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1. 发明申请

WO2017066619A1 TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE OR NON-ALCOHOLIC STEATOHEPATITIS WITH DELAYED-RELEASE 6-MERCAPTOPURINE 审中-公开
标题翻译：治疗非酒精性脂肪肝肝炎或非酒精性肝炎肝炎及延迟释放6-巯基嘌呤
公开(公告)号：WO2017066619A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/057111
申请日：2016-10-14
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , ILAN, Yaron , HAYDEN, Michael , ROMAN, Doina, Cosma , AMIT-ROMACH, Einat
发明人： ILAN, Yaron , HAYDEN, Michael , ROMAN, Doina, Cosma , AMIT-ROMACH, Einat
IPC分类号： A61K9/16 , A61K9/22 , A61K31/522 , A61K31/52
CPC分类号： A61K31/52 , A61K9/0053 , A61K9/20 , A61K9/2846 , A61K45/06
摘要： Methods of treating patients suffering from non-alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepaiitis (NASH), including those also suffering from type II diabetes mellitus (T2DM), with a delayed release pharmaceutical composition comprising 6-mercaptopurine are disclosed.
摘要翻译：治疗患有非酒精性脂肪肝疾病（NAFLD）和非酒精性脂肪性肝炎（NASH）的患者的方法，所述患者包括也患有II型糖尿病（T2DM）的那些患者，以延迟释放药物组合物包括6-巯基嘌呤。

2. 发明申请

WO2011061743A1 METADOXINE AND DERIVATIVES THEREOF FOR USE IN THE TREATMENT OF INFLAMMATION AND IMMUNE-RELATED DISORDERS 审中-公开
标题翻译：用于治疗感染和免疫相关疾病的代谢物及其衍生物
公开(公告)号：WO2011061743A1
公开(公告)日：2011-05-26
申请号：PCT/IL2010/000969
申请日：2010-11-18
申请人： ALCOBRA LTD. , ILAN, Yaron , YAMIN, Rina , LALAZAR, Gadi , BEN-YA'ACOV, Ami
发明人： ILAN, Yaron , YAMIN, Rina , LALAZAR, Gadi , BEN-YA'ACOV, Ami
IPC分类号： A61K9/00 , A61K31/40 , A61K31/4425 , A61K31/45 , A61K31/55 , A61P37/00 , A61P37/06 , A61P9/10 , A61P29/00 , A61P3/06
CPC分类号： A61K31/45 , A61K31/40 , A61K31/4425 , A61K31/55 , A61K2300/00
摘要： The invention provides to the use of metadoxine and derivatives thereof in the treatment of inflammatory and immune-related disorders.
摘要翻译：本发明提供了使用替多他辛及其衍生物治疗炎症和免疫相关疾病。

3. 发明申请

WO2010125565A2 ANTI-LPS ENRICHED IMMUNOGLOBULIN PREPARATION FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF A PATHOLOGIC DISORDER 审中-公开
标题翻译：抗LPS增强的免疫球蛋白制剂用于治疗和/或预防病理学疾病的预防
公开(公告)号：WO2010125565A2
公开(公告)日：2010-11-04
申请号：PCT/IL2010/000339
申请日：2010-04-27
申请人： HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , ILAN, Yaron , LALAZAR, Gadi , ADAR, Tomer , MIZRAHI, Meir , BEN-YA'ACOV, Ami
发明人： ILAN, Yaron , LALAZAR, Gadi , ADAR, Tomer , MIZRAHI, Meir , BEN-YA'ACOV, Ami
IPC分类号： C07K16/04 , C07K16/12 , A61K39/395 , A61K35/20 , G01N33/68 , C07K16/26
CPC分类号： A61K39/39508 , A61K2039/505 , A61K2039/507 , C07K16/04 , C07K16/1232 , C07K16/26 , C07K2317/12
摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.
摘要翻译：本发明涉及富含抗LPS抗体的制剂的使用，例如衍生自哺乳动物初乳或禽卵的那些制剂，以及任选的抗疾病相关抗原，初乳，乳或乳制品组分的任何其它抗体以及任何用于治疗，延缓或预防慢性肝病，肝硬化以及与之相关的任何并发症或紊乱等病理疾病的进展。本发明还涉及组合的组合物，其包含抗LPS富集的抗体制剂和识别至少一种对病理学病症特异性的抗原的抗体的组合及其在治疗免疫相关疾病中的用途。

