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1. 发明申请

WO2009128649A2 METHOD OF SEPARATING AND PURIFYING CELLULAR COMPONENTS USING NON-COVALENT BOND BETWEEN CUCURBITURIL DERIVATIVE AND GUEST COMPOUND AND APPARATUS USING THE SAME 审中-公开
标题翻译：使用菊核衍生物与客体化合物和使用该化合物的装置之间的非共价键将细胞成分分离和纯化的方法
公开(公告)号：WO2009128649A2
公开(公告)日：2009-10-22
申请号：PCT/KR2009001947
申请日：2009-04-15
申请人： POSTECH ACAD IND FOUND , LEE DON-WOOK , RYU SUNG HO , HA SANG HOON , JUNG HYUNTAE , MAINAK BANERJEE , SELVAPALAM NARAYANAN , KIM KIMOON , PARK KYENG-MIN
发明人： LEE DON-WOOK , RYU SUNG HO , HA SANG HOON , JUNG HYUNTAE , MAINAK BANERJEE , SELVAPALAM NARAYANAN , KIM KIMOON , PARK KYENG-MIN
IPC分类号： C12N15/10
CPC分类号： C07K1/22
摘要： Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferrin, and any mixtures thereof.
摘要翻译：提供了分离细胞组分的方法，所述方法包括：a）使客体化合物结合的反应性化合物与细胞接触; b）裂解细胞; c）将包含宿主化合物的固相添加到包含细胞裂解物的溶液中以制备混合物; d）从混合物中分离与细胞组分结合的客体化合物和与固相结合的宿主化合物的结合对，并纯化结合对; 和e）从结合对中分离细胞组分，其中客体化合物结合的反应性化合物通过反应性化合物和由客体化学式2表示的客体化合物之间的共价键获得，结合宿主化合物的固相通过固相和由下式1表示的主体化合物之间的共价键，并且反应性化合物包括选自生物分子，N-羟基琥珀酰亚胺，抗原，抗体，适体，叶酸，转铁蛋白及其任何混合物。

2. 发明申请

WO2008096985A1 METHODS OF STORING AND SEPARATING GASES USING MICROPOROUS METAL FORMATES 审中-公开
标题翻译：使用微波金属氧化物存储和分离气体的方法
公开(公告)号：WO2008096985A1
公开(公告)日：2008-08-14
申请号：PCT/KR2008/000625
申请日：2008-02-01
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , KIM, Kimoon , KIM, Hyunuk , PARK, Kyeng-Min , SAMSONENKO, Denis G. , SUN, Yinyong
发明人： KIM, Kimoon , KIM, Hyunuk , PARK, Kyeng-Min , SAMSONENKO, Denis G. , SUN, Yinyong
IPC分类号： C07C7/12 , C07C11/24
CPC分类号： B01D53/04 , B01D2253/20 , B01D2257/104 , B01D2257/7022 , C01B13/02 , C07C7/12 , F17C11/005 , F17C11/007 , C07C11/24
摘要： Provided are methods of storing and separating acetylene or oxygen using microporous metal formates having a three-dimensional structure of metal and formate ion (HCOO - ). Microporous metal formates used in the method selectively and stably adsorb a large amount of a specific gas within its structure. Therefore, those methods can be used in industrial appliances related to, for example, synthesis and transportation of high-purity gas.
摘要翻译：提供了使用具有金属和甲酸根离子（HCOO）的三维结构的微孔金属甲酸盐来储存和分离乙炔或氧的方法。该方法中使用的微孔金属甲酸盐在其结构内选择性且稳定地吸附大量的特定气体。因此，这些方法可以用于与例如合成和运输高纯度气体有关的工业设备中。

3. 发明申请

WO2005113564A1 DISUBSTITUTED CUCURBITURIL-BONDED SILICA GEL 审中-公开
标题翻译：分离的CUCURBITURIL粘结二氧化硅凝胶
公开(公告)号：WO2005113564A1
公开(公告)日：2005-12-01
申请号：PCT/KR2005/001127
申请日：2005-04-20
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , KIM, Kimoon , OH, Dong-Hyun , ERUMAIPATTY RAJAGOUNDER, Nagarajan , RAJU, Nandha Kumar , CHOI, Ju-Young , KO, Young-Ho
发明人： KIM, Kimoon , OH, Dong-Hyun , ERUMAIPATTY RAJAGOUNDER, Nagarajan , RAJU, Nandha Kumar , CHOI, Ju-Young , KO, Young-Ho
IPC分类号： C07F7/02
CPC分类号： C07F7/1836 , C07B2200/11
摘要： A disubstituted cucurbituril-bonded silica gel and its use are provided. The disubstituted cu-curbituril-bonded silica gel is useful for removal of air pollutants or water contaminants, and separation and purification of biological, organic, inorganic, or ionic substances.
摘要翻译：提供二取代的葫芦巴结合硅胶及其用途。二取代的巧克力百里草键合硅胶可用于去除空气污染物或水污染物，以及生物，有机，无机或离子物质的分离和纯化。

