专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2002052246A3 METHOD AND DEVICE FOR DETECTING AND IDENTIFYING BIO-AEROSOL PARTICLES IN THE AIR 审中-公开
公开(公告)号：WO2002052246A3
公开(公告)日：2002-07-04
申请号：PCT/NL2001/000914
申请日：2001-12-14
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , STOWERS, Michael, Anthony , WUIJCKHUIJSE, Arjan, Laurens , MARIJNISSEN, Johannes, Cornelis, Maria , KIENTZ, Charles, Eliza
发明人： STOWERS, Michael, Anthony , WUIJCKHUIJSE, Arjan, Laurens , MARIJNISSEN, Johannes, Cornelis, Maria , KIENTZ, Charles, Eliza
IPC分类号： H01J49/40
摘要： In a method for detecting and identifying bioaerosol particles in the air, the bioaerosol particles in a particle stream are selected in an ATOFMS (aerosol time-of-flight mass spectrometer) by means of fluorescence techniques, and only the selected bioaerosol particles are ionized, for instance on the basis of MALDI (matrix-assisted laser desorption/ionization), after which the resulting ions are detected and the bioaerosol particles are identified.The selection of bioaerosol particles takes place by means of laser radiation, generated by a first laser device, of a wavelength which in specifice substances in bioaerosol particles effects a fluorescence, after which by means of a fluorescence detector the bioaerosol particles are selected and a second laser device is triggered to emit light of a wavelength which effects the ionization of the bioaerosol particles selected only by the fluorescence detector.

2. 发明申请

WO02052246A2 METHOD AND DEVICE FOR DETECTING AND IDENTIFYING BIO-AEROSOL PARTICLES IN THE AIR 审中-公开
标题翻译：用于检测和鉴定空气中生物油雾颗粒的方法和装置
公开(公告)号：WO02052246A2
公开(公告)日：2002-07-04
申请号：PCT/NL0100914
申请日：2001-12-14
申请人： TNO , STOWERS MICHAEL ANTHONY , WUIJCKHUIJSE ARJAN LAURENS , MARIJNISSEN JOHANNES CORNELIS , KIENTZ CHARLES ELIZA
发明人： STOWERS MICHAEL ANTHONY , WUIJCKHUIJSE ARJAN LAURENS , MARIJNISSEN JOHANNES CORNELIS , KIENTZ CHARLES ELIZA
IPC分类号： G01N27/60 , G01N15/14 , G01N21/64 , G01N27/62 , G01N27/64 , H01J49/16 , H01J49/40
CPC分类号： H01J49/164 , G01N15/14 , H01J49/0445 , H01J49/40
摘要： In a method for detecting and identifying bioaerosol particles in the air, the bioaerosol particles in a particle stream are selected in an ATOFMS (aerosol time-of-flight mass spectrometer) by means of fluorescence techniques, and only the selected bioaerosol particles are ionized, for instance on the basis of MALDI (matrix-assisted laser desorption/ionization), after which the resulting ions are detected and the bioaerosol particles are identified. The selection of bioaerosol particles takes place by means of laser radiation, generated by a first laser device, of a wavelength which in specifice substances in bioaerosol particles effects a fluorescence, after which by means of a fluorescence detector the bioaerosol particles are selected and a second laser device is triggered to emit light of a wavelength which effects the ionization of the bioaerosol particles selected only by the fluorescence detector.
摘要翻译：在用于检测和鉴定空气中的生物气溶胶颗粒的方法中，通过荧光技术在ATOFMS（气溶胶飞行时间质谱仪）中选择颗粒物流中的生物气溶胶颗粒，并且仅选择的生物气溶胶颗粒被电离，例如基于MALDI（基质辅助激光解吸/电离）的基础，之后检测所得到的离子并鉴定生物溶胶颗粒。生物溶胶颗粒的选择通过由第一激光装置产生的激光辐射进行，该激光辐射是在生物气溶胶颗粒中的物质中产生荧光的波长，之后通过荧光检测器选择生物气溶胶颗粒，激光装置被触发以发射波长的光，该波长影响仅由荧光检测器选择的生物气溶胶颗粒的电离。

3. 发明申请

WO2009064180A1 MALDI MATRIX AND MALDI METHOD 审中-公开
标题翻译： MALDI矩阵和MALDI方法
公开(公告)号：WO2009064180A1
公开(公告)日：2009-05-22
申请号：PCT/NL2008/050721
申请日：2008-11-13
申请人： NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO , WUIJCKHUIJSE, Arjan Laurens , KIENTZ, Charles Eliza , DEGENHARDT-LANGELAAN, Carla Elisabeth Anna Maria
发明人： WUIJCKHUIJSE, Arjan Laurens , KIENTZ, Charles Eliza , DEGENHARDT-LANGELAAN, Carla Elisabeth Anna Maria
IPC分类号： G01N33/68 , H01J49/04
CPC分类号： H01J49/0418 , H01J49/0445 , Y10T436/24
摘要： Matrix for real-time aerosol mass spectrometry of atmospheric aerosols and real-time aerosol MALDI MS method Abstract The invention is directed to a matrix material for MALDI mass spectrometry, to a matrix composition for MALDI mass spectrometry, in particular for aerosol MALDI mass spectrometry, to a MALDI mass spectrometry method, in particular an aerosol MALDI mass spectrometry method, to the use of a specific compound as a MALDI matrix material, and to the use of a MALDI matrix composition in a gas phase coating method. The matrix material of the invention comprises a 2-mercapto-4,5-dialkylthiazole according to formula (I), wherein X is chosen from S, O or N, and wherein R 1 and R 2 are independently chosen from hydrogen, methyl, methoxy, ethoxy, and propoxy, or wherein R 1 and R 2 are taken together to form an optionally substituted aromatic ring structure, optionally comprising one or more heteroatoms, or a tautomeric form thereof. A matrix composition preferably includes the matrix material and an alcohol. The alcohol can be halogenated. The MALDI MS method comprises contacting the analyte with the matrix material or the matrix composition; ionising at least part of the analyte, and separating the ionised components using a mass spectrometer, e.g. TOF-MS. Preferably, bioaerosols are contacted with the matrix material in the gas phase.
摘要翻译：用于大气气溶胶和实时气溶胶的实时气溶胶质谱的基质MALDI MS方法摘要本发明涉及用于MALDI质谱法的基质材料，用于MALDI质谱法的基质组合物，特别是气相MALDI质谱法，以MALDI质谱法，特别是气溶胶MALDI质谱法，使用特定化合物作为MALDI基质材料，以及在气相涂布法中使用MALDI基质组合物。本发明的基质材料包含式（I）的2-巯基-4,5-二烷基噻唑，其中X选自S，O或N，并且其中R 1和R 2独立地选自氢，甲基，甲氧基，乙氧基和丙氧基，或其中R 1和R 2一起形成任选取代的芳环结构，任选地包含一个或多个杂原子或其互变异构体。基质组合物优选包括基质材料和醇。酒精可以被卤化。 MALDI MS方法包括使分析物与基质材料或基质组合物接触; 电离至少部分分析物，并使用质谱仪分离离子化的组分，例如， TOF-MS。优选地，生物气溶胶在气相中与基质材料接触。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式