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1. 发明申请

WO2012050623A2 NOVEL PHENOXYISOBUTYRIC ACID COMPOUNDS AND METHODS FOR SYNTHESIS 审中-公开
标题翻译：新的苯氧基异丁基酸化合物及合成方法
公开(公告)号：WO2012050623A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/001890
申请日：2011-11-09
申请人： CELL VIABLE CORPORATION , LALEZARI, Iraj , FABRICANT, Jill
发明人： LALEZARI, Iraj , FABRICANT, Jill
IPC分类号： C07C233/00 , C07C217/18 , A61K31/165 , A61P25/28
CPC分类号： C07D307/87 , A61K8/411 , A61K8/42 , A61K8/4926 , A61Q19/08 , C07C215/76 , C07C229/40 , C07C233/75 , C07C235/72 , C07C235/74 , C07C275/34 , C07C275/42 , C07D215/12 , C07D215/14 , C07D215/50 , C07D215/52 , C07D219/04
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了合成取代的苯氧基甲基丙酸和相关化合物的方法。这些化合物可用于抑制AGEs（晚期糖基化终产物）的形成。

2. 发明申请

WO2004071416A2 NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGES) 审中-公开
标题翻译：新型糖化终产品形成的新型抑制剂（AGES）
公开(公告)号：WO2004071416A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/003203
申请日：2004-02-05
申请人： CITY OF HOPE , LALEZARI, Iraj , RAHBAR, Samuel
发明人： LALEZARI, Iraj , RAHBAR, Samuel
IPC分类号： A61K
CPC分类号： A23L3/3526 , A61K31/155 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/40 , A61K31/435 , A61K31/606
摘要： The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become disturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.
摘要翻译：蛋白质的非酶促糖基化和交联是老化过程的一部分，糖化终产物和长寿命蛋白质的交联随着年龄的增加而增加。这种过程在血液中和细胞内环境中还原糖浓度升高时增加，例如糖尿病。受影响分子的结构和功能完整性受到这些修饰的干扰，并可能导致严重后果。本发明化合物可用于抑制非酶糖化过程，因此可抑制由糖尿病或衰老引起的一些不良作用。该化合物还可用于预防食物中过早老化，蛋白质变质，并可防止牙齿变色。

3. 发明申请

WO2004071416A3 NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGES) 审中-公开
标题翻译：新型糖化终产品形成的新型抑制剂（AGES）
公开(公告)号：WO2004071416A3
公开(公告)日：2004-10-14
申请号：PCT/US2004003203
申请日：2004-02-05
申请人： HOPE CITY , LALEZARI IRAJ , RAHBAR SAMUEL
发明人： LALEZARI IRAJ , RAHBAR SAMUEL
IPC分类号： A23L3/3526 , A61K20060101 , A61K31/155 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/40 , A61K31/435 , A61K35/14 , A61K38/16 , A61P3/10 , A61P9/10 , A61P19/02 , A61P25/00 , A61P25/28 , A61P31/10 , A61P39/00 , C07C69/76 , C07C229/00
CPC分类号： A23L3/3526 , A61K31/155 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/40 , A61K31/435 , A61K31/606
摘要： The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become disturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.
摘要翻译：蛋白质的非酶促糖基化和交联是老化过程的一部分，糖化终产物和长寿命蛋白质的交联随着年龄而增加。这种过程在血液中和细胞内环境中还原糖浓度升高时增加，例如糖尿病。受影响分子的结构和功能完整性受到这些修饰的干扰，并可能导致严重后果。本发明化合物可用于抑制非酶糖化过程，因此可抑制由糖尿病或衰老引起的一些不良作用。该化合物还可用于预防食物中过早老化，蛋白质变质，并可防止牙齿变色。

4. 发明申请

WO1989012622A1 METHOD OF SYNTHESIS AND NOVEL COMPOUNDS FOR PHARMACEUTICAL USES 审中-公开
标题翻译：合成方法和新药化学药物用途
公开(公告)号：WO1989012622A1
公开(公告)日：1989-12-28
申请号：PCT/US1989002621
申请日：1989-06-15
申请人： LALEZARI, Iraj , LALEZARI, Parviz
IPC分类号： C07C127/19
CPC分类号： C07C273/1827 , C07C233/75 , C07C275/34
摘要： The present invention is concerned with a process for the synthesis of susbtituted arylureidophenoxy-methylpropionic acids and an analogous benzamido series of compounds which have activity in the dissociation of oxygen from hemoglobin. In addition the process may be utilized to prepare compounds which are known.

