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1. 发明申请

WO2016140449A1 STERILIZATION METHOD AND APPARATUS USING THE SAME 审中-公开
标题翻译：灭菌方法及其使用方法
公开(公告)号：WO2016140449A1
公开(公告)日：2016-09-09
申请号：PCT/KR2016/001596
申请日：2016-02-17
申请人： LEADGENEX INC.
发明人： KIM, Sang-Woong , LEE, Chang-Ick , LEE, Eun-Ju , KIM, Solomon L.
IPC分类号： A61L2/20
CPC分类号： A61L2/202 , A61L2/206 , A61L2/208 , A61L2202/14 , A61L2202/15 , A61L2202/24
摘要： A sterilization method and a sterilization apparatus using the sterilization method are provided. The sterilization method includes: forming a low-pressure atmosphere having a pressure lower than atmospheric pressure in a chamber by discharging gas from the chamber using a high-speed blower; primarily supplying an oxidative gas to the chamber maintained at a pressure lower than atmospheric pressure; forming a high-pressure atmosphere having a pressure higher than atmospheric pressure in the chamber by introducing external gas into the chamber using the blower; and secondarily supplying the oxidative gas to the chamber maintained at a pressure higher than atmospheric pressure. Therefore, sterilization may be effectively performed by adjusting the interior pressure of the chamber using the blower without using a vacuum pump. Furthermore, continuous circulation of gas in the chamber that is difficult in case of using a vacuum pump may guarantee effective sterilization, and humidity may easily be adjusted during sterilization.
摘要翻译：提供灭菌方法和使用灭菌方法的杀菌装置。灭菌方法包括：使用高速鼓风机从室中排出气体，在室内形成压力低于大气压的低压气氛; 主要向保持在低于大气压的压力的室供给氧化性气体; 通过使用鼓风机将外部气体引入室内，在室内形成压力高于大气压的高压气氛; 二次将氧化气体供给到保持在高于大气压的压力下的室内。因此，可以通过使用鼓风机调节室的内部压力而不使用真空泵来有效地进行灭菌。此外，在使用真空泵的情况下在室内的气体的连续循环可以保证有效的灭菌，并且在灭菌期间可以容易地调节湿度。

2. 发明申请

WO2004046081A1 BETA-NITROSTYRENE COMPOUND AND TELOMERASE INHIBITOR HAVING AN ANTICANCER ACTIVITY 审中-公开
标题翻译：具有抗病毒活性的β-硝基苯并噻唑类化合物和TELOMERASE抑制剂
公开(公告)号：WO2004046081A1
公开(公告)日：2004-06-03
申请号：PCT/KR2003/002402
申请日：2003-11-10
申请人： DNA LINK, INC. , LEADGENEX, INC. , CHUNG, In Kwon , LEE, Jong-Eun , KIM, Joo Hee , KIM, Jun Hyun , LEE, Gun Eui , KIM, Sang Woong , LEE, Eun Ju , LEE, Jung Gyu
发明人： CHUNG, In Kwon , LEE, Jong-Eun , KIM, Joo Hee , KIM, Jun Hyun , LEE, Gun Eui , KIM, Sang Woong , LEE, Eun Ju , LEE, Jung Gyu
IPC分类号： C07C205/04
CPC分类号： C07C205/04 , C07C205/09 , C07C205/32 , C07C205/42 , C07C309/73 , C07C309/76 , C07C311/21
摘要： The present invention relates to beta-nitrostyrene compounds, and pharmaceutically acceptable salts and hydrates thereof having the following formula (I) and showing anticancer activity. Formula (I) wherein R 1 to R 5 are each independently any one selected from the group consisting of hydrogen, halogen, halogenated phenoxy and a radical of R 6 -Y-X- (-X- is -O- or -NH-, -Y- is -SO 2 -or -CO-, R 6 is benzene substituted with at least any one selected from the group consisting of hydrogen, alkyl, halogen and NO 2 ), or R 3 forms a benzene ring along with R 4 ; provided that R 1 , R 2 , R 3 , R 4 and R 5 are not hydrogen at the same time. These compounds can selectively inhibit the activity of telomerase specifically expressed in cancer cells and thus be used as an anticancer with minimized side effects of the conventional anticancer agents.
摘要翻译：本发明涉及具有下式（I）的β-硝基苯乙烯化合物及其药学上可接受的盐和水合物并显示抗癌活性。式（I）其中R 1至R 5各自独立地为选自氢，卤素，卤代苯氧基和R 6 -YX-（-X-为-O- 或-NH-，-Y-是-SO 2 - 或-CO-，R 6是被选自氢，烷基，卤素和NO 2中的至少任意一个取代的苯或R 3形式苯环与R 4连接; 条件是R 1，R 2，R 3，R 4和R 5不同时为氢。这些化合物可以选择性地抑制癌细胞中特异性表达的端粒酶的活性，因此可以用作抗癌剂，其常规抗癌剂的副作用最小。

