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1. 发明申请

WO1991009495A2 A SYSTEM FOR QUANTITATIVE RADIOGRAPHIC IMAGING 审中-公开
标题翻译：一种定量放射成像系统
公开(公告)号：WO1991009495A2
公开(公告)日：1991-06-27
申请号：PCT/US1990007178
申请日：1990-12-05
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： H04N05/32
CPC分类号： A61B6/505 , A61B6/4042 , A61B6/4241 , A61B6/4258 , A61B6/4488 , A61B6/482 , A61B6/508 , H04N5/2253 , H04N5/32
摘要： A system for spectroscopic imaging of bodily tissue in which a scintillation screen and a charged coupled device (CCD) are used to accurately image selected tissue. Applications include the imaging of radionuclide distributions within the human body or the use of a dual energy source to provide a dual photon bone densitometry apparatus that uses stationary or scanning acquisition techniques. X-rays are generated by an X-ray source which pass through a region of a subject's body, forming an X-ray image which reaches the scintillation screen. The scintillation screen reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. A dual energy X-ray source that delivers two different energy levels provides quantitative information regarding the object being imaged using dual photon absorptiometry techniques.
摘要翻译：一种用于身体组织的光谱成像的系统，其中使用闪烁屏和电荷耦合器件（CCD）来精确地图像所选择的组织。应用包括人体内放射性核素分布的成像或使用双能源来提供使用固定或扫描采集技术的双光子骨密度测量装置。 X射线由通过被检体的区域的X射线源产生，形成到达闪烁屏的X射线图像。闪烁屏重新辐射与图像相对应的空间强度图案，该图案由CCD传感器检测。图像由传感器数字化，并由控制器进行处理，然后作为电子图像存储。提供两种不同能级的双能量X射线源提供了使用双光子吸收测定技术成像对象的定量信息。

2. 发明申请

WO2003045246A2 SYSTEM AND METHOD FOR X-RAY FLUOROSCOPIC IMAGING 审中-公开
标题翻译：用于X射线荧光成像的系统和方法
公开(公告)号：WO2003045246A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/037435
申请日：2002-11-21
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew , VEDANTHAM, Srinivasan , SURYANARAYANAN, Sankararaman
发明人： KARELLAS, Andrew , VEDANTHAM, Srinivasan , SURYANARAYANAN, Sankararaman
IPC分类号： A61B6/00
CPC分类号： A61B6/504 , A61B6/481 , A61B6/482 , H01L27/14831 , H01L31/02322 , H04N5/32
摘要： A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8 x 8-cm three-side buttable CCDs coupled to a CsI:Tl scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16 x 16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78,156 or 234-μm pixel pitch modes. The CCD sensor may also provide multi-resolution imaging. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Other preferred embodiments may include each image being directed on flat panel imagers made from but not limited to, amorphous silicon and/or amorphous selenium to generate individual electronic representations of the separate images used for diagnostic or therapeutic applications.
摘要翻译：用于身体组织的X射线透视成像的系统，其中使用闪烁屏和电荷耦合器件（CCD）来精确地成像所选择的组织。 X射线源产生通过被检体的区域的X射线，形成到达闪烁屏的X射线图像。闪烁屏重新辐射与图像相对应的空间强度图案，该图案由CCD传感器检测。在一个优选实施例中，成像器使用四个8×8cm三边对照CCD，其通过直的（非锥形）光纤和平铺耦合到CsI：T1闪烁体，以实现16×16cm的视场（FOV）在图像平面。可以通过以类似的方式平铺更多的CCD来实现更大的FOV。成像系统可以以多个像素间距模式操作，例如78,156或234μm像素间距模式。 CCD传感器还可以提供多分辨率成像。图像由传感器数字化，并由控制器处理，然后作为电子图像存储。其他优选实施例可以包括每个图像被引导到由但不限于非晶硅和/或非晶硒制成的平板成像器上，以产生用于诊断或治疗应用的单独图像的单独电子表示。

