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1. 发明申请

WO0140187A3 COMPOUND HAVING EFFECT OF PROMOTING NEURON DIFFERENTIATION 审中-公开
标题翻译：具有促进神经元分化作用的化合物
公开(公告)号：WO0140187A3
公开(公告)日：2002-07-11
申请号：PCT/JP0008090
申请日：2000-11-16
申请人： NIPPON KAYAKU KK
发明人： BHAGWAT SHRIPAD , PALANKI MOORTHY , ERDMAN PAUL , DOUBLEDAY MARY , SATO HIROSHI
IPC分类号： C07D213/55 , A61K31/4406 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/498 , A61K31/5377 , A61P9/00 , A61P9/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07C323/59 , C07D213/50 , C07D213/56 , C07D213/81 , C07D239/26 , C07D277/24 , C07D277/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , A61K31/44
CPC分类号： C07D213/81 , C07C323/59 , C07D213/50 , C07D239/26 , C07D277/24 , C07D277/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Neuroprotective agents are disclosed having structure: (I) and stereoisomers and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl; R2 is -OR2a or -NR2bR2c; R3 is hydrogen, keto, -C(=O)OR3a or -C(=O)NR3bR3c; R4 is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, -C(=O)R4a, -C(=O)OR4b, -C(=O)NR4cR4d, -OC(=O)NR4cR4d or -SO2R4c or wherein R3 and R4 taken together form a heterocyclic ring or substituted heterocyclic ring; and R5 is hydrogen, alkyl or substituted alkyl. Such compounds have utility in the treatment of conditions which benefit from administration of neuroprotective agents generally, including treatment of central and peripheral nervous condition as well as promoting nerve cell differentiation. Methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more of the compounds of this invention.
摘要翻译：公开了具有以下结构的神经保护剂：（I）及其立体异构体及其药学上可接受的盐，其中R1是烷基，取代的烷基，芳基，取代的芳基，芳基烷基，取代的芳基烷基，杂环，取代的杂环，杂环烷基或取代的杂环烷基; R2是-OR2a或-NR2bR2c; R3是氢，酮基，-C（= O）OR3a或-C（= O）NR3bR3c; R4是氢，烷基，取代的烷基，芳基，取代的芳基，-C（= O）R4a，-C（= O）OR4b，-C（= O）NR4cR4d，-OC（= O）NR4cR4d或-SO2R4c， R3和R4一起形成杂环或取代的杂环; 并且R 5是氢，烷基或取代的烷基。这些化合物通常用于治疗受益于神经保护剂的治疗的病症，包括治疗中枢和周围神经疾病以及促进神经细胞分化。还公开了治疗这些病症的方法，以及含有一种或多种本发明化合物的药物组合物。

2. 发明申请

WO2006116083A3 THE 1, 5-ANHYDROGLUCITOL (1, 5-AG) ASSAY AND A1C/1. 5-AG ASSAY COMBINATION FOR MEASURING BLOOD GLUCOSE EXCURSIONS IN GENERAL AND POSTPRANDIAL HYPERGLYCEMIA IN DIABETIC PATIENTS 审中-公开
标题翻译： 1,5-ANHYDROGLUCITOL（1,5-AG）测定和A1C / 1。用于测量糖尿病患者一般和仰卧位高血压的血液葡萄糖激素的5-AG测定组合
公开(公告)号：WO2006116083A3
公开(公告)日：2007-04-12
申请号：PCT/US2006015091
申请日：2006-04-21
申请人： NIPPON KAYAKU KK , TOMEN AMERICA INC , BUSE JOHN B , DUNGAN KATHLEEN , WITTLIN STEVEN D , BUTTON ERIC A , KATO SHUHEI , TANABE TOSHIO
发明人： BUSE JOHN B , DUNGAN KATHLEEN , WITTLIN STEVEN D , BUTTON ERIC A , KATO SHUHEI , TANABE TOSHIO
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , G01N33/66 , G01N2800/042
摘要： The invention is a method of measuring blood glucose excursions in general, and postprandial hyperglycemia in diabetic patients in particular, by the 1,5-anhydroglucitol assay (1,5-AG) or A1C/1,5-AG assay combination. 1,5-AG levels and percent changes of 1,5-AG levels in short period are indicative of differing postmeal glucose levels in moderately-controlled diabetic patients with similar AlC levels. Thereby 1,5-AG assay is useful to identify diabetic patients who may be at risk for cardiovascular complications which would not be identifiable by AlC levels alone. Furthermore, ratios of AlC divided by 1,5-AG in each patient are superior indicators to 1,5-AG levels.
摘要翻译：本发明是通常通过1,5-脱水葡萄糖醇测定（1,5-AG）或A1C / 1,5-AG测定组合来测量糖尿病患者的血糖偏差和餐后高血糖的方法。 1,5-AG水平和1,5-AG水平在短时间内的百分比变化表明具有相似的AlC水平的中度控制的糖尿病患者的不同的后期葡萄糖水平。因此，1,5-AG测定法可用于鉴定可能患有心血管并发症风险的糖尿病患者，这些患者不能单独使用AlC水平鉴定。此外，每个患者的AlC除以1,5-AG的比例是1,5-AG水平的优异指标。

