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1. 发明申请

WO2011060174A1 SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A BIOLOGICAL STATUS USING PLOT 审中-公开
标题翻译：用于检测生物状态存在的系统和方法
公开(公告)号：WO2011060174A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056387
申请日：2010-11-11
申请人： BECKMAN COULTER, INC. , LU, Jiuliu , WANG, Zihua , REYES, Antonio Arevalo , GUSTAFSON, Erik Alan , RILEY, John Steven
发明人： LU, Jiuliu , WANG, Zihua , REYES, Antonio Arevalo , GUSTAFSON, Erik Alan , RILEY, John Steven
IPC分类号： G06F19/26 , G06T11/20
CPC分类号： G06F19/26 , G06F19/12 , G06F19/18 , G06F19/24 , G06T11/206
摘要： Systems and methods for identifying Methicillin resistant strains of Staphylococcus aureus (MRSA) in a sample are used that are based on the fact that an MRSA positive sample should have roughly the same copy numbers of mecA, SCCmec, and a Staphylococcus aureus-specific target gene sequence. The systems and methods may further present the three assays simultaneously on a 2-D plot with each axis of the plot 120 degrees apart. According to one embodiment, a Y plot is used for the 2-D display. If a given sample has similar readings of mecA, SCCmec, and a Staphylococcus aureus-specific target gene sequence, the sample's measured copy numbers of mecA, SCCmec, and the Staphylococcus aureus-specific target gene sequence can plot close to the origin regardless of the sample's absolute assay readings. With the help of this transformation, a boundary function can be defined that can be used to distinguish MRSA-positive samples from MRSA-negative samples.
摘要翻译：使用用于鉴定样品中的甲氧西林抗性金黄色葡萄球菌（MRSA）的系统和方法，其基于以下事实：MRSA阳性样品应具有与mecA，SCCmec和金黄色葡萄球菌特异性靶基因大致相同的拷贝数序列。系统和方法可以进一步在2-D图上同时进行三个测定，每个图的每个轴分开120度。根据一个实施例，Y图被用于2-D显示。如果给定的样品具有类似的mecA，SCCmec和金黄色葡萄球菌特异性靶基因序列的读数，则样品的mecA，SCCmec和金黄色葡萄球菌特异性靶基因序列的测试拷贝数可以靠近原点绘图，不管样品的绝对测定读数。在这种转化的帮助下，可以定义可用于区分MRSA阳性样本和MRSA阴性样本的边界函数。

2. 发明申请

WO2011060222A9 SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A BIOLOGICAL STATUS USING CLUSTERING 审中-公开
标题翻译：用集群检测生物状态的系统和方法
公开(公告)号：WO2011060222A9
公开(公告)日：2011-05-19
申请号：PCT/US2010/056455
申请日：2010-11-12
申请人： BECKMAN COULTER, INC. , LU, Jiuliu , WANG, Zihua , REYES, Antonio Arevalo , GUSTAFSON, Erik Alan , RILEY, John Steven
发明人： LU, Jiuliu , WANG, Zihua , REYES, Antonio Arevalo , GUSTAFSON, Erik Alan , RILEY, John Steven
IPC分类号： G06F19/24

3. 发明申请

WO2010056740A1 METHOD OF CORRECTION OF PARTICLE INTERFERENCE TO HEMOGLOBIN MEASUREMENT 审中-公开
标题翻译：校正粒子干扰测定法的方法
公开(公告)号：WO2010056740A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/064021
申请日：2009-11-11
申请人： BECKMAN COULTER, INC. , ZHANG, Shuliang , LU, Jiuliu , ZHENG, Min , GRACE, Eric, M. , LI, Jing , LAVERNIA, Maritza , BRITTON, Ted, W.
发明人： ZHANG, Shuliang , LU, Jiuliu , ZHENG, Min , GRACE, Eric, M. , LI, Jing , LAVERNIA, Maritza , BRITTON, Ted, W.
IPC分类号： G01N33/72
CPC分类号： G01N33/721 , G01N33/491 , Y10T436/10 , Y10T436/101666 , Y10T436/25 , Y10T436/25125
摘要： A method of correction of particle interference to hemoglobin measurement of a blood sample on a hematology analyzer is provided. The method includes mixing an aliquot of a blood sample with a lytic reagent to lyse red blood cells and forming a sample mixture; measuring absorbance of the sample mixture at a predetermined wavelength of a hemoglobin chromogen formed in the sample mixture, and obtaining an apparent hemoglobin concentration of the blood sample using obtained absorbance; measuring concentration and size of cellular particles remaining in the sample mixture; removing contribution of the cellular particles to the apparent hemoglobin concentration using the concentration and the size of the cellular particles to obtain a corrected hemoglobin concentration of the blood sample; and reporting the corrected hemoglobin concentration of the blood sample.
摘要翻译：提供了一种在血液分析仪上校正血液样品血红蛋白测量的粒子干扰的方法。该方法包括将血样的等分试样与裂解试剂混合以溶解红细胞并形成样品混合物; 测量在样品混合物中形成的血红蛋白色原子的预定波长处的样品混合物的吸光度，并使用所获得的吸光度获得血液样品的表观血红蛋白浓度; 测量残留在样品混合物中的细胞颗粒的浓度和尺寸; 使用细胞颗粒的浓度和大小去除细胞颗粒对表观血红蛋白浓度的贡献，以获得血液样品的校正血红蛋白浓度; 并报告血样的校正血红蛋白浓度。

