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1. 发明申请

WO2017053462A1 SYSTEMS AND METHODS FOR LIVE HELP 审中-公开
标题翻译：用于现场帮助的系统和方法
公开(公告)号：WO2017053462A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/052930
申请日：2016-09-21
申请人： INTEGENX INC.
发明人： KING, David , PARK, Chungsoo Charles
IPC分类号： G06F3/00
CPC分类号： G06F9/453
摘要： A live help system provides an intuitive display of help information on a user's graphical user interface. A request is received from a client device for help, and a live help provider interface is initiated at a live help location. Data is acquired regarding a user's location, including data on external devices in the user's location. Indicators are provided to allow the live help provider to point to or otherwise indicate items on the user interface or outside of the user interface. Live help input is captured at the live help provider interface. Instructions are then transmitted to the display of the client device to display live help input, as though the agent were present and interacting with or indicating items on the screen or off the screen.
摘要翻译：实时帮助系统可以直观显示用户图形用户界面上的帮助信息。从客户端设备收到请求以获取帮助，并在现场帮助位置启动实时帮助提供程序接口。获取有关用户位置的数据，包括用户位置中外部设备的数据。提供指示器以允许实时帮助提供者指向或以其他方式指示用户界面上或用户界面外的项目。在线帮助提供者接口捕获实时帮助输入。然后将指令发送到客户端设备的显示器，以显示实时帮助输入，就像代理人存在并与屏幕上的项目或屏幕上的项目进行交互或指示。

2. 发明申请

WO2011011172A1 MICROFLUIDIC DEVICES AND USES THEREOF 审中-公开
标题翻译：微流体装置及其用途
公开(公告)号：WO2011011172A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/040490
申请日：2010-06-29
申请人： INTEGENX, INC. , STERN, Seth , BOGDAN, Greg
发明人： STERN, Seth , BOGDAN, Greg
IPC分类号： C12M1/34
CPC分类号： B01L3/502738 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L2200/025 , B01L2300/1822 , B01L2400/0481
摘要： The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification.
摘要翻译：本发明提供用于将微芯片连接到墨盒和气动歧管的装置和方法。墨盒，微芯片和气动歧管的设计可以允许使用磁力来捕获形成在微芯片和墨盒之间的腔室中的磁珠或微芯片内的腔室。本发明的装置可用于mRNA的扩增和纯化。

3. 发明申请

WO2018217789A2 COMPOSITIONS, METHODS, KITS AND DEVICES FOR MOLECULAR ANALYSIS 审中-公开
公开(公告)号：WO2018217789A2
公开(公告)日：2018-11-29
申请号：PCT/US2018/033939
申请日：2018-05-22
申请人： INTEGENX INC.
发明人： MACK, Scott , BARRON, Annelise
IPC分类号： G01N27/447 , B01J20/285
摘要： Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C.

4. 发明申请

WO2016205428A1 VALVED CARTRIDGE AND SYSTEM 审中-公开
标题翻译：阀门和系统
公开(公告)号：WO2016205428A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/037711
申请日：2016-06-15
申请人： INTEGENX INC.
发明人： WUNDERLE, Philip, Justus , PARK, Chungsoo, Charles , KING, David , LEHTO, Dennis
IPC分类号： G01N27/447 , B01L3/00 , F16K7/00 , F16K7/16 , F16K99/00 , G01N27/26
CPC分类号： C12Q1/6874 , B01F13/0059 , B01F13/02 , B01L3/502738 , B01L3/502753 , B01L7/52 , B01L2200/04 , B01L2200/0668 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/043 , B01L2400/0478 , B01L2400/0655 , C12Q1/686 , F16K99/0015 , F16K99/0034 , F16K2099/0078 , F16K2099/0084
摘要： This disclosure provides, among other things, a cartridge comprising: (a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel; and (b) a layer comprising a deformable material bonded to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve; wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment and wherein the deformable material covering the at least one valve body retains sufficient elasticity after deformation such that in a ground state the valve is open. Also disclosed is an instrument comprising a cartridge interface and a cartridge as described herein engaged with the cartridge interface.
摘要翻译：本公开尤其提供了一种盒，其包括：（a）包括可延展材料的盒体，并且具有设置在主体表面上的至少一个阀体，其包括阀入口和阀出口，每个阀体流体连接到流体通道; 和（b）包含结合到所述盒体表面的可变形材料并且在附接点处密封所述至少一个阀体从而形成至少一个阀的层; 其中所述至少一个阀体相对于所述连接点在所述盒体中被压下，并且其中覆盖所述至少一个阀体的所述可变形材料在变形之后保持足够的弹性，使得在基础状态下所述阀是打开的。还公开了一种包括如本文所述的盒接口和盒与盒接口接合的仪器。