4. 发明申请

WO2009074985A2 METHOD AND SYSTEM FOR DETECTION OF PRE-FAINTING AND OTHER CONDITIONS HAZARDOUS TO THE HEALTH OF A PATIENT 审中-公开
标题翻译：检测预防和危及患者健康的其他条件的方法和系统
公开(公告)号：WO2009074985A2
公开(公告)日：2009-06-18
申请号：PCT/IL2008001600
申请日：2008-12-10
申请人： HADASIT MED RES SERVICE , BEN-OREN ILAN , ILAN YARON
发明人： BEN-OREN ILAN , ILAN YARON
IPC分类号： A61B5/16
CPC分类号： A61B5/024 , A61B5/01 , A61B5/021 , A61B5/026 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61B5/4094 , A61B5/4261 , A61B5/4839 , A61B5/7275 , G16H40/63 , G16H50/20 , G16H50/50
摘要： The invention is a method and system for the detection and warning of the presence of pre-fainting and other conditions that are hazardous to the health of a patient having one or more types of disease or disorder. A wide range of physiological and physical parameters are monitored and at least two of the monitored parameters are logically and/or mathematically combining to form a function that is used to determine the value of a new parameter called the risk parameter alpha. The parameters that appear in the function are selected according to the patient's known pathological condition. An initial threshold value for alpha based on known normal values of the monitored parameters as determined by statistical studies is determined. The current value of alpha, defined as alpha(t), is determined from the function and compared to the initial value of alpha. If the comparison shows that there exists danger of the onset of a pre-fainting and/or other medically hazardous condition a warning signal is emitted. The values of alpha and the terms and parameters that comprise the function used to determine alpha(t) are continually determined and, if relevant, updated according to the history of the patient. In preferred embodiments of the invention self learning techniques are used to update the values of alpha and the function.
摘要翻译：本发明是用于检测和警告对具有一种或多种类型的疾病或病症的患者的健康有害的预晕化和其它状况的检测和警告的方法和系统。监测范围广泛的生理和物理参数，并且所监视的参数中的至少两个在逻辑上和/或数学上组合以形成用于确定称为风险参数α的新参数的值的函数。根据患者已知的病理状况选择功能中出现的参数。确定基于通过统计学研究确定的所监测参数的已知正常值的α的初始阈值。 α的当前值，定义为α（t），从该函数确定并与α的初始值进行比较。如果比较表明存在发生预晕和/或其他医疗危险状况的危险，则发出警告信号。 α和包含用于确定α（t）的函数的术语和参数的值是不断确定的，并且如果相关的话根据患者的病史更新。在本发明的优选实施例中，使用自学习技术来更新α和功能的值。

5. 发明申请

WO2007138574A3 MONITORING RESPONSIVENESS TO AND SCREENING FOR THERAPEUTIC COMPOUNDS THAT MODULAT COMPOSITION AND STRUCTURE OF CELL MEMBRANES 审中-公开
标题翻译：监测调节组合物和细胞膜结构的治疗化合物的反应和筛选
公开(公告)号：WO2007138574A3
公开(公告)日：2009-04-23
申请号：PCT/IL2007000633
申请日：2007-05-24
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A61K31/7028 , C12Q1/02 , G01N33/53
CPC分类号： G01N33/5047
摘要： The present invention relates to modulation of structure and composition of cell membranes by a given therapeutic compound, preferably, a ß-glycolipid and thereby to modulation and treatment of pathologic disorders. More particularly, the invention relates to the use of modulation of structure and composition of immune cell membranes by a candidate therapeutic compound as a diagnostic marker for prediction and monitoring of response to treatment. The invention further provides a method of screening for substances which modulate the structure and composition of cell membranes, as well as compositions and methods using the substances identified by the screening method of the invention, for the treatment of pathologic disorders.
摘要翻译：本发明涉及通过给定的治疗化合物，优选β-糖脂调节细胞膜的结构和组成，从而调节和治疗病理性疾病。更具体地，本发明涉及通过候选治疗化合物调节免疫细胞膜的结构和组成的用途，作为对治疗反应的预测和监测的诊断标记。本发明还提供了筛选调节细胞膜的结构和组成的物质的方法，以及使用通过本发明的筛选方法鉴定的物质用于治疗病理性疾病的组合物和方法。