4. 发明申请

WO2010053868A2 MULTIDIMENSIONAL PARTICLE ANALYSIS DATA CLUSTER RECONSTRUCTION 审中-公开
标题翻译：多维粒子分析数据集群重构
公开(公告)号：WO2010053868A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/062979
申请日：2009-11-02
申请人： BECKMAN COULTER, INC. , RAMIREZ, Carlos, A. , PARK, Jaesang , LU, Jiuliu
发明人： RAMIREZ, Carlos, A. , PARK, Jaesang , LU, Jiuliu
IPC分类号： G06K9/00 , G06K9/62
CPC分类号： G06K9/00147 , G06K9/622
摘要： Systems and methods for multidimensional particle analysis data cluster mapping and reconstruction are provided. In one embodiment, a method for reconstructing multidimensional particle analysis data clusters is provided. The method includes obtaining a set of segmented two-dimensional projections corresponding to multidimensional particle analysis data associated with a biological sample of particles. Each segmented two-dimensional projection has two-dimensional clusters associated with particle populations in the biological sample. The method also includes reconstructing one or more multidimensional clusters based on the two-dimensional clusters in the segmented two-dimensional projections.
摘要翻译：提供了多维粒子分析数据集群映射和重建的系统和方法。在一个实施例中，提供了重建多维粒子分析数据簇的方法。该方法包括获得对应于与生物样品颗粒相关联的多维粒子分析数据的一组分割的二维投影。每个分割的二维投影具有与生物样品中的粒子群相关联的二维簇。该方法还包括基于分割的二维投影中的二维聚类重建一个或多个多维聚类。

5. 发明申请

WO2011060222A2 SYSTEMS AND METHODS FOR DETECTING THE PRESENCE OF A BIOLOGICAL STATUS USING CLUSTERING 审中-公开
标题翻译：用于检测使用聚类的生物状态存在的系统和方法
公开(公告)号：WO2011060222A2
公开(公告)日：2011-05-19
申请号：PCT/US2010056455
申请日：2010-11-12
申请人： BECKMAN COULTER INC , LU JIULIU , WANG ZIHUA , REYES ANTONIO AREVALO , GUSTAFSON ERIK ALAN , RILEY JOHN STEVEN
发明人： LU JIULIU , WANG ZIHUA , REYES ANTONIO AREVALO , GUSTAFSON ERIK ALAN , RILEY JOHN STEVEN
IPC分类号： G06F19/24
CPC分类号： G06F19/24 , C12Q1/689 , C12Q2600/112 , G06F19/12 , G06F19/18
摘要： A method for determining the presence of a biological entity. The method may include entering into a digital computer, at least a plurality of first input values associated with a first genetic element (e.g., mecA), a plurality of second input values associated with a second genetic element (femA), and a plurality of third input values associated with a third genetic element (e.g., orfX) associated with a plurality of samples. Each sample includes a first input value in the plurality of first input values, a second input value in the plurality of second input values, and a third input value in the plurality of third input values. The method also includes determining a threshold value associated with the third genetic element, separating the samples using the threshold value into a first set of samples and a second set of samples, clustering the first set of samples in a feature space defined by the first genetic element and the second genetic element, defining a first boundary space using the first set of samples, and defining a second boundary space using the second set of samples. The first and second boundary spaces differentiate a biological entity from other biological statuses. Other embodiments may also include the use of a genetic element such as SCCmec.
摘要翻译：用于确定生物实体的存在的方法。该方法可以包括进入数字计算机，与第一遗传元素（例如，mecA）相关联的至少多个第一输入值，与第二遗传元件（femA）相关联的多个第二输入值，以及多个与与多个样本相关联的第三遗传元素（例如，orfX）相关联的第三输入值。每个样本包括多个第一输入值中的第一输入值，多个第二输入值中的第二输入值和多个第三输入值中的第三输入值。该方法还包括确定与第三遗传元件相关联的阈值，使用阈值将样本分离成第一组样本和第二组样本，将第一组样本聚集在由第一遗传学定义的特征空间中元素和第二遗传元素，使用第一组样本定义第一边界空间，以及使用第二组样本定义第二边界空间。第一和第二边界空间将生物体与其他生物状态区分开来。其他实施方案还可以包括遗传元件如SCCmec的使用。

