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1. 发明申请

WO2023073115A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL 审中-公开
公开(公告)号：WO2023073115A1
公开(公告)日：2023-05-04
申请号：PCT/EP2022/080104
申请日：2022-10-27
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： GRIESINGER, Christian , RUHE, Jonas , RYAZANOV, Sergey , KEMEN, Eric , LEONOV, Andrei
IPC分类号： A01N43/56 , A01N43/50 , A01N43/653 , A01N43/76 , A01N43/80 , A01N43/82 , A01P1/00 , A01P3/00 , C07D231/12 , C07D233/58 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D233/64 , C07D405/04 , C07D413/04
摘要： The present invention relates to the use of the compound of the formula (I) and the composition thereof as control agent for plant diseases caused by fungi, oomycetes and bacteria. Plant pathogens produce self-aggregating proteins, like beta-amyloid proteins, that can be important parts of extracellular structures, for example cell walls, adhesion structures to biological surfaces and other pathogenicity related infection structures. This invention discloses that the compound of the formula (I) interferes with the aggregation of such proteins and thus reduce plant pathogen growth significantly.

2. 发明申请

WO2023031485A1 METHOD FOR THE DIAGNOSIS AND/OR CLASSIFICATION OF A DISEASE IN A SUBJECT 审中-公开
公开(公告)号：WO2023031485A1
公开(公告)日：2023-03-09
申请号：PCT/EP2022/074773
申请日：2022-09-06
申请人： CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL , FACHHOCHSCHULE KIEL , FREIE UNIVERSITÄT BERLIN , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： MÜLLER, Franz-Josef , BRÄNDL, Björn Fabian , SCHULDT, Bernhard , ROHRANDT, Christian , VAN BÖMMEL, Alena , KRETZMER, Helene
IPC分类号： G16B40/20 , G16B5/20 , G16B20/20 , G16B25/10 , G16B30/10 , G16H50/20
摘要： The present invention relates to a method for the diagnosis and/or classification of a disease in a subject based on the genetic and/or epigenetic information of a sample obtained from the subject, the method comprising the steps of: a) providing data from said sample, wherein said data comprises genetic and/or epigenetic information of a random subset of genomic positions; b) assigning said sample to a sample class based on genetic and/or epigenetic information of said random subset of genomic positions by employing a computational model, which discriminates a plurality of sample classes based on genetic and/or epigenetic information of a set of genomic positions comprising said random subset, wherein the computational model has been trained with pre-determined genetic and/or epigenetic information obtained from a plurality of pre-classified samples of known diseases and wherein said computational model processes the genetic and/or epigenetic information of a genomic position of said random subset independently of the genetic and/or epigenetic information of another genomic position of said random subset, wherein said computational model is preferably in the form of a linear classifier with independent feature sampling.

3. 发明申请

WO2023012314A1 ANTI-PLEXIN-B1 ANTIBODIES 审中-公开
公开(公告)号：WO2023012314A1
公开(公告)日：2023-02-09
申请号：PCT/EP2022/072030
申请日：2022-08-04
申请人： LIFEARC , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： WORZFELD, Thomas , OFFERMANNS, Stefan , MATTHEWS, David , OLEKSY, Arkadiusz , TROKTER, Martina , PATEL, Seema , KAUR NIJJAR, Sharandip
IPC分类号： A61P19/10 , A61P25/00 , C07K16/28 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/76
摘要： The invention relates to antibodies and antigen binding fragments thereof that specifically bind to Plexin-B1 and their therapeutic uses. The antibodies are useful in treating osteoporosis, multiple sclerosis, a neoplastic disease or a neurodegenerative disease in a subject.

