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1. 发明申请

WO2012089844A1 EFFICIENT LIGNOCELLULOSE HYDROLYSIS WITH INTEGRATED ENZYME PRODUCTION 审中-公开
标题翻译：具有综合酶生产的高效液体纤维素水解
公开(公告)号：WO2012089844A1
公开(公告)日：2012-07-05
申请号：PCT/EP2012/050009
申请日：2012-01-02
申请人： SÜD-CHEMIE AG , RARBACH, Markus , DRAGOVIC, Zdravko , KOHL, Andreas , GERLACH, Jochen , BARTUCH, Jörg , BRÜCK, Thomas
发明人： RARBACH, Markus , DRAGOVIC, Zdravko , KOHL, Andreas , GERLACH, Jochen , BARTUCH, Jörg , BRÜCK, Thomas
IPC分类号： C12P7/06 , C12P19/02
CPC分类号： C12P19/14 , C12N9/2434 , C12P7/10 , Y02E50/16 , Y02E50/17
摘要： The present invention provides a process for degradation of lignocellulosic biomass, which has optionally been pre- treated. It is based on the finding that hydrolysis efficiency of the biomass is enhanced in the presence of a mechanically or chemically treated microorganism capable of producing the respective hydrolytic enzymes. The invention therefore provides a process for degradation of lignocellulosic biomass with integrated produced enzyme cocktails. The invention also provid.es a process wherein the part of the optionally pre-treated lignocellulosic biomass is incorporated into the final growth medium of the fungus.
摘要翻译：本发明提供了一种用于木质纤维素生物质降解的方法，该方法任选地经过预处理。基于这样的发现，即在存在能够产生相应的水解酶的机械或化学处理的微生物的情况下，生物质的水解效率得到提高。因此，本发明提供了一种用综合生产的酶混合物降解木质纤维素生物质的方法。本发明还提供了一种方法，其中任选预处理的木质纤维素生物质的一部分并入真菌的最终生长培养基中。

2. 发明申请

WO2004022402A1 ELEKTROHYDRAULISCHE BREMSANLAGE UND VERFAHREN ZU DEREN ÜERWACHUNG 审中-公开
标题翻译：电动液压制动系统和方法ÜERWACHUNG
公开(公告)号：WO2004022402A1
公开(公告)日：2004-03-18
申请号：PCT/EP2003/008872
申请日：2003-08-09
申请人： CONTINENTAL TEVES AG & CO. OHG , KOHL, Andreas , PUFF, Rüdiger
发明人： KOHL, Andreas , PUFF, Rüdiger
IPC分类号： B60T17/22
CPC分类号： B60T17/221 , B60T8/4036 , B60T8/404 , B60T8/4081 , B60T13/148
摘要： Die Erfindung betrifft eine elektrohydraulische Bremsanlage für Kraftfahrzeuge, vom Typ "Brake-by-wire" mit einer mittels einer elektronischen Steuereinheit ansteuerbaren hydraulischen Druckquelle, die aus einer durch einen Elektromotor angetriebenen hydraulischen Pumpe sowie einem durch die Pumpe aufladbaren Hochdruckspeicher gebildet ist. Ausserdem betrifft die Erfindung ein Verfahren zur Überwachung einer elektrohydraulischen Bremsanlage der eingangs genannten Gattung. Um eine zuverlässige Erkennung von Gas- bzw. Luftmengen bereits beim Eintritt in das System durchzuführen, wird erfindungsgemäss vorgeschlagen die Saugseite der hydraulischen Pumpe (23) zu überwachen. Dies wird erreicht, indem die elektrischen Kenndaten des die Pumpe (23) antreibenden Elektromotors (22) dahingehend ausgewertet werden, dass eine Veränderung der hydraulischen Förderleistung erkannt wird.
摘要翻译：本发明涉及一种用于机动车辆的电动液压制动系统中，具有可控制的由电子控制单元的液压压力源，它是从一个由电动马达的液压泵驱动的形成，并且由泵高压蓄压器的可再充电的“制动线控”型。此外，本发明涉及用于监测上述类型的电液制动系统的方法。为了确保在进入系统中已经进行了气体或空气量的可靠的检测，本发明提出要监视的液压泵（23）的吸入侧。这是由泵（23）的驱动电动机（22）的电特性来实现，以进行评估，以该检测到的液压流量变化的影响。

