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1. 发明申请

WO2016081679A1 HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF 审中-公开
标题翻译：异氟醚化合物作为IRAK抑制剂及其用途
公开(公告)号：WO2016081679A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061463
申请日：2015-11-19
申请人： MERCK PATENT GMBH , JORAND-LEBRUN, Catherine , JONES, Reinaldo , WON, Annie Cho , NGUYEN, Ngan , JOHNSON, Theresa L. , DESELM, Lizbeth Celeste , PANDA, Kausik
发明人： JORAND-LEBRUN, Catherine , JONES, Reinaldo , WON, Annie Cho , NGUYEN, Ngan , JOHNSON, Theresa L. , DESELM, Lizbeth Celeste , PANDA, Kausik
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D417/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P19/02 , A61P13/02 , A61P43/00 , C07D451/14 , C07D487/04
CPC分类号： C07D451/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D451/14 , C07D487/04
摘要： The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, useful as IRAK inhibitors.
摘要翻译：本发明涉及可用作IRAK抑制剂的式I化合物或其药学上可接受的盐。

2. 发明申请

WO2014159234A1 GLYCOSIDASE INHIBITORS 审中-公开
标题翻译：甘氨酸酶抑制剂
公开(公告)号：WO2014159234A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/022630
申请日：2014-03-10
申请人： MERCK PATENT GMBH , YU, Henry , LIU-BUJALSKI, Lesley , JOHNSON, Theresa L.
发明人： YU, Henry , LIU-BUJALSKI, Lesley , JOHNSON, Theresa L.
IPC分类号： C07D471/04 , C12Q1/34
CPC分类号： C07D417/06 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/498 , C07D277/46 , C07D413/06 , C07D417/14 , G01N33/6893
摘要： Compounds of formula (I) wherein X 1 , X 2 , W, R 1 to R 5 , L and m have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.
摘要翻译：其中X1，X2，W，R1至R5，L和m具有根据权利要求所述含义的式（I）化合物是葡糖苷酶抑制剂，并且可以用于治疗阿尔茨海默氏病。

3. 发明申请

WO2014093230A2 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY 审中-公开
标题翻译：用BTK抑制活性生产吡嗪和吡啶化合物的组合物和方法
公开(公告)号：WO2014093230A2
公开(公告)日：2014-06-19
申请号：PCT/US2013/073895
申请日：2013-12-09
申请人： MERCK PATENT GMBH , LIU-BUJALSKI, Lesley , JOHNSON, Theresa L. , GOUTOPOULOS, Andreas , QIU, Hui
发明人： LIU-BUJALSKI, Lesley , JOHNSON, Theresa L. , GOUTOPOULOS, Andreas , QIU, Hui
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/14 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D413/12 , C07D495/04 , C07D213/68 , A61K31/506 , A61K31/513 , A61K31/505 , A61K31/5377 , A61K31/4418 , A61P35/00 , A61P35/02
CPC分类号： C07D403/12 , A61K31/4418 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/12 , C07D413/14 , C07D471/08 , C07D471/10 , C07D487/10 , C07D495/04
摘要： The present invention provides novel pyrimidine and pyridine compounds which are attached to a warhead, and the manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. The invention also describes kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译：本发明提供附着于弹头的新型嘧啶和吡啶化合物，以及用于治疗过度增殖性疾病的制造和用途，包括但不限于癌症，狼疮，过敏性疾病，干燥病和类风湿性关节炎。本发明还描述了激酶抑制剂，包括但不限于Bruton酪氨酸激酶的抑制剂。

4. 发明申请

WO2011140330A2 AN AEROSOL SHAVE COMPOSITION COMPRISING A HYDROPHOBICAL AGENT FORMING AT LEAST ONE MICRODROPLET 审中-公开
标题翻译：包含形成最少一个微孔的疏水剂的气溶胶组合物
公开(公告)号：WO2011140330A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035347
申请日：2011-05-05
申请人： GILLETTE CO , ALWATTARI ALI ABDELAZIZ , HOLDEN MARCIA J , DECKNER GEORGE ENDEL , JOHNSON THERESA LOUISE , CORNELIUS VICTORIA LYNN
发明人： ALWATTARI ALI ABDELAZIZ , HOLDEN MARCIA J , DECKNER GEORGE ENDEL , JOHNSON THERESA LOUISE , CORNELIUS VICTORIA LYNN
IPC分类号： A61K8/06
CPC分类号： A61K8/046 , A61K8/062 , A61K8/068 , A61K8/31 , A61K8/891 , A61K2800/21 , A61Q9/02
摘要： An aerosol shave composition, preferably a post foaming shave gel, comprising a hydrophobic agent, such as a silicone, in the form of a microdroplet having a particle size from about 0.15 microns to about 10 microns.
摘要翻译：气溶胶刮刮组合物，优选是后发泡剃须凝胶，其包含具有约0.15微米至约10微米粒度的微滴形式的疏水剂，例如硅氧烷。