4. 发明申请

WO2023006264A1 RNAYLATION 审中-公开
公开(公告)号：WO2023006264A1
公开(公告)日：2023-02-02
申请号：PCT/EP2022/060525
申请日：2022-04-21
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , UNIVERSITÄT HEIDELBERG
发明人： HÖFER, Katharina , JÄSCHKE, Andres
IPC分类号： C12N9/10 , C12Q1/48 , A61P35/00 , C07K2319/00 , C07K2319/30 , C07K2319/70 , C12N9/1077 , C12Y204/0203
摘要： The present invention relates to a method for attaching a 5'-nicotinamidnucleobasedinucleotide (NND)- capped nucleic acid sequence to a fusion protein or to a complex, comprising (a) contacting (i) a heterologous fusion protein which comprises a poly(peptide) of interest being fused to a tag, or (ii) a complex wherein a protein is under physiological conditions complexed with a tag with the 5'-NAD- capped nucleic acid sequence and an ADP-ribosyltransferase (ART) under conditions wherein the 5'- NND-capped nucleic acid sequence is covalently attached to the tag, wherein the tag comprises a recognition motif of the ART and preferably comprises or consists of (i) SEQ ID NO: 1 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (ii) SEQ ID NO: 2 ora sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (iii) SEQ ID NO: 3 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif DVRPVRD (SEQ ID NO: 7) is conserved and preferably SEQ ID NO: 7 is conserved; (iv) SEQ ID NO: 4 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved; (v) SEQ ID NO: 5 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved; or (vi) SEQ ID NO: 6 or a sequence being at least 80% identical thereto provided that the underlined Arg in the amino acid motif LADGVEGYLRASEASRDRVE (SEQ ID NO: 8) is conserved and preferably SEQ ID NO: 8 is conserved.

5. 发明申请

WO2022269041A1 CONTINUOUS FLOW PROCESS FOR PRODUCTION OF CATIONIC LIPIDS 审中-公开
公开(公告)号：WO2022269041A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067361
申请日：2022-06-24
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： SEEBERGER, Peter , PLUTSCHACK, Matthew , CAMBIE, Dario , WOLF, Jakob
IPC分类号： C07C219/06 , C07C51/60 , C07C55/36 , C07C67/14 , C07C67/313 , C07C69/28 , C07C213/00
摘要： The present invention is directed to a method for continuous production of cationic lipids. Said cationic lipids are particularly useful in combination with other lipid components for forming lipid nanoparticles with oligonucleotides (e.g. mRNA) to facilitate delivery of therapeutically active nucleic acids.

6. 发明申请

WO2022263227A1 METHOD OF PRODUCING AN ELECTRODE, ELECTRODE, DRY COATING COMPOSITION, BATTERY AND ELECTRONIC CIRCUIT 审中-公开
公开(公告)号：WO2022263227A1
公开(公告)日：2022-12-22
申请号：PCT/EP2022/065384
申请日：2022-06-07
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： HACKNER, Maximilian , SPATZ, Joachim , HOTZ, Daniel
IPC分类号： H01M4/04 , H01M4/66 , H01M10/052
摘要： The present invention relates to a method of producing an electrode, comprising the following steps: Step (A) of providing a conductive base material, Step (B) of providing a coating composition comprising an electrode active material and optionally a binder, wherein the coating composition is a free-flowing powder, Step (C) of coating the conductive base material provided in step (A) with the coating composition provided in Step (B), and Step (D) of heating the coated conductive base material obtained in step (C) and optionally compressing the coated conductive base material (14), e.g. by calendering. Further, the present invention relates to an electrode, a dry coating composition, a battery and an electric circuit.

7. 发明申请

WO2022258547A1 PHOTONIC ELEMENT FOR A QUANTUM INFORMATION PROCESSING DEVICE AND METHOD FOR PRODUCING SUCH 审中-公开
公开(公告)号：WO2022258547A1
公开(公告)日：2022-12-15
申请号：PCT/EP2022/065281
申请日：2022-06-03
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： REISERER, Andreas , GRITSCH, Andreas , WEISS, Lorenz
IPC分类号： G02B6/134
摘要： Some embodiments relate to a photonic element (10) for a quantum information processing device. The photonic element (10) comprises a high-purity silicon layer (20), wherein the high-purity silicon layer (20) contains integrated rare-earth element dopants (22), REE dopants, at a concentration of 1019 cm-3 or less and wherein an optical transition between the lowest crystal field levels of the REE dopants (22) integrated in the high-purity silicon layer (20) exhibits a homogeneous linewidth of 1 MHz or less at a temperature of 4 K or less. Other embodiments relate to a method for producing a photonic element (10).

