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1. 发明申请

WO2009117388A1 THERAPEUTIC SUBSTITUTED CYCLOPENTANES 审中-公开
标题翻译：治疗性替代性CYCLOPENTANES
公开(公告)号：WO2009117388A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037355
申请日：2009-03-17
申请人： ALLERGAN, INC. , DONDE, Yariv , BURK, Robert, M , NGUYEN, Jeremiah, H
发明人： DONDE, Yariv , BURK, Robert, M , NGUYEN, Jeremiah, H
IPC分类号： C07C405/00 , A61P17/14
CPC分类号： C07C405/00 , C07C2601/08 , C07D295/08 , C07D333/38
摘要： Therapeutic compounds are disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed. The compounds described herein are used to treat ocular conditions, bowel disease and baldness.
摘要翻译：本文公开了治疗性化合物。还公开了与之相关的方法，组合物和药物。本文所述的化合物用于治疗眼部病症，肠病和秃发。

2. 发明申请

WO2009061811A1 SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDING ACTIVITY 审中-公开
标题翻译：具有前列腺活性的取代环戊
烷类化合物
公开(公告)号：WO2009061811A1
公开(公告)日：2009-05-14
申请号：PCT/US2008082469
申请日：2008-11-05
申请人： ALLERGAN INC , DONDE YARIV , NGUYEN JEREMIAH H , BURK ROBERT M
发明人： DONDE YARIV , NGUYEN JEREMIAH H , BURK ROBERT M
IPC分类号： C07D263/34 , A61K31/381 , A61P27/06 , C07D333/40
CPC分类号： C07D333/40 , C07D263/34
摘要： Disclosed herein are compounds having a formula: (I) Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
摘要翻译：本文公开了具有下式的化合物：（I）还公开了与其相关的治疗方法，药物和组合物。

3. 发明申请

WO2004071428A3 10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
公开(公告)号：WO2004071428A3
公开(公告)日：2004-08-26
申请号：PCT/US2004/003433
申请日：2004-02-06
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： A61K31/557
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I); wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the α (down) configuration, and the solid triangle indicates the β (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH 2 , S or O; Y is any pharmaceutically acceptable salt of C0 2 H, or C0 2 R, CONR 2 , CONHCH 2 CH 2 0H, CON(CH 2 CH 2 OH) 2 ,CH 2 OR, P(O)(OR) 2 , CONRSO 2 R, SONR 2 , or formula (Ia) R is H, C 1-6 alkyl or C 2-6 alkenyl; R 2 and R 3 are C 1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached.

4. 发明申请

WO2009132085A1 SUBSTITUTED ARYLCYCLOPENTENES AS PROSTAGLANDIN EP2 AGONISTS 审中-公开
标题翻译：取代的ARYLCYCLOPENTENES作为PROSTAGLANDIN EP2激动剂
公开(公告)号：WO2009132085A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041385
申请日：2009-04-22
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07D333/38 , A61K31/381 , A61P27/06 , A61P17/14
CPC分类号： C07D333/38 , Y10S514/88
摘要： Compounds comprising formula (I) or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, and B are as described. Methods, compositions, and medicaments for the treatment of glaucoma, ocula hypertension and inflammatory bowel disease, and for the stimulation of hair growth are also disclosed.
摘要翻译：公开了包含式（I）化合物或其药学上可接受的盐或前体药物的化合物，其中Y，A和B如上所述。还公开了用于治疗青光眼，高眼压症和炎症性肠病以及用于刺激头发生长的方法，组合物和药物。

5. 发明申请

WO2007130890A2 THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：治疗化合物
公开(公告)号：WO2007130890A2
公开(公告)日：2007-11-15
申请号：PCT/US2007/067736
申请日：2007-04-30
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
CPC分类号： C07C59/90 , C07B2200/07 , C07C69/738 , C07C405/00 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/30 , C07D257/04 , C07D277/56 , C07D307/42 , C07D307/68 , C07D333/16 , C07D333/38
摘要： Therapeutic substituted cyclopentane compounds, and compositions, medicaments, and therapeutic methods related thereto are disclosed herein.
摘要翻译：本文公开了治疗性取代的环戊烷化合物及其组合物，药物和治疗方法。

6. 发明申请

WO2007115020A3 THERAPEUTIC PROSTAGLANDIN COMPOUNDS FOR THE TREATMENT OF GLAUCOMA 审中-公开
公开(公告)号：WO2007115020A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/065010
申请日：2007-03-27
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H. , HOLOBOSKI, Mark , POSNER, Mari, F. , BURK, Robert, M.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H. , HOLOBOSKI, Mark , POSNER, Mari, F. , BURK, Robert, M.
IPC分类号： C07C59/56 , C07C59/86 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/40 , A61K31/5575 , A61P27/06
摘要： Compounds having a structure are disclosed herein (Formula I). Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.

