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    • 1. 发明申请
    • (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY
    • (4,4-DIFLUOROBUT-3-ENYLTHIO) - 具有杀虫活性的杂环化合物或碳环化合物
    • WO1995024403A1
    • 1995-09-14
    • PCT/GB1995000400
    • 1995-02-27
    • ZENECA LIMITEDTURNBULL, Michael, DrysdaleBANSAL, Harjinder, SinghSMITH, Alison, MarySALMON, RogerFITZJOHN, StevenGODFREY, Christopher, Richard, AylesHOTSON, Matthew, BrianSILLARS, Nan, CatherineDOWLING, Alan, John
    • ZENECA LIMITED
    • C07D307/64
    • C07D213/70A01N33/22A01N43/08A01N43/10A01N43/40A01N43/50A01N43/54A01N43/56A01N43/58A01N43/64A01N43/66A01N43/707A01N43/713A01N43/74A01N43/80A01N43/82C07C17/087C07C17/23C07C323/09C07D213/71C07D213/80C07D213/82C07D213/85C07D231/18C07D231/28C07D231/30C07D233/86C07D233/90C07D233/92C07D237/18C07D237/30C07D241/18C07D241/44C07D251/22C07D253/04C07D253/07C07D253/075C07D253/10C07D257/04C07D261/10C07D261/18C07D263/34C07D263/46C07D271/07C07D271/113C07D275/03C07D277/36C07D277/56C07D277/58C07D285/08C07D285/125C07D285/135C07D307/64C07D333/34C07D333/38C07D333/62C07D409/04C07D413/04C07D417/04C07D471/04C07C19/14C07C21/18
    • A compound of formula (I), or a salt thereof, wherein n is 0, 1 or 2; and R is a group of formulae (II) to (XXI), wherein: the S(O)nCH2CH2CH=CF2 group is at least one of R1 (when attached to a carbon atom), R2, R3, R4, R5 or R6; R1 (when attached to a carbon atom), R2, R3, R4, R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, alkoxy, alkenyloxy, alkynyloxy, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkoxy, optionally substituted heteroaryloxyalkyl, haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy, haloalkenyloxy, haloalkynyloxy, halogen, hydroxy, cyano, nitro, -NR7R8, -NR7COR8, -NR7CSR8, -NR7SO2R8, -N(SO2R7)(SO2R8), -COR7, -CONR7R8, -alkylCONR7R8, CR7NR8, -COOR7, -OCOR7, -SR7, -SOR7, SO2R7, -alkylSR7, -alkylSOR7, -alkylSO2R7, -OSO2R7, -SO2NR7R8, -CSNR7R8, SiR7R8R9, -OCH2CO2R7, -OCH2CH2CO2R7, -CONR7SO2R8, -alkylCONR7SO2R8, -NHCONR7R8, -NHCSNR7R8, or an adjacent pair of R1, R2, R3, R4, R5 and R6 when taken together form a fused 5- or 6-membered carbocyclic or heterocyclic ring; R1 (when attached to a nitrogen atom) is hydrogen, optionally substituted alkyl, cycloalkyl, alkylcycloalkyl, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryl, optionally substituted heteroarylakyl, optionally substituted heteroaryloxyalkyl, haloalkyl, hydroxy, cyano, nitro, -NR7R8, -NR7COR8, NR7CSR8, -NR7COOR8, -NR7SO2R8, -N(SO2R7)(SO2R8), -COR7, -CONR7R8, -alkylCONR7R8, -CR7NR8, -COOR7, -OCOR7, -SOR7, -SO2R7, -alkylSR7, -alkylSOR7, -alkylSO2R7, -OSO2R7, -SO2NR7NR8, -SR7, -SOR7, -SO2R7, -CSNR7R8, -SiR7R8R7, -OCH2CO2R7, -OCH2CH2CO2R7, -CONR7SO2R8, -alkylCONR7SO2R8, -NHCOR7R8, or -NHCSR7R8; and R7, R8 and R9 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, optionally substituted aryl or optionally substituted arylalkyl, haloalkyl, haloalkenyl, haloalkynyl, halogen, or hydroxy.