3. 发明申请

WO1998006611A1 METHOD FOR THE CONTROL OF A HYDRAULIC PUMP IN A REGULATED BRAKING SYSTEM 审中-公开
标题翻译：方法控制液压泵受控制动系统
公开(公告)号：WO1998006611A1
公开(公告)日：1998-02-19
申请号：PCT/EP1997004232
申请日：1997-08-04
申请人： ITT MANUFACTURING ENTERPRISES, INC. , KOHL, Andreas , SCHMIDT, Robert , BURKHARD, Dieter , WOYWOD, Jürgen
发明人： ITT MANUFACTURING ENTERPRISES, INC.
IPC分类号： B60T08/40
CPC分类号： B60T8/4059
摘要： In a method for the adaptive steering of a hydraulic pump in a braking system containing low-pressure accumulators (NDS1, 2), which receive the pressure derived during regulation from the wheel brakes and which are drained by the hydraulic pump (HP), the braking pressure curve (PR) is determined first for each individual wheel with the help of a wheel pressure model. On the basis of the wheel pressure model a volume model (VM1, 2) is subsequently designed for each each individual brake radius, reproducing the approximate level of the low-pressure accumulators (NSD1, 2). The maximum level (maxV) and the control frequency or the time interval (T) between the two consecutive braking pressure reduction phases (PH2) are determined. The hydaulic pump (HP) capacity is such that the time interval (T) between the two consecutive braking pressure reduction phases is precisely sufficient to drain the low-pressure accumulator (NDS1, 2) entirely.
摘要翻译：包含在用于制动系统，所述低压蓄压器（NDS1，2），其接收从车轮制动器作为规则压力介质和由液压泵（HP）所导出的被清空的液压泵的自适应控制的方法，所述制动压力图案（P R）首先与每个车轮反应一个轮压的帮助下确定。然后，将车轮压力的基础上单独地制电路形成的体积模型（VM1，2），该大致再现低压蓄压器的电平（NDS1，2）。确定的最大电平（MAXV）和控制频率或两个连续的制动压力降低阶段（Ph2的）之间的时间间隔（T）。液压泵（HP）的排出流量的尺寸使得对于低压蓄压器（NDS1，2）刚好足够的完全排空两个连续的制动压力降低阶段（PH 2）之间的时间间隔（T）。

4. 发明申请

WO2012001102A1 CELLOBIOSE PRODUCTION FROM BIOMASS 审中-公开
标题翻译：生物质的细胞生产
公开(公告)号：WO2012001102A1
公开(公告)日：2012-01-05
申请号：PCT/EP2011/061005
申请日：2011-06-30
申请人： SÜD-CHEMIE AG , KOHL, Andreas , BRÜCK, Thomas , GERLACH, Jochen , ZAVREL, Michael , RÖCHER, Lutz , KRAUS, Michael
发明人： KOHL, Andreas , BRÜCK, Thomas , GERLACH, Jochen , ZAVREL, Michael , RÖCHER, Lutz , KRAUS, Michael
IPC分类号： C12P19/12
CPC分类号： C12P19/14 , A23K20/163 , A23L33/21 , A61K31/7016 , C07H1/00 , C07H3/04 , C12P7/58 , C12P19/12 , C12P2203/00 , C12Y101/03004 , C12Y302/01091 , C13K1/02 , C13K13/007
摘要： The invention is directed to a method for the enzymatic production of cellobiose from sugar beet and other cellulose- containing biomass. Cellobiose is a disaccharide which consists of two molecules of glucose connected via a β-1,4 linkage. The process of the current invention allows for economic production of cellobiose and high yields. The process for producing cellobiose according to the invention comprises the following steps: subjecting a cellulose containing material to a cellulase treatment at a dry matter content between 7.5 and 50 % (w/w), preferably between 10 and 25% (w/w), and more preferably between 12 and 20% (w/w), followed by separating the cellobiose containing liquid phase from the solid phase.
摘要翻译：本发明涉及从甜菜和其它含纤维素生物质酶促生产纤维二糖的方法。纤维二糖是由通过β-1,4键连接的两分子葡萄糖组成的二糖。本发明的方法允许纤维二糖的经济生产和高产率。根据本发明的纤维二糖的制备方法包括以下步骤：使干燥物质含量为7.5〜50％（w / w），优选为10〜25％（w / w），更优选在12％至20％（w / w）之间，然后从固相中分离含纤维二糖的液相。