3. 发明申请

WO2003055393A1 SCATTER REDUCING IMAGING DEVICE 审中-公开
标题翻译：减光成像装置
公开(公告)号：WO2003055393A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/041240
申请日：2002-12-20
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew , SURYANARAYANAN, Sankararaman , VEDANTHAM, Srinivasan
发明人： KARELLAS, Andrew , SURYANARAYANAN, Sankararaman , VEDANTHAM, Srinivasan
IPC分类号： A61B6/00
CPC分类号： A61B6/505 , A61B6/00 , A61B6/06 , A61B6/4035 , A61B6/405 , A61B6/4233 , A61B6/469 , A61B6/482 , A61B6/502 , A61B6/587 , G21K1/025
摘要： The present invention related to a system and method for performing scatter correction in x-ray imaging systems. A pixellated solid state imaging detector is used in which an electronic window or slot is scanned across the two dimensional surface of the detector to selectively record image data. In a preferred embodiment, a collimator is used to define relative movement between an x-ray beam and the x-ray detector. A scatter correction program can be used to correct for scattering in the detected image data to provide for improved imaging in medical, scientific and industrial applications.
摘要翻译：本发明涉及一种用于在x射线成像系统中执行散射校正的系统和方法。使用像素化固态成像检测器，其中电子窗口或狭槽在检测器的二维表面上扫描以选择性地记录图像数据。在优选实施例中，使用准直器来限定x射线束和x射线检测器之间的相对运动。可以使用散射校正程序来校正检测到的图像数据中的散射，以在医学，科学和工业应用中提供改进的成像。

4. 发明申请

WO9635372A3 A SYSTEM FOR QUANTITATIVE RADIOGRAPHIC IMAGING 审中-公开
标题翻译：一种定量放射成像系统
公开(公告)号：WO9635372A3
公开(公告)日：1997-01-30
申请号：PCT/US9606838
申请日：1996-05-13
申请人： UNIV MASSACHUSETTS MEDICAL , KARELLAS ANDREW
发明人： KARELLAS ANDREW
IPC分类号： A61B5/00 , A61B6/00 , A61B6/03 , A61B6/14 , G21K1/10 , G21K3/00 , G21K4/00 , H04N5/225 , H04N5/32
CPC分类号： H04N5/2253 , A61B5/0091 , A61B6/06 , A61B6/145 , A61B6/4035 , A61B6/405 , A61B6/4233 , A61B6/4241 , A61B6/4258 , A61B6/4291 , A61B6/4423 , A61B6/4488 , A61B6/502 , A61B6/505 , A61B6/508 , G21K1/10 , G21K4/00 , H04N5/32
摘要： A system for spectroscopic imaging of bodily tissue in which a scintillation screen (20) and a charged coupled device (24) (CCD) are used to accurately image selected tissue. An x-ray source (12) generates X-rays which pass through a region of a subject's body, forming an X-ray image which reaches the scintillation screen (20). The scintillation screen (20) reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor (24). The image is digitized by the sensor (24) and processed by a controller (30) before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.
摘要翻译：一种用于身体组织的光谱成像的系统，其中使用闪烁屏和电荷耦合器件（CCD）来精确地图像所选择的组织。应用包括人体内放射性核素分布的成像或使用双能源来提供使用固定或扫描采集技术的双光子骨密度测量装置。 X射线源产生通过被检体的区域的X射线，形成到达闪烁屏的X射线图像。闪烁屏重新辐射与图像相对应的空间强度图案，该图案由CCD传感器检测。图像由传感器数字化，并由控制器进行处理，然后作为电子图像存储。提供两种不同能级的双能量X射线源提供了使用双光子吸收测定技术成像对象的定量信息。双闪烁屏可用于同时产生低能量和高能量X射线图案的图像。每个图像被引导到相关联的相应的CCD或非晶硅检测器上，以生成单独的图像的单独的电子表示。

