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1. 发明申请

WO2012175587A3 CRYSTALLINE CEFOPERAZONE INTERMEDIATE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL USE THEREOF 审中-公开
标题翻译：晶体蛋白酶中间体，其制备方法及其药物应用
公开(公告)号：WO2012175587A3
公开(公告)日：2013-03-28
申请号：PCT/EP2012061912
申请日：2012-06-21
申请人： DSM SINOCHEM PHARM NL BV , MOODY HAROLD MONRO , CUSAN CLAUDIA , IJPEIJ EDWIN GERARD
发明人： MOODY HAROLD MONRO , CUSAN CLAUDIA , IJPEIJ EDWIN GERARD
IPC分类号： C12P35/04 , A61K31/545 , A61P31/04 , C07D501/24
CPC分类号： C07D501/24 , A61K31/545 , C12P35/04
摘要： The present invention relates to a crystalline form of an intermediate for cefoperazone of formula (1 ) and to a process for the preparation thereof by enzymatic condensation of a 3'-thiosubstituted beta-lactam nucleus with a phenylglycine derivative.
摘要翻译：本发明涉及式（1）的头孢哌酮的中间体的结晶形式，以及通过3'-取代的β-内酰胺核与苯基甘氨酸衍生物的酶缩缩来制备其的方法。

2. 发明申请

WO2009121374A1 SUSPENSION OF CATALYST COMPONENTS 审中-公开
标题翻译：悬浮催化剂组分
公开(公告)号：WO2009121374A1
公开(公告)日：2009-10-08
申请号：PCT/EP2008/002536
申请日：2008-03-31
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard
发明人： IJPEIJ, Edwin, Gerard
IPC分类号： C08F4/659 , C08F10/00
CPC分类号： C08F10/00 , C08F4/65908
摘要： A method for feeding a catalyst component for polymerization of an olefin in a diluent continuously to a reactor, wherein the diluent has a density D with 0.9 p C p C , wherein p c is the average density of the catalyst component, which is at least 1000 kg/m 3 .
摘要翻译：一种将烯烃在稀释剂中连续聚合到催化剂中的催化剂组分的方法，其中稀释剂具有0.9p Cp C的密度D，其中pc是催化剂组分的平均密度，其至少为1000kg /立方米。

3. 发明申请

WO2005090418A1 POLIMERIZATION CATALYST COMPRISING AN AMIDINE LIGAND 审中-公开
标题翻译：包含AMIDINE LIGAND的POLIMERIZATION催化剂
公开(公告)号：WO2005090418A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/002812
申请日：2005-03-14
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard , WINDMULLER, Peter, Jozef, Hubert , ARTS, Henricus, Johannes , VAN DER BURGT, Francis , VAN DOREMAELE, Gerardus, Henricus, Josephus , ZUIDEVELD, Martin, Alexander
发明人： IJPEIJ, Edwin, Gerard , WINDMULLER, Peter, Jozef, Hubert , ARTS, Henricus, Johannes , VAN DER BURGT, Francis , VAN DOREMAELE, Gerardus, Henricus, Josephus , ZUIDEVELD, Martin, Alexander
IPC分类号： C08F10/00
CPC分类号： C08F10/00 , C08F4/65908 , C08F4/65912 , C08F210/18 , C08F236/20 , C08F2420/04 , C08F4/6592 , C08F210/06 , C08F2500/25 , C08F2500/03 , C08F2500/17
摘要： The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C 2-20 olefin in the presence of an ionic catalyst, comprising an organometallic compound and an activator, and optionally a scavenger, characterized in that the organometallic compound is a compound according to formula (1): where: M is a metal of group 3, 4, 5, 6 or 7, or the lanthanide series, and p is the valency of the metal M, A represents a neutral or anionic spectator ligand whose valency v is 0, 1 or 2, and q is an integer denoting the number of spectator ligands A, Z is an optional bridging moiety, n is the integer number of parallel bridging moieties Z, Y is an amidine-containing spectator ligand represented by formula (2): wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, Sub 1 is a substituent, which comprises a group 14 atom through which Sub 1 is bonded to the imine carbon atom. Sub 2 is a substituent, which comprises a heteroatom of group 15-16, through which Sub 2 is bonded to the imine carbon atom, r is an integer > 0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, and X is an anionic ligand. The invention further relates to a organometallic compound according to formula (1) and a process for the preparation of this compound as well as to a UHMWPE having a weight average molecular weight of at least 4.000 kg/mol and a molecular weight distribution M w /M n of less than 2.6.
摘要翻译：本发明涉及一种在离子催化剂存在下制备包含至少一种脂族或芳族烃基C 2-20烯烃的聚合物的方法，所述离子催化剂包含有机金属化合物和活化剂，以及任选的清除剂，其特征在于有机金属化合物是根据式（1）的化合物：其中：M是第3,4,5,6或7族的金属或镧系，p是金属M的化合价，A代表中性或阴离子观察配体，其价态v为0,1或2，q为表示观察配体A数的整数，Z为任选的桥接部分，n为平行桥连部分Z的整数，Y为含脒的旁观者由式（2）表示的配位体：其中含脒配体通过亚胺氮原子与金属M共价结合，Sub1为取代基，其包含Sub1与亚胺碳原子键合的14族原子。 Sub2是一个取代基，它包含15-16的杂原子，Sub2与亚氨基碳原子键合，r是大于0的整数，L是任选的中性路易斯碱性配体，j是一个整数，中性配体L和X是阴离子配体。本发明还涉及式（1）的有机金属化合物和该化合物的制备方法以及重均分子量至少为4.000kg / mol，分子量分布Mw / Mn的UHMWPE 小于2.6。

