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1. 发明申请

WO2021156345A1 INJECTABLE COMPOSITION FOR SKIN AND SOFT TISSUE AUGMENTATION 审中-公开
公开(公告)号：WO2021156345A1
公开(公告)日：2021-08-12
申请号：PCT/EP2021/052627
申请日：2021-02-04
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： NOWAG, Bartosch , SCHÄFER, Daniela
IPC分类号： A61K9/00 , A61K8/24 , A61K8/73 , A61K9/08 , A61K9/10 , A61K31/728 , A61K33/42 , A61K47/10 , A61K47/36 , A61P17/00 , A61P31/00 , A61P43/00 , A61Q19/00 , A61Q19/08 , A61K8/02
摘要： The present invention relates to the synergistic effect of calcium hydroxyapatite particles and hyaluronic acid on the bio-stimulation. The invention refers to an injectable composition comprising one or more types of calcium hydroxyapatite particles and hyaluronic acid and to a method for preparing such injectable composition. Furthermore, it relates to a cosmetic method for improving appearance of the skin and/or contour of a subject by means of the injectable composition. Moreover, the invention refers to the injectable composition for use in a method of treating a pathologic condition associated with pathologic deterioration of connective tissue.

2. 发明申请

WO2019007509A1 NOVEL RECOMBINANT BOTULINUM NEUROTOXINS WITH INCREASED DURATION OF EFFECT 审中-公开
公开(公告)号：WO2019007509A1
公开(公告)日：2019-01-10
申请号：PCT/EP2017/066891
申请日：2017-07-06
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： FREVERT, Jürgen , HOFMANN, Fred , JURK, Marcel , LÓPEZ DE LA PAZ, Manuela , SCHEPS, Daniel
IPC分类号： C07K14/33 , A61K38/48
摘要： This invention relates to novel recombinant botulinum neurotoxins serotype A exhibiting both (i) an increased duration of effect and (ii) a high specific biological activity. These novel recombinant botulinum neurotoxins comprise at least two additional domains consisting of proline, alanine and an additional amino acid residue and at least one amino acid modification which is located at the alpha-exosite or at the beta-exosite of the light chain of the neurotoxin. The invention further relates to novel recombinant single-chain precursor botulinum neurotoxins and compositions comprising the recombinant botulinum neurotoxin with an increased duration of effect and a high specific biological activity.

3. 发明申请

WO2018233813A1 NOVEL RECOMBINANT BOTULINUM TOXIN WITH INCREASED DURATION OF EFFECT 审中-公开
公开(公告)号：WO2018233813A1
公开(公告)日：2018-12-27
申请号：PCT/EP2017/065096
申请日：2017-06-20
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： HOFMANN, Fred , JURK, Marcel , LÓPEZ DE LA PAZ, Manuela , SCHEPS, Daniel , FREVERT, Jürgen
IPC分类号： C07K14/33 , A61K8/64 , A61K8/99 , A61K38/16 , C12N15/62
摘要： This invention relates to novel recombinant clostridial neurotoxins exhibiting an increased duration of effect without a delayed onset of effect and to methods for the manufacture of such recombinant clostridial neurotoxins. These novel recombinant clostridial neurotoxins comprise a domain consisting of proline, alanine, serine, threonine, glycine and glutamate residues, and the methods comprise the steps of inserting a nucleic acid sequence coding for said domain into a nucleic acid sequence coding for a parental clostridial neurotoxin and expression of the recombinant nucleic acid sequence comprising said domain-coding sequence in a host cell. The invention further relates to novel recombinant single-chain precursor clostridial neurotoxins used in such methods, nucleic acid sequences encoding such recombinant single-chain precursor clostridial neurotoxins, and pharmaceutical compositions comprising the recombinant clostridial neurotoxin with an increased duration of effect without a delayed onset of effect.

