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1. 发明申请

WO2012129146A2 METHODS AND APPARATUS FOR A MANUAL RADIAL ARTERY COMPRESSION DEVICE 审中-公开
标题翻译：用于手动径向动脉压缩装置的方法和设备
公开(公告)号：WO2012129146A2
公开(公告)日：2012-09-27
申请号：PCT/US2012029600
申请日：2012-03-19
申请人： MARINEPOLYMER TECH INC , FINKIELSZTEIN SERGIO , FINKIELSZTEIN MARCO
发明人： FINKIELSZTEIN SERGIO , FINKIELSZTEIN MARCO
IPC分类号： A61B17/08
CPC分类号： A61B17/135 , A61B17/1325 , A61B2017/00557 , A61F5/022
摘要： A vascular compression apparatus and method for applying pressure onto an area of a patient generally including a blood vessel and a wound site, such as a blood vessel puncture after a cannulated procedure, for the purpose of controlling bleeding and achieving hemostasis.
摘要翻译：一种血管压迫装置和方法，用于在腔管手术之后向通常包括血管和伤口部位（诸如血管穿刺）的患者区域施加压力，以控制出血并实现止血。

2. 发明申请

WO2008103345A3 HEMOSTATIC COMPOSITIONS AND THERAPEUTIC REGIMENS 审中-公开
标题翻译： HEMOSTATIC组合物和治疗方案
公开(公告)号：WO2008103345A3
公开(公告)日：2009-09-24
申请号：PCT/US2008002172
申请日：2008-02-19
申请人： MARINEPOLYMER TECH INC , FINKIELSZTEIN SERGIO , VOURNAKIS JOHN N
发明人： FINKIELSZTEIN SERGIO , VOURNAKIS JOHN N
IPC分类号： A61L15/28 , A61L26/00 , C08J3/28 , C08L5/08
CPC分类号： A61L15/28 , A61L15/20 , A61L15/44 , A61L26/0066 , A61L27/54 , A61L2300/23 , A61L2300/404 , A61L2300/414 , A61L2430/34 , C08B37/0024 , C08J3/28 , C08J2305/08 , C08L5/08 , Y10T428/298
摘要： The present invention relates generally to the field of hemostasis, including methods, compositions, and devices that can be employed to treat wounds. More specifically the present invention relates to hemostatic compositions that reduce the need for, and cost of, nursing care of patients with chronic wounds by reducing the frequency of wound dressing changes.
摘要翻译：本发明一般涉及止血领域，包括可用于治疗伤口的方法，组合物和装置。更具体地，本发明涉及通过减少伤口敷料变化的频率来减少慢性伤口患者的护理护理需要和成本的止血组合物。

3. 发明申请

WO2006105153A3 METHODS AND APPARATUS FOR A MANUAL VASCULAR COMPRESSION DEVICE 审中-公开
标题翻译：手动血管压缩装置的方法和装置
公开(公告)号：WO2006105153A3
公开(公告)日：2007-12-06
申请号：PCT/US2006011395
申请日：2006-03-29
申请人： MARINEPOLYMER TECH INC , FINKIELSZTEIN SERGIO , FINKIELSZTEIN MARCO , VOURNAKIS JOHN N
发明人： FINKIELSZTEIN SERGIO , FINKIELSZTEIN MARCO , VOURNAKIS JOHN N
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/12 , A61B2017/12004
摘要： A vascular compression apparatus and method for applying pressure onto an area of a patient generally including a blood vessel and a wound site, such as a blood vessel puncture, after a cannulated procedure for the purpose of controlling bleeding and achieving hemostasis. The vascular compression apparatus includes a handle, a shaft and a pad. The shaft extends generally downward from the center of the bottom side of the handle. The pad is connected generally off-center of its top side to the bottom end of the shaft. The bottom side of the pad is convex to allow the vascular compression device to be rocked back and forth. In use, the pad is generally placed proximal to the catheter insertion site and over the blood vessel containing the catheter. The device is rocked proximally to control blood flow while removing the catheter. After the catheter is removed from the puncture site, the device is rocked distally to the puncture site , where pressure is applied until hemostasis is achieved.
摘要翻译：一种血管压缩装置和方法，用于在用于控制出血和实现止血的插管程序之后，将压力通常包括血管和伤口部位（例如血管穿刺）施加到患者的区域上。血管压缩装置包括手柄，轴和垫。轴从手柄底部的中心大致向下延伸。垫的上侧通常偏离轴的底端。垫的底部是凸的以允许血管压缩装置来回摇摆。在使用中，垫通常放置在导管插入部位的近侧并且在包含导管的血管上方。该装置向近侧摇摆以控制血液流动同时移除导管。导管从穿刺部位取出后，将装置向远端向穿刺部位进行摇摆，在该部位施加压力，直到达到止血。