5. 发明申请

WO1997042877A1 A SYSTEM FOR QUANTITATIVE RADIOGRAPHIC IMAGING 审中-公开
标题翻译：一种定量放射成像系统
公开(公告)号：WO1997042877A1
公开(公告)日：1997-11-20
申请号：PCT/US1997008102
申请日：1997-05-13
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： A61B06/14
CPC分类号： A61B6/505 , A61B5/0091 , A61B6/06 , A61B6/145 , A61B6/4035 , A61B6/405 , A61B6/4233 , A61B6/4241 , A61B6/4258 , A61B6/4291 , A61B6/4423 , A61B6/4488 , A61B6/482 , A61B6/502 , A61B6/508 , G21K1/10 , G21K4/00
摘要： A system for spectroscopic imaging of bodily tissue in which an optical storage element (1500) and a charged coupled device (CCD) are used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the optical storage element (1500). The optical storage element (1500) reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images. The optical storage element (1500) is contained in a sleeve (1504) which is inserted into the patient's mouth adjacent to the teeth to be imaged. A slip (1502) that absorbs the transmitted x-rays is also inserted into the sleeve (1504).
摘要翻译：一种用于光学存储元件（1500）和电荷耦合器件（CCD）的身体组织的光谱成像系统用于精确地图像所选择的组织。 x射线源产生通过被检体的区域的X射线，形成到达光存储元件（1500）的X射线图像。光学存储元件（1500）重新辐射对应于图像的空间强度图案，该图案由CCD传感器检测。图像由传感器数字化，并由控制器进行处理，然后作为电子图像存储。每个图像被引导到相关联的相应的CCD或非晶硅检测器上，以生成单独的图像的单独的电子表示。光学存储元件（1500）被容纳在与待成像的牙齿相邻的套筒（1504）中，套筒（1504）插入患者的口中。吸收透射的X射线的滑块（1502）也插入到套筒（1504）中。

6. 发明申请

WO1996005505A1 STRUCTURED SCINTILLATION SCREENS 审中-公开
标题翻译：结构化扫描屏
公开(公告)号：WO1996005505A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010392
申请日：1995-08-08
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： G01N23/083
CPC分类号： G01T1/202 , G21K4/00
摘要： A method for fabricating x-ray detecting structured screens using laser-based micro-machining techniques results in devices having improved spatial resolution. In one case, each pixel (74) of the screen contains an optically active scintillating material (72) surrounded with an optically inactive material (76) having a relatively lower refractive index; following absorption of light, each pixel (74) channels x-ray-induced phosphorescence to a small region of a detector. Alternatively, the optically active material (72) can be a photoconducting material, such as selenium, and the surrounding optically inactive material (76) is chosen to have a relatively high resistivity.
摘要翻译：使用基于激光的微加工技术制造x射线检测结构化屏幕的方法导致具有改善的空间分辨率的装置。在一种情况下，屏幕的每个像素（74）包含由具有相对较低折射率的光学惰性材料（76）包围的光学活性闪烁材料（72）在吸收光之后，每个像素（74）将x射线诱导的磷光通道传送到检测器的小区域。或者，光学活性材料（72）可以是诸如硒的光导材料，并且选择周围的光学非活性材料（76）以具有相对高的电阻率。

7. 发明申请

WO2013126296A1 APPARATUS AND METHOD FOR X-RAY PHASE CONTRAST IMAGING 审中-公开
标题翻译：用于X射线相位对比成像的装置和方法
公开(公告)号：WO2013126296A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/026530
申请日：2013-02-15
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL , VEDANTHAM, Srinivasan , KARELLAS, Andrew
发明人： VEDANTHAM, Srinivasan , KARELLAS, Andrew
IPC分类号： G01N23/04
CPC分类号： G01N23/20075 , A61B6/4035 , A61B6/4291 , A61B6/4452 , A61B6/484 , G01N23/04 , G01N2223/313 , G01N2223/6126 , G21K1/067 , G21K2201/067 , H05G1/30
摘要： An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer grating move as a single entity relative to an object of interest. The phase grating and the analyzer grating remain in fixed relative location and fixed relative orientation with respect to one another. The detected x-rays are converted to a time sequence of electrical signals. In some cases, the apparatus is controlled, and the electrical signals are analyzed by, by a general purpose programmable computer provided with instructions recorded on a machine readable medium. One or more x-ray phase contrast images of the object of interest are generated, and can be recorded or displayed.
摘要翻译：一种X射线相位成像装置及其操作方法。该装置将由X射线源产生的X射线依次传递给源光栅，感兴趣对象，相位光栅和分析器光栅。 X射线源，源光栅，相位光栅和分析器光栅相对于感兴趣对象移动为单个实体。相位光栅和分析器光栅相对于彼此保持固定的相对位置和固定的相对取向。检测到的x射线被转换成电信号的时间序列。在一些情况下，通过设置有记录在机器可读介质上的指令的通用可编程计算机来控制装置，并且电信号被分析。生成感兴趣对象的一个或多个X射线相位对比图像，并且可以被记录或显示。