4. 发明申请

WO2003004500A1 WATER- AND ORGANIC-SOLUBLE CUCURBITURIL DERIVATIVES, THEIR PREPARATION METHODS, THEIR SEPARATION METHODS AND USES 审中-公开
标题翻译：水溶性有机溶剂衍生物及其制备方法及其分离方法及用途
公开(公告)号：WO2003004500A1
公开(公告)日：2003-01-16
申请号：PCT/KR2002/001259
申请日：2002-07-03
申请人： POSTECH FOUNDATION , KIM, Kimoon , ZHAO, Jianzhang , KIM, Hee-Joon , KIM, Soo-Young , OH, Jinho
发明人： KIM, Kimoon , ZHAO, Jianzhang , KIM, Hee-Joon , KIM, Soo-Young , OH, Jinho
IPC分类号： C07D487/22
CPC分类号： C07D487/08 , C07D487/22
摘要： Provided are cucurbituril derivatives having the formula (1), their preparation methods and uses: where X is O, S or NH; R 1 and R 2 are each independently selected from the group consisting of hydrogen, alkyl groups of 1 to 30 carbon atoms, alkenyl groups of 1 to 30 carbon atoms, alkynyl groups of 1 to 30 carbon atoms, alkylthio groups of 1 to 30 carbon atoms, alkylcarboxyl groups of 1 to 30 carbon atoms, hydroxyalkyl groups of 1 to 30 carbon atoms, alkylsilyl groups of 1 to 30 carbon atoms, alkoxy groups of 1 to 30 carbon atoms, haloalkyl groups of 1 to 30 carbon atoms, nitro group, alkylamine groups of 1 to 30 carbon atoms, amine group, aminoalkyl groups of 1 to 30 carbon atoms, unsubstituted cycloalkyl groups of 5 to 30 carbon atoms, cycloalkyl groups of 4 to 30 carbon atoms with hetero atoms, unsubstituted aryl groups of 6 to 30 carbon atoms, and aryl groups of 6 to 30 carbon atoms with hetero atoms; and n and m are independently integers from 4 to 20 and from 1 to 7, respectively. The cucurbituril derivative has enhanced solubility in common solvents, thereby providing wider applications.
摘要翻译：提供具有式（1）的葫芦巴衍生物，其制备方法和用途：其中X是O，S或NH; R 1和R 2各自独立地选自氢，碳原子数1〜30的烷基，碳原子数1〜30的烯基，碳原子数1〜30的炔基，碳原子数1〜30的烷硫基， 1〜30个碳原子的烷基羧基，1〜30个碳原子的羟基烷基，1〜30个碳原子的烷基甲硅烷基，1〜30个碳原子的烷氧基，1〜30个碳原子的卤代烷基，硝基，烷基胺基 1〜30个碳原子的胺基，1〜30个碳原子的氨基烷基，5〜30个碳原子的未取代环烷基，4〜30个碳原子的环烷基，杂原子，6〜30个碳原子的未取代芳基和具有6〜30个碳原子的芳基具有杂原子; 并且n和m分别独立地为4至20和1至7的整数。葫芦巴衍生物在常用溶剂中具有增强的溶解性，从而提供更广泛的应用。

