置（70）在其顶部封闭容器，并且可以由第二，第三等无菌布置（77）代替，而不损害无菌性。

2. 发明申请

WO2009099380A1 METHOD AND DEVICE FOR GAS SUPPLY DURING CARDIOPULMONARY RESUSCITATION 审中-公开
标题翻译：方法和设备在心脏电图恢复期间的气体供应
公开(公告)号：WO2009099380A1
公开(公告)日：2009-08-13
申请号：PCT/SE2009/000074
申请日：2009-02-09
申请人： XENODEVICE AB , STEEN, Stig , PASKEVICIUS, Audrius
发明人： STEEN, Stig , PASKEVICIUS, Audrius
IPC分类号： G01B11/30
CPC分类号： A61M16/04 , A61H31/007 , A61M11/00 , A61M16/024 , A61M16/042 , A61M16/0484 , A61M16/0486 , A61M16/10 , A61M16/204 , A61M16/205 , A61M2016/0027 , A61M2016/0042 , A61M2016/0413 , A61M2202/0208 , A61M2205/50 , A61M2230/202 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/005
摘要： A method and device for providing ventillation gas to a patient during cardiopulmonary resuscitation, mechanically or manually. The device comprises: a gas source (35), a tracheal tube arranged in the trachea of a patient, a gas channel (24) in the tracheal tube, for supplying gas, such as oxygen, to the bronchi of the patient, a central channel (23) for connecting the bronchi to the atmosphere, a flow valve (37) for adjusting the flow rate of the gas supplied, and a switch valve for initiating and terminating the gas supply. The device is operated by a computer (30) over the following operational phases: phase one, in which the supply of gas is initiated for inhaling gas into the lungs, for supplying a predetermined amount of gas to the lungs, phase two, in which the compression of the thorax is performed, for providing a high compression pressure, phase three or 'chest compressed, gas on' phase, in which blood flows out from thorax to the aorta, phase four, in which the supply of gas is terminated, for exhaling gas out of the lungs, phase five, in which the de-compression of the thorax is performed, for lowering the pressure in the thorax to provide a decompression in which blood from vena cava replenishes the thorax, and phase six or 'chest decompressed, gas off for perfusion of the coronary vessels.
摘要翻译：一种用于在心肺复苏期间机械地或手动地向患者提供排气的方法和装置。该装置包括：气源（35），布置在患者气管中的气管管，气管管中的气体通道（24），用于将诸如氧气的气体供应到患者的支气管，中央用于将支气管连接到大气的通道（23），用于调节供应气体的流量的流量阀（37）和用于启动和终止气体供应的开关阀。该设备在以下操作阶段由计算机（30）操作：第一阶段，其中开始供应气体以将气体吸入肺部，用于向肺部提供预定量的气体，其中第二阶段执行胸部的压缩，以提供血液从胸部向主动脉流出的高压缩压力，三相或“胸部压缩，气体接通”阶段，其中气体供应终止的第四阶段，用于从肺部呼出气体，其中进行胸部解除压缩的第五阶段，用于降低胸部的压力以提供减压，其中来自腔静脉的血液补充胸部，以及第六或六胸减压，气体灌注冠状动脉血管。