    • 式(I)化合物或其盐,其中n为0,1或2; 其中:S(O)nCH 2 CH 2 CH = CF 2基团是R 1(当连接到碳原子上),R 2,R 3,R 4,R 5或R 6中的至少一个时 ; R1(当连接到碳原子上)时,R 2,R 3,R 4,R 5和R 6各自独立地为氢,任选取代的烷基,任选取代的烯基,炔基,环烷基,烷基环烷基,烷氧基,烯氧基,炔氧基,羟烷基,烷氧基烷基, 芳基,任选取代的芳基烷基,任选取代的杂芳基,任选取代的杂芳基烷基,任选取代的芳氧基,任选取代的芳基烷氧基,任选取代的芳氧基烷基,任选取代的杂芳氧基,任选取代的杂芳基烷氧基,任选取代的杂芳氧基烷基,卤代烷基,卤代烯基,卤代炔基,卤代烷氧基, 卤素,羟基,氰基,硝基,-NR7R8,-NR7COR8,-NR7CSR8,-NR7SO2R8,-N(SO2R7)(SO2R8),-COR7,-CONR7R8, - 烷基CONR7R8,CR7NR8,-COOR7,-OCOR7,-SR7, SOR 7,SO 2 R 7, - 烷基R 7, - 烷基SOR 7, - 烷基SO 2 R 7,-OSO 2 R 7,-SO 2 NR 7 R 8,-CSNR 7 R 8,SiR 7 R 8 R 9,-OCH 2 CO 2 R 7,-OCH 2 CH 2 CO 2 R 7,-CONR 7 SO 2 R 8, - 烷基CONR 7 SO 2 R 8, NR7R8,-NHCSNR7R8或相邻的R1,R2,R3,R4,R5和R6组合在一起形成稠合的5元或6元碳环或杂环; R 1(当连接到氮原子时)是氢,任选取代的烷基,环烷基,烷基环烷基,羟烷基,烷氧基烷基,任选取代的芳基,任选取代的芳基烷基,任选取代的芳氧基烷基,任选取代的杂芳基,任选取代的杂芳基,任选取代的杂芳基烷基,卤代烷基, 羟基,氰基,硝基,-NR7R8,-NR7COR8,NR7CSR8,-NR7COOR8,-NR7SO2R8,-N(SO2R7)(SO2R8),-COR7,-CONR7R8, - 烷基CONR7R8,-CR7NR8,-COOR7,-OCOR7,-SOR7, -SO 2 R 7, - 烷基R 7, - 烷基SOR 7, - 烷基SO 2 R 7,-OSO 2 R 7,-SO 2 NR 7 NR 8,-SR 7,-SOR 7,-SO 2 R 7,-CSNR 7 R 8,-SiR 7 R 8 R 7,-OCH 2 CO 2 R 7,-OCH 2 CH 2 CO 2 R 7,-CONR 7 SO 2 R 8, - 烷基CONR 7 SO 2 R 8,-NHCOR 7 R 8 - NHCSR7R8; 并且R 7,R 8和R 9各自独立地为氢,任选取代的烷基,任选取代的烯基,炔基,任选取代的芳基或任选取代的芳基烷基,卤代烷基,卤代烯基,卤代炔基,卤素或羟基。
    • 7. 发明申请
    • 8-AZABICYCLO[3.2.1]OCTANE-, 8-AZABICYCLO[3.2.1]OCT-6-ENE-, 9-AZABICYCLO[3.3.1]NONANE-, 9-AZA-3-OXABICYCLO[3.3.1]NONANE- AND 9-AZA-3-THIABICYCLO[3.3.1]NONANE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INSECTICIDES
    • 8-亚氨基双环[3.2.1]十八烷,8-亚氨基二环[3.2.1] OCT-6-ENE-,9-异亚氨基[3.3.1] NONANE-,9-亚氨基-3-氧代羰基[3.3.1] NONANE - 和9-氨基-3-噻唑啉[3.3.1] NONANE衍生物,其制备及其作为杀虫剂的用途
    • WO1998025924A1
    • 1998-06-18
    • PCT/GB1997003054
    • 1997-11-06
    • ZENECA LIMITEDURCH, Christopher, JohnLEWIS, TerenceSUNLEY, Raymond, LeoSALMON, RaymondGODFREY, Christopher, Richard, AylesBRIGHTWELL, Christopher, IanHOTSON, Matthew, Brian
    • ZENECA LIMITED
    • C07D451/14
    • C07D451/02A01N43/90A01N47/16A01N47/18C07D451/04C07D451/06C07D451/14
    • A compound of formula (I) wherein A represents a bidentate group of the formula -CH2-X-CH2- (wherein X is methylene, sulfur or oxygen), X'C=CY or X'WC-CYZ (wherein X', W, Y and Z are independently hydrogen, hydroxy, acyloxy, alkoxy, alkylsilyloxy, cyano or halogen, or X' and W or Y and Z together with the carbon to which they are attached form a carbonyl group), provided that A is not CH2-CH2; Ar is an optionally substituted phenyl or 5- or 6-membered heterocyclic ring system containing from 1 to 3 heteroatoms individualy selected