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    • 8. 发明申请
    • ANALYTE EXTRACTION APPARATUS AND METHOD
    • 分析提取装置和方法
    • WO2012049491A3
    • 2012-06-07
    • PCT/GB2011051958
    • 2011-10-11
    • SPHERE MEDICAL LTDPETTIGREW DAVID MICHAELLIU BOLAITENBERGER PETER GEORGBATES STEPHEN
    • PETTIGREW DAVID MICHAELLIU BOLAITENBERGER PETER GEORGBATES STEPHEN
    • G01N30/06B01D11/02G01N33/15
    • G01N33/948G01N30/06G01N30/24G01N2030/067G01N2030/085Y10T436/11Y10T436/203332Y10T436/255
    • Disclosed is an apparatus for automatically extracting i2,6-diisopropylphenol (Propofol), from a complex sample matrix comprising cellular material, e.g. blood, the apparatus comprising a sample reception stage having on output for providing a defined quantity of the complex sample matrix; a mixing stage having a first input in fluidic connection with the output of the sample reception stage, a second input for receiving a lysing agent and an output for providing a mixture of the defined quantity of the complex sample matrix and the lysing agent; a delay stage having an input in fluidic connection with the output of the mixing stage and an output for providing the delayed mixture of the defined quantity of the complex sample matrix and the lysing agent; a filtering stage comprising a sorbent material for mechanically lysing the cellular material, said sorbent material having an affinity for binding Propofol, said filtering stage having an input in fluidic connection with the output of the delay stage; and a controller for controlling the flow rate of the mixture of the defined quantity of the complex sample matrix and the lysing agent through said delay stage. A method for such extraction is also disclosed.
    • 公开了一种用于从包含细胞材料的复杂样品基质中自动提取i2,6-二异丙基苯酚(异丙酚)的装置,例如, 血液,所述装置包括具有用于提供限定量的所述复样本矩阵的输出的样本接收台; 混合阶段具有与样品接收台的输出流体连接的第一输入,用于接收裂解剂的第二输入和用于提供所定量的复合样品基质和裂解剂的混合物的输出; 具有与混合级的输出流体连接的输入的延迟级和用于提供限定量的复合样品基质和裂解剂的延迟混合物的输出; 过滤阶段包括用于机械裂解细胞材料的吸附剂材料,所述吸附剂材料具有对结合丙泊酚的亲和力,所述过滤级具有与延迟级的输出流体连接的输入; 以及控制器,用于通过所述延迟级来控制所述限定量的所述复合样本矩阵和所述裂解剂的混合物的流量。 还公开了这种提取的方法。