3. 发明申请

WO2005067567A3 PHOTORESIST COMPOSITIONS AND PROCESSESS OF USE 审中-公开
标题翻译：光电组合物和使用过程
公开(公告)号：WO2005067567A3
公开(公告)日：2006-07-13
申请号：PCT/US2005000156
申请日：2005-01-05
申请人： MICROCHEM CORP , NIPPON KAYAKU KK
发明人： WEBER WILLIAM , MORI SATOSHI , HONDA NAO
IPC分类号： G03F7/038 , G03C1/76 , G03F7/004 , G03F7/11 , G03F7/30 , G03F7/40
CPC分类号： G03F7/40 , G03F7/038
摘要： Photoresist compositions that demonstrate superior photolithographic performance and hardened resist films that show superior resistance to solvents, have excellent resistance to under plating during the electrodeposition of metals, and show excellent resist stripping characteristics. These photoresist compositions according to the invention are well-suited as for applications in the manufacture of MEMS and micromachine devices. These photoresist compositions according to the invention comprise one or more epoxide-substituted, polycarboxylic acid Resin Component (A), one or more photoacid generator compounds (B), and one or more solvent (C).
摘要翻译：显示优异的光刻性能的光刻胶组合物和显示出优异的耐溶剂性的硬化抗蚀剂膜，在金属电沉积期间具有优异的耐镀层性，并且显示出优异的抗剥离特性。根据本发明的这些光致抗蚀剂组合物非常适用于制造MEMS和微机械装置的应用。根据本发明的这些光致抗蚀剂组合物包含一种或多种环氧化物取代的多元羧酸树脂组分（A），一种或多种光酸产生剂化合物（B）和一种或多种溶剂（C）。

4. 发明申请

WO0071103A3 USE OF 15-DEOXYSPERGUALIN FOR THE TREATMENT OF HYPERREACTIVE INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译： 15-DEOXYSPERGUALIN用于治疗超敏感性炎症疾病和自身免疫性疾病的应用
公开(公告)号：WO0071103A3
公开(公告)日：2001-06-21
申请号：PCT/EP0003430
申请日：2000-04-14
申请人： EURO NIPPON KAYAKU GMBH , NIPPON KAYAKU KK , BIRCK RAINER , DREXLER JOHANNES , HOTTA OSAMU , NOWACK RAINER , WOUDE FOKKU JOHANNES V D
发明人： BIRCK RAINER , DREXLER JOHANNES , HOTTA OSAMU , NOWACK RAINER , VAN DER WOUDE FOKKU JOHANNES
IPC分类号： A61K45/00 , A61K31/16 , A61K31/164 , A61K31/27 , A61K31/56 , A61P1/04 , A61P9/00 , A61P9/14 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00
CPC分类号： A61K31/16 , A61K31/164 , A61K31/27
摘要： The invention describes the use of deoxyspergualin (DSG) or an analogue thereof for the preparation of a medicament for the treatment of and/or prophylaxis against hyperreactive inflammatory diseases and autoimmune diseases, wherein the treatment is performed in cycles. The autoimmune disease is collegenoses, vasculitis, arthritis, granulomatoses, organ specific autoimmunopathies as Morbus Crohn, ulcerative colitis and GvHD.
摘要翻译：本发明描述了脱氧精胍菌素（DSG）或其类似物在制备用于治疗和/或预防高反应性炎性疾病和自身免疫性疾病的药物中的用途，其中所述治疗是以周期进行的。自身免疫性疾病是同事，血管炎，关节炎，肉芽肿病，器官特异性自身免疫病，如Morbus Crohn，溃疡性结肠炎和GvHD。