4. 发明申请

WO2018229117A1 MIXING NOZZLE, APPLICATION DEVICE, KIT AND METHOD USING THE MIXING NOZZLE OR APPLICATION DEVICE 审中-公开
公开(公告)号：WO2018229117A1
公开(公告)日：2018-12-20
申请号：PCT/EP2018/065642
申请日：2018-06-13
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： VILLAIN, Franck , WORTMANN, Uwe , KASPERS, Norbert , EGGER, Johannes , REINHOLD, Thomas Sowden , POPP, Guido , KUNZ, Michael , MASON, Jonathan
IPC分类号： A61M5/19 , A61M5/24 , B65D81/32
摘要： The present invention generally relates to a mixing nozzle (12) for mixing at least two liquid compositions such as a first liquid composition and a second liquid composition. The mixing nozzle(10)is configured to be coupled to a body (11) of a multi-component application device(10), in particular to a body (11) of a two- component syringe assembly,for injection of a liquid composition, which body(11)is configured to separately store said at least two solutions. The present invention further relates to a multi-component application device(10)comprising said mixing nozzle (12) and to a kit comprising said mixing nozzle (12) or said application device (10). Furthermore, the present invention relates to a methodusing said application device or said kit, for examplefor replacing or filling a biological tissue or increasing the volume of a biological tissue.

5. 发明申请

WO2017178601A1 MEDICAL IRRADIATION DEVICE 审中-公开
标题翻译：医疗照射装置
公开(公告)号：WO2017178601A1
公开(公告)日：2017-10-19
申请号：PCT/EP2017/058960
申请日：2017-04-13
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： BERLEKAMP, Uwe , OTTO, Sabine , ENSLING, David , JÜSTEL, Thomas , MALYSA, Beata
IPC分类号： A61N5/06
CPC分类号： A61N5/0616 , A61N5/062 , A61N5/0625 , A61N2005/063 , A61N2005/0643 , A61N2005/0653 , A61N2005/0661 , A61N2005/0663
摘要： Medical irradiation device, comprising: (A) first means comprising at least one OLED or LED configured to emit light; (B) second means comprising at least one luminescent material configured to emit light by converting said light emitted from said first means comprising at least one OLED or LED (A); wherein said luminescent material is a luminescent organic compound or a quantum dot-comprising material; (C) third means comprising an optical waveguide configured to guide said light emitted by said at least one OLED or LED comprised in said first means (A) to said at least one luminescent material comprised in said second means (B); wherein said third means (C) connects the first means (A) to the second means (B).
摘要翻译：医疗照射装置，其包括：（A）第一装置，其包括被配置为发光的至少一个OLED或LED; （B）包括至少一种发光材料的第二装置，所述至少一种发光材料被配置为通过转换从包括至少一个OLED或LED（A）的所述第一装置发射的所述光来发光; 其中所述发光材料是发光有机化合物或含量子点材料; （C）包括光波导的第三装置，所述光波导被配置为将包含在所述第一装置（A）中的由所述至少一个OLED或LED发射的所述光引导到包含在所述第二装置（B）中的所述至少一种发光材料; 其中所述第三装置（C）将第一装置（A）连接到第二装置（B）。

6. 发明申请

WO2016097243A1 MEANS AND METHODS FOR THE DETERMINATION OF THE BIOLOGICAL ACTIVITY OF BONT/E IN CELLS 审中-公开
标题翻译：用于确定细胞中BONT / E生物活性的方法和方法
公开(公告)号：WO2016097243A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080395
申请日：2015-12-18
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： BRÜNN, Cornelia , MANDER, Gerd
IPC分类号： C07K16/18 , G01N33/50 , G01N33/94
CPC分类号： G01N33/5014 , C07K16/18 , C07K2317/34 , G01N2333/33 , G01N2800/709
摘要： The present invention pertains to a polyclonal or monoclonal antibody specifically binding to BoNT/E-cleaved SNAP-25. Further, the invention provides a method for directly determining the biological activity of BoNT/E in cells, comprising the steps of: a) incubating cells susceptible to BoNT/E intoxication with BoNT/E for a time and under conditions which allow for the BoNT/E to exert its biological activity; b) fixing the cells and, optionally, permeabilizing the cells with a detergent; c) contacting the cells with at least a first capture antibody specifically binding to non-cleaved and BoNT/E-cleaved SNAP-25, and with at least a second capture antibody specifically binding to BoNT/E-cleaved SNAP-25, wherein the second capture antibody is an antibody of the invention, under conditions which allow for binding of said capture antibodies to the indicated substrates; d) contacting the cells with at least a first detection antibody specifically binding to the first capture antibody, under conditions which allow for binding of said first detection antibody to said first capture antibody, thus forming first detection complexes, and with at least a second detection antibody specifically binding to the second capture antibody, under conditions which allow for binding of said second detection antibody to said second capture antibody, thus forming second detection complexes, and wherein the first detection antibody is different from the second detection antibody; e) determining the amount of the first and second detection complexes of step d); and f) calculating the amount of SNAP-25 cleaved by BoNT/E in said cells by means of the second detection complexes, thereby determining the biological activity of BoNT/E in said cells. Furthermore, the invention relates to a kit for carrying out the method of the invention.
摘要翻译：本发明涉及与BoNT / E切割的SNAP-25特异性结合的多克隆或单克隆抗体。此外，本发明提供了一种用于直接测定细胞中BoNT / E的生物学活性的方法，包括以下步骤：a）在BoNT / E中与BoNT / E中毒易感的细胞一段时间并在允许BoNT / E发挥其生物活性; b）固定细胞，并且任选地用洗涤剂使细胞透化; c）使细胞与至少一种特异性结合未切割的和BoNT / E切割的SNAP-25的第一捕获抗体以及与至少一种特异性结合于BoNT / E切割的SNAP-25的第二捕获抗体接触，其中第二捕获抗体是本发明的抗体，在允许所述捕获抗体与指定底物结合的条件下; d）在允许所述第一检测抗体与所述第一捕获抗体结合的条件下，使所述细胞与至少一种特异性结合第一捕获抗体的第一检测抗体接触，从而形成第一检测复合物，并至少具有第二检测在允许所述第二检测抗体与所述第二捕获抗体结合的条件下，特异性结合第二捕获抗体的抗体，从而形成第二检测复合物，并且其中第一检测抗体不同于第二检测抗体; e）确定步骤d）的第一和第二检测复合物的量; 和f）通过第二检测复合物计算BoNT / E在所述细胞中切割的SNAP-25的量，由此确定所述细胞中BoNT / E的生物学活性。此外，本发明涉及一种用于实施本发明方法的试剂盒。