5. 发明申请

WO2015179098A1 FLUIDIC CARTRIDGE WITH VALVE MECHANISM 审中-公开
标题翻译：具有阀门机构的流体盘
公开(公告)号：WO2015179098A1
公开(公告)日：2015-11-26
申请号：PCT/US2015/028510
申请日：2015-04-30
申请人： INTEGENX INC.
发明人： EBERHART, David , NIELSEN, William, D. , FRANKLIN, Helen , JOVANOVICH, Stevan, B. , LEHTO, Dennis , CHEAR, Kaiwan , KING, David , KLEVENBERG, James , PARK, Chungsoo, Charles , SMITH, Corey , WUNDERLE, Philip, Justus
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0681 , B01L2300/0848 , B01L2300/087 , B01L2300/123 , B01L2400/0406 , B01L2400/0478 , C12Q1/686 , G01N27/44743 , G01N27/44791 , C12Q1/6846 , C12Q2565/629
摘要： Provided herein is a fluidic cartridge having a body comprising a malleable material and a layer comprising a deformable material bonded to a surface of the body that seals one or more fluidic channels that communicate with one or more valve bodies formed in a surface of the body. The valve can be closed by applying pressure to the deformable material sufficient to crush and close off a fluidic channel in the body. Also provided are a cartridge interface configured to engage the cartridge. Also provided is a system including a cartridge interface and methods of using the cartridge and system.
摘要翻译：本文提供了一种流体盒，其具有包括可延展材料的主体和包含结合到主体表面的可变形材料的层，所述可变形材料密封与形成在主体表面中的一个或多个阀体连通的一个或多个流体通道。可以通过向可变形材料施加足够的压力来关闭阀门，以压缩和关闭体内的流体通道。还提供了构造成接合盒的盒接口。还提供了包括盒式接口和使用盒和系统的方法的系统。

6. 发明申请

WO2013130910A1 SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEMS 审中-公开
标题翻译：样品制备，处理和分析系统
公开(公告)号：WO2013130910A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028462
申请日：2013-02-28
申请人： INTEGENX INC. , EBERHART, David , LI, Yuan , OGG, James , VAN GELDER, Ezra , WILLIAMS, Stephen, J. , WOUDENBERG, Timothy , BURGI, Dean, S. , NIELSEN, William, D.
发明人： EBERHART, David , LI, Yuan , OGG, James , VAN GELDER, Ezra , WILLIAMS, Stephen, J. , WOUDENBERG, Timothy , BURGI, Dean, S. , NIELSEN, William, D.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , B01L3/502715 , B01L7/52 , B01L2200/04 , B01L2200/0684 , B01L2200/10 , B01L2200/16 , B01L2300/0861 , B01L2300/123 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2400/0478 , B01L2400/0616 , B01L2400/0655 , B01L2400/0683 , C12Q1/686 , C12Q2565/629
摘要： This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
摘要翻译：本公开提供了一种集成且自动化的样本到回答系统，其从包含生物材料的样本开始，在不到两个小时内生成遗传图谱。在某些实施方案中，生物材料是DNA并且遗传谱涉及确定受试者的一个或多个基因座（例如遗传基因座）处的等位基因，例如STR（短串联重复序列）分布，例如如在 CODIS系统。该系统可以执行多种操作，包括（a）提取和分离核酸; （b）扩增选定基因座的核苷酸序列（例如遗传基因座）; 和（c）扩增产物的检测和分析。这些操作可以在包含几个集成模块的系统中执行，包括分析物准备模块; 一个检测和分析模块以及一个控制模块。