5. 发明申请

WO9005730A3 NOVEL CYCLOBUTANE DERIVATIVE AND PROCESS FOR PRODUCING SAME 审中-公开
标题翻译：新的循环生成方法及其生产方法
公开(公告)号：WO9005730A3
公开(公告)日：1990-09-07
申请号：PCT/JP8901190
申请日：1989-11-22
申请人： NIPPON KAYAKU KK
发明人： ICHIKAWA YUH-ICHIRO , NARITA AYA , MATSUO KAORU , AOYAMA KEIKO , MATSUMURA FUMIKO , NISHIYAMA YUKIHIRO , MATSUBARA KENICHI , NAGAHATA TAKEMITSU , HOSHINO HIROO , SEKI JUN-ICHI , NARASAKA KOICHI , HAYASHI YUJIRO
IPC分类号： C07D239/42 , C07D239/54 , C07D239/545 , C07D239/553 , C07D473/00 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/34 , A61K31/52 , C07D239/46
CPC分类号： C07D239/54 , C07D239/42 , C07D239/545 , C07D239/553 , C07D473/00 , C07D473/16 , C07D473/18 , C07D473/30 , C07D473/34 , Y02P20/55
摘要： This invention relates to cyclobutane derivatives represented by general formula (IV), wherein B represents a nucleic acid base and R4 represents hydrogen atom or a protecting group, which is expectedly useful as an antiviral agent or a carcinostatic agent.

6. 发明申请

WO9506473A3 MEDICAL USE OF POLYSULFONIC ACID COMPOUND 审中-公开
标题翻译：多糖酸化合物的医疗用途
公开(公告)号：WO9506473A3
公开(公告)日：1995-07-20
申请号：PCT/JP9401410
申请日：1994-08-25
申请人： NIPPON KAYAKU KK , EKIMOTO HISAO , IIZUKA ERI , TABEI TOHRU , OKADA MINEAKI , AONO MASAKO
发明人： EKIMOTO HISAO , IIZUKA ERI , TABEI TOHRU , OKADA MINEAKI , AONO MASAKO
IPC分类号： A61K31/655 , C07C309/50 , C07D251/50 , C07D251/54 , A61K31/53 , C07C309/61
CPC分类号： A61K31/655 , C07C309/50 , C07D251/50 , C07D251/54
摘要： Polysulfonic acid compounds shown by formula (1) or (2) or pharmaceutically acceptable salts thereof exhibit an in vivo antitumor effect on rat prostatic cancer and an antiangiogenic activity by the rat aorta ring assay and the rabbit corneal assay. The compounds are thus expected to be useful as antitumor and angiogenic inhibitors. In formula (1) and (2) M, X, X1, X2, Y1, Y2 and Z represent a specific group, respectively.
摘要翻译：式（1）或（2）所示的聚磺酸化合物或其药学上可接受的盐，通过大鼠主动脉环测定法和兔角膜测定法显示对大鼠前列腺癌的体内抗肿瘤作用和抗血管生成活性。因此预期这些化合物可用作抗肿瘤和血管发生抑制剂。在式（1）和（2）中，M，X，X1，X2，Y1，Y2和Z分别表示特定的基团。

7. 发明申请

WO1982001317A1 ADHESIVE PREPARATION FOR HEART DISEASE AND PROCESS FOR ITS PREPARATION 审中-公开
标题翻译：用于心脏疾病的胶粘剂制剂及其制备方法
公开(公告)号：WO1982001317A1
公开(公告)日：1982-04-29
申请号：PCT/JP1981000291
申请日：1981-10-19
申请人： NICHIBAN CO LTD , NIPPON KAYAKU KK , TAIHO PHARMA CO LTD , ITO TOSHIO
发明人： NICHIBAN CO LTD , NIPPON KAYAKU KK , TAIHO PHARMA CO LTD
IPC分类号： A61K09/70
CPC分类号： A61K9/7061 , A61L15/58 , A61L15/44 , C08L33/10
摘要： Un preparation adhesive pour les maladies du coeur, sensibilisant moins la peau, comprend un materiau de base ayant un revetement d'une composition adhesive contenant un copolymere consistant essentiellement en un monomere de methacrylate de dodecyle et une quantite appropriee de nitroglycerol comme ingredient effectif. Cette composition possede d'excellentes proprietes de liberation du nitroglycerol et un equilibre excellent d'adhesion et de cohesion.