5. 发明申请

WO2013078446A3 DERIVATIVES OF PHENOXYISOBUTYRIC ACID 审中-公开
标题翻译：苯氧基异丁酸的衍生物
公开(公告)号：WO2013078446A3
公开(公告)日：2013-07-25
申请号：PCT/US2012066443
申请日：2012-11-23
申请人： FABRICANT JILL S , LALEZARI IRAJ
发明人： FABRICANT JILL S , LALEZARI IRAJ
IPC分类号： C07C233/75 , A61K31/16 , A61P17/18
CPC分类号： C07D265/30 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61Q19/08 , C07C217/84 , C07C217/92 , C07C233/25 , C07C233/75 , C07C235/74 , C07C237/40 , C07C2601/14 , C07D209/48 , C07D211/08 , C07D213/36 , C07D213/55 , C07D235/14 , C07D235/18 , C07D295/096 , C07D295/125
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了合成取代的苯氧基甲基丙酸和相关化合物的方法。这些化合物可用于抑制AGEs（晚期糖基化终产物）的形成。

6. 发明申请

WO2013078446A2 DERIVATIVES OF PHENOXYISOBUTYRIC ACID 审中-公开
标题翻译：苯甲酸的衍生物
公开(公告)号：WO2013078446A2
公开(公告)日：2013-05-30
申请号：PCT/US2012/066443
申请日：2012-11-23
申请人： FABRICANT, Jill, S. , LALEZARI, Iraj
发明人： FABRICANT, Jill, S. , LALEZARI, Iraj
CPC分类号： C07D265/30 , A61K8/411 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4946 , A61Q19/08 , C07C217/84 , C07C217/92 , C07C233/25 , C07C233/75 , C07C235/74 , C07C237/40 , C07C2601/14 , C07D209/48 , C07D211/08 , C07D213/36 , C07D213/55 , C07D235/14 , C07D235/18 , C07D295/096 , C07D295/125
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了一种合成取代的苯氧基甲基丙酸及其相关化合物的方法。该化合物可用于抑制AGEs（高级糖化终产物）的形成。

7. 发明申请

WO2012050623A3 NOVEL PHENOXYISOBUTYRIC ACID COMPOUNDS AND METHODS FOR SYNTHESIS 审中-公开
标题翻译：新型酚氧化合物和合成方法
公开(公告)号：WO2012050623A3
公开(公告)日：2012-07-19
申请号：PCT/US2011001890
申请日：2011-11-09
申请人： CELL VIABLE CORP , LALEZARI IRAJ , FABRICANT JILL
发明人： LALEZARI IRAJ , FABRICANT JILL
IPC分类号： C07C233/00 , A61K31/165 , A61P25/28 , C07C217/18
CPC分类号： C07D307/87 , A61K8/411 , A61K8/42 , A61K8/4926 , A61Q19/08 , C07C215/76 , C07C229/40 , C07C233/75 , C07C235/72 , C07C235/74 , C07C275/34 , C07C275/42 , C07D215/12 , C07D215/14 , C07D215/50 , C07D215/52 , C07D219/04
摘要： The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).
摘要翻译：本发明提供了一种合成取代的苯氧基甲基丙酸和相关化合物的方法。该化合物可用于抑制AGEs（高级糖化终产物）的形成。

8. 发明申请

WO2004071416B1 NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGES) 审中-公开
标题翻译：形成高级糖化终产物（AGES）的新型抑制剂
公开(公告)号：WO2004071416B1
公开(公告)日：2004-11-25
申请号：PCT/US2004003203
申请日：2004-02-05
申请人： HOPE CITY , LALEZARI IRAJ , RAHBAR SAMUEL
发明人： LALEZARI IRAJ , RAHBAR SAMUEL
IPC分类号： A23L3/3526 , A61K20060101 , A61K31/155 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/40 , A61K31/435 , A61K35/14 , A61K38/16 , A61P3/10 , A61P9/10 , A61P19/02 , A61P25/00 , A61P25/28 , A61P31/10 , A61P39/00 , C07C69/76 , C07C229/00
CPC分类号： A23L3/3526 , A61K31/155 , A61K31/167 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/198 , A61K31/40 , A61K31/435 , A61K31/606
摘要： The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become disturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.
摘要翻译：蛋白质的非酶糖基化和交联是老化过程的一部分，其中长期存在的蛋白质的糖基化终产物和交联随着年龄增加。在血液中和细胞内环境中还原糖浓度升高时，如糖尿病发生，该过程增加。受影响的分子的结构和功能完整性受到这些修饰的干扰，可能导致严重后果。本发明的化合物可用于抑制非酶糖基化的方法，并因此抑制由糖尿病或老化引起的一些不良作用。这些化合物也可用于预防食物过早老化，蛋白质变质，并可防止牙齿变色。

