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1. 发明申请

WO2012026743A3 LABELING AGENT AND AMINO ACID SEQUENCE USING SAME, AND METHOD FOR PERFORMING SIMULTANEOUS QUANTITATIVE ANALYSIS OF MULTIPLE PROTEINS 审中-公开
标题翻译：标记剂和使用该标记的氨基酸序列以及用于进行多蛋白质的同时定量分析的方法
公开(公告)号：WO2012026743A3
公开(公告)日：2012-08-23
申请号：PCT/KR2011006225
申请日：2011-08-23
申请人： POSTECH ACAD IND FOUND , SHIN SEUNG KOO , YOON HYE JOO , JUNG YONG SIK , LEE HEE YOON , SUH MIN SOO , SEO JONG CHEOL
发明人： SHIN SEUNG KOO , YOON HYE JOO , JUNG YONG SIK , LEE HEE YOON , SUH MIN SOO , SEO JONG CHEOL
IPC分类号： C07C233/47 , G01N33/58 , G01N33/68
CPC分类号： C07C237/12 , C07B2200/05 , C07C233/47 , C07C233/51 , C07C237/20 , G01N33/6848 , G01N2458/15 , G01N2560/00
摘要： Disclosed is a compound that uses a hydrogen isotope that is capable of reducing costs for labeling agent synthesis and also simultaneously quantifying multiple samples. The present invention also relates to a novel method of quantitatively analyzing protein and peptide analyzers of mutually different quantities using a labeling agent, wherein after the labeling agent is coupled to the analyzer, only a portion of the labeling agent is removed through tandem quantitative analysis, and quantitative analysis is performed using a y-type fragment ion of a large quantity including the analyzer.
摘要翻译：公开了一种使用氢同位素的化合物，其能够降低用于标记剂合成的成本并且还同时定量多个样品。本发明还涉及使用标记试剂定量分析相互不同量的蛋白质和肽分析仪的新方法，其中在标记试剂与分析仪偶联之后，通过串联定量分析仅除去一部分标记试剂，使用包含分析仪的大量的y型碎片离子进行定量分析。

2. 发明申请

WO2008108517A2 PIPERAZINYL-PROPYL-PYRAZOLE DERIVATIVES AS DOPAMINE D4 RECEPTOR ANTAGONISTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：作为DOPAMINE D4受体拮抗剂的哌嗪衍生物 - 吡咯并吡啶衍生物，以及含有它们的药物组合物
公开(公告)号：WO2008108517A2
公开(公告)日：2008-09-12
申请号：PCT/KR2007/003415
申请日：2007-07-13
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KONG, Jae Yang , PARK, Woo-Kyu , CHO, Heeyeong , JEONG, Daeyoung , CHOI, Gildon , KOH, Hun Yeong , KIM, Sang Hee , PAE, Ae Nim , CHO, Yong Seo , CHA, Joo Hwan , CHOO, Hyunah , CHAE, Sang Eun , LEE, Hee-Yoon
发明人： KONG, Jae Yang , PARK, Woo-Kyu , CHO, Heeyeong , JEONG, Daeyoung , CHOI, Gildon , KOH, Hun Yeong , KIM, Sang Hee , PAE, Ae Nim , CHO, Yong Seo , CHA, Joo Hwan , CHOO, Hyunah , CHAE, Sang Eun , LEE, Hee-Yoon
IPC分类号： C07D401/06
CPC分类号： C07D403/06
摘要： The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.
摘要翻译：本发明涉及一种新的哌嗪基 - 丙基 - 吡唑衍生物，其制备方法和包含其的药学上可接受的组合物。本发明的新型哌嗪基 - 丙基 - 吡唑衍生物对多巴胺D4受体具有优异的选择性亲和力，可有效抑制阿扑吗啡诱导的精神病性行为（笼养），并在小鼠旋转试验中具有较低的不良反应。因此，它可以被开发为用于治疗和预防中枢神经系统（CNS）障碍，特别是精神分裂症，注意缺陷多动障碍，抑郁症，压力疾病，恐慌症，恐惧症，强迫症，创伤后疼痛的治疗剂压力障碍，认知障碍，阿尔茨海默病，帕金森病，焦虑症，过敏性反应，躁狂症，癫痫发作，人格障碍，偏头痛，药物成瘾，酒精成瘾，肥胖，进食障碍和睡眠障碍。