3. 发明申请

WO2008020711A1 QUINAZOLINE DERIVATIVE AS PHOSPHODIESTERASE INHIBITOR AND A PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：喹诺酮衍生物作为磷酸酯酶抑制剂及其制备方法
公开(公告)号：WO2008020711A1
公开(公告)日：2008-02-21
申请号：PCT/KR2007/003908
申请日：2007-08-16
申请人： CHONG KUN DANG PHARMACEUTICAL CORP. , LEADGENEX INC. , AHN, Soon Kil , LEE, Sungsook , CHOI, Nam Song , LEE, Jae Kwang , MOON, Seung Kee , CHOI, Hojin , KIM, Su Jin , KIM, Young Hoon , KANG, Sung Kwon , LEE, Hong Woo , SHIN, Jaesoo , KIM, Sang Woong , LEE, Eun Ju , KIM, Eon Kyeom , LEE, Jung Gyu , YOO, Chung Youl , LEE, Dae Yon , IM, Dai Sig
发明人： AHN, Soon Kil , LEE, Sungsook , CHOI, Nam Song , LEE, Jae Kwang , MOON, Seung Kee , CHOI, Hojin , KIM, Su Jin , KIM, Young Hoon , KANG, Sung Kwon , LEE, Hong Woo , SHIN, Jaesoo , KIM, Sang Woong , LEE, Eun Ju , KIM, Eon Kyeom , LEE, Jung Gyu , YOO, Chung Youl , LEE, Dae Yon , IM, Dai Sig
IPC分类号： C07D239/94 , A61K31/517 , A61P15/10 , A61P9/00
CPC分类号： C07D239/94 , C07D239/95 , C07D401/04 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D498/04
摘要： The present invention relates to a quinazoline derivative, a preparation method thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, a hydrate thereof, a pharmaceutical composition comprising the same and use thereof as a therapeutic agent. The present inveniont relates to a quinazoline derivative exhibiting inhibitory activity against C
摘要翻译：本发明涉及喹唑啉衍生物，其制备方法，其药学上可接受的盐，其溶剂化物，其水合物，包含该喹啉衍生物的药物组合物及其作为治疗剂的用途。本发明涉及对C显示抑制活性的喹唑啉衍生物

4. 发明申请

WO2006071095A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY 审中-公开
标题翻译：治疗和预防糖尿病和肥胖的喹唑啉衍生物
公开(公告)号：WO2006071095A1
公开(公告)日：2006-07-06
申请号：PCT/KR2005/004664
申请日：2005-12-30
申请人： SK CHEMICALS, CO., LTD. , LEADGENEX INC. , INDUSTRY ACADEMIC COOPERATION FOUNDATION OF KYUNGHEE UNIVERSITY , LEE, Nam Kyu , LEE, Jun Won , LEE, Sukho , IM, Guang-Jin , HAN, Hye Young , KIM, Tae Kon , KIM, Yong Hyuk , KWAK, Wie-Jong , KIM, Sang Woong , HA, Joohun , KIM, Eon Kyum , LEE, Jung Kyu , YOO, Choong Yeul , LEE, Dae Yeon
发明人： LEE, Nam Kyu , LEE, Jun Won , LEE, Sukho , IM, Guang-Jin , HAN, Hye Young , KIM, Tae Kon , KIM, Yong Hyuk , KWAK, Wie-Jong , KIM, Sang Woong , HA, Joohun , KIM, Eon Kyum , LEE, Jung Kyu , YOO, Choong Yeul , LEE, Dae Yeon
IPC分类号： C07D239/94 , A61K31/517 , A61P3/04 , A61P3/10
CPC分类号： C07D413/12 , C07D239/88 , C07D239/93 , C07D239/94 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12
摘要： The present invention relates to novel quinazoline derivatives effective in lowering blood glucose level and body weight, and a medicine for treatment and/ or prevention of diabetes and/ or obesity, which comprises the compound as an active ingredient.
摘要翻译：本发明涉及有效降低血糖水平和体重的新型喹唑啉衍生物，以及用于治疗和/或预防糖尿病和/或肥胖症的药物，其包含该化合物作为活性成分。

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