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1. 发明申请

WO2009013333A1 ALKYLACETYLENE SUBSTITUTED ACYLTRYPTOPHANOLS 审中-公开
标题翻译：烷基乙烯取代的乙酰胆碱
公开(公告)号：WO2009013333A1
公开(公告)日：2009-01-29
申请号：PCT/EP2008/059703
申请日：2008-07-24
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian Peter , SCHREY, Anna Katharina , KÜHNE, Ronald
发明人： WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian Peter , SCHREY, Anna Katharina , KÜHNE, Ronald
IPC分类号： C07D405/12 , C07D209/14 , A61K31/404 , A61P15/16
CPC分类号： C07D209/14 , C07D405/12
摘要： The present invention relates to acyltryptophanols of the general formula (I) in which R1, R2, R3, Q and X have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及通式（I）的酰基色氨酸，其中R1，R2，R3，Q和X具有如说明书中所定义的含义。根据本发明的化合物是有效的FSH拮抗剂，可以用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

2. 发明申请

WO2010081600A2 ROTATING SURFACES FOR SDR 审中-公开
标题翻译：旋转表面特别提款权
公开(公告)号：WO2010081600A2
公开(公告)日：2010-07-22
申请号：PCT/EP2009066944
申请日：2009-12-11
申请人： CONSTR RES & TECH GMBH , LIESENER FLORIAN , CAI ZHIZHONG , MEZGER JOCHEN , FLAKUS SILKE , KLAPDOHR SIMONE , WALTHER BURKHARD , MACK HELMUT , AUSTERMANN TOBIAS
发明人： LIESENER FLORIAN , CAI ZHIZHONG , MEZGER JOCHEN , FLAKUS SILKE , KLAPDOHR SIMONE , WALTHER BURKHARD , MACK HELMUT , AUSTERMANN TOBIAS
IPC分类号： B01J19/00 , B01J19/02 , B01J19/18
CPC分类号： B01J19/02 , B01J19/0013 , B01J19/0073 , B01J19/1887 , B01J2219/00085 , B01J2219/00166 , B01J2219/00189
摘要： The invention relates to a spinning disc reactor substantially comprising a horizontally rotating disc-shaped and temperature-controlled carrier element comprising an outer reaction surface, infeed means for feeding at least one reactant to the reaction surface, and interior structures for controlling the temperature of the reaction surface. Said reactor further comprises at least one precipitating device for collecting and removing the reaction product from the reaction surface. The carrier element is particularly characterized in that it is made of two components a) and b) disposed horizontally one over the other and having substantially identical surface area dimensions. Said two components are interlocked closely together during the operating time, and the lower component a) comprises at least one flat milled and substantially uninterrupted groove in the top side thereof facing the interior of the carrier element for receiving, routing, and conducting a heat transfer fluid. Said component further comprises at least two holes for acting on and conducting the heat transfer fluid, wherein at least one profile seal circularly encompassing the outer surface area is disposed between the component a) and the component b). The two components a) and b) are connected overall reversibly to each other. The specific features named provide a simply designed reactor having advantageous maintenance, widely applicable, and thereby allowing targeted control of the chemical reaction on the rotating surface thereof.
摘要翻译：从本质上说，所提出的旋转圆盘反应器包括一个具有外部反应表面的水平旋转圆盘形和温度可控的载体元件，供料装置供给至少一种反应物到所述反应表面和用于控制反应表面的温度的内部结构。它也包含用于从反应表面收集和去除反应产物的至少一个分离装置。其特征在于该载体元件特别特征在于）它由两个水平叠置组分a）和具有基本相同的基重B的。这两个部件中的动作时间带正电和紧密地彼此连接和下组分a）具有在其面向支承部件上侧朝向研磨的至少一个表面，并且基本上连续的槽，用于接收传热流体的，传输和耗散的内部区域。它也具有至少两个孔中，用于加压和排放热传递流体，）被布置包含组分a）和组分b之间的外轮廓密封至少一个圆形表面区域。这两种组分a）和b）的总可逆地连接在一起。由于所提到的具体特征是有简单的结构和维护工业上有利的反应器，它是高度通用的，从而允许它的旋转表面上的化学反应的选择性控制。