8. 发明申请

WO2012106204A1 TOMOSYNTHESIS IMAGING 审中-公开
标题翻译： TOMOSYNTHESIS成像
公开(公告)号：WO2012106204A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/022936
申请日：2012-01-27
申请人： UNIVERSITY OF MASSACHUSETTS , VEDANTHAM, Srinivasan , KARELLAS, Andrew
发明人： VEDANTHAM, Srinivasan , KARELLAS, Andrew
IPC分类号： A61B6/03 , G01N23/087 , G01N23/04
CPC分类号： A61B6/022 , A61B6/025 , A61B6/0414 , A61B6/4007 , A61B6/4233 , A61B6/4291 , A61B6/502 , A61B6/5282
摘要： Systems and methods for providing radiographic, stereoscopic and tomographic images of an object of interest. Examples of objects of interest are body parts of living beings, such as the human breast and the human chest. The apparatus includes a high-fluence rate x-ray source and a plurality of satellite x-ray sources operating at lower fluence rate than the high-fluence rate source. A controller controls the operation and locations of the sources, and the operation of a detector. The method provides procedures in which the operation of the high-fluence source and the satellite sources are individually controlled as to location and orientation relative to the object of interest. In some operations, one satellite source may be operating while another satellite source may be repositioning. By proper control, a reduced x-ray dose and reduced operating time can be attained, thereby improving image quality, patient care, and patient experience.
摘要翻译：用于提供感兴趣对象的放射照相，立体和断层图像的系统和方法。感兴趣的对象的例子是生物的身体部位，例如人乳房和人体胸部。该装置包括高通量率x射线源和以比高通量率源更低注量率运行的多个卫星X射线源。控制器控制源的操作和位置以及检测器的操作。该方法提供了程序，其中高流量源和卫星源的操作被单独地控制为相对于感兴趣对象的位置和取向。在某些操作中，一个卫星源可能在运行，而另一个卫星源可能正在重新定位。通过适当的控制，可以实现减少的X射线剂量和减少的操作时间，从而提高图像质量，患者护理和患者体验。