5. 发明申请

WO2011098551A2 OPTIMIZED CELLULASE ENZYMES 审中-公开
标题翻译：优化的纤维素酶
公开(公告)号：WO2011098551A2
公开(公告)日：2011-08-18
申请号：PCT/EP2011/052023
申请日：2011-02-11
申请人： SÜD-CHEMIE AG , KETTLING, Ulrich , REISINGER, Christoph , BRÜCK, Thomas , KOLTERMANN, Andre , GERLACH, Jochen , UNTERSTRASSER, Isabel , RÖCHER, Lutz , RARBACH, Markus , CLAREN, Jörg , KOHL, Andreas , PIECK, Jan Carsten , SCHLOSSER, Dominik
发明人： KETTLING, Ulrich , REISINGER, Christoph , BRÜCK, Thomas , KOLTERMANN, Andre , GERLACH, Jochen , UNTERSTRASSER, Isabel , RÖCHER, Lutz , RARBACH, Markus , CLAREN, Jörg , KOHL, Andreas , PIECK, Jan Carsten , SCHLOSSER, Dominik
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/24 , C12Y302/01091
摘要： The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed.
摘要翻译：本发明公开了具有优化的用于加工含纤维素和木质素纤维素的底物的纤维素酶。特别地，公开了具有优选特性的纤维二糖水解酶。本发明提供了这种酶的融合，插入，缺失和/或取代变体。酶变体在极端pH下具有增强的热稳定性，蛋白水解稳定性，比活性和/或稳定性。公开了编码所述酶的核酸分子，包含所述酶的组合物，制备方法以及用于纤维素加工和/或生产生物燃料的用途。

6. 发明申请

WO2010136404A2 LIQUEFIED BIOMASS 审中-公开
标题翻译：液化生物量
公开(公告)号：WO2010136404A2
公开(公告)日：2010-12-02
申请号：PCT/EP2010/057045
申请日：2010-05-21
申请人： SÜD-CHEMIE AG , KOLTERMANN, Andre , RARBACH, Markus , BRÜCK, Thomas , GERLACH, Jochen , UNTERSTRAßER, Isabel , KOHL, Andreas , DRAGOVIC, Zdravko , KETTLING, Ulrich
发明人： KOLTERMANN, Andre , RARBACH, Markus , BRÜCK, Thomas , GERLACH, Jochen , UNTERSTRAßER, Isabel , KOHL, Andreas , DRAGOVIC, Zdravko , KETTLING, Ulrich
IPC分类号： C12P5/00
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