3. 发明申请

WO1995028397A1 ALPHA1C ADRENERGIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO1995028397A1
公开(公告)日：1995-10-26
申请号：PCT/US1995004590
申请日：1995-04-13
申请人： MERCK & CO., INC. , HUFF, Joel, R. , LEE, Hee-Yoon , NERENBERG, Jennie, B. , THOMPSON, Wayne, J.
发明人： MERCK & CO., INC.
IPC分类号： C07D401/04
CPC分类号： C07D417/06 , C07D417/14 , C07D471/04 , C07D491/10 , C07D513/04 , C07D513/10
摘要： This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha1C adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hypertrophy. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha1C receptor subtype without at the same time inducing orthostatic hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.
摘要翻译：本发明涉及某些新化合物及其衍生物，其合成及其作为选择性α1肾上腺素能受体拮抗剂的用途。这些化合物的一种应用是治疗良性前列腺肥大。这些化合物具有选择性地放松富集α1C受体亚型的平滑肌组织的能力，而不会同时引起体位性低血压。发现一个这样的组织围绕尿道衬里。因此，本发明化合物的一个用途是通过允许较少的受阻尿流量来对患有良性前列腺增生的男性提供急性缓解。通过与人5-α还原酶抑制化合物的组合提供本发明化合物的另一种用途，使得可以实现急性和慢性缓解来自良性前列腺增生的作用。

4. 发明申请

WO2008108517A3 PIPERAZINYL-PROPYL-PYRAZOLE DERIVATIVES AS DOPAMINE D4 RECEPTOR ANTAGONISTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME 审中-公开
标题翻译：作为多巴胺D4受体拮抗剂的哌嗪基 - 丙基 - 吡唑衍生物，以及含有该化合物的药物组合物
公开(公告)号：WO2008108517A3
公开(公告)日：2008-11-06
申请号：PCT/KR2007003415
申请日：2007-07-13
申请人： KOREA RES INST CHEM TECH , KONG JAE YANG , PARK WOO-KYU , CHO HEEYEONG , JEONG DAEYOUNG , CHOI GILDON , KOH HUN YEONG , KIM SANG HEE , PAE AE NIM , CHO YONG SEO , CHA JOO HWAN , CHOO HYUNAH , CHAE SANG EUN , LEE HEE-YOON
发明人： KONG JAE YANG , PARK WOO-KYU , CHO HEEYEONG , JEONG DAEYOUNG , CHOI GILDON , KOH HUN YEONG , KIM SANG HEE , PAE AE NIM , CHO YONG SEO , CHA JOO HWAN , CHOO HYUNAH , CHAE SANG EUN , LEE HEE-YOON
IPC分类号： C07D401/06
CPC分类号： C07D403/06
摘要： The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine D4 receptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.
摘要翻译：本发明涉及新的哌嗪基 - 丙基 - 吡唑衍生物，其制备方法和包含其的药学上可接受的组合物。本发明的新型哌嗪基丙基吡唑衍生物对多巴胺D4受体具有优良的选择性亲和力，能有效地抑制阿扑吗啡诱导的精神行为（爬笼），对小鼠旋转杆菌试验有不利影响。因此，它可以作为治疗和预防中枢神经系统（CNS）疾病，特别是精神分裂症，注意力缺陷多动障碍，抑郁症，压力疾病，恐慌症，恐惧症，强迫症，创伤后治疗压力障碍，认知障碍，阿尔茨海默病，帕金森氏病，焦虑症，肾盂肾炎，躁狂症，癫痫发作障碍，人格障碍，偏头痛，药物成瘾，酒瘾，肥胖症，进食障碍和睡眠障碍。