5. 发明申请

WO2011139669A1 PERSONAL CARE PRODUCT DISPENSER 审中-公开
标题翻译：个人护理产品分销商
公开(公告)号：WO2011139669A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/033884
申请日：2011-04-26
申请人： THE GILLETTE COMPANY , GROH, David, Matthew , JOHNSON, Theresa, Louise , CHAN, John, Geoffrey , O'BRIEN, Lawrence, Edward
发明人： GROH, David, Matthew , JOHNSON, Theresa, Louise , CHAN, John, Geoffrey , O'BRIEN, Lawrence, Edward
IPC分类号： B65D83/00 , B65D83/14
CPC分类号： B65D83/0061 , B65D83/285
摘要： A device for dispensing a personal care product onto skin comprising: a brush head (906) comprising a base and a plurality of bristles, and a device body operatively connected to said brush head (900) about said base, said device body comprising: an outer container (500); an at least partially expanded collapsible bag (418) disposed in the outer container (500), an elastic member (14) surrounding at least a portion of the collapsible bag (418) such that the elastic member (14) is stretched axially and radially, the elastic member (14) being constructed of an elastically extensible material that permits the transfer of infrared radiation through at least a portion of the elastic member (14); at least one fluid dispensing conduit (926) in fluid communication with said collapsible bag (418), extending through said base.
摘要翻译：一种用于将个人护理产品分配到皮肤上的装置，包括：包括基部和多个刷毛的刷头（906），以及围绕所述基部可操作地连接到所述刷头（900）的装置主体，所述装置主体包括：外容器（500）; 设置在所述外部容器（500）中的至少部分膨胀的可折叠袋（418），围绕所述可折叠袋（418）的至少一部分的弹性构件（14），使得所述弹性构件（14）被轴向和径向地拉伸，所述弹性构件（14）由可弹性延伸的材料构成，所述材料允许红外辐射通过所述弹性构件（14）的至少一部分传递; 与所述可折叠袋（418）流体连通的至少一个流体分配管道（926）延伸穿过所述底座。

6. 发明申请

WO2009124049A1 PACKAGE FOR DISPENSING A PERSONAL CARE PRODUCT 审中-公开
标题翻译：用于分配个人护理产品的包装
公开(公告)号：WO2009124049A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/038953
申请日：2009-03-31
申请人： THE PROCTER & GAMBLE COMPANY , GROH, David, Matthew , JOHNSON, Theresa, Louise , SCHENNUM, Steven , MCKEON, Thomas , ABEL, Jeremy
发明人： GROH, David, Matthew , JOHNSON, Theresa, Louise , SCHENNUM, Steven , MCKEON, Thomas , ABEL, Jeremy
IPC分类号： A45D34/04 , A45D27/04 , A46B11/00
CPC分类号： A46B11/00 , A45D27/04 , A45D34/042 , A45D2200/055 , A45D2200/056 , A46B2200/1033
摘要： A package for dispensing a liquid personal care product, the package comprising: a body for grasping with a user's hand; an applicator comprising an applicator base and a skin-contacting portion extending from the applicator base to a first height; a dispensing conduit through which a liquid personal care product is dispensable from the body, wherein the dispensing conduit comprises a proximal end and a distal end, wherein the proximal end comprises an inlet that is in fluid communication with the body, wherein the distal end extends from the applicator base to a second height that is less than the first height; and a flow-restricting member associated with the dispensing conduit.
摘要翻译：一种用于分配液体个人护理产品的包装，所述包装包括：用户用手抓握的主体; 涂抹器，其包括施用器基部和从所述施用器基部延伸到第一高度的皮肤接触部分; 液体个人护理产品通过所述分配导管从身体是不可分配的，其中所述分配导管包括近端和远端，其中所述近端包括与所述主体流体连通的入口，其中所述远端延伸从所述施用器基座到达小于所述第一高度的第二高度; 以及与分配管道相关联的流动限制构件。

