专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010045987A1 SUBSTITUTED (AZA) -1-METHYL-1H-QUIN0LIN-2-0NES AS ANTIBACTERIALS 审中-公开
标题翻译：取代（AZA）-1-甲基-1H-喹啉-2-酮作为抗菌剂
公开(公告)号：WO2010045987A1
公开(公告)日：2010-04-29
申请号：PCT/EP2008/065505
申请日：2008-11-13
申请人： GLAXO GROUP LIMITED , JONES, Graham, Elgin , MARKWELL, Roger, Edward , HENNESSY, Alan Joseph , MILES, Timothy , PEARSON, Neil David
发明人： JONES, Graham, Elgin , MARKWELL, Roger, Edward , HENNESSY, Alan Joseph , MILES, Timothy , PEARSON, Neil David
IPC分类号： C07D471/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04 , C07D513/04 , A61K31/4704 , A61P31/04
CPC分类号： C07D513/04 , C07D471/04 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04
摘要： Bicyclic nitrogen containing compounds and their use as antibacterials (Formula I).
摘要翻译：双环含氮化合物及其作为抗菌剂的用途（式I）。

2. 发明申请

WO2007115947A1 PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS 审中-公开
标题翻译：吡咯烷 - 喹喔啉酮衍生物作为抗菌剂
公开(公告)号：WO2007115947A1
公开(公告)日：2007-10-18
申请号：PCT/EP2007/053056
申请日：2007-03-29
申请人： GLAXO GROUP LIMITED , JONES, Graham, Elgin , MILES, Timothy, James , PEARSON, Neil, David
发明人： JONES, Graham, Elgin , MILES, Timothy, James , PEARSON, Neil, David
IPC分类号： C07D487/06 , A61K31/498 , A61P31/04
CPC分类号： C07D487/06
摘要： Tricyclic nitrogen containing compounds of the following Formula (I) and their use as antibacterials.
摘要翻译：下式（I）的三环氮化合物及其作为抗菌剂的用途。

3. 发明申请

WO2004002992A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2004002992A1
公开(公告)日：2004-01-08
申请号：PCT/EP2003/006756
申请日：2003-06-25
申请人： GLAXO GROUP LIMITED , AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
发明人： AXTEN, Jeffrey, Michael , DAINES, Robert, A. , DAVIES, David, Thomas , GALLAGHER, Timothy, Francis , JONES, Graham, Elgin , MILLER, William, Henry , PEARSON, Neil, David , PENDRAK, Israil
IPC分类号： C07D491/06
CPC分类号： C07D493/04 , C07D417/12 , C07D513/04
摘要： Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. A compound of formula (I) or a pharmaceutically acceptable derivative thereof: (I) R A is an optionally substituted bicyclic carbocyclic or heterocyclic ring system of structure: containing 0-3 heteroatmoms in each ring in which: at least one of the rings (x) and (y) is aromatic; one of Z 4 and Z 5 is C or N and the other is C; Z 3 is N, NR 13 , O, S(O) x , CO, CR 1 or CR 1 R 1a ; Z1 and Z2 are indendently a 2 or 3 atom linker group each atom of which is independently selected from N, NR 13 , O, S(O) x , CO, CR 1 , and CR 1 R 1a ; such that each ring is independently substituted with 0-3 groups R 1 and/or R 1a . R 4 is a group -CH 2 -R 5 1 in which R 5 1 is selected from: (C 4-8 ) alkyl; hydroxy (C 4-8 ) alkyl; (C 1-4 )alkoxy (C 4-8 )alkyl; (C 1-4 ) alkanoyloxy (C 4-8 ) alkyl; (C 3-8 )cycloalkyl (C 4-8 )alkyl;hydroxy-, (C 1-6 ) alkoxy- or (C 1-6 ) alkanoyloxy-(C 3-8 )cycloalkyl (C 4-8 )alkyl; cyano(C 4-8 )alkyl; (C 4-8 )alkenyl; (C 4-8 )alkynyl; tetrahydrofuryl; mono- or di-(C 1-6) alkylamino (C 4-8 )alkyl; acylamino (C 4-8 )alkyl; C( 1-6 )alkyl- or acyl-aminocarbonyl (C 4-8 ) alkyl; mono- or di- (C 1-6 )alkylamino(hydroxy) (C 4-8 )alkyl; or R 4 is a group-U-R 5 2 where R 5 2 is an optionally substituted bicyclic carbocyclic or heterocyclic ring system (A): containing up to four heteroatoms in each ring in which at least one of rings (a) and (b) is aromatic; X 1 is C or N when part of an aromatic ring or CR 14 when part of a non-aromatic ring.
摘要翻译：环己烷和环己烯衍生物及其药学上可接受的衍生物可用于治疗哺乳动物，特别是人的细菌感染的方法。式（I）化合物或其药学上可接受的衍生物：（I）R AA是任选取代的双环碳环或杂环体系，其结构为：在每个环中含有0-3个异质体，其中：至少一个环（x）和（y）是芳族的; Z 4和Z 5之一是C或N，另一个是C; Z 3为N，NR 13，O，S（O）x，CO，CR 1或CR 1 R 1a; Z1和Z2独立地是2或3个原子连接基团，其各自的原子独立地选自N，NR 13，O，S（O）x，CO，CR 1和CR 1 R 1a >; 使得每个环独立地被0-3个基团R 1和/或R 1a取代。 R 4是基团-CH 2 -R 5 1，其中R 5选自：（C 4-8）烷基; 羟基（C 4-8）烷基; （C 1-4）烷氧基（C 4-8）烷基; （C 1-4）烷酰氧基（C 4-8）烷基; （C 3-8）烷基;羟基 - ，（C 1-6）烷氧基 - 或（C 1-6）烷酰氧基 - （C 3-8）环烷基（C 4-8）烷基; 氰基（C 4-8）烷基; （C4-8）链烯基; （C4-8）炔基; 四氢呋喃; 单 - 或二 - （C 1-6）烷基氨基（C 4-8）烷基; 酰基氨基（C 4-8）烷基; C（1-6）烷基 - 或酰基 - 氨基羰基（C 4-8）烷基; 单 - 或二 - （C 1-6）烷基氨基（羟基）（C 4-8）烷基; 或R 4是基团UR 5，其中R 5是任选取代的双环碳环或杂环系统（A）：在每个环中含有至多四个杂原子，其中至少一个环（ a）和（b）是芳香族的; 当芳族环的一部分或非芳族环的一部分时，X 1为C或N。