5. 发明申请

WO2010027113A3 PROCESS FOR PREPARING (S)-(-)-FELODIPINE 审中-公开
标题翻译：制备（S） - （ - ） - 费洛膦的方法
公开(公告)号：WO2010027113A3
公开(公告)日：2010-07-15
申请号：PCT/KR2008005239
申请日：2008-09-04
申请人： AHN GOOK PHARMACEUTICAL CO LTD , KOREA ADVANCED INST SCI & TECH , AUH JIN , WON DUK KWON , MOON BYUNG HYUN , KWON O ZOON , JONG CHANG WOO , JIN KYUNG YONG , BAE KYOUNG HO , LEE HEE YOON , SHIN JUNG AH
发明人： AUH JIN , WON DUK KWON , MOON BYUNG HYUN , KWON O ZOON , JONG CHANG WOO , JIN KYUNG YONG , BAE KYOUNG HO , LEE HEE YOON , SHIN JUNG AH
IPC分类号： C07D211/90 , C07D213/80
CPC分类号： C07D211/90
摘要： The embodiment proposes a method for preparing (S)-(-)- ethyl methyl 4-(2,3-dichlorophenyl)- 1,4-dihydro-2,6-dimethyl-3,5-pyridine- dicarboxylate (hereinafter, referring to as "(S)-(-)-felodipine", and more particularly, a method for effectively preparing the (S)-(-)-felodipine through a selective transesterification of -hydroxy ester after synthesizing a felodipine derivate including a chiral separation compound and isolating (S)-isomers. The chiral separation compound is synthesized from (R)-glycidol or (S)-glycidol through reaction with various nucleophiles and epoxide.
摘要翻译：该实施方案提出了制备（S） - （ - ） - 4-（2,3-二氯苯基）-1,4-二氢-2,6-二甲基-3,5-吡啶二甲酸乙酯的方法（以下称为作为“（S） - （ - ） - 非洛地平”，更具体地说，涉及一种在合成包含手性分离的非洛地平衍生物之后，通过选择性酯交换 - 羟基酯有效制备（S） - （ - ） - 非洛地平的方法化合物和分离（S） - 异构体，通过与各种亲核试剂和环氧化物反应，由（R） - 缩水甘油或（S） - 缩水甘油合成手性分离化合物。

6. 发明申请

WO1995011230A1 PROCESS FOR THE PREPARATION OF AN OXIRANE, AZIRIDINE OR CYCLOPROPANE 审中-公开
标题翻译：制备氧化亚胺，亚胺基或环丙基的方法
公开(公告)号：WO1995011230A1
公开(公告)日：1995-04-27
申请号：PCT/GB1994002280
申请日：1994-10-19
申请人： ZENECA LIMITED , AGGARWAL, Varinder, Kumar , ABDEL-RAHMAN, Hesham, Nimer, Hasan , LEE, Hee, Yoon
发明人： ZENECA LIMITED
IPC分类号： C07D203/24
CPC分类号： C07D203/22 , C07C2/868 , C07C2601/02 , C07D203/02 , C07D203/24 , C07D301/02 , C07D303/04 , C07D303/08 , C07D303/16 , C07D303/40 , C07D303/46 , C07D407/04 , C07F9/564 , C07C13/04
摘要： A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein, X is oxygen, NR or CHR ; R is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R is hydrogen, alkyl, aryl, heteroaromatic, CO2R , CHR NHR , heterocyclic or cycloalkyl; or R and R join together to form a cycloalkyl ring; R is hydrogen, alkyl, aryl, heteroaromatic, CO2R , R 3Sn, CONR R or trimethylsilyl; R and R are, independently, alkyl, cycloalkyl, aryl, heteroaromatic, SO2R , SO3R , COR , CO2R , CONR R or CN, or R can also be P(O)(aryl)2; R and R are independently alkyl, aryl or arylalkyl; R and R are independently hydrogen, alkyl or aryl; the process comprising reacting a mixture of a compound of formula (II), wherein R , R and X are as defined above, and a sulphide of formula SR R , wherein R and R are independently alkyl, aryl or heteroaomatic, or R and R join together to form a cycloalkyl ring which optionally includes an additional heteroatom, with either (i) a metallocarbon obtainable by reacting an alkylmetal with a methane derivative of formula CHR X'X'', wherein R is as defined above, and X' and X'' are independently, a leaving group, or (ii) a metallocarbon obtainable by reacting a compound of formula (III), (wherein R may not be hydrogen) with a suitable organometallic or inorganic reagent.
摘要翻译：制备式（I）的环氧乙烷，氮丙啶或环丙烷的方法，其中X是氧，NR 4或CHR 5; R 1是氢，烷基，芳基，杂芳族，杂环或环烷基; R 2是氢，烷基，芳基，杂芳族，CO 2 R 8，CHR 14 NHR 13，杂环或环烷基; 或R 1和R 2连接在一起形成环烷基环; R 3是氢，烷基，芳基，杂芳族，CO 2 R 8，R 8 3 n，CONR 8 R 9或三甲基甲硅烷基; R 4和R 5独立地是烷基，环烷基，芳基，杂芳族，SO 2 R 8，SO 3 R 8，COR 8，CO 2 R 8，CONR 8 R 9或 CN或R 4也可以是P（O）（芳基）2; R 8和R 9独立地是烷基，芳基或芳基烷基; R 13和R 14独立地是氢，烷基或芳基; 该方法包括使式（II）化合物（其中R 1，R 2和X如上定义）和式SR 6 R 7的硫化物的混合物反应，其中R 6 >和R 7独立地是烷基，芳基或杂芳基，或R 6和R 7连接在一起形成环烷基环，其任选地包括另外的杂原子，与（i）可通过使烷基金属与式CHR 3 X'X“的甲烷衍生物，其中R 3如上所定义，X'和X”独立地为离去基团，或（ii）金属碳，其可通过使式（III）化合物（其中R 3不可以是氢）与合适的有机金属或无机试剂反应。