6. 发明申请

WO2010042401A1 DETECTING AND HANDLING COINCIDENCE IN PARTICLE ANALYSIS 审中-公开
标题翻译：检测和处理粒子分析中的相关性
公开(公告)号：WO2010042401A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/059363
申请日：2009-10-02
申请人： BECKMAN COULTER, INC. , BRITTON, Ted, W. , LU, Jiuliu , ROSE, Jeffrey, L.
发明人： BRITTON, Ted, W. , LU, Jiuliu , ROSE, Jeffrey, L.
IPC分类号： G01N21/00
CPC分类号： G01N15/1429 , G01N15/1459 , G01N2015/1037 , G01N2015/1461
摘要： Methods and systems substantially eliminate data representative of coincident events from particle analyzer data. A fluid sample containing particles for analysis is prepared. Using an electrical or optical measurement device, signals are sensed. Each signal corresponds to events detected in a sub-sample of the fluid sample flowing through a measurement region in the particle analyzer. The existence of coincidence in the events is determined based on measuring a peak and first and second points of each of the signals. The first and second points have a signal value corresponding to a predetermined portion of the peak. Results data based upon the coincident events and non-coincident events is generated. The results data is then analyzed. In various examples, the method is applicable to a variety of particle types, and may be implemented on different types of particle analyzers including hematology analyzer and flow cytometers.
摘要翻译：方法和系统基本上消除了代表颗粒分析仪数据的重合事件的数据。制备含有用于分析的颗粒的流体样品。使用电气或光学测量设备，感测到信号。每个信号对应于在流过粒子分析仪中的测量区域的流体样品的子样本中检测到的事件。基于测量每个信号的峰值和第一和第二点来确定事件中的一致性的存在。第一和第二点具有对应于峰值的预定部分的信号值。生成基于一致事件和非重合事件的结果数据。然后分析结果数据。在各种实施例中，该方法适用于各种粒子类型，并且可以在包括血液分析仪和流式细胞仪在内的不同类型的粒子分析仪上实施。

7. 发明申请

WO2010042267A2 SHAPE PARAMETER FOR HEMATOLOGY INSTRUMENTS 审中-公开
标题翻译：造型仪器的形状参数
公开(公告)号：WO2010042267A2
公开(公告)日：2010-04-15
申请号：PCT/US2009/052125
申请日：2009-07-29
申请人： BECKMAN COULTER, INC. , LU, Jiuliu , CHEWPUTTANAGUL, Phaisit
发明人： LU, Jiuliu , CHEWPUTTANAGUL, Phaisit
IPC分类号： G06F17/18
CPC分类号： G01N15/147 , G01N15/12 , G01N15/1404 , G01N15/1429 , G01N15/1459 , G01N2015/1037 , G01N2015/129
摘要： Systems, methods, and computer program products are provided for describing characteristics of a data sample. This description is used to represent the shape of a histogram of the data sample.
摘要翻译：提供了系统，方法和计算机程序产品，用于描述数据样本的特征。该描述用于表示数据样本的直方图的形状。