4. 发明申请

WO1995021844A1 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES 审中-公开
标题翻译： 5HT2B受体拮抗剂浓缩吲哚
公开(公告)号：WO1995021844A1
公开(公告)日：1995-08-17
申请号：PCT/EP1995000427
申请日：1995-02-06
申请人： SMITHKLINE BEECHAM PLC , FORBES, Ian, Thomson , JONES, Graham, Elgin
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of formula (I) wherein: R , R , R and R are independently hydrogen or alkyl, or R and R together form a bond, or R and R or R and R together form a C alkylene chain, and n NOTEQUAL 5 2 or 3. Compounds of formula (I) have 5HTC2C receptor antagonist activity, and certain compounds are potential 5HT2B antagonists. Compounds of the invention are believed to be of potential use in the treatment of CNS disorders such as anxiety, depression, epilepsy, obsessive compulsive disorders, migraine, Alzheimer's disease, sleep disorders, feeding disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia, and also disorders associated with spinal trauma and/or head injury such as hydrocephalus. Compounds of the invention are also expected to be of use in the treatment of certain GI disorders such as IBS as well as microvascular diseases such as macular oedema retinopathy.
摘要翻译：式（I）化合物其中：R 2，R 3，R 10和R 11独立地是氢或烷基，或R 10和R 11一起形成键，或R 式（I）化合物具有5HTC2C受体拮抗剂活性，其中R 1，R 2，R 3，R 3，R 3和R 11一起形成C 2-6亚烷基链，某些化合物是潜在的5HT2B拮抗剂。认为本发明的化合物在治疗CNS疾病如焦虑，抑郁，癫痫，强迫症，偏头痛，阿尔茨海默氏病，睡眠障碍，喂食障碍如厌食症和贪食症，惊恐发作，急性发作药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类，精神分裂症，以及与脊髓损伤和/或头部损伤（如脑积水）相关的疾病。也预期本发明的化合物可用于治疗某些GI病症如IBS以及微血管疾病如黄斑水肿视网膜病变。

5. 发明申请

WO2003087098A1 NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS 审中-公开
标题翻译：含氮的双环杂环化合物作为抗生素使用
公开(公告)号：WO2003087098A1
公开(公告)日：2003-10-23
申请号：PCT/EP2002/005708
申请日：2002-05-24
申请人： SMITHKLINE BEECHAM P.L.C. , BROOKS, Gerald , DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
发明人： BROOKS, Gerald , DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
IPC分类号： C07D471/04
CPC分类号： C07D401/12 , C07D405/12 , C07D417/12 , C07D471/04 , C07D491/04 , C07D513/04
摘要： Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.
摘要翻译：环己烷和环己烯衍生物及其药学上可接受的衍生物可用于哺乳动物，特别是人的细菌感染治疗方法。

6. 发明申请

WO1996023783A1 INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST 审中-公开
标题翻译：作为5-HT受体拮抗剂的吲哚衍生物
公开(公告)号：WO1996023783A1
公开(公告)日：1996-08-08
申请号：PCT/EP1996000368
申请日：1996-01-26
申请人： SMITHKLINE BEECHAM PLC , GASTER, Laramie, Mary , WYMAN, Paul, Adrian , MULHOLLAND, Keith, Raymond , DAVIES, David, Thomas , DUCKWORTH, David, Malcom , FORBES, Ian, Thomson , JONES, Graham, Elgin
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： The invention relates to heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders such as anxiety.
摘要翻译：本发明涉及具有药理活性的杂环化合物，其制备方法，含有它们的组合物及其在治疗CNS疾病如焦虑症中的用途。