7. 发明申请

WO2005004861A1 A USE OF NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：新型2-氧杂环化合物的使用和包含其的药物组合物
公开(公告)号：WO2005004861A1
公开(公告)日：2005-01-20
申请号：PCT/KR2004/001764
申请日：2004-07-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DAEWOONG PHARMACEUTICAL CO., LTD. , HAN, Gyoon Hee , KIM, Hwan Mook , PARK, Song Kyu , LEE, Chang Woo , HAN, Sang Bae , LEE, Ki Hoon , KHO, Yung Hee , YANG, Jin Hyuk , PARK, Bum Woo , LEE, Hyang Woo , HAN, Jeung Whan , RYU, Dong Kyu , LEE, Jin Ha , CHUN, Tae Gyu , KIM, Yong Kee , LEE, Hee Yoon , LEE, Bong Yong , KIM, Jeom Yong , KIM, Ji Duck , YU, Kyunga , KIM, Sun Young
发明人： HAN, Gyoon Hee , KIM, Hwan Mook , PARK, Song Kyu , LEE, Chang Woo , HAN, Sang Bae , LEE, Ki Hoon , KHO, Yung Hee , YANG, Jin Hyuk , PARK, Bum Woo , LEE, Hyang Woo , HAN, Jeung Whan , RYU, Dong Kyu , LEE, Jin Ha , CHUN, Tae Gyu , KIM, Yong Kee , LEE, Hee Yoon , LEE, Bong Yong , KIM, Jeom Yong , KIM, Ji Duck , YU, Kyunga , KIM, Sun Young
IPC分类号： A61K31/4015
CPC分类号： A61K31/454 , A61K31/4015 , A61K31/4545 , C07D207/38 , C07D211/86 , C07D223/10 , C07D417/06
摘要： The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the cancer disease comprising lung cancer, bone cancer, pancreatic cancer, skin cancer, cancer of the head and neck, cutaneous or intraocular melanoma, uterine cancer, ovarian cancer, rectal cancer or cancer of the anal region, stomach cancer, colon cancer, breast cancer, gynecologic tumors, Hodgkin's disease, cancer of the esophagus, cancer of the small intestine, cancer of the endocrine system, sarcomas of soft tissues, cancer of the urethra, cancer of the penis, prostate cancer, chronic or acute leukemia, solid tumors of childhood, lymphocytic lymphonas, cancer of the bladder, cancer of the kidney or ureter, or neoplasms of the central nervous system, therefore, it can be used as the therapeutics for treating and preventing cancer diseases.
摘要翻译：本发明涉及具有抗癌活性的2-氧代杂环化合物及其制备方法的新用途以及包含其的药物组合物。本发明提供了用于预防和治疗包括肺癌，骨癌，胰腺癌，皮肤癌，头颈癌，皮肤或眼内黑素瘤，子宫癌，卵巢癌，直肠癌或癌症的癌症疾病的药物组合物肛门区域，胃癌，结肠癌，乳腺癌，妇科肿瘤，霍奇金病，食管癌，小肠癌，内分泌系统癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，儿童实体瘤，淋巴细胞淋巴管，膀胱癌，肾或输尿管癌，或中枢神经系统肿瘤，因此可用作治疗和预防的治疗剂癌症疾病