7. 发明申请

WO2006101867A2 TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：炎症性皮肤病的治疗
公开(公告)号：WO2006101867A2
公开(公告)日：2006-09-28
申请号：PCT/US2006009222
申请日：2006-03-14
申请人： ALLERGAN INC , DONDE YARIV , NGUYEN JEREMIAH H , KEDZIE KAREN M , GIL DANIEL W , DONELLO JOHN E , IM WHA-BIN
发明人： DONDE YARIV , NGUYEN JEREMIAH H , KEDZIE KAREN M , GIL DANIEL W , DONELLO JOHN E , IM WHA-BIN
IPC分类号： A61K31/5575 , C07C405/00 , C07D333/56 , C07D333/62 , C07D409/08
CPC分类号： C07D333/56 , A61K31/557 , A61K31/5575 , A61K31/559 , C07C57/26 , C07C57/48 , C07C59/90 , C07C69/732 , C07C69/738 , C07D333/62 , C07D409/08
摘要： Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R 2 , R 3 , R 4 , R 5 , R 6 and n have the meanings found herein.
摘要翻译：本文公开了一种方法，其包括向患有炎症性肠病的哺乳动物施用化合物用于治疗所述疾病，所述化合物具有式I的结构，其中X，Y，B，R 2， R 3，R 4，R 5，R 6和n具有本文找到的含义。

8. 发明申请

WO2006063179A1 12-ARYL PROSTAGLANDIN ANALOGS 审中-公开
公开(公告)号：WO2006063179A1
公开(公告)日：2006-06-15
申请号：PCT/US2005/044501
申请日：2005-12-08
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C405/00 , A61K31/5575 , A61P27/06
CPC分类号： C07C405/00 , C07C59/56 , C07C59/90 , C07C2601/04 , C07C2601/14
摘要： Compounds comprising the formula (I) are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP 2 selective agonist wherein the ω-chain comprises a substituted phenyl, wherein at least one substituent consists of hydrocarbyl or non-linear hydroxyhydrocarbyl is also disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译：公开了包含式（I）的化合物，其中Y，A，X，R，D和n如上所述。包含前列腺素EP 2选择性激动剂的化合物，其中α-链包含取代的苯基，其中至少一个取代基由烃基或非直链羟基烃基组成。还公开了与之相关的方法，组合物和药物。

9. 发明申请

WO2004071428A2 10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE 审中-公开
标题翻译： 10,10-二甲基丙酸衍生物作为降低室内压力的试剂
公开(公告)号：WO2004071428A2
公开(公告)日：2004-08-26
申请号：PCT/US2004003433
申请日：2004-02-06
申请人： ALLERGAN INC , DONDE YARIV , NGUYEN JEREMIAH H
发明人： DONDE YARIV , NGUYEN JEREMIAH H
IPC分类号： A61K31/5575 , C07C405/00 , C07D333/56 , C07D333/62 , C07D409/08 , A61K
CPC分类号： C07D333/62 , A61K31/5575 , C07C405/00 , C07D333/56 , C07D409/08
摘要： The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I); wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the alpha (down) configuration, and the solid triangle indicates the beta (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH2, S or O; Y is any pharmaceutically acceptable salt of C02H, or C02R, CONR2, CONHCH2CH20H, CON(CH2CH2OH)2,CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or formula (Ia) R is H, C1-6 alkyl or C2-6 alkenyl; R and R are C1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached.
摘要翻译：本发明提供一种治疗眼高血压或青光眼的方法，其包括向具有高眼压症或青光眼的动物施用治疗有效量的由通式（I）表示的化合物; 其中虚线表示存在或不存在键，阴影楔指示α（向下）构型，并且实心三角形表示β（向上）构型; B是单，双或三重共价键; n为0-6; X是CH 2，S或O; Y是任何药学上可接受的CO 2 H或CO 2 R，CONR 2，CONHCH 2 CH 2 OH，CON（CH 2 CH 2 OH）2，CH 2 OR，P（O）（OR）2，CONRSO 2 R，SONR 2或式（Ia）或C 2-6烯基; R 2和R 3是可以相同或不同的C 1-6直链烷基，并且可以彼此键合，使得它们形成结合有它们通常连接的碳的环。

10. 发明申请

WO2007131012A1 12-ARYL OR HETEROARYL PROSTAGLANDIN ANALOGS 审中-公开
公开(公告)号：WO2007131012A1
公开(公告)日：2007-11-15
申请号：PCT/US2007/067985
申请日：2007-05-02
申请人： ALLERGAN, INC. , DONDE, Yariv , NGUYEN, Jeremiah, H.
发明人： DONDE, Yariv , NGUYEN, Jeremiah, H.
IPC分类号： C07C59/90 , C07C59/56 , C07C59/54 , C07D333/40 , A61K31/5575 , A61K31/559 , A61P27/06
CPC分类号： C07C59/90 , C07C59/56 , C07C65/17 , C07D277/56 , C07D307/68 , C07D333/38 , C07D333/40 , C07D409/12 , C07D417/12
摘要： A compound having structure (I) is disclosed herein. Compositions, medicaments, and therapeutic methods related thereto are also disclosed.
摘要翻译：本文公开了具有结构（I）的化合物。还公开了与其有关的组合物，药物和治疗方法。

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