4. 发明申请

WO2005014665A1 PROCESS FOR THE PREPARATION OF A METALLOORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND 审中-公开
标题翻译：制备包含至少一个IMINE LIGAND的金属化合物的方法
公开(公告)号：WO2005014665A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008714
申请日：2004-08-03
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo
发明人： IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo
IPC分类号： C08F4/64
CPC分类号： C08F10/00 , C07F7/00 , C07F7/28 , C07F7/30 , C07F9/00 , C07F9/5355 , C07F17/00 , C07F19/00 , C08F4/65908 , C08F4/6592 , C08F210/06 , C08F210/16 , C08F2420/04 , C08F2500/17
摘要： The invention relates to a process for the preparation of a metalorganic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula 1, or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 in the presence of at least 1, respectively 2 equivalents of an inorganic or metal-organic base, wherein Y=N-R (formula 1), Y is selected from a substituted carbon, nitrogen or phosphorous atom, R represents a proton, a protic or an aprotic substituent, and the metal organic compound is: M v (L 1 ) k (L 2 ) I (L 3 ) m (L 4 ) n X (formula 2) wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L 1 , L 2 , L 3 , and L 4 represent ligands on M and may be equal or different, X represents a group 17 halogen atom, and k, 1, m, n = 0, 1, 2, 3, 4 with k+l+m+n+l =V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor.
摘要翻译：本发明涉及一种制备金属有机化合物的方法，该方法包括至少一种亚胺配体，其特征在于，具有式1的亚胺配体或其HA加合物，其中HA代表酸，其中H代表其质子和A的共轭碱在至少1个分别为2当量的无机或金属有机碱（其中Y = NR（式1））存在下与式2的金属有机试剂接触，Y选自取代的碳，氮或磷原子，R表示质子，质子或非质子取代基，金属有机化合物为：M（（L1）k（L2）I（L3）m（L4）nX 2）其中：M表示第4族或第5族金属离子，V表示金属离子的化合价，为3,4或5，L1，L2，L3和L4表示M上的配体，可以相同或不同， X表示17族卤素原子，k，1，m，n = 0,1,2,3,4，其中k + 1 + m + n + 1 = V。本发明还涉及通过制备根据本发明方法的金属 - 有机化合物来制备聚烯烃的方法，其中所述碱是烯烃聚合相容性碱，所述金属 - 有机化合物在任何地方或之前被活化聚合反应器。