6. 发明申请

WO2017002104A1 DEVICES FOR GASTROINTESTINAL STIMULATION AND USES THEREOF 审中-公开
标题翻译：胃肠道刺激装置及其用途
公开(公告)号：WO2017002104A1
公开(公告)日：2017-01-05
申请号：PCT/IL2016/050666
申请日：2016-06-22
申请人： ILAN, Yaron
发明人： ILAN, Yaron
IPC分类号： A61N1/36
CPC分类号： A61H23/02 , A61F7/00 , A61F7/12 , A61F2007/0022 , A61F2007/0093 , A61F2007/0094 , A61F2007/0095 , A61F2007/0228 , A61H9/0078 , A61H11/00 , A61H15/00 , A61H23/004 , A61H23/0218 , A61H2011/005 , A61H2015/0042 , A61H2023/0209 , A61H2201/0103 , A61H2201/0207 , A61H2201/0214 , A61H2201/0228 , A61H2201/1207 , A61H2201/1628 , A61H2201/165 , A61H2201/1685 , A61H2201/5007 , A61H2201/501 , A61H2201/5012 , A61H2201/5035 , A61H2201/5082 , A61H2205/02 , A61H2205/04 , A61H2205/06 , A61H2205/083 , A61H2230/08 , A61H2230/70 , A61H2230/705 , A61H2230/80 , A61H2230/805 , A61N1/0509 , A61N1/36007 , A61N1/36053 , A61N1/36139 , A61N1/3756 , A61N2/006
摘要： A gastrointestinal stimulation devices including a random stimulation delivery mechanism(s), configured to provide stimuli to a bodily tissue in a vicinity of the stimulation capsule, the provided random stimuli being characterized by a stimulation parameter, and a control circuitry in communication with said physical stimulation delivery mechanism, and configured to set and alter the stimulation parameter non- systematically, thereby altering the characterization of the stimuli provided to the bodily tissue. The algorithm may be patient tailored, and may have a learning machinery which responds to data being received from the patient.
摘要翻译：包括随机刺激递送机制的胃肠刺激装置，其被配置为向刺激胶囊附近的身体组织提供刺激，所提供的随机刺激的特征在于刺激参数，以及控制电路，与所述物理刺激递送机构，并且被配置为非系统地设置和改变刺激参数，从而改变提供给身体组织的刺激的表征。算法可以是患者定制的，并且可以具有对从患者接收的数据进行响应的学习机器。

7. 发明申请

WO2012017435A3 SOYBEAN EXTRACTS FOR THE TREATMENT OF HEPATIC DISORDERS 审中-公开
标题翻译：大豆提取物治疗肝脏疾病
公开(公告)号：WO2012017435A3
公开(公告)日：2016-05-19
申请号：PCT/IL2011000632
申请日：2011-08-04
申请人： HADASIT MED RES SERVICE , ILAN YARON
发明人： ILAN YARON
IPC分类号： A23J1/14 , A61K36/00 , C07K1/00 , C07K14/00
CPC分类号： A61K36/48 , A61K31/167
摘要： The invention provides methods and uses of different soybean extracts, for example, enzymatic, hexane, ethanol or aqueous soybean extracts and combinations thereof for the treatment of hepatic disorders, drug induced hepatic injury, the Metabolic Syndrome or an immune-related disorder in a subject in need thereof. The invention further provides pharmaceutical compositions, kits and methods thereof for treating and preventing hepatic disorders.
摘要翻译：本发明提供不同大豆提取物的方法和用途，例如酶促，己烷，乙醇或水性大豆提取物及其组合，用于治疗受试者的肝脏疾病，药物诱导的肝损伤，代谢综合征或免疫相关疾病需要它。本发明还提供了用于治疗和预防肝脏疾病的药物组合物，试剂盒及其方法。