3. 发明申请

WO2011037511A1 METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING 审中-公开
标题翻译：方法，设备和流体用于治疗心脏后收集
公开(公告)号：WO2011037511A1
公开(公告)日：2011-03-31
申请号：PCT/SE2010/000227
申请日：2010-09-22
申请人： VIVOLINE MEDICAL AB , STEEN, Stig , PASKEVICIUS, Audrius
发明人： STEEN, Stig , PASKEVICIUS, Audrius
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0226 , A01N1/0273
摘要： Method and device for treatment of a heart after harvesting and before transplantation. The device comprises a container (32) intended to comprise the heart (31); a first line (54) for connection to an aorta (30) of the heart; a fluid circuit comprising an oxygenator (37) for oxygenating said fluid and a heater/cooler (38) for regulating the temperature of said fluid; and a pump (36) for perfusion of said fluid through the coronary blood vessels of the heart. The fluid comprises an oncotic agent exerting an oncotic pressure larger than about 30 mmHg; and is cardioplegic by comprising a potassium concentration, which is between 15mM and 30 mM. A control device is arranged for controlling the pump to perform said perfusion intermittently, whereby the perfusion time is less than half of the cycle time. The perfusion is performed at a pressure, which is at least 15 mmHg and at least 15 mmHg lower than said oncotic pressure. The container (32) may be purged with fluid bypassing the heart between the perfusion steps. The perfusion cycle time may be 75 minutes and the perfusion time may be 15 minutes.
摘要翻译：收集后和移植前治疗心脏的方法和装置。该装置包括旨在包括心脏（31）的容器（32）; 用于连接到心脏的主动脉（30）的第一线（54）流体回路，包括用于使所述流体充氧的氧合器（37）和用于调节所述流体温度的加热器/冷却器（38）以及用于通过心脏的冠状血管灌注所述流体的泵（36）。流体包含施用大于约30mmHg的肿瘤压力的肿瘤剂; 并且通过包含在15mM和30mM之间的钾浓度来产生心脏停搏。控制装置被布置成用于控制泵间歇地执行所述灌注，由此灌注时间小于循环时间的一半。灌注在压力下进行，压力至少为15mmHg，并且比所述的起始压力低至少15mmHg。可以在灌注步骤之间绕过心脏的流体清洗容器（32）。灌注循环时间可能为75分钟，灌注时间可能为15分钟。

4. 发明申请

WO2011037512A1 CONTAINER AND SUPPORTING STRUCTURE FOR HOUSING AN ORGAN 审中-公开
标题翻译：集装箱和支持结构房屋的一个组织
公开(公告)号：WO2011037512A1
公开(公告)日：2011-03-31
申请号：PCT/SE2010/000232
申请日：2010-09-24
申请人： VIVOLINE MEDICAL AB , STEEN, Stig , PASKEVICIUS, Audrius , BEYER, Anna , JOHANSSON, Morgan , KING, Benjamin , SÖDERLUND, Anna , LINDSTEN, Anders , SEBELIUS, Peter , SPERLINGSSON, Maria , NILSSON, Joakim
发明人： STEEN, Stig , PASKEVICIUS, Audrius , BEYER, Anna , JOHANSSON, Morgan , KING, Benjamin , SÖDERLUND, Anna , LINDSTEN, Anders , SEBELIUS, Peter , SPERLINGSSON, Maria , NILSSON, Joakim
IPC分类号： A01N1/02 , A61J1/00
CPC分类号： A01N1/0247 , A01N1/0273
摘要： A container intended for evaluation, preservation and perfusion of an organ, such as a lung. The container comprises a bottom portion (11), an insert portion (12) and a lid portion (13). A pulmonary artery tube (91) is intended to be connected to the lung pulmonary artery and a trachea tube (94) is intended to be connected to the trachea of the lungs. A bent tube (17) connects the pulmonary artery tube (91) to a circuit for providing a fluid to the pulmonary artery. The circuit comprising a pump and an oxygenator (15) and an optional leukocyte-filter (16). Moreover, there is a holder for connecting the trachea tube (94) to a source of respiration. There is an oxygenator tube set (18) and a leukocyte-filter tube set (19). A supporting structure (221) for the container comprises a recess (222) sized for enclosing said container and a display panel (223). Moreover, there are two handles (226, 227), which may be unfolded into a position for supporting a sterile cloth (228).
摘要翻译：用于评估，保存和灌注器官如肺的容器。容器包括底部（11），插入部分（12）和盖部分（13）。肺动脉管（91）旨在连接到肺肺动脉，气管（94）旨在连接到肺气管。弯管（17）将肺动脉管（91）连接到用于向肺动脉提供流体的回路。该电路包括泵和氧合器（15）和可选的白细胞过滤器（16）。此外，存在用于将气管（94）连接到呼吸源的保持器。有一个充氧管套（18）和一个白细胞过滤管套（19）。用于容器的支撑结构（221）包括用于封闭所述容器和显示面板（223）的凹部（222）。此外，有两个把手（226,227）可以展开到用于支撑无菌布（228）的位置。