7. 发明申请

WO2016079310A1 METHODS FOR THE DETERMINATION OF THE BIOLOGICAL ACTIVITIES OF NEUROTOXIN POLYPEPTIDES 审中-公开
标题翻译：测定神经毒素多糖生物活性的方法
公开(公告)号：WO2016079310A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/077245
申请日：2015-11-20
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： EISELE, Karl-Heinz
IPC分类号： G01N33/569 , C07K14/00
CPC分类号： G01N33/6809 , C07K14/70571 , C07K2319/61 , G01N33/56911
摘要： The present invention pertains to a method for determining the biological activity of a neurotoxin, the method comprising the steps of: (a) expressing a fusion protein comprising (i) an anchor protein, (ii) a reporter protein and (iii) a neurotoxin cleavage site intervening the anchor protein and the reporter protein, in neurotoxin-sensitive cells; (b) incubating the neurotoxin-sensitive cells of (a) with a neurotoxin and cultivating the cells under conditions which allow the neurotoxin to exert its biological activity; (c) permeabilizing the neurotoxin-sensitive cells of (b) under conditions which allow the release of the reporter protein but not the release of the anchor protein from the permeabilized neurotoxin-sensitive cells; and (d) quantifying the activity of the reporter protein released from the cells, thereby determining the biological activity of the neurotoxin. In addition, the invention relates to a fusion protein comprising (i) an anchor protein, (ii) a reporter protein, and (iii) a neurotoxin cleavage site intervening the anchor protein and the reporter protein, for determining the biological activity of a neurotoxin, in neurotoxin-sensitive cells. Further encompassed by the present invention is a kit comprising the fusion protein of the invention. Finally, the invention pertains to the use of a fusion protein of the invention for determining the biological activity of a neurotoxin, in neurotoxin-sensitive cells.
摘要翻译：本发明涉及一种用于测定神经毒素生物活性的方法，所述方法包括以下步骤：（a）表达融合蛋白，其包含（i）锚蛋白，（ii）报道蛋白和（iii）神经毒素在神经毒素敏感细胞中插入锚蛋白和报告蛋白的切割位点; （b）将（a）的神经毒素敏感细胞与神经毒素孵育并在允许神经毒素发挥其生物活性的条件下培养细胞; （c）在允许释放报告蛋白但不从透化的神经毒素敏感细胞释放锚蛋白的条件下使（b）的神经毒素敏感细胞透化; 和（d）定量从细胞释放的报道蛋白的活性，从而确定神经毒素的生物活性。此外，本发明涉及融合蛋白，其包含（i）锚蛋白，（ii）报道蛋白，和（iii）插入锚蛋白和报道蛋白的神经毒素切割位点，用于确定神经毒素的生物学活性，在神经毒素敏感细胞。本发明进一步包括的是包含本发明的融合蛋白的试剂盒。最后，本发明涉及本发明的融合蛋白在神经毒素敏感细胞中用于测定神经毒素的生物学活性的用途。