9. 发明申请

WO1991001322A1 METHOD OF SYNTHETIZING POLYESTERS 审中-公开
标题翻译：合成聚酯的方法
公开(公告)号：WO1991001322A1
公开(公告)日：1991-02-07
申请号：PCT/US1990004029
申请日：1990-07-18
申请人： LALEZARI, Iraj
IPC分类号： C07H13/02
CPC分类号： C07H13/06 , A23L33/26 , C07C69/33
摘要： A process for the preparation of an ester of formula (I), wherein R is the carbon residue of a polyol; R is selected from straight or branched chain alkyl or hydroxy alkyl groups of from 3 to 30 carbon atoms; straight or branched chain alkenyl or hydroxy alkenyl of from 3 to 30 carbon atoms; alkaryl; aralkyl; aryl; cycloalkyl of from 5 to 7 carbons and mixtures thereof; n is from 1 to the total number of replaceable hydroxyl groups on the polyol; r is 0 or is equal to the total number of unesterified OH groups; n + r are equal to the total number of replaceable OH groups in the polyol. The process comprises contacting an acid with an alkyl chloroformate in an aqueous medium that is 100 % water to form an anhydride and thereafter contacting said anhydride with a polyol to form said ester. Also disclosed is a foodstuff composition which comprises an edible base material and a non-nutritive ester.
摘要翻译：一种制备式（I）酯的方法，其中R是多元醇的碳残基; R 1选自3至30个碳原子的直链或支链烷基或羟基烷基; 具有3至30个碳原子的直链或支链烯基或羟基烯基; 烷; 芳; 芳基; 5至7个碳原子的环烷基及其混合物; n为1至多元醇上的可置换羟基的总数; r为0或等于未酯化的OH基团的总数; n + r等于多元醇中可置换的OH基团的总数。该方法包括使酸与氯甲酸烷基酯在100％水的水性介质中接触以形成酸酐，然后使所述酸酐与多元醇接触以形成所述酯。还公开了包含可食用基础材料和非营养酯的食品组合物。

10. 发明申请

WO1988010113A1 COMPOUND, COMPOSITION AND METHOD FOR THE REDUCTION OF LIPIDS THE MODIFICATION OF THE AFFINITY OF HEMOGLOBIN FOR OXYGEN AND THE PREVENTION OF PLATELET AGGREGATION 审中-公开
标题翻译：用于减少脂肪的化合物，组合物和方法修饰乙酰胆碱对氧气的影响和防止血小板聚集
公开(公告)号：WO1988010113A1
公开(公告)日：1988-12-29
申请号：PCT/US1988002092
申请日：1988-06-15
申请人： LALEZARI, Iraj , RAHBAR, Samuel , LALEZARI, Parviz
IPC分类号： A61K31/24
CPC分类号： C07C275/34
摘要： Novel compounds are disclosed which have formula (I), wherein R1, R2, R3 and R4 may be the same or different and independently selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl of from 1-6 carbon atoms, aryl, cycloalkyl of 4 to 7 carbon atoms; and alkoxy of 1 to 6 carbon atoms; R5 and R6 may be the same or different and are selected from the group consisting of hydrogen, halogen, straight and branched chain alkyl groups of from 1-6 carbon atoms, aralkyl groups wherein the alkyl portion has from 1-6 carbon atoms, cycloalkyl of from 4-7 carbon atoms and aryl; R7 is hydrogen or a straight or branched chain alkyl group of 1-6 carbon atoms and the pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of hyperlipidemia and for the in vivo and in vitro treatment of hemoglobin or blood to modify the affinity of hemoglobin for oxygen.
摘要翻译：公开了具有式（I）的新型化合物，其中R 1，R 2，R 3和R 4可以相同或不同，并且独立地选自氢，卤素，1-6个碳原子的直链和支链烷基，芳基，4-7个碳原子的环烷基; 和1-6个碳原子的烷氧基; R5和R6可以相同或不同，并且选自氢，卤素，1-6个碳原子的直链和支链烷基，其中烷基部分具有1-6个碳原子的芳烷基，环烷基的4-7个碳原子和芳基; R7是氢或1-6个碳原子的直链或支链烷基及其药学上可接受的盐。这些化合物可用于治疗高脂血症和用于体内和体外治疗血红蛋白或血液以改变血红蛋白对氧的亲和力。

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