4. 发明申请

WO2004076637A3 CELL-POLYMER FIBER COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：细胞聚合物纤维组合物及其用途
公开(公告)号：WO2004076637A3
公开(公告)日：2005-12-22
申请号：PCT/US2004005648
申请日：2004-02-24
申请人： MARINEPOLYMER TECH INC , VOURNAKIS JOHN N , FINKIELSZTEIN SERGIO
发明人： VOURNAKIS JOHN N , FINKIELSZTEIN SERGIO
IPC分类号： A01N63/00 , A61K31/737 , C12N20060101 , C12N1/00
CPC分类号： A61L26/0057 , A01N1/02 , A01N1/0205 , A01N1/0231 , A61K35/16 , A61L26/0023 , A61K2300/00 , C08L5/08
摘要： The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-beta-1->4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.
摘要翻译：本发明涉及包含人细胞和聚合物纤维的复合物的组合物及其用于治疗目的的方法。还提供了制备这种组合物的方法。本发明包括包含聚-β-1→4-N-乙酰氨基葡萄糖聚合物和储存的血小板的组合物及其用于促进伤口愈合和实现止血的用途。

5. 发明申请

WO2005027993A3 VASCULAR ACCESS PRESERVATION IN HEMODIALYSIS PATIENTS 审中-公开
标题翻译：血液透析患者血管通路保存
公开(公告)号：WO2005027993A3
公开(公告)日：2005-09-29
申请号：PCT/US2004030142
申请日：2004-09-13
申请人： MARINEPOLYMER TECH INC , VOURNAKIS JOHN M , FINKIELSZTEIN SERGIO , PARISER ERNST R
发明人： VOURNAKIS JOHN M , FINKIELSZTEIN SERGIO , PARISER ERNST R
IPC分类号： A61L15/44 , A61L24/00 , A61L26/00 , A61M20060101 , A61M31/00 , A61M37/00
CPC分类号： A61M37/00 , A61L15/44 , A61L24/0015 , A61L26/0066 , A61L2300/418 , A61M31/00
摘要： The present invention relates generally to the field of hemodialysis, including methods and kits that can be employed to improve hemodialysis therapy. The present invention encompasses methods and kits useful for reducing vascular access complications associated with hemodialysis therapy and prolonging the period of time for which a vascular access site can be used in a patient.
摘要翻译：本发明一般涉及血液透析领域，包括可用于改善血液透析治疗的方法和试剂盒。本发明包括可用于减少与血液透析治疗相关的血管通路并发症的方法和试剂盒，并且延长可在患者体内使用血管通路部位的时间段。

6. 发明申请

WO02063961B1 COMPOSITION AND METHODS FOR MODULATION OF VASCULAR STRUCTURE AND/OR FUNCTION 审中-公开
标题翻译：用于调节血管结构和/或功能的组合物和方法
公开(公告)号：WO02063961B1
公开(公告)日：2003-03-06
申请号：PCT/US0203792
申请日：2002-02-08
申请人： MARINEPOLYMER TECH INC
发明人： VOURNAKIS JOHN N , FINKEILSZTEIN SERGIO
IPC分类号： A61K9/10 , A61K9/107 , A61K31/715 , A61K31/726 , A61P7/04 , A61P9/14 , A61P43/00 , C08B37/00 , C08B37/08 , A01N43/04 , A61K31/70 , C07B37/00 , C07B37/08 , C07H1/00 , C07H5/04 , C07H5/06
CPC分类号： A61K31/726 , A61K9/0014 , A61K9/7007 , A61K31/715 , A61K31/722 , A61K31/737 , C08B37/0027 , C08B37/003 , Y10S514/93
摘要： The present invention relates to compositions comprising semi-crystalline beta -1-4-N-acetylglucosamine polymers (p-GlcNac) and methods utilizing such polymers modulation of vascular structure and/or function. The compositions and methods disclosed are useful for stimulating, in a p-GlcNac concentration-dependent manner, endothelin-1 release, vasoconstriction, and/or reduction in blood flow out of a breached vessel, as well as for contributing to or effecting cessation of bleeding. The methods of the present invention comprise topical administration of materials comprising semi-crystalline p-GlcNac polymers that are free of proteins, and substantially free of single amino acids as well as other organic and inorganic contaminants, and whose constituent monosaccharide sugars are attached in a beta -1-4 conformation.
摘要翻译：本发明涉及包含半结晶β-4-N-乙酰葡糖胺聚合物（p-GlcNac）的组合物和利用这种聚合物调节血管结构和/或功能的方法。所公开的组合物和方法可用于以p-GlcNac浓度依赖性方式刺激内皮素-1释放，血管收缩和/或从破裂的血管中减少血流，以及促进或停止流血的。本发明的方法包括局部施用包含不含蛋白质的半结晶p-GlcNac聚合物的材料，并且基本上不含单一氨基酸以及其它有机和无机污染物，并且其构成单糖糖连接在 β-4-1构象。