5. 发明申请

WO2009136838A1 APPARATUS FOR HOUSING AN ORGAN DURING EVALUATION AND PRESERVATION 审中-公开
标题翻译：用于在评估和保存期间容纳一个有机体的装置
公开(公告)号：WO2009136838A1
公开(公告)日：2009-11-12
申请号：PCT/SE2009/000228
申请日：2009-05-06
申请人： IGELÖSA TRANSPLANTATION SCIENCE AB , STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin Martin
发明人： STEEN, Stig , PASKEVICIUS, Audrius , KING, Benjamin Martin
IPC分类号： A01N1/02 , A61J1/00
CPC分类号： A01N1/02 , A01N1/0242 , A01N1/0247
摘要： A vessel for housing an organ such as lungs from a mammal ex-vivo, for evaluation or preservation. A liquid solution suitable for evaluation or preservation of the lungs surrounds the organ, at least partly. The solution is circulated via an outlet and an inlet. Two pressure chambers are arranged between the walls of the vessel and the organ. A gas is introducible to the pressure chamber in order to expand the pressure chamber for occupying the spaces surrounding the organ. Then, the pressure inside the pressure chambers is increased in order to push the solution to a higher level so that the organ is immersed in the solution without necessitating addition of further solution. Alternatively, the vessel is exposed to an under pressure and the pressure chambers are open to the atmosphere. In a further alternative embodiment, a solution collection space has variable volume.
摘要翻译：用于容纳来自哺乳动物的器官如肺的器官，用于评估或保存。适于评估或保护肺的液体溶液至少部分地包围器官。溶液通过出口和入口循环。两个压力室布置在容器的壁和器官之间。气体可以被引入压力室，以便扩大用于占据器官周围空间的压力室。然后，增加压力室内的压力以便将溶液推到更高的水平，使得器官浸入溶液中，而不需要添加另外的溶液。或者，容器暴露于低压下，并且压力室对大气敞开。在另一替代实施例中，解集合空间具有可变容量。

6. 发明申请

WO2009020412A1 SYSTEM AND METHOD FOR ORGAN EVALUATION AND PRESERVATION 审中-公开
标题翻译：用于有机评估和保存的系统和方法
公开(公告)号：WO2009020412A1
公开(公告)日：2009-02-12
申请号：PCT/SE2008/000435
申请日：2008-07-07
申请人： XENODEVICE AB , STEEN, Stig , PASKEVICIUS, Audrius
发明人： STEEN, Stig , PASKEVICIUS, Audrius
IPC分类号： A01N1/02 , A61M5/168 , A61M5/36
CPC分类号： A01N1/02 , A01N1/0247 , A01N1/0278
摘要： A method and system for organ evaluation and preservation for connection to an organ and for recirculation of a perfusion medium there through. The system comprises a first collection device (2) for collection of the perfusion medium perfused through the organ (1) and a second collection device (5) arranged in an outlet conduit (3) from the first collection device (2). A pump (9) passes the perfusion medium from the second collection device (5) to the organ (1) via a conduit (12). A flow regulation device (4), such as an on-off clamp, is arranged in the outlet conduit (3) for controlling the flow in the outlet conduit in order to maintain a constant fill of the second collection device (5) as measured by a fluid level sensing device (6).
摘要翻译：用于与器官连接并通过灌注介质再循环的器官评估和保存的方法和系统。该系统包括用于收集通过器官（1）灌注的灌注介质的第一收集装置（2）和布置在来自第一收集装置（2）的出口导管（3）中的第二收集装置（5）。泵（9）通过导管（12）将灌注介质从第二收集装置（5）传递到器官（1）。在出口导管（3）中布置有流量调节装置（4），例如开关夹，用于控制出口导管中的流动，以便维持第二收集装置（5）的恒定填充量通过液位感测装置（6）。

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