8. 发明申请

WO2012139047A2 IDENTIFYING AND ENUMERATING EARLY GRANULATED CELLS (EGCS) 审中-公开
标题翻译：鉴定和计算早期颗粒细胞（EGCS）
公开(公告)号：WO2012139047A2
公开(公告)日：2012-10-11
申请号：PCT/US2012/032603
申请日：2012-04-06
申请人： BECKMAN COULTER, INC. , RAMIREZ, Carlos, A. , LU, Jiuliu
发明人： RAMIREZ, Carlos, A. , LU, Jiuliu
IPC分类号： G01N33/50 , G01N33/80
CPC分类号： G01N15/147 , G01N15/1429 , G01N21/53 , G01N33/5094 , G01N2021/4707 , G01N2021/4769
摘要： Methods and systems for automatically identifying and enumerating early granulated cells (EGC) in blood samples are disclosed. In one embodiment a method for identifying EGC in a blood sample includes analyzing white blood cells of the blood sample using a low angle light scatter (LALS) parameter, separating the EGCs from the other white blood cells using the LALS parameter, and enumerating the separated EGCs.
摘要翻译：公开了用于在血液样品中自动识别和计数早期造粒细胞（EGC）的方法和系统。在一个实施方案中，用于鉴定血液样品中的EGC的方法包括使用低角度光散射（LALS）参数分析血液样品的白细胞，使用LALS参数将EGC与其他白细胞分离，并列举分离的电梯群控系统。

9. 发明申请

WO2010053868A3 MULTIDIMENSIONAL PARTICLE ANALYSIS DATA CLUSTER RECONSTRUCTION 审中-公开
标题翻译：多维粒子分析数据集群重构
公开(公告)号：WO2010053868A3
公开(公告)日：2011-12-29
申请号：PCT/US2009062979
申请日：2009-11-02
申请人： BECKMAN COULTER INC , RAMIREZ CARLOS A , PARK JAESANG , LU JIULIU
发明人： RAMIREZ CARLOS A , PARK JAESANG , LU JIULIU
IPC分类号： G06K9/00 , G06K9/62
CPC分类号： G06K9/00147 , G06K9/622
摘要： Systems and methods for multidimensional particle analysis data cluster mapping and reconstruction are provided. In one embodiment, a method for reconstructing multidimensional particle analysis data clusters is provided. The method includes obtaining a set of segmented two-dimensional projections corresponding to multidimensional particle analysis data associated with a biological sample of particles. Each segmented two-dimensional projection has two-dimensional clusters associated with particle populations in the biological sample. The method also includes reconstructing one or more multidimensional clusters based on the two-dimensional clusters in the segmented two-dimensional projections.
摘要翻译：提供了多维粒子分析数据集群映射和重建的系统和方法。在一个实施例中，提供了重建多维粒子分析数据簇的方法。该方法包括获得对应于与生物样品颗粒相关联的多维粒子分析数据的一组分割的二维投影。每个分割的二维投影具有与生物样品中的粒子群相关联的二维簇。该方法还包括基于分割的二维投影中的二维聚类重建一个或多个多维聚类。

10. 发明申请

WO2010053869A3 SYSTEMS AND METHODS FOR CELLULAR ANALYSIS DATA PATTERN GLOBAL POSITIONING 审中-公开
标题翻译：细胞分析数据模式的全球定位系统与方法
公开(公告)号：WO2010053869A3
公开(公告)日：2010-07-15
申请号：PCT/US2009062980
申请日：2009-11-02
申请人： BECKMAN COULTER INC , RAMIREZ CARLOS A , PARK JAESANG , LU JIULIU
发明人： RAMIREZ CARLOS A , PARK JAESANG
IPC分类号： G06K9/64 , G06T7/00
CPC分类号： G06K9/00127 , G06T7/32
摘要： In accordance with the principles of the invention, methods, systems, and computer- readable mediums are provided for positioning cellular analysis data including measuring a similarity between pixel data in a target sample data and pixel data in a template data. An offset position is determined based on the measured similarity. The pixel data in the template data is shifted based on the offset position to produce shifted template data having pixel data at shifted locations which match the corresponding pixel data in the target sample data.
摘要翻译：根据本发明的原理，提供了用于定位细胞分析数据的方法，系统和计算机可读介质，包括测量目标样本数据中的像素数据和模板数据中的像素数据之间的相似度。基于所测量的相似度来确定偏移位置。基于偏移位置移动模板数据中的像素数据，以产生具有与目标样本数据中的对应像素数据匹配的偏移位置处的像素数据的移位的模板数据。

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