7. 发明申请

WO2011098551A3 OPTIMIZED CELLULASE ENZYMES 审中-公开
标题翻译：优化的纤维素酶
公开(公告)号：WO2011098551A3
公开(公告)日：2012-05-31
申请号：PCT/EP2011052023
申请日：2011-02-11
申请人： SUED CHEMIE AG , KETTLING ULRICH , REISINGER CHRISTOPH , BRUECK THOMAS , KOLTERMANN ANDRE , GERLACH JOCHEN , UNTERSTRASSER ISABEL , ROECHER LUTZ , RARBACH MARKUS , CLAREN JOERG , KOHL ANDREAS , PIECK JAN CARSTEN , SCHLOSSER DOMINIK
发明人： KETTLING ULRICH , REISINGER CHRISTOPH , BRUECK THOMAS , KOLTERMANN ANDRE , GERLACH JOCHEN , UNTERSTRASSER ISABEL , ROECHER LUTZ , RARBACH MARKUS , CLAREN JOERG , KOHL ANDREAS , PIECK JAN CARSTEN , SCHLOSSER DOMINIK
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C12N9/24 , C12Y302/01091
摘要： The invention discloses cellulase enzymes with optimized properties for processing of cellulose- and lignocellulose-containing substrates. In particular, cellobiohydrolase enzymes with preferred characteristics are disclosed. The present invention provides fusion, insertion, deletion and/or substitution variants of such enzymes. Enzyme variants have enhanced thermostability, proteolytic stability, specific activity and/or stability at extreme pH. Nucleic acid molecules encoding said enzymes, a composition comprising said enzymes, a method for preparation, and the use for cellulose processing and/or for the production of biofuels are disclosed.
摘要翻译：本发明公开了具有优化的用于加工含纤维素和木质素纤维素的底物的纤维素酶。特别地，公开了具有优选特性的纤维二糖水解酶。本发明提供了这种酶的融合，插入，缺失和/或取代变体。酶变体在极端pH下具有增强的热稳定性，蛋白水解稳定性，比活性和/或稳定性。公开了编码所述酶的核酸分子，包含所述酶的组合物，制备方法以及用于纤维素加工和/或生产生物燃料的用途。

8. 发明申请

WO2011080078A2 THERMOSTABLE XYLANASE FOR THE SELECTIVE HYDROLYSIS OF PENTOSE-CONTAINING POLYSACCHARIDES 审中-公开
标题翻译：热稳定木聚糖酶用于选择性水解含戊糖的多糖
公开(公告)号：WO2011080078A2
公开(公告)日：2011-07-07
申请号：PCT/EP2010/069736
申请日：2010-12-15
申请人： SÜD-CHEMIE AG , KOHL, Andreas , UNTERSTRASSER, Isabel , RARBACH, Markus , KOLTERMANN, Andre , REISINGER, Christoph , BRÜCK, Thomas , KETTLING, Ulrich , HREGGVIDSSON, Gudmundur Oli , FRIDJONSSON, Olafur Hedinn
发明人： KOHL, Andreas , UNTERSTRASSER, Isabel , RARBACH, Markus , KOLTERMANN, Andre , REISINGER, Christoph , BRÜCK, Thomas , KETTLING, Ulrich , HREGGVIDSSON, Gudmundur Oli , FRIDJONSSON, Olafur Hedinn
IPC分类号： C12N15/09
CPC分类号： C12N9/248
摘要： The present invention relates to polypeptides having xylanase activity and nucleic acid sequences encoding such polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides. One specific application of the xylanase is the selective hydrolysis of pentose sugar components of hemicelluiose-containing plant biomass. The nucleotide sequence may be used for the production of the xylanase or optimized mutants thereof.
摘要翻译：本发明涉及具有木聚糖酶活性的多肽和编码这些多肽的核酸序列。本发明还涉及包含核酸构建体的核酸构建体，载体和宿主细胞以及生产和使用该多肽的方法。木聚糖酶的一个具体应用是选择性水解含半纤维素的植物生物质的戊糖组分。该核苷酸序列可用于生产木聚糖酶或其优化的突变体。