7. 发明申请

WO1995001976A1 INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS 审中-公开
标题翻译：吲哚衍生物作为5HT2C拮抗剂
公开(公告)号：WO1995001976A1
公开(公告)日：1995-01-19
申请号：PCT/EP1994002148
申请日：1994-06-30
申请人： SMITHKLINE BEECHAM PLC , HAM, Peter , JONES, Graham, Elgin , FORBES, Ian, Thomson
发明人： SMITHKLINE BEECHAM PLC
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D413/12
摘要： A compound of formula (I) or a salt thereof, wherein: P represents phenyl, a quinoline or isoquinoline residue, or a 5-membered or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; R is hydrogen, C1-6 alkyl, halogen, CF3, NR R or OR where R , R and R are independently hydrogen, C1-6 alkyl or arylC1-6alkyl; R is hydrogen or C1-6 alkyl; R is C1-6 alkyl; n is 0 to 3; m is 0 to 4; and R groups are independently C1-6 alkyl optionally substituted by one or more halogen atoms, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 cycloalkylC1-6 alkyl, C1-6 alkylthio, C3-6cycloalkylthio, C3-6 cycloalkylC1-6 alkylthio, halogen, nitro, CF3, OCF3, SCF3, SO2CF3, SO2F, formyl, C2-6 alkanoyl, cyano, optionally substituted phenyl or thienyl, NR R , CONR R , or OR where R , R and R are as defined for R , CO2R where R is hydrogen or C1-6 alkyl. The compounds have 5HT2C receptor antagonist activity. Certain compounds of the invention also exhibit 5HT2B antagonist activity. 5HT2C/2B receptor antagonists are believed to be of potential use in the treatment of CNS disorders.
摘要翻译：式（I）化合物或其盐，其中：P表示苯基，喹啉或异喹啉残基或含有至多三个选自氮，氧或硫的杂原子的5元或6元芳族杂环; R 1是氢，C 1-6烷基，卤素，CF 3，NR 7 R 8或OR 9，其中R 7，R 8和R 9独立地是氢，C1- 6烷基或芳基C 1-6烷基; R 2是氢或C 1-6烷基; R 3是C 1-6烷基; n为0〜3; m为0〜4; R 4基团独立地为任选被一个或多个卤素原子取代的C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基，C 3-6环烷基C 1-6烷基，C 1-6烷硫基，C 3 C6环烷基硫基，C 3-6环烷基C 1-6烷硫基，卤素，硝基，CF 3，OCF 3，SCF 3，SO 2 CF 3，SO 2 F，甲酰基，C 2-6烷酰基，氰基，任选取代的苯基或噻吩基，NR 7 R 8，CONR R 7，或OR 9，其中R 7，R 8和R 9如对R 1，CO 2 R 10所定义，其中R 10是氢或C1 -6烷基。该化合物具有5HT2C受体拮抗剂活性。本发明的某些化合物还表现出5HT2B拮抗剂活性。据信5HT2C / 2B受体拮抗剂在治疗CNS疾病方面具有潜在的用途。

8. 发明申请

WO2010046388A1 SUBSTITUTED (AZA) -1-METHYL-1H-QUINOLIN-2-ONES AS ANTIBACTERIALS 审中-公开
标题翻译：取代（AZA）-1-甲基-1H-喹啉-2-酮作为抗生素
公开(公告)号：WO2010046388A1
公开(公告)日：2010-04-29
申请号：PCT/EP2009/063789
申请日：2009-10-21
申请人： GLAXO GROUP LIMITED , HENNESSY, Alan, Joseph , JONES, Graham Elgin , MARKWELL, Roger Edward , MILES, Timothy , PEARSON, Neil, David
发明人： HENNESSY, Alan, Joseph , JONES, Graham Elgin , MARKWELL, Roger Edward , MILES, Timothy , PEARSON, Neil, David
IPC分类号： C07D471/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04 , C07D513/04 , A61K31/4704 , A61P31/04
CPC分类号： C07D513/04 , C07D471/04 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04
摘要： Bicyclic nitrogen containing compounds and their use as antibacterials.
摘要翻译：双环含氮化合物及其作为抗菌剂的用途。

10. 发明申请

WO2003010138A3 PIPERIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
公开(公告)号：WO2003010138A3
公开(公告)日：2003-02-06
申请号：PCT/EP2002/008319
申请日：2002-07-25
申请人： SMITHKLINE BEECHAM PLC , DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
发明人： DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
IPC分类号： C07D471/04
摘要： Piperidine derivatives (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. Formula (I):

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式