7. 发明申请

WO2012024658A3 INTEGRATED ANALYSIS SYSTEM 审中-公开
标题翻译：综合分析系统
公开(公告)号：WO2012024658A3
公开(公告)日：2012-05-31
申请号：PCT/US2011048528
申请日：2011-08-20
申请人： INTEGENX INC , JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
发明人： JOVANOVICH STEVAN B , STERN SETH , VAN GELDER EZRA , VANGBO MATTIAS
IPC分类号： C12Q1/70 , B01F3/00 , B01J19/00 , G01N1/00
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，库构建，扩增和测序。集成分析可以在一个或多个流体连接的模块中进行。一个或多个模块可以由计算机控制和/或自动化。可以对组织样品，临床样品或环境样品进行综合分析。集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。

8. 发明申请

WO2012024658A2 INTEGRATED ANALYSIS SYSTEM 审中-公开
标题翻译：综合分析系统
公开(公告)号：WO2012024658A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/048528
申请日：2011-08-20
申请人： INTEGENX, INC. , JOVANOVICH, Stevan, B. , STERN, Seth , VAN GELDER, Ezra , VANGBO, Mattias
发明人： JOVANOVICH, Stevan, B. , STERN, Seth , VAN GELDER, Ezra , VANGBO, Mattias
IPC分类号： C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
摘要： The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
摘要翻译：本发明提供用于执行综合分析的系统，设备，方法和套件。综合分析可以包括样品处理，文库构建，扩增和测序。综合分析可以在彼此流体连接的一个或多个模块内执行。一个或多个模块可以由计算机控制和/或自动化。综合分析可以在组织样本，临床样本或环境样本上进行。综合分析系统可以有一个紧凑的格式，并在指定的时间内返回结果。

9. 发明申请

WO2018217816A1 COMPOSITIONS, METHODS, KITS AND DEVICES FOR MOLECULAR ANALYSIS 审中-公开
公开(公告)号：WO2018217816A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033972
申请日：2018-05-22
申请人： INTEGENX INC. , LIFE TECHNOLOGIES CORPORATION
发明人： LIU, Jen-Kuei , SOLANKI, Bharti , WENZ, Hans Michael , MERCER, Frank , AKIN, Cevat , KARGER, Achim , BARRON, Annelise , MACK, Scott
IPC分类号： G01N27/447
摘要： Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C. Also provided herein are sieving compositions, including polymer-based sieving compositions, for molecular sieving as well as related kits, devices and methods of use. Such compositions can be useful for separation of biomolecules such as nucleic acids, proteins, glycoproteins and glycans.

10. 发明申请

WO2018217789A3 COMPOSITIONS, METHODS, KITS AND DEVICES FOR MOLECULAR ANALYSIS 审中-公开
公开(公告)号：WO2018217789A3
公开(公告)日：2018-11-29
申请号：PCT/US2018/033939
申请日：2018-05-22
申请人： INTEGENX INC.
发明人： MACK, Scott , BARRON, Annelise
IPC分类号： G01N27/447 , B01J20/285
摘要： Provided herein is an electrophoresis separation medium comprising: (a) a non-crosslinked or sparsely cross-linked polymer or copolymer; (b) one or more denaturant compounds, in an amount sufficient to inhibit re-naturation of single stranded polynucleotides; (c) an aqueous solvent; (d) optionally, a wall-coating material suited to inhibition of electroosmotic flow; and (e) optionally, an organic water miscible solvent such as DMSO or acetonitrile, wherein the electrophoresis separation medium exhibits functional stability for at least seven days at 23° C.

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