8. 发明申请

WO2015041325A8 SILICONE-MODIFIED EPOXY RESIN AND COMPOSITION AND CURED ARTICLE THEREOF 审中-公开
标题翻译：硅氧烷改性环氧树脂及其组合物及其固化物
公开(公告)号：WO2015041325A8
公开(公告)日：2015-06-18
申请号：PCT/JP2014074864
申请日：2014-09-19
申请人： SHINETSU CHEMICAL CO , NIPPON KAYAKU KK
发明人： SHIOBARA TOSHIO , SAWADA JUNICHI , WAKAO MIYUKI , KASHIWAGI TSUTOMU , MIYAGAWA NAOFUSA , KAWATA YOSHIHIRO , SASAKI CHIE , NAKANISHI MASATAKA , KUBOKI KENICHI
IPC分类号： C08G59/30
CPC分类号： C08G59/306 , C08G59/30
摘要： [Problem] The purpose of the invention, in view of the above circumstances, is to provide a silicone-modified epoxy resin composition giving a cured article having low gas permeability and excellent strength and an epoxy resin cured article obtained by curing this composition. [Solution] Epoxy resin represented by formula (1). (In the formula, R1 represents an alkylene group having 2-6 carbon atoms optionally containing an ether bond, R2 represents a monovalent aliphatic hydrocarbon group having 1-6 carbon atoms or a monovalent aromatic hydrocarbon group having 6-12 carbon atoms, R3 represents an oxygen atom or phenylene group, k represents 1-10 by average value, m represents an integer of 0-2, and n represents 0-10 by average value. Multiple R1-R3, k, and m present in the formula may each be the same or different.)
摘要翻译：发明内容鉴于上述情况，本发明的目的是提供一种赋予透气性低，强度优异的固化物的硅氧烷改性环氧树脂组合物和通过固化该组合物而得到的环氧树脂固化物。 [溶液]式（1）表示的环氧树脂。（式中，R 1表示可以含有醚键的碳原子数2〜6的亚烷基，R 2表示碳原子数1〜6的1价脂肪族烃基或碳原子数为6〜12的1价芳香族烃基，氧原子或亚苯基，k表示1-10以平均值表示，m表示0-2的整数，n表示0〜10的平均值，式中的多个R 1，R 3，k，m各自为相同或不同）

9. 发明申请

WO2013084500A3 CATALYST FOR THE MANUFACTURING OF ACRYLIC ACID AND A PROCESS FOR PRODUCING ACRYLIC ACID BY USING THE CATALYST 审中-公开
标题翻译：催化剂用于制备丙烯酸和使用催化剂生产丙烯酸的方法
公开(公告)号：WO2013084500A3
公开(公告)日：2013-07-25
申请号：PCT/JP2012007834
申请日：2012-12-06
申请人： NIPPON KAYAKU KK
发明人： OKUMURA KIMITO , KOBAYASHI YASUSHI
IPC分类号： B01J23/88 , C07B61/00 , C07C27/00 , C07C45/38 , C07C47/22 , C07C51/235 , C07C57/04
CPC分类号： B01J37/0036 , B01J23/002 , B01J27/199 , B01J37/0045 , B01J37/08 , B01J2523/00 , C07C45/52 , C07C51/235 , C07C57/04 , C07C47/22 , B01J2523/17 , B01J2523/53 , B01J2523/55 , B01J2523/68 , B01J2523/69
摘要： This invention provides a catalyst for producing unsaturated carboxylic acid from unsaturated aldehyde which is obtained by dehydration reaction of alcohol. In particular, this invention provides a catalyst for producing acrylic acid from acrolein obtained by dehydration reaction of glycerin. This invention provides also a process for producing unsaturated carboxylic acid, especially acrylic acid by using the catalyst. Catalyst used contains an active ingredient having a composition represented by following formula (1): Mo12 Va Wb Cuc Sbd Xe Yf Zg Oh (1), in which Mo, V, W, Cu, Sb and O represent respectively molybdenum, vanadium, tungsten, copper, antimony and oxygen, X is at least one element selected from a group comprising alkali metals and thallium, Y is at least one element selected from a group comprising magnesium, calcium, strontium, barium and zinc, Z is at least one element selected from a group comprising niobium, cerium, tin, chromium, manganese, iron, cobalt, samarium, germanium, titanium and arsenic, "a", "b", "c", "d", "e", "f", "g" and "h" each represents an atom ratio of element and satisfies following respective range when a value for molybdenum atom is considered as 12: "a" is greater than 0 but not greater than 10, "b" is not less than 0 but not greater than 10, "c" is greater than 0 but not greater than 6, "d" is greater than 0 but not greater than 10, "e" is not less than 0 but not greater than 0.5, "f" is not less than 0 but not greater than 1, "g" is not less than 0 but less than 6 and "h" is a number of oxygen atom required for satisfying the valences of above elements.
摘要翻译：本发明提供一种由醇脱水反应得到的不饱和醛生产不饱和羧酸的催化剂。特别是，本发明提供一种由甘油脱水反应得到的丙烯醛生产丙烯酸的催化剂。本发明还提供了一种使用该催化剂生产不饱和羧酸，特别是丙烯酸的方法。所用催化剂含有具有下式（1）所示组成的活性成分：其中Mo，V，W，Cu，Sb和O分别代表钼，钒，钨，铜，锑和氧，X是选自碱金属和铊中的至少一种元素，Y是选自镁，钙，锶，钡和锌中的至少一种元素，Z是至少一种元素选自包括铌，铈，锡，铬，锰，铁，钴，钐，锗，钛和砷，“a”，“b”，“c”，“d”，“e”，“f” ，“g”和“h”各自表示元素的原子比并且当将钼原子的值视为12时满足以下各自的范围：“a”大于0但不大于10，“b”不小于比0大但不大于10，“c”大于0但不大于6，“d”大于0但不大于10，“e”不小于0但不大于0.5，“f”不小于0但不大于1，“g”不小于0但小于6，“h”是满足上述元素化合价所需的氧原子数。