5. 发明申请

WO2004003030A1 CATALYST COMPOSITION FOR OLEFIN POLYMERIZATION 审中-公开
标题翻译：烯烃聚合催化剂组合物
公开(公告)号：WO2004003030A1
公开(公告)日：2004-01-08
申请号：PCT/NL2003/000472
申请日：2003-06-26
申请人： DSM IP ASSETS B.V. , SABIC POLYPROPYLENES B.V. , SABIC POLYETHYLENES B.V. , FRIEDERICHS, Nicolaas, Hendrika , IJPEIJ, Edwin, Gerard , MUELLER, Adrian, Gallus , SCHOTTENBERGER, Herwig , WANG, Bing , WURST, Klaus
发明人： FRIEDERICHS, Nicolaas, Hendrika , IJPEIJ, Edwin, Gerard , MUELLER, Adrian, Gallus , SCHOTTENBERGER, Herwig , WANG, Bing , WURST, Klaus
IPC分类号： C08F10/00
CPC分类号： C07F3/003 , C08F4/65927 , C08F10/00 , C08F110/02 , C08F110/06 , C08F210/16 , C08F4/65908 , C08F4/80 , C08F2500/03 , C08F2500/01 , C08F2500/04 , C08F210/06
摘要： The invention relates to a catalyst composition comprising a salt of a non- or weakly coordinating anion, said non- or weakly coordinating anion comprising at least one metal or metalloid ion M with valency v+, v representing an integer between 1 and 5, and at least one bidentate ligand coordinating to this metal or metalloid ion, and a catalyst that can be activated by said non- or weakly coordinating anion, characterized in that said bidentate ligand is a bidentate monoanionic ligand of formula (I): (R 1 q A 1 -X-A 2 R 2 r ), wherein X represents a bridging moiety; A 1 and A 2 are each independently chosen from the group comprising N, O, P, S, and C; R 1 and R 2 are each independently chosen from the group comprising an optionally substituted linear or branched (hetero)alkyl group, an optionally substituted (hetero)aryl group, and a Si containing group; and q and r each independently represent an integer with 0 ≤ q,r ≤ 2.
摘要翻译：本发明涉及包含非配位或弱配位阴离子盐的催化剂组合物，所述非配位阴离子或弱配位阴离子包含至少一种价态v +的金属或准金属离子M，v表示1和5之间的整数，与该金属或准金属离子配位的至少一个二齿配体和可由所述非配位或弱配位阴离子活化的催化剂，其特征在于所述二齿配位体是式（I）的二齿单阴离子配位体：（R 1） qA 1 -XA 2 R 2 r），其中X表示桥连部分; A 1和A 2各自独立地选自N，O，P，S和C; R 1和R 2各自独立地选自包含任选取代的直链或支链（杂）烷基，任选取代的（杂）芳基和含Si基团; q和r各自独立地表示0 <= q，r <= 2的整数。

6. 发明申请

WO2011104333A1 COMPOSITION FOR OXIDATION OF ORGANIC SUBSTRATES 审中-公开
标题翻译：用于氧化有机基质的组合物
公开(公告)号：WO2011104333A1
公开(公告)日：2011-09-01
申请号：PCT/EP2011/052805
申请日：2011-02-25
申请人： DSM IP Assets B.V. , BROWNE, Wesley Richard , ALSTERS, Paulus Lambertus , SUMMEREN VAN, Ruben Petrus , IJPEIJ, Edwin Gerard , BOER, Johannes Wietse , SAISAHA, Pattama , PIJPER, Dirk , FERINGA, Bernard Lucas
发明人： BROWNE, Wesley Richard , ALSTERS, Paulus Lambertus , SUMMEREN VAN, Ruben Petrus , IJPEIJ, Edwin Gerard , BOER, Johannes Wietse , SAISAHA, Pattama , PIJPER, Dirk , FERINGA, Bernard Lucas
IPC分类号： C07B33/00 , C07D213/127 , C07D309/30
CPC分类号： C07B33/00 , C07C45/294 , C07C45/33 , C07C51/285 , C07D213/127 , C07D309/30 , C07C49/403 , C07C47/45 , C07C49/413 , C07C49/67 , C07C63/06
摘要： The invention relates to a composition comprising a soluble source of manganese, a ligand, a base, hydrogen peroxide and a ketone or an aldehyde, wherein the ligand is a pyridine heterocycle containing carboxylic acid or a precursor thereof, wherein the nitrogen atom of the pyridine ring is capable of coordinating to the carboxylate bonded manganese center, wherein the 2-position relative to the nitrogen atom is part of the N(pyridine)-Mn-O(carboxylate) containing chelate ring and the second 2-position relative to the nitrogen atom in the ring is not a carboxylic acid group. Furthermore, the invention relates to a process for oxidation of an organic substrate using the composition of the invention.
摘要翻译：本发明涉及包含锰，配体，碱，过氧化氢和酮或醛的可溶性源的组合物，其中配体是含有羧酸或其前体的吡啶杂环，其中吡啶的氮原子环可以配位到羧酸键合的锰中心，其中相对于氮原子的2-位是含有N（吡啶）-Mn-O（羧酸酯）的螯合环的一部分，而相对于氮的第二个2-位是环中的原子不是羧酸基团。此外，本发明涉及使用本发明的组合物氧化有机底物的方法。