7. 发明申请

WO2012061803A3 COMPOSITIONS AND METHODS FOR NANOPOLYMER-BASED NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于纳米聚合物的核酸递送的组合物和方法
公开(公告)号：WO2012061803A3
公开(公告)日：2012-08-16
申请号：PCT/US2011059558
申请日：2011-11-07
申请人： MARINEPOLYMER TECH INC , VOURNAKIS JOHN N , DEMCHEVA MARINA V
发明人： VOURNAKIS JOHN N , DEMCHEVA MARINA V
IPC分类号： A61K9/14
CPC分类号： A61K9/5161 , A61K9/0019 , A61K48/00 , A61K48/0075 , C12N15/88
摘要： Provided herein are p-GlcNAc nanoparticle/nucleic acid compositions. In one aspect, the p-GlcNAc nanoparticle/nucleic acid compositions comprise deacetylated poly-N- acetylglucosamine lactate derivative nanoparticles less than 500 nm and a nucleic acid. Also, provided herein are methods for administering a nucleic acid to a subject, the method comprising administering to the subject a p-GlcNAc nanoparticle/nucleic acid composition. In certain embodiments, the p-GlcNAc nanoparticle/nucleic acid composition is administered subcutaneous ly to the subject.
摘要翻译：本文提供了p-GlcNAc纳米颗粒/核酸组合物。一方面，p-GlcNAc纳米颗粒/核酸组合物包含小于500nm的脱乙酰化聚-N-乙酰葡糖胺衍生物纳米颗粒和核酸。此外，本文提供的是向受试者施用核酸的方法，所述方法包括向受试者施用p-GlcNAc纳米颗粒/核酸组合物。在某些实施方案中，将p-GlcNAc纳米颗粒/核酸组合物皮下给予受试者。

8. 发明申请

WO2011130479A2 APPLICATION OF POLYMERIC MATERIALS TO SCREENS TO FACILITATE HEMOSTASIS AND WOUND HEALING 审中-公开
标题翻译：将聚合物材料应用于筛选，以促进血管瘤和创伤治疗
公开(公告)号：WO2011130479A2
公开(公告)日：2011-10-20
申请号：PCT/US2011032434
申请日：2011-04-14
申请人： MARINEPOLYMER TECH INC , ORGILL DENNIS P , PIETRAMAGGIORI GIORGIO , FINKIELSZTEIN SERGIO , VOURNAKIS JOHN N
发明人： ORGILL DENNIS P , PIETRAMAGGIORI GIORGIO , FINKIELSZTEIN SERGIO , VOURNAKIS JOHN N
IPC分类号： A61M27/00 , A61F13/00 , A61K38/39 , A61L15/42 , A61L15/44 , A61P7/04
CPC分类号： A61M35/00 , A61F13/0216 , A61F13/0226 , A61F2013/00174 , A61F2013/00468 , A61F2013/00472 , A61F2013/00536 , A61L15/28 , A61L15/44 , A61L2300/232 , A61L2300/418 , A61L2300/622 , A61L2400/04 , A61M1/0088 , C08L5/00
摘要： This invention relates in general to a method and device for facilitating hemostasis and wound healing. In particular, the invention relates to the device comprising a polymeric material disposed on a scaffold that facilitates hemostasis and wound healing. Specifically, the invention contemplates the use of such scaffolds in conjunction with a negative pressure device.
摘要翻译：本发明一般涉及促进止血和伤口愈合的方法和装置。特别地，本发明涉及包括设置在支架上的促进止血和伤口愈合的聚合材料的装置。具体地说，本发明考虑了与负压装置结合使用这种支架。

9. 发明申请

WO2009002562A3 COMPLEXES OF IL-15 AND IL-15RALPHA AND USES THEREOF 审中-公开
标题翻译： IL-15和IL-15RALPHA的复合物及其用途
公开(公告)号：WO2009002562A3
公开(公告)日：2009-02-26
申请号：PCT/US2008008084
申请日：2008-06-27
申请人： MARINEPOLYMER TECH INC , US HEALTH , PAVLAKIS GEORGE N , VOURNAKIS JOHN N , FELBER BARBARA K , FINKIELSZTEIN SERGIO
发明人： PAVLAKIS GEORGE N , VOURNAKIS JOHN N , FELBER BARBARA K , FINKIELSZTEIN SERGIO
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： A61K38/2086 , A61K35/13 , A61K38/1793 , A61K39/0011 , A61K47/36 , A61K2039/5152 , A61K2039/5156 , A61K2039/55527 , C07K16/244 , C07K16/2866 , C07K2317/24 , C07K2317/76 , C12N5/0686 , C12N15/85 , C12N2500/90 , C12N2510/00
摘要： The present invention relates to agents that modulate interle?kin-15 ("IL-15") signal transduction or function ("Therapeutic Agents") and the use ol" those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers, such as poly-ß- 1- ?4-N-acetylglucosamine. for administration to a human subject to modulate IL-15-mediated immune function.
摘要翻译：本发明涉及调节白介素-15（“IL-15”）信号转导或功能（“治疗剂”）和使用“这些试剂调节免疫功能”的药物。治疗剂靶向IL -15和其受体并调节IL-15诱导的信号转导。治疗剂可以与聚合物如聚-β-1-β-N-乙酰葡糖胺一起配制，用于给予受试者调节IL-15 介导的免疫功能。

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