10. 发明申请

WO2013018752A3 CATALYST FOR MANUFACTURE OF ACROLEIN AND ACRYLIC ACID BY MEANS OF DEHYDRATION OF GLYCERIN, AND MANUFACTURING METHOD FOR SAME 审中-公开
标题翻译：通过甘油脱水制备丙烯酸和丙烯酸的催化剂及其制备方法
公开(公告)号：WO2013018752A3
公开(公告)日：2013-03-21
申请号：PCT/JP2012069305
申请日：2012-07-30
申请人： NIPPON KAYAKU KK , OKUMURA KIMITO , KOBAYASHI YASUSHI , HIRAOKA RYOTA , DUBOIS JEAN-LUC
发明人： OKUMURA KIMITO , KOBAYASHI YASUSHI , HIRAOKA RYOTA , DUBOIS JEAN-LUC
IPC分类号： B01J27/188 , B01J23/30 , B01J35/10 , B01J37/08 , C07B61/00 , C07C45/52 , C07C47/22
CPC分类号： B01J27/188 , B01J23/30 , B01J35/1038 , B01J35/108 , C07C45/52 , C07C51/235 , C07C51/25 , C07C57/04 , C07C47/22
摘要： The present invention provides a glycerin dehydration catalyst which enables the high-yield production of unsaturated aldehydes and unsaturated carboxylic acid by dehydrating glycerin, and exhibits little reduction over time in glycerin conversion ratio, or in the yield of unsaturated aldehydes and unsaturated carboxylic acid. The present invention provides, in particular, a glycerin dehydration catalyst which has a long life and can produce acrolein and acrylic acid at high yields by dehydrating glycerin. Furthermore, the present invention is for the purpose of providing a manufacturing method for such a catalyst. A catalyst for glycerin dehydration used to produce acrolein and acrylic acid by contact-dehydrating glycerin, the catalyst having a W-containing metal oxide supported on a support which contains at least one kind of metal oxide selected from TiO2, SiO2, Al2O3, ZrO2 and Nb2O5, and which has bimodal pores wherein the ratio of the pore volume of micropores of 50nm or more relative to the pore volume of mesopores, which are bigger than 2nm but smaller than 50nm, is at least 0.5; in addition to the W-containing metal oxide, at least one kind of element-containing metal oxide selected from P, Si, Mo and V can also be supported.
摘要翻译：本发明提供甘油脱水催化剂，其能够通过使甘油脱水而高收率地制造不饱和醛和不饱和羧酸，甘油转化率或不饱和醛和不饱和羧酸的收率的经时降低少。本发明特别提供甘油脱水催化剂，其具有长寿命并且可以通过使甘油脱水以高产率生产丙烯醛和丙烯酸。此外，本发明的目的在于提供这种催化剂的制造方法。甘油脱水用催化剂，用于通过使甘油接触 - 脱水来生产丙烯醛和丙烯酸，所述催化剂具有负载在载体上的含W的金属氧化物，所述载体含有选自TiO 2，SiO 2，Al 2 O 3，ZrO 2和ZrO 2中的至少一种金属氧化物; Nb2O5，其具有双峰孔径，其中，50nm以上的微孔的孔体积相对于大于2nm小于50nm的中孔孔隙体积的比例至少为0.5; 除了含W的金属氧化物之外，还可以负载选自P，Si，Mo和V中的至少一种含元素的金属氧化物。

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