3. 发明申请

WO2009016253A3 CYANOMETHYL SUBSTITUTED N-ACYL TRYPTAMINES 审中-公开
标题翻译：氰基取代的N-亚乙基三羟甲基纤维素
公开(公告)号：WO2009016253A3
公开(公告)日：2009-03-26
申请号：PCT/EP2008060123
申请日：2008-08-01
申请人： BAYER SCHERING PHARMA AG , WORTMANN LARS , KOPPITZ MARCUS , MUHN HANS-PETER , FRENZEL THOMAS , LIESENER FLORIAN PETER , SCHREY ANNA KATHARINA , KUEHNE RONALD
发明人： WORTMANN LARS , KOPPITZ MARCUS , MUHN HANS-PETER , FRENZEL THOMAS , LIESENER FLORIAN PETER , SCHREY ANNA KATHARINA , KUEHNE RONALD
IPC分类号： C07D209/16 , A61K31/4045 , A61P5/06 , A61P19/10 , C07D209/14 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D209/16 , C07D209/14 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula (I) in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及式（I）的氰基甲基取代的N-酰基色氨胺，其中R1，R2，R3，R4，R5，Q，X和W具有如说明书中所定义的含义。根据本发明的化合物是有效的FSH拮抗剂，可以用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

4. 发明申请

WO2008116671A1 2,3,4,9-TETRAHYDRO-1H-CARBAZOLES 审中-公开
标题翻译： 2,3,4,9-四氢-1H-咔唑
公开(公告)号：WO2008116671A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/002654
申请日：2008-03-27
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian, Peter , SCHREY, Anna , KUEHNE, Ronald
发明人： WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian, Peter , SCHREY, Anna , KUEHNE, Ronald
IPC分类号： C07D209/88 , C07D401/12 , C07D405/12 , A61K31/403 , A61P5/08 , A61P19/10
CPC分类号： C07D401/12 , C07D209/88 , C07D405/12
摘要： The present invention relates to 2,3,4,9-tetrahydro-1H-carbazoles of the general formula (I), in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及通式（I）的2,3,4,9-四氢-1H-咔唑，其中Q，X，W，R 1，R 2，R 3，R 4和R 5具有如描述。根据本发明的化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

5. 发明申请

WO2010081600A3 ROTIERENDE OBERFLÄCHEN FÜR SDR 审中-公开
公开(公告)号：WO2010081600A3
公开(公告)日：2010-07-22
申请号：PCT/EP2009/066944
申请日：2009-12-11
申请人： CONSTRUCTION RESEARCH & TECHNOLOGY GMBH , LIESENER, Florian , CAI, Zhizhong , MEZGER, Jochen , FLAKUS, Silke , KLAPDOHR, Simone , WALTHER, Burkhard , MACK, Helmut , AUSTERMANN, Tobias
发明人： LIESENER, Florian , CAI, Zhizhong , MEZGER, Jochen , FLAKUS, Silke , KLAPDOHR, Simone , WALTHER, Burkhard , MACK, Helmut , AUSTERMANN, Tobias
IPC分类号： B01J19/00 , B01J19/02 , B01J19/18
摘要： Der vorgeschlagene Spinning Disc Reaktor umfasst im Wesentlichen ein horizontal rotierbares, scheibenförmiges und temperierbares Trägerelement, welches eine äußere Reaktionsoberfläche, Zufuhrmittel zum Zuführen mindestens eines Reaktanden auf die Reaktionsoberfläche sowie innenliegende Strukturen zum Temperieren der Reaktionsoberfläche aufweist. Außerdem enthält er mindestens eine Abscheidevorrichtung zum Sammeln und Abführen des Reaktionsproduktes von der Reaktionsoberfläche. Gekennzeichnet ist das Trägerelement insbesondere dadurch, dass es aus zwei horizontal übereinander angeordneten Bauteilen a) und b) mit im Wesentlichen identischen Flächenmassen besteht. Diese beiden Bauteile sind während der Betriebszeit miteinander formschlüssig und dicht verbunden und das untere Bauteil a) weist auf seiner dem Innenbereich des Trägerelements zugewandten Oberseite mindestens eine flächig eingefräste und im Wesentlichen ununterbrochene Nut zur Aufnahme, Weiterleitung und Ableitung eines Wärmeübertragungsfluids auf. Außerdem verfügt es über mindestens zwei Bohrungen zur Beaufschlagung und Ableitung des Wärmeübertragungsfluids, wobei zwischen dem Bauteil a) und dem Bauteil b) mindestens eine den äußeren Flächenbereich kreisförmig umfassende Profildichtung angeordnet ist. Die beiden Bauteile a) und b) sind insgesamt reversibel miteinander verbunden. Durch die genannten spezifischen Merkmale liegt ein einfach konstruierter und wartungstechnisch vorteilhafter Reaktor vor, der vielfältig einsetzbar ist und dabei eine gezielte Steuerung der chemischen Reaktion auf seiner rotierenden Oberfläche erlaubt.