7. 发明申请

WO2008151776A1 IMINE CATALYST 审中-公开
标题翻译：动物催化剂
公开(公告)号：WO2008151776A1
公开(公告)日：2008-12-18
申请号：PCT/EP2008/004626
申请日：2008-06-10
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard
发明人： IJPEIJ, Edwin, Gerard
IPC分类号： C08F10/00 , C08F4/64
CPC分类号： C08F10/00 , C08F210/06 , C08F2420/04 , C08F4/65908 , C08F4/65922 , C08F210/18 , C08F236/20 , C08F2500/25 , C08F210/16
摘要： The invention relates to a process for the preparation of a polyolefin wherein said process is being performed in the presence of a one component imine catalyst system according a single component catalyst system of formula (1), wherein Cp is a cyclopentadienyl comprising ligand, N=Y is an anionic imine ligand chosen from the group of phosphinimine, amidine, iminoimidazolidine, or ketimide, M is Ti, Zr, or Hf, and X is Cl, Br, or I, Z is a borate anion and further in the presence of a scavenger, that is able to exchange the X group of the catalyst of the present invention with an hydrocarbyl group of said scavenger.
摘要翻译：本发明涉及一种制备聚烯烃的方法，其中所述方法是在单组分亚胺催化剂体系存在下，按照式（1）的单组分催化剂体系进行的，其中Cp是含有配体的环戊二烯基，N = Y是选自次膦亚胺，脒，亚氨基咪唑烷或酮亚胺的阴离子亚胺配体，M为Ti，Zr或Hf，X为Cl，Br或I，Z为硼酸根阴离子，一种清除剂，其能够将X族本发明的催化剂与所述清除剂的烃基交换。

8. 发明申请

WO2007071317A1 ZWITTERIONIC GUANIDINE CATALYST 审中-公开
标题翻译： ZWITTERICIC GUANIDINE催化剂
公开(公告)号：WO2007071317A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/011639
申请日：2006-12-05
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard , ZUIDEVELD, Martin, Alexander , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus
发明人： IJPEIJ, Edwin, Gerard , ZUIDEVELD, Martin, Alexander , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus
IPC分类号： C08F4/76 , C08F10/00 , C07F7/28
CPC分类号： C07F7/006 , C08F4/65916 , C08F10/00 , C08F4/16 , C08F4/76 , C08F4/659 , C08F4/64113
摘要： The invention relates to an organometallic compound according to formula (I), wherein M is a group 4 metal with valency v, with v being 3 or 4, preferably Ti, Y p is a monoanionic guanidine ligand with p ≥ 1, X m is an anionic ligand with m = ≥ 1, with m = v - p - 1 , and m being the number of anionic ligands and Q r is a coordinating ligand which is a Lewis base with r ≥ 0 being the number of ligands, and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 can be chosen independently from hydrogen atoms and optionally substituted alkyl or aryl groups having 1 to 20 carbon atoms. The invention further relates to the use of the compound according to Formula (I) as a catalyst for the preparation of polyolefins.
摘要翻译：本发明涉及一种根据式（I）的有机金属化合物，其中M是价态v的第4族金属，v为3或4，优选Ti，Y 1是单阴离子胍配体， p = 1，X m是具有m = = 1的阴离子配体，m = v-p-1，m是阴离子配体的数量和Q 是配位配体，其是具有r = 0的配位体数目的路易斯碱，R 1，R 2，R 3， R 4，R 5，R 6，R 7，R 8和R 8和 R 9可以独立于氢原子和任选取代的具有1至20个碳原子的烷基或芳基选择。本发明还涉及根据式（I）的化合物作为制备聚烯烃的催化剂的用途。