9. 发明申请

WO03045246A3 X-RAY FLUOROSCOPIC IMAGING 审中-公开
标题翻译： X射线荧光成像
公开(公告)号：WO03045246A3
公开(公告)日：2003-08-28
申请号：PCT/US0237435
申请日：2002-11-21
申请人： UNIV MASSACHUSETTS MEDICAL , KARELLAS ANDREW , VEDANTHAM SRINIVASAN , SURYANARAYANAN SANKARARAMAN
发明人： KARELLAS ANDREW , VEDANTHAM SRINIVASAN , SURYANARAYANAN SANKARARAMAN
IPC分类号： A61B6/00 , H01L27/148 , H01L31/0232
CPC分类号： A61B6/504 , A61B6/481 , A61B6/482 , H01L27/14831 , H01L31/02322 , H04N5/32
摘要： A system for x-ray fluoroscopic imaging of bodily tissue in which a scintillation screen and a charge coupled device (CCD) is used to accurately image selected tissue. An x-ray source generates x-rays which pass through a region of a subject's body, forming an x-ray image which reaches the scintillation screen. The scintillation screen re-radiates a spatial intensity pattern corresponding to the image, the pattern being detected by the CCD sensor. In a preferred embodiment the imager uses four 8 x 8-cm three-side buttable CCDs coupled to a CsI:Tl scintillator by straight (non-tapering) fiberoptics and tiled to achieve a field of view (FOV) of 16 x 16-cm at the image plane. Larger FOVs can be achieved by tiling more CCDs in a similar manner. The imaging system can be operated in a plurality of pixel pitch modes such as 78,156 or 234- mu m pixel pitch modes. The CCD sensor may also provide multi-resolution imaging. The image is digitized by the sensor and processed by a controller before being stored as an electronic image. Other preferred embodiments may include each image being directed on flat panel imagers made from but not limited to, amorphous silicon and/or amorphous selenium to generate individual electronic representations of the separate images used for diagnostic or therapeutic applications.
摘要翻译：用于身体组织的X射线透视成像的系统，其中使用闪烁屏和电荷耦合器件（CCD）来精确地成像所选择的组织。 X射线源产生通过被检体的区域的X射线，形成到达闪烁屏的X射线图像。闪烁屏重新辐射与图像相对应的空间强度图案，该图案由CCD传感器检测。在一个优选实施例中，成像器使用四个8×8cm三边对照CCD，其通过直的（非锥形）光纤和平铺耦合到CsI：T1闪烁体，以实现16×16cm的视场（FOV）在图像平面。可以通过以类似方式平铺更多的CCD来实现更大的FOV。成像系统可以以多个像素间距模式操作，例如78,156或234μm像素间距模式。 CCD传感器还可以提供多分辨率成像。图像由传感器数字化，并由控制器进行处理，然后作为电子图像存储。其他优选实施例可以包括每个图像被引导到由但不限于非晶硅和/或非晶硒制成的平板成像器上，以产生用于诊断或治疗应用的单独图像的各个电子表示。

10. 发明申请

WO1996035372A2 A SYSTEM FOR QUANTITATIVE RADIOGRAPHIC IMAGING 审中-公开
标题翻译：一种量化放射成像系统
公开(公告)号：WO1996035372A2
公开(公告)日：1996-11-14
申请号：PCT/US1996006838
申请日：1996-05-13
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER , KARELLAS, Andrew
发明人： UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER
IPC分类号： A61B06/14
CPC分类号： H04N5/2253 , A61B5/0091 , A61B6/06 , A61B6/145 , A61B6/4035 , A61B6/405 , A61B6/4233 , A61B6/4241 , A61B6/4258 , A61B6/4291 , A61B6/4423 , A61B6/4488 , A61B6/502 , A61B6/505 , A61B6/508 , G21K1/10 , G21K4/00 , H04N5/32
摘要： A system for spectroscopic imaging of bodily tissue in which a scintillation screen (20) and a charged coupled device (24) (CCD) are used to accurately image selected tissue. An x-ray source (12) generates X-rays which pass through a region of a subject's body, forming an X-ray image which reaches the scintillation screen (10). The scintillation screen (20) reradiates a spatial intensity pattern corresponding to the image, the pattern being detected by a CCD sensor (24). The image is digitized by the sensor (24) and processed by a controller (30) before being stored as an electronic image. Each image is directed onto an associated respective CCD or amorphous silicon detector to generate individual electronic representations of the separate images.
摘要翻译：一种用于身体组织的光谱成像的系统，其中使用闪烁屏（20）和电荷耦合器件（24）（CCD）来精确地图像选择的组织。 X射线源（12）产生穿过被检体的区域的X射线，形成到达闪烁屏（10）的X射线图像。闪烁屏幕（20）重新辐射与图像相对应的空间强度图案，该图案由CCD传感器（24）检测。图像由传感器（24）数字化，并且在被存储为电子图像之前由控制器（30）处理。每个图像被引导到相关联的相应的CCD或非晶硅检测器上以产生单独的图像的单独的电子表示。

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