9. 发明申请

WO2010136404A3 LIQUEFIED BIOMASS 审中-公开
标题翻译：液化生物量
公开(公告)号：WO2010136404A3
公开(公告)日：2011-02-24
申请号：PCT/EP2010057045
申请日：2010-05-21
申请人： SUED CHEMIE AG , KOLTERMANN ANDRE , RARBACH MARKUS , BRUECK THOMAS , GERLACH JOCHEN , UNTERSTRASER ISABEL , KOHL ANDREAS , DRAGOVIC ZDRAVKO , KETTLING ULRICH
发明人： KOLTERMANN ANDRE , RARBACH MARKUS , BRUECK THOMAS , GERLACH JOCHEN , UNTERSTRASER ISABEL , KOHL ANDREAS , DRAGOVIC ZDRAVKO , KETTLING ULRICH
IPC分类号： C12P5/00
CPC分类号： C12P19/02 , C12P19/14 , Y02E50/17
摘要： The invention is directed to a liquefied sugar beet and/or sugar cane biomass material as well as production methods and uses thereof. The liquefied biomass is storage stable and can be used for the production of a product resulting from fermentation.
摘要翻译：本发明涉及液化甜菜和/或甘蔗生物质材料及其生产方法和用途。液化生物质储存稳定，可用于生产发酵产物。

10. 发明申请

WO2008142366A3 METHODS FOR SELECTING OR DESIGNING MODULATORS, BASED ON THE CRYSTAL STRUCTURE OF LEUKOTRIENE C4 SYNTHASE (LTC4S) 审中-公开
标题翻译：基于LEUKOTRIENE C4合成酶（LTC4S）的晶体结构选择或设计调节剂的方法
公开(公告)号：WO2008142366A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008001584
申请日：2008-05-07
申请人： BIOLIPOX AB , MCNEENEY STEPHEN PHILLIP , KOHL ANDREAS , ESHAGHI SAID , MOLINA DANIEL MARTINEZ , NORDLUND PAER , WETTERHOLM ANDERS , HAEGGSTROEM JESPER Z
发明人： KOHL ANDREAS , ESHAGHI SAID , MOLINA DANIEL MARTINEZ , NORDLUND PAER , WETTERHOLM ANDERS , HAEGGSTROEM JESPER Z
IPC分类号： G06F19/16
CPC分类号： C12Q1/25 , C07K2299/00 , C12N9/1085 , C12Y404/0102 , G01N33/92 , G01N2500/04 , G06F19/16
摘要： A method for selecting or designing a compound expected to modulate the activity of Leukotriene C4 synthase (LTC4S), the method comprising the step of using molecular modelling means to select or design a compound that is predicted to interact with the catalytic site or a substrate binding region of LTC4S, wherein a three-dimensional structure of at least a part of the catalytic site or a substrate binding region of LTC4S is compared with a three-dimensional structure of a compound, and a compound that is predicted to interact with the said catalytic site or substrate binding region is selected. The selected compound may be predicted to bind to at least a part of a region of the structure termed the "GSH substrate binding cavity" (formed by residues including residues Arg51, Arg30, Arg104, Gln53, Asn55, Glu58, Tyr59, Tyr93, Tyr97, Ile27, Pro37, Leu108 of full length human LTC4S, or equivalent residues); the "lipophilic substrate binding crevice" (formed by residues including Ala20, Leu24, Ile27, Tyr59, Trp116, Ala112, Leu115, Leu108, Tyr109, Leu62, VaI119, Thr66, Val119 and Leu17, or equivalent residues); or the "catalytic site" (formed by residues including Arg104 or Arg31, or equivalent residues).
摘要翻译：选择或设计预期调节白三烯C4合酶（LTC4S）的活性的化合物的方法，所述方法包括使用分子建模手段来选择或设计预测与催化位点相互作用的化合物或底物结合 LTC4S的区域，其中将LTC4S的至少一部分催化位点或底物结合区域的三维结构与化合物的三维结构进行比较，以及预测与所述催化剂相互作用的化合物选择位点或底物结合区。可以预期所选择的化合物可结合称为“GSH底物结合腔”的结构的至少一部分（由残基Arg51，Arg30，Arg104，Gln53，Asn55，Glu58，Tyr59，Tyr93，Tyr97 ，全长人LTC4S的Ile27，Pro37，Leu108或相当的残基）; （由Ala20，Leu24，Ile27，Tyr59，Trp116，Ala112，Leu115，Leu108，Tyr109，Leu62，Val119，Thr66，Val119和Leu17等残基形成的“亲脂性底物结合缝隙”）。或“催化位点”（由包含Arg104或Arg31的残基或等同残基形成）。

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