9. 发明申请

WO2005014666A1 PROCESS FOR THE PREPARATION OF A METAL-ORGANIC COMPOUND COMPRISING AT LEAST ONE IMINE LIGAND 审中-公开
标题翻译：制备包含至少一个IMINE LIGAND的金属有机化合物的方法
公开(公告)号：WO2005014666A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008844
申请日：2004-08-03
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo , VAN DER BURGT, Francis , ZUIDEVELD, Martin, Alexander
发明人： IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo , VAN DER BURGT, Francis , ZUIDEVELD, Martin, Alexander
IPC分类号： C08F4/64
CPC分类号： C08F10/00 , C07F7/00 , C07F7/28 , C07F7/30 , C07F9/00 , C07F9/5355 , C07F17/00 , C07F19/00 , C08F4/65908 , C08F4/6592 , C08F210/06 , C08F210/16 , C08F2420/04 , C08F2500/17
摘要： A process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula (1) or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula (2) in the presence of at least 1, respectively at least 2 equivalents of a base, with Y=N-R as formula (1), wherein Y is selected from a substituted carbon, or nitrogen atom and R represents a substituent, and with M v (L 1 )k(L 2 )I(L 3 )m(L 4 )n X as formula (2), wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L 1 , L 2 , L 3 , and L 4 represent a ligand or a group 17 halogen atom on M and may be equal or different, X represents a group 17 halogen atom, k, I, m, n = 0, 1, 2, 3, 4 with k+l+m+n+l=V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal- organic compound is activated anywhere in, or before a polymerisation reactor.
摘要翻译：一种制备包含至少一种亚胺配体的金属 - 有机化合物的方法，其特征在于根据式（1）的亚胺配体或其HA加合物，其中HA表示酸，其中H表示其质子，将其共轭碱与式（2）的金属有机试剂在至少1个分别具有至少2当量的碱，Y = NR的式（1）的存在下接触，其中Y选自取代的碳或氮原子，R表示取代基，M为（Ⅴ）（L1）k（L2）I（L3）m（L4）nⅩ，其中：M表示基团 4或5族金属离子，V表示金属离子的化合价，为3,4或5，L1，L2，L3和L4表示M上的配位体或17族卤素原子，可以相同或不同，X 代表17族卤素原子，k，I，m，n = 0,1,2,3,4，其中k + 1 + m + n + 1 = V。本发明还涉及通过制备根据本发明方法的金属 - 有机化合物来制备聚烯烃的方法，其中所述碱是烯烃聚合相容性碱，该金属 - 有机化合物在任何地方或之前被活化聚合反应器。

10. 发明申请

WO2005014601A2 PROCESS FOR THE PREPARATION OF A POLYOLEFIN 审中-公开
标题翻译：制备聚烯烃的方法
公开(公告)号：WO2005014601A2
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008709
申请日：2004-08-03
申请人： DSM IP ASSETS B.V. , IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo , VAN DER BURGT, Francis , ZUIDEVELD, Martin, Alexander
发明人： IJPEIJ, Edwin, Gerard , ARTS, Henricus, Johannes , VAN DOREMAELE, Gerardus, Henricus, Josephus , BEIJER, Felix, Hugo , VAN DER BURGT, Francis , ZUIDEVELD, Martin, Alexander
IPC分类号： C07F
CPC分类号： C08F10/00 , C07F7/00 , C07F7/28 , C07F7/30 , C07F9/00 , C07F9/5355 , C07F17/00 , C07F19/00 , C08F4/65908 , C08F4/6592 , C08F210/06 , C08F210/16 , C08F2420/04 , C08F4/65912 , C08F4/64044 , C08F2500/17
摘要： The invention related to a process for the polymerization of at least one aliphatic or aromatic hydrocarbyl C2-20 mono- or multiolefin in the presence of a catalyst and a boron comprising co-catalyst, wherein the catalyst comprises a composition of a metal-organic reagent, a spectator ligand and optionally at least one equivalent of a hydrocarbylating agent. The invention further relates to a polymer obtainable by the process of the invention.
摘要翻译：本发明涉及在催化剂和含硼助催化剂的存在下聚合至少一种脂族或芳族烃基C2-20单烯或多烯烃的方法，其中催化剂包含金属 - 有机试剂，旁观者配体和任选的至少一当量的烃基化剂。本发明还涉及可通过本发明的方法获得的聚合物。

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