5. 发明申请

WO2009128649A3 METHOD OF SEPARATING AND PURIFYING CELLULAR COMPONENTS USING NON-COVALENT BOND BETWEEN CUCURBITURIL DERIVATIVE AND GUEST COMPOUND AND APPARATUS USING THE SAME 审中-公开
公开(公告)号：WO2009128649A3
公开(公告)日：2009-10-22
申请号：PCT/KR2009/001947
申请日：2009-04-15
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , LEE, Don-Wook , RYU, Sung Ho , HA, Sang Hoon , JUNG, Hyuntae , MAINAK, Banerjee , SELVAPALAM, Narayanan , KIM, Kimoon , PARK, Kyeng-Min
发明人： LEE, Don-Wook , RYU, Sung Ho , HA, Sang Hoon , JUNG, Hyuntae , MAINAK, Banerjee , SELVAPALAM, Narayanan , KIM, Kimoon , PARK, Kyeng-Min
IPC分类号： C12N15/10
摘要： Provided is a method of separating cellular components, the method including: a) contacting a guest compound-bound reactive compound with cells; b) lysing the cells; c) adding a host compound-bound solid phase to a solution including the lysates of the cells to prepare a mixture; d) separating binding pairs of the guest compound bound to cellular components and the host compound bound to the solid phase from the mixture, and purifying the binding pairs; and e) separating the cellular components from the binding pairs, wherein the guest compound-bound reactive compound is obtained through a covalent bond between a reactive compound and a guest compound represented by Formula 2 below guest, the host compound-bound solid phase is obtained through a covalent bond between a solid phase and a host compound represented by Formula 1 below, and the reactive compound includes at least one selected from the group consisting of a biomolecule, N-hydroxysuccimide, an antigen, an antibody, an aptamer, folic acid, transferrin, and any mixtures thereof.

6. 发明申请

WO2007111390A1 STATIONARY PHASE AND COLUMN USING CUCURBITURIL BONDED SILICA GEL, AND SEPARATION METHOD OF TAXOL USING THE COLUMN 审中-公开
标题翻译：使用CUCURBITURIL粘结二氧化硅凝胶的固定相和柱，以及使用柱的TAXOL分离方法
公开(公告)号：WO2007111390A1
公开(公告)日：2007-10-04
申请号：PCT/KR2006/001096
申请日：2006-03-24
申请人： POSTECH FOUNDATION , POSTECH ACADEMY-INDUSTRY FOUNDATION , KIM, Kimoon , KO, Young-Ho , PARK, Kyeng-Min , SELVAPALAM, Narayanan , NAGARAJAN, Erumaipatty, R.
发明人： KIM, Kimoon , KO, Young-Ho , PARK, Kyeng-Min , SELVAPALAM, Narayanan , NAGARAJAN, Erumaipatty, R.
IPC分类号： C07D305/14 , C07D487/04
CPC分类号： C07D487/04 , B01J20/286 , C07D305/14
摘要： Provided are a stationary phase and a column using a cucurbituril-bound silica g el, and a method of separating taxane using the column. The taxane separation meth od includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represen ted by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formul a 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; ap plying the taxane-containing solution to the column; supplying a mobile-phase solvent t o the column to obtain a taxane extract from the column; and purifying taxane from the t axane extract. Therefore, highly purified taxane can be separated from a low-purity cr ude taxane extract.
摘要翻译：提供了使用葫芦巴结合二氧化硅的固定相和柱，以及使用该柱分离紫杉烷的方法。紫杉烷分离方法包括：制备紫杉烷分离柱，柱用包含葫芦素结合硅胶的固定相填充，其中由式1或2表示的葫芦巴共价结合到由 Formul a 3; 将紫杉烷粉末溶解在溶剂中以制备含紫杉烷的溶液; 将含有紫杉烷的溶液置于色谱柱上; 在柱上供应流动相溶剂以从塔中获得紫杉烷提取物; 并从t轴提取物中纯化紫杉烷。因此，高纯度紫杉烷可与低纯度紫杉烷提取物分离。

7. 发明申请

WO2007102634A1 CUCURBITURIL ADDED CIGARETTES AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译： CUCURBITURIL添加香烟及其制造方法
公开(公告)号：WO2007102634A1
公开(公告)日：2007-09-13
申请号：PCT/KR2006/000841
申请日：2006-03-09
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , KIM, Kimoon , PARK, Kyeng-Min , KO, Young-Ho , SELVAPALAM, Narayanan
发明人： KIM, Kimoon , PARK, Kyeng-Min , KO, Young-Ho , SELVAPALAM, Narayanan
IPC分类号： A24D3/04
CPC分类号： A24D1/002 , A24D3/14
摘要： Provided is a cucurbituril-containing tobacco. The cucurbituril-containing tobacco includes a cucurbituril represented by Formula 1. The cucurbituril-containing tobacco can produce a reduced amount of harmful substances.
摘要翻译：提供含有葫芦素的烟草。含葫芦素的烟草包括由式1表示的葫芦巴脲。含葫芦素的烟草可以产生减少量的有害物质。