8. 发明申请

WO2022258156A1 LASER OSCILLATOR SYSTEM AND METHOD FOR GENERATING LIGHT PULSES 审中-公开
公开(公告)号：WO2022258156A1
公开(公告)日：2022-12-15
申请号：PCT/EP2021/065370
申请日：2021-06-08
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
发明人： MAK, Ka Fai , KRAUSZ, Ferenc , STEINLEITNER, Philipp , NAGL, Nathalie
IPC分类号： H01S3/08 , H01S3/11 , H01S3/16 , H01S3/00 , H01S3/0941 , H01S3/10 , H01S3/105
摘要： Some embodiments relate to a laser oscillator system (10) comprising a resonator cavity (12) for confining an intra-cavity laser beam (13). The laser oscillator system further comprises a Cr-doped II-VI gain medium (14) arranged within the resonator cavity (12), and an imaging unit (18) forming part of the resonator cavity (12). The imaging unit (18) is adapted to decouple a spot size (100) of the intra-cavity laser beam (13) at the gain medium (14) from an intra-cavity length (102) of the resonator cavity (12). Moreover, the resonator cavity (12) and the imaging unit (18) are adapted such that the laser oscillator system (10) emits laser pulses at a repetition rate of 50 MHz or less. Further embodiments relate to a laser system (30) and to methods for generating light pulses having spectral components at a wavelength of at least 2 µm.

9. 发明申请

WO2022248894A1 APPARATUS AND METHOD FOR A MEASUREMENT OF A SPECTRAL RESPONSE OF A SAMPLE, INCLUDING A QUANTUM-CASCADE-LASER-BASED LIGHT AMPLIFICATION 审中-公开
公开(公告)号：WO2022248894A1
公开(公告)日：2022-12-01
申请号：PCT/HU2021/050030
申请日：2021-05-27
申请人： MOLEKULÁRIS- UJJLENYOMAT KUTATÓ KÖZPONT NONPROFIT KFT. , MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. , LUDWIG-MAXIMILIANS-UNIVERSITÄT MÜNCHEN
发明人： WEIGEL, Alexander , SHIZHEN, Qu , MAK, Ka Fai , KRAUSZ, Ferenc
IPC分类号： G01N21/35 , G01N21/3586
摘要： A spectroscopic measuring apparatus (100) being configured for measuring a spectral response of a sample (1), in particular a biological sample, comprises a fs laser source de-vice (10) being arranged for an irradiation of the sample (1) with a sequence of probe light pulses (2) having a primary spectrum, a detector device (20) being arranged for a temporally and/or spectrally resolved detection of response light pulses (2') having an altered spectrum and/or temporal structure and resulting from an interaction of the probe light pulses (2) with the sample (1), and a pulse modification device (30) comprising at least one quantum cascade laser (31…3N), wherein the pulse modification device (30) is configured to modify at least one of the probe light pulses (2) and the response light pulses (2') by amplifying one or more spectral components of the at least one of the probe light pulses (2) and the response light pulses (2') with the at least one quantum cascade laser (31…3N). Furthermore, a method of measuring a spectral and/or temporal response of a sample (1), preferably a biological sample, is described.

10. 发明申请

WO2022238413A1 NETWORK OF METAL FIBERS AND METHOD OF ASSEMBLING A FIBER NETWORK 审中-公开
公开(公告)号：WO2022238413A1
公开(公告)日：2022-11-17
申请号：PCT/EP2022/062655
申请日：2022-05-10
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： HACKNER, Maximilian , SPATZ, Joachim
IPC分类号： D04H1/4234 , B01D39/10 , B01D39/12 , B01D39/20 , B22F3/00 , H01M4/04 , H01M4/80 , B01D39/2041 , B01D39/2044 , B22F3/002 , H01M4/0471 , H01M4/806
摘要： The invention relates to a method of assembling a fiber network comprising a plurality of metal fibers, wherein the method comprises the following steps: providing a loose network out of the plurality of metal fibers at an assembling site; fixing the plurality of metal fibers to one another by forming contact points between the single metal fibers by heating the plurality of fibers at a heating rate higher than 50 K/min, in particular higher than 100 K/min, especially higher than 200 K/min, preferably higher than 1000 K/min, to a fixation temperature selected in the range of 50 to 98% of their melting point temperature; and cooling the plurality of fibers at a cooling rate higher than 50 K/min, preferably higher than 100 K/min. The invention further relates to a network of metal fibers comprising a plurality of metal fibers fixed one to another at contact points, wherein the metal fibers non- round cross section, in particular a rectangular, quadratic, partial circular or an elliptical cross section with a large axis and a small axis, or wherein the metal fibers comprise a round cross section, and wherein the fibers comprise a width which is generally constant along a length of the fiber such that a variation of the width of the fiber along its length is less than 40%, preferably less than 30%, in particular less than 20%. 20

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