6. 发明申请

WO2009016253A2 CYANOMETHYL SUBSTITUTED N-ACYL TRYPTAMINES 审中-公开
标题翻译：氰甲基取代的N-酰基三聚氰胺
公开(公告)号：WO2009016253A2
公开(公告)日：2009-02-05
申请号：PCT/EP2008/060123
申请日：2008-08-01
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian Peter , SCHREY, Anna Katharina , KÜHNE, Ronald
发明人： WORTMANN, Lars , KOPPITZ, Marcus , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian Peter , SCHREY, Anna Katharina , KÜHNE, Ronald
IPC分类号： C07D209/16 , C07D209/14 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/4045 , A61P5/06 , A61P19/10
CPC分类号： C07D209/16 , C07D209/14 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula (I) in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及式（I）的氰甲基取代的N-酰基色胺，其中R 1，R 2，R 3，R 4，R 5，Q，X和W具有如在说明书中所定义的含义。根据本发明的化合物是有效的FSH拮抗剂，并且可以用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

7. 发明申请

WO2009013354A1 ARYLMETHYLENE SUBSTITUTED N-ACYL-β-AMINO ALCOHOLS 审中-公开
标题翻译：亚磺酰基取代的N-亚氨基 - 氨基醇
公开(公告)号：WO2009013354A1
公开(公告)日：2009-01-29
申请号：PCT/EP2008/059798
申请日：2008-07-25
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , KOPPITZ, Marcus , MENZENBACH, Bernd , KOSEMUND, Dirk , SCHMEES, Norbert , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian, Peter , SCHREY, Anna, Katharina , KÜHNE, Ronald
发明人： WORTMANN, Lars , KOPPITZ, Marcus , MENZENBACH, Bernd , KOSEMUND, Dirk , SCHMEES, Norbert , MUHN, Hans-Peter , FRENZEL, Thomas , LIESENER, Florian, Peter , SCHREY, Anna, Katharina , KÜHNE, Ronald
IPC分类号： A61K31/381 , A61K31/407 , A61K31/47 , A61P5/24 , A61P5/28 , A61P5/32 , A61P5/36 , A61P15/16 , A61P15/18 , A61P19/10 , C07D215/20 , C07D409/12 , C07D471/04
CPC分类号： C07D215/20 , C07D215/52 , C07D333/58 , C07D409/12 , C07D471/04
摘要： The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula (I) : in which Y is selected from the aryl or heteroaryl groups: formula (II); and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及式（I）的芳基亚甲基取代的N-酰基-β-氨基醇：其中Y选自芳基或杂芳基：式（II）; 并且R1，R2，R3，R4，R5，Q，X和W具有如说明书中定义的含义。根据本发明的化合物是有效的FSH拮抗剂，可以用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