8. 发明申请

WO2005010004A1 NANO-PARTICLES COMPRISING CUCURBITURIL DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：包含CURGBITURIL衍生物的纳米颗粒，含有它们的药物组合物及其制备方法
公开(公告)号：WO2005010004A1
公开(公告)日：2005-02-03
申请号：PCT/KR2004/001874
申请日：2004-07-26
申请人： POSTECH FOUNDATION , KIM, Kimoon , JON, Sang-Yong , JEON, Young-Jin , OH, Dong-Hyun , SELVAPALAM, Narayanan
发明人： KIM, Kimoon , JON, Sang-Yong , JEON, Young-Jin , OH, Dong-Hyun , SELVAPALAM, Narayanan
IPC分类号： C07D487/04
CPC分类号： C07D487/22
摘要： Provided are nanoparticles prepared by the aggregation of cucurbituril derivatives and having a particle size of 1 to 1, 000 nm, a pharmaceutical composition in which a pharmaceutically active substance is loaded into the nanoparticles, and preparation methods thereof.
摘要翻译：本发明提供了通过葫芦素衍生物的聚集制备的粒径为1〜1000nm的纳米颗粒，其中药物活性物质被加载到纳米颗粒中的药物组合物及其制备方法。

9. 发明申请

WO2007014214A3 INTROVERTED CUCURBITURIL COMPOUNDS 审中-公开
标题翻译：内置化学品
公开(公告)号：WO2007014214A3
公开(公告)日：2007-05-31
申请号：PCT/US2006028841
申请日：2006-07-24
申请人： UNIV MARYLAND , UNIV POHANG , ISAACS LYLE DAVID , LIU SIMIN , KIM KIMOON , PARK SANG-KYU , KO YOUNG HO , KIM HYUNUK , KIM YOUNGKOOK , SELVAPALAM NARAYANAN
发明人： ISAACS LYLE DAVID , LIU SIMIN , KIM KIMOON , PARK SANG-KYU , KO YOUNG HO , KIM HYUNUK , KIM YOUNGKOOK , SELVAPALAM NARAYANAN
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： This application is drawn to introverted cucurbituril compounds and methods of their production. The compounds have at least one pair of hydrogen atoms protruding inside the macrocylic cavity of the cucurbituril. The compounds are used for the molecular recognition of guest compounds.
摘要翻译：本应用案例描述了内向型葫芦素化合物及其生产方法。化合物在葫芦素的大环腔内部突出有至少一对氢原子。该化合物用于客体化合物的分子识别。

10. 发明申请

WO2005010058A1 CUCURBITURIL-CONTAINING POLYMER, STATIONARY PHASE AND COLUMN USING THE SAME 审中-公开
标题翻译：含有聚碳酸酯的聚合物，使用其的静置相和柱
公开(公告)号：WO2005010058A1
公开(公告)日：2005-02-03
申请号：PCT/KR2004/001845
申请日：2004-07-24
申请人： POSTECH FOUNDATION , KIM, Kimoon , OH, Dong-Hyun , NAGARAJAN, Erumaipatty Rajagounder , KO, Young-Ho , SAMAL, Shashadhar
发明人： KIM, Kimoon , OH, Dong-Hyun , NAGARAJAN, Erumaipatty Rajagounder , KO, Young-Ho , SAMAL, Shashadhar
IPC分类号： C08F8/30
CPC分类号： C07D487/22 , B01J20/28042 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3255 , B01J2220/82 , B01J2220/84 , C08F8/30 , C08F8/34 , C08F212/08 , C08F220/06 , C08K3/36 , C08L25/08
摘要： Provided is a cucurbituril-containing polymer. The cucurbituril-containing polymer can be used in removal, separation, or purification of air pollutants, water contaminants, biological substances, organic or inorganic substances, alkaline metals, heavy metals, ionic or water-soluble biological substances. Provided is also a stationary phase for column chromatography using the polymer.
摘要翻译：提供含葫芦素的聚合物。含葫芦素的聚合物可用于除去，分离或净化空气污染物，水污染物，生物物质，有机或无机物质，碱金属，重金属，离子或水溶性生物物质。还提供了使用聚合物的柱色谱的固定相。

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