8. 发明申请

WO2004101523A1 NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND THE PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：新型2-氧杂环化合物和包含其的药物组合物
公开(公告)号：WO2004101523A1
公开(公告)日：2004-11-25
申请号：PCT/KR2004/001169
申请日：2004-05-17
申请人： Korea Research Institute of Bioscience and Biotechnology , KHO, Yung Hee , HAN, Gyoon Hee , LEE, Ho Jae , PARK, Bum Woo , CHUN, Hyo Kon , KIM, Hwan Mook , PARK, Song Kyu , HAN, Sang Bae , RYU, Dong Kyu , CHUN, Tae Gyu , LEE, Jin Ha , LEE, Chang Woo , LEE, Ki Hoon , LEE, Hee Yoon
发明人： KHO, Yung Hee , HAN, Gyoon Hee , LEE, Ho Jae , PARK, Bum Woo , CHUN, Hyo Kon , KIM, Hwan Mook , PARK, Song Kyu , HAN, Sang Bae , RYU, Dong Kyu , CHUN, Tae Gyu , LEE, Jin Ha , LEE, Chang Woo , LEE, Ki Hoon , LEE, Hee Yoon
IPC分类号： C07D211/88
CPC分类号： C07D207/26 , C07D207/38 , C07D211/86 , C07D409/06
摘要： The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.
摘要翻译：本发明涉及新的2-氧代环状化合物及其制备方法和包含其的药物组合物。本发明提供了用于预防和治疗炎性疾病的药物组合物，其包括由风湿性疾病引起的疼痛或炎症，例如类风湿性关节炎，脊椎动物病变，痛风，骨关节炎，系统性红斑狼疮和幼年关节炎以及炎性综合征，例如，肌炎，牙龈炎，滑膜炎，强直性脊柱炎，爆发性炎症，烧伤和瘢痕，炎性克罗恩病，I型糖尿病。因此，它可以用作治疗和预防炎性疾病的治疗剂。

9. 发明申请

WO2010027113A2 PROCESS FOR PREPARING (S)-(-)-FELODIPINE 审中-公开
标题翻译：制备（S） - （ - ） - 菲洛地平的方法
公开(公告)号：WO2010027113A2
公开(公告)日：2010-03-11
申请号：PCT/KR2008/005239
申请日：2008-09-04
申请人： AHN-GOOK PHARMACEUTICAL CO., LTD , KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY , AUH, Jin , WON, Duk Kwon , MOON, Byung Hyun , KWON, O Zoon , JONG, Chang Woo , JIN, Kyung Yong , BAE, Kyoung Ho , LEE, Hee Yoon , SHIN, Jung Ah
发明人： AUH, Jin , WON, Duk Kwon , MOON, Byung Hyun , KWON, O Zoon , JONG, Chang Woo , JIN, Kyung Yong , BAE, Kyoung Ho , LEE, Hee Yoon , SHIN, Jung Ah
IPC分类号： C07D211/90 , C07D213/80
CPC分类号： C07D211/90
摘要： The embodiment proposes a method for preparing (S)-(-)- ethyl methyl 4-(2,3-dichlorophenyl)- 1,4-dihydro-2,6-dimethyl-3,5-pyridine- dicarboxylate (hereinafter, referring to as "(S)-(-)-felodipine", and more particularly, a method for effectively preparing the (S)-(-)-felodipine through a selective transesterification of -hydroxy ester after synthesizing a felodipine derivate including a chiral separation compound and isolating (S)-isomers. The chiral separation compound is synthesized from (R)-glycidol or (S)-glycidol through reaction with various nucleophiles and epoxide.
摘要翻译：本实施方案提出了制备（S） - （ - ） - 乙基甲基4-（2,3-二氯苯基）-1,4-二氢-2,6-二甲基-3,5 （ - ） - 非洛地平“的方法，更具体地说，涉及通过选择性地酯化（S） - （ - ） - 非洛地平来制备（S） - （ - ） - 非洛地平的方法（R） - 缩水甘油或（S） - 缩水甘油通过与各种亲核试剂和环氧化物反应而合成手性分离化合物。合成包含手性分离化合物和分离（S） - 异构体的非洛地平衍生物。

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