8. 发明申请

WO2008104597A3 SULFONYLTRYPTOPHANOLS 审中-公开
公开(公告)号：WO2008104597A3
公开(公告)日：2008-12-24
申请号：PCT/EP2008052449
申请日：2008-02-28
申请人： BAYER SCHERING PHARMA AG , WORTMANN LARS , MENZENBACH BERND , KOPPITZ MARCUS , KOSEMUND DIRK , MUHN HANS-PETER , SCHREY ANNA , KUEHNE RONALD , FRENZEL THOMAS , LIESENER FLORIAN PETER
发明人： WORTMANN LARS , MENZENBACH BERND , KOPPITZ MARCUS , KOSEMUND DIRK , MUHN HANS-PETER , SCHREY ANNA , KUEHNE RONALD , FRENZEL THOMAS , LIESENER FLORIAN PETER
IPC分类号： C07D209/16 , A61K31/4045 , A61P15/00 , C07D405/12 , C07D405/14 , C07D409/14
CPC分类号： C07D209/16 , C07D405/12 , C07D405/14 , C07D409/14
摘要： The present invention relates to sulfonyltryptophanols of the general formula (I), in which Q, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH receptor antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及通式（I）的磺酰基色氨酸，其中Q，X，W，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8具有如说明书中所定义的含义。根据本发明的化合物是有效的FSH受体拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

9. 发明申请

WO2008131972A1 ARYLMETHYLEN SUBSTITUTED N-ACYL-GAMMA-AMINOALCOHOLS 审中-公开
标题翻译：亚乙基取代的N-亚氨基 - 氨基醇
公开(公告)号：WO2008131972A1
公开(公告)日：2008-11-06
申请号：PCT/EP2008/003647
申请日：2008-04-25
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , MENZENBACH, Bernd , KOSEMUND, Dirk , FRENZEL, Thomas , SCHREY, Anna, Katharina , KÜHNE, Ronald , MUHN, Peter , LIESENER, Florian, Peter , KOPPITZ, Marcus
发明人： WORTMANN, Lars , MENZENBACH, Bernd , KOSEMUND, Dirk , FRENZEL, Thomas , SCHREY, Anna, Katharina , KÜHNE, Ronald , MUHN, Peter , LIESENER, Florian, Peter , KOPPITZ, Marcus
IPC分类号： C07D209/16 , C07D215/52 , C07D401/12 , C07D405/12 , C07D409/12 , C07C235/60 , A61K31/404 , A61P5/08
CPC分类号： C07D401/12 , C07C235/60 , C07D209/16 , C07D215/52 , C07D405/12 , C07D409/12
摘要： The present invention relates to arylmethylen substituted N-acyl-γ-aminoalcohols of the general formula (I) in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description. The Compounds according to the invention are effective FSH modulators and can be used for example for fertility regulation in men or in women.
摘要翻译：本发明涉及通式（I）的芳基亚甲基取代的N-酰基-β-氨基醇，其中Q，X，W，R 1，R 2，R 3，R 4和R 5具有如说明书中所定义的含义。根据本发明的化合物是有效的FSH调节剂，并且可以用于例如男性或女性的生殖调节。

10. 发明申请

WO2008104597A2 SULFONYLTRYPTOPHANOLS 审中-公开
公开(公告)号：WO2008104597A2
公开(公告)日：2008-09-04
申请号：PCT/EP2008/052449
申请日：2008-02-28
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , WORTMANN, Lars , MENZENBACH, Bernd , KOPPITZ, Marcus , KOSEMUND, Dirk , MUHN, Hans-Peter , SCHREY, Anna , KUEHNE, Ronald , FRENZEL, Thomas , LIESENER, Florian Peter
发明人： WORTMANN, Lars , MENZENBACH, Bernd , KOPPITZ, Marcus , KOSEMUND, Dirk , MUHN, Hans-Peter , SCHREY, Anna , KUEHNE, Ronald , FRENZEL, Thomas , LIESENER, Florian Peter
IPC分类号： C07D209/16 , C07D405/12 , C07D405/14 , C07D409/14 , A61K31/4045 , A61P15/00
CPC分类号： C07D209/16 , C07D405/12 , C07D405/14 , C07D409/14
摘要： The present invention relates to sulfonyltryptophanols of the general formula (I), in which Q, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH receptor antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
摘要翻译：本发明涉及通式（I）的磺酰基色氨醇，其中Q，X，W，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8具有如所定义的含义在描述中。本发明化合物是有效的FSH受体拮抗剂，可用于例如男性或女性的生育控制，或用于预防和/或治疗骨质疏松症。

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