8. 发明申请

WO2016074794A1 DERMAL FILLER BASED ON CROSSLINKED HYALURONIC ACID AND CARBOXYMETHYL CELLULOSE LUBRICANT 审中-公开
标题翻译：基于交联羟丙酸和羧甲基纤维素润滑剂的真空填料
公开(公告)号：WO2016074794A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/002270
申请日：2015-11-12
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： HAGEDORN, Nadine , STRAGIES, Roland , VILLAIN, Franck
IPC分类号： A61L27/20 , A61L27/26 , A61L27/52
CPC分类号： A61L27/26 , A61L27/20 , A61L27/52 , A61L27/58 , C08B37/0072 , C08L5/08
摘要： The present invention relates to injectable dermal filler compositions in the form of a gel, comprising hyaluronic acid (HA), carboxymethyl cellulose (CMC) and, optionally, microparticles such as calcium hydroxyapatite (CaHAP) microparticles. The injectable dermal filler compositions have improved rheological properties while at the same time have low extrusion forces. The present invention further relates to a method for preparing such injectable dermal filler compositions and their use for cosmetic and therapeutic purposes.
摘要翻译：本发明涉及凝胶形式的可注射皮肤填充剂组合物，其包含透明质酸（HA），羧甲基纤维素（CMC）和任选的微粒如羟基磷灰石（CaHAP）微粒。可注射的皮肤填充剂组合物具有改善的流变性能，同时具有低的挤出力。本发明还涉及制备这种可注射的皮肤填充剂组合物的方法及其用于化妆和治疗目的的用途。

9. 发明申请

WO2015149946A1 IN VIVO DEGRADATION OF POLYSACCHARIDE-CONTAINING FILLERS 审中-公开
标题翻译：含多糖包膜的体内降解
公开(公告)号：WO2015149946A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/000711
申请日：2015-04-01
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： KRAUSE, Andreas , DRABE, Colin , BELKOVI, Lubin , VILLAIN, Franck
IPC分类号： A61Q1/12 , A61Q90/00 , A61K45/06 , A61K8/22 , A61K31/375
CPC分类号： A61K8/22 , A61K8/42 , A61K8/676 , A61K31/07 , A61K31/122 , A61K31/167 , A61K31/355 , A61K31/375 , A61K33/18 , A61K33/20 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/34 , A61K33/40 , A61K45/06 , A61K2800/91 , A61Q19/08 , A61Q90/00 , A61K2300/00
摘要： The present invention relates to a composition for the in vivo degradation of polysaccharide-containing fillers by radical degradation. The composition of the invention comprising at least one source of oxygen free radicals and at least one catalyst of oxygen free radical generation from the at least one source of oxygen free radicals. The present invention further relates to methods and uses of said composition for filler correction or reversal.
摘要翻译：本发明涉及一种通过自由基降解体内降解含多糖的填料的组合物。本发明的组合物包含至少一种氧自由基源和至少一种来自氧自由基的至少一种氧自由基产生的至少一种氧自由基催化剂。本发明还涉及所述组合物用于填料校正或反转的方法和用途。

10. 发明申请

WO2015149941A1 POLYSACCHARIDE SOFT TISSUE FILLERS WITH IMPROVED PERSISTENCE 审中-公开
标题翻译：具有改进持久性的多糖软组织填料
公开(公告)号：WO2015149941A1
公开(公告)日：2015-10-08
申请号：PCT/EP2015/000701
申请日：2015-03-31
申请人： MERZ PHARMA GMBH & CO. KGAA
发明人： LINKO, Alexander , KRAUSE, Andreas , VILLAIN, Franck
IPC分类号： A61L27/20
CPC分类号： A61L27/20 , A61L27/26 , A61L27/50 , A61L27/52 , A61L2400/06 , A61L2430/34 , C08L5/10
摘要： The present invention relates to polysaccharide soft tissue fillers comprising heparosan and processes for their preparation. The polysaccharide soft tissue fillers of the present invention are advantageously used in therapeutic or cosmetic applications such as for the filling of wrinkles.
摘要翻译：本发明涉及包含heparosan的多糖软组织填充剂及其制备方法。本发明的多糖软组织填料有利地用于治疗或美容应用，例如用于填充皱纹。

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