8. 发明申请

WO2012171077A1 METHOD AND COMPOSITION FOR TREATMENT OR INHIBITION OF MUCOSITIS ASSOCIATED WITH CHEMOTHERAPY OR RADIATION DAMAGE 审中-公开
标题翻译：用于治疗或抑制与化疗或放射性损伤相关的粘液病的方法和组合物
公开(公告)号：WO2012171077A1
公开(公告)日：2012-12-20
申请号：PCT/AU2012/000700
申请日：2012-06-18
申请人： IMMURON LIMITED , RAWLIN, Grant, Thomas , ROBINS-BROWNE, Roy, Michael , ILAN, Yaron
发明人： RAWLIN, Grant, Thomas , ROBINS-BROWNE, Roy, Michael , ILAN, Yaron
IPC分类号： C07K16/02 , C07K16/04 , C07K16/12 , A61K35/20 , A61K35/54 , A61K39/02 , A61K39/40 , A61P1/04
CPC分类号： C07K16/1203 , A61K35/00 , A61K39/02 , A61K39/025 , A61K39/40 , A61K2039/505 , C07K2317/12 , A61K2300/00
摘要： This invention relates to a method of treatment or inhibition of the development of alimentary mucositis arising from chemotherapy or radiation damage, to a composition for use in such treatment, to the use of such composition in manufacture of a medicament for treatment or inhibition of the development of alimentary mucositis arising from chemotherapy or radiation damage. In particular the invention is directed to treatment of alimentary mucositis arising from chemotherapy or exposure to radiation, including cancer therapy.
摘要翻译：本发明涉及一种治疗或抑制由化学疗法或辐射损伤引起的消化性粘膜炎发展的方法，用于这种治疗的组合物，以及在制备用于治疗或抑制发展的药物中的用途的化疗或放射性损伤引起的消化性粘膜炎。特别地，本发明涉及治疗由化学疗法或暴露于辐射引起的消化性粘膜炎，包括癌症治疗。

9. 发明申请

WO2012023051A3 ANTI-LPS ENRICHED IMMUNOGLOBULIN PREPARATION FOR USE IN TREATMENT AND/OR PROPHYLAXIS OF A PATHOLOGIC DISORDER 审中-公开
标题翻译：抗LPS丰富的免疫球蛋白制剂用于治疗和/或预防病理性疾病
公开(公告)号：WO2012023051A3
公开(公告)日：2012-04-26
申请号：PCT/IB2011002596
申请日：2011-08-17
申请人： IMMURON LTD , ADAR TOMER , MIZRAHI MEIR , LALAZAR GADI , ILAN YARON , BEN-YA ACOV AMI
发明人： ADAR TOMER , MIZRAHI MEIR , LALAZAR GADI , ILAN YARON , BEN-YA ACOV AMI
IPC分类号： A61K39/02 , C07K16/04 , C07K16/20
CPC分类号： A61K39/40 , A61K2039/505 , C07K16/1203 , C07K2317/12
摘要： Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.
摘要翻译：治疗包括肝功能障碍在内的病症的方法和组合物，例如与脂肪肝相关的; 葡萄糖不耐症; 通过施用包含富含抗LPS免疫球蛋白的初乳制剂的组合物。

10. 发明申请

WO2011135544A3 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS WITH ANTI-CD3 IMMUNE MOLECULE THERAPY 审中-公开
标题翻译：用抗CD3免疫分子治疗乙型肝炎的方法和组合物
公开(公告)号：WO2011135544A3
公开(公告)日：2012-01-05
申请号：PCT/IB2011051900
申请日：2011-04-29
申请人： NASVAX LTD , HADASIT MEDICAL RES SERVICE AND DEV CO LTD , ILAN YARON , ELLIS RONALD
发明人： ILAN YARON , ELLIS RONALD
IPC分类号： C07K16/28 , A61P1/16
CPC分类号： A61K39/3955 , A61K2039/505 , A61K2039/541 , C07K16/2809
摘要： A method or composition comprising an anti-CD3 immune molecule for treatment of hepatitis in a subject.
摘要翻译：一种包含用于治疗受试者的肝炎的抗CD3免疫分子的方法或组合物。

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