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    • 9. 发明申请
    • PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS, AND METHOD FOR SCREENING FOR ACTIVE SUBSTANCES FOR PROMOTING ANGIOGENESIS
    • 用于促进血管发生的药物组合物以及用于促进血管生成的活性物质的筛选方法
    • WO2012023810A3
    • 2012-05-24
    • PCT/KR2011006065
    • 2011-08-18
    • KOREA INST RADIOLOGICAL & MEDICAL SCIENCESLEE YOON JINLEE YUN-SILLEE HAE-JUNECHOI SEO-HYUNKIM KYENG-JUNG
    • LEE YOON JINLEE YUN-SILLEE HAE-JUNECHOI SEO-HYUNKIM KYENG-JUNG
    • A61K39/395A61P9/00A61P9/04A61P9/10
    • A61K39/3955A61K39/395A61K2039/505C07K16/18C07K2317/76
    • The present invention relates to a pharmaceutical composition for promoting angiogenesis, containing an antibody that specifically binds to heat shock protein (HSP) 27. In addition, the present invention relates to a pharmaceutical composition containing an antibody that specifically binds to heat shock protein (HSP) 27, for treating an angiogenesis-dependent ailment selected from a group consisting of a wound, chronic ulcer, ischemic stroke, myocardial infarction, angina pectoris, and cerebrovascular dementia. In addition, the present invention relates to a method for promoting the in vitro growth of endothelial cells using an antibody that specifically binds to HSP27. In addition, the present invention relates to a method for screening for active substances for promoting angiogenesis or for active substances for treating an angiogenesis-dependent ailment, said method comprising the following steps: treating vascular endothelial cell lines with each specimen; measuring the content of HSP27 in the respective vascular endothelial cell lines; and selecting a specimen in which the HSP27 content in the vascular endothelial cell lines are decreased as compared to a control group.
    • 本发明涉及用于促进血管生成的药物组合物,其含有与热休克蛋白(HSP)27特异性结合的抗体。此外,本发明涉及含有特异性结合热休克蛋白(HSP)的抗体的药物组合物 )27,用于治疗选自由伤口,慢性溃疡,缺血性中风,心肌梗塞,心绞痛和脑血管性痴呆组成的组的血管生成依赖性疾病。 此外,本发明涉及使用特异性结合HSP27的抗体促进内皮细胞的体外生长的方法。 此外,本发明涉及用于筛选促进血管生成的活性物质或用于治疗血管发生依赖性疾病的活性物质的方法,所述方法包括以下步骤:用每个样品处理血管内皮细胞系; 测量各个血管内皮细胞系中HSP27的含量; 并选择其中血管内皮细胞系中的HSP27含量与对照组相比降低的样本。