7. 发明申请

WO2008099343A1 SHAVING SYSTEM 审中-公开
标题翻译：剃须系统
公开(公告)号：WO2008099343A1
公开(公告)日：2008-08-21
申请号：PCT/IB2008/050507
申请日：2008-02-12
申请人： THE GILLETTE COMPANY , JOHNSON, Theresa, Louise
发明人： JOHNSON, Theresa, Louise
IPC分类号： B26B21/22 , B26B21/40 , B26B21/44 , A45D27/22
CPC分类号： B26B21/40 , A45D27/22 , B26B21/405 , B26B21/44
摘要： A shaving system including a handle (11), a first head (12) and a second head (13). The handle includes' a power source (17) and a head attachment member (15). The first head (12) includes a rotating member (32) The rotating member (32) comprises an abrasive surface. (33) for scrubbing away dirt and dead skin. The first head (12) is attachable to the handle (11) by the head attachment member (15)-. The power source (17) supplies power to the first head (12) to rotate the rotating member (32). The second head (13) includes a plurality of razor blades (44). The second head (13) is attachable to the handle (11) by the head attachment member (15).
摘要翻译：一种剃须系统，包括手柄（11），第一头部（12）和第二头部（13）。手柄包括电源（17）和头部附接构件（15）。第一头部（12）包括旋转构件（32）。旋转构件（32）包括研磨表面。（33）用于擦洗污垢和死皮。第一头部（12）通过头部附接构件（15）可附接到手柄（11）。电源（17）向第一磁头（12）供电以旋转旋转部件（32）。第二头部（13）包括多个剃刀刀片（44）。第二头部（13）通过头部附接构件（15）附接到手柄（11）。

8. 发明申请

WO2006135884A8 ASSORTMENT OF PERSONAL CARE PRODUCTS HAVING SYNERGISTIC IDENTIFIERS COMMUNICATING PRODUCTS TO BE PURCHASED TOGETHER 审中-公开
标题翻译：具有协同标识符的个人护理产品的交付通讯产品将被收购
公开(公告)号：WO2006135884A8
公开(公告)日：2008-06-19
申请号：PCT/US2006022999
申请日：2006-06-13
申请人： PROCTER & GAMBLE , SCAVONE TIMOTHY ALAN , JOHNSON THERESA LOUISE , THOMAS MICHAEL EDWARD
发明人： SCAVONE TIMOTHY ALAN , JOHNSON THERESA LOUISE , THOMAS MICHAEL EDWARD
IPC分类号： B65D25/20
CPC分类号： A61Q5/00 , A61K8/02 , A61K2800/59 , A61K2800/88 , A61Q15/00 , B65D25/205 , G06Q10/103

9. 发明申请

WO2012170976A2 COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY 审中-公开
标题翻译：用BTK抑制活性生产吡嗪和吡啶化合物的组合物和方法
公开(公告)号：WO2012170976A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041803
申请日：2012-06-10
申请人： MERCK PATENT GMBH , HODOUS, Brian L. , LIU-BUJALSKI, Lesley , JONES, Reinaldo , BANKSTON, Donald , JOHNSON, Theresa L. , MOCHALKIN, Igor , NGUYEN, Ngan , QIU, Hui , GOUTOPOULOS, Andreas , BRUGGER, Nadia
发明人： HODOUS, Brian L. , LIU-BUJALSKI, Lesley , JONES, Reinaldo , BANKSTON, Donald , JOHNSON, Theresa L. , MOCHALKIN, Igor , NGUYEN, Ngan , QIU, Hui , GOUTOPOULOS, Andreas , BRUGGER, Nadia
IPC分类号： C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D213/68 , C07D213/73 , C07D213/74 , C07D413/14 , C07D495/04 , A61K31/506 , A61K31/513 , A61K31/505 , A61K31/5377 , A61K31/4418 , A61P35/00 , A61P35/02
CPC分类号： A61K31/69 , A61K31/44 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/10 , C07D495/04 , C07F5/022
摘要： The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译：本发明提供了式（I），式（II），式（III），式（IV）和式（V））的新型嘧啶和吡啶化合物用于治疗过度增殖性疾病的制造和用途，包括但不限于癌症，狼疮，过敏性疾病，干燥病和类风湿性关节炎。在优选的实施方案中，本发明描述不可逆激酶抑制剂，包括但不限于Bruton酪氨酸激酶的抑制剂。

10. 发明申请

WO2012162491A1 BRUSH FOR USE WITH A COMPOSITION 审中-公开
标题翻译：用于组合物的刷子
公开(公告)号：WO2012162491A1
公开(公告)日：2012-11-29
申请号：PCT/US2012/039326
申请日：2012-05-24
申请人： THE GILLETTE COMPANY , STURGIS, Thomas Arthur , FRANCKHAUSER, Andrew William , JOHNSON, Theresa Louise , SMITH, Evan Lloyd , TSE, Leonard Lik-Hang
发明人： STURGIS, Thomas Arthur , FRANCKHAUSER, Andrew William , JOHNSON, Theresa Louise , SMITH, Evan Lloyd , TSE, Leonard Lik-Hang
IPC分类号： A46B9/02 , A46B11/00 , A46B5/00
CPC分类号： A46B5/0095 , A46B9/02 , A46B11/001
摘要： A brush suitable for use as part of a product dispensing container which includes various characteristics which provide desirable product performance during use.
摘要翻译：适用于产品分配容器的一部分的刷子，其包括在使用期间提供期望的产品性能的各种特性。

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