from nitrogen, oxygen and sulfur atoms, and at least one unsaturation (double bond) between adjacent atoms in the ring, said heterocyclic ring being optionally fused to a benzene ring, wherein the substituents, if present, are selected from halogen atoms, cyano, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkenyl, alkylthio and alkyl amino groups, any of which groups contain up to six carbon atoms; R is hydrogen or cyano or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkenyloxycarbonyl, aralkylocycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl or X''R (where X'' represents oxygen or a group NR ), provided that when R is alkenyl, aralkenyl or alkynyl said group does not have an unsaturated carbon atom bonding directly to the ring nitrogen of formula (I); R is hydrogen, cyano, hydroxy, alkyl, alkoxy, amino, nitro, isocyanato, acylamino, hydroxyalkyl, optionally substituted heteroaryl, alkoxyalkyl, haloalkyl, halohydroxyalkyl, aralkyloxyalkyl, acyloxyalkyl, amidoximido, sulfonyloxyalkyl, aminoalkyl, alkoxycarbonylamino, acylaminoalkyl, cyanoalkyl, imino, formyl, acyl or carboxylic acid or an ester or amide thereof, or alkenyl or alkynyl either of which is optionally substituted by halogen, alkoxy, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or cyano; R and R are, independently, hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl or carboxylic acyl; alkyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, amino, acylamino, imidate and phosphonato groups; aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, alkoxycarbonyl, alkanesulfonyl, arenesulfonyl, alkanyloxycarbonyl, aralkyloxycarbonyl, aryloxycarbonyl, heterocyclylalkyl, carbamyl, dithiocarboxyl moieties of R, R and R comprise from 1 to 15 carbon atoms, and are optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl, alkyl, amino, acylamino, imidate and phosphonato groups; or an acid addition salt, quaternary ammonium salt or N -oxide derived therefrom; an insecticidal, acaricidal or nematicidal composition comprising a compound of formula (I) and a suitable carrier or diluent therefor; a method of combating and controlling insect, acarine or nematode pests at a locus which comprises treating the pests or the locus of the pests with an effective amount of a compound of formula (I) or a composition as hereinbefore described.
    • 式(I)的化合物,其中A表示式-CH 2 -X-CH 2 - (其中X是亚甲基,硫或氧),X'C = CY或X'WC-CYZ(其中X', W,Y和Z独立地是氢,羟基,酰氧基,烷氧基,烷基甲硅烷氧基,氰基或卤素,或X'和W或Y和Z与它们所连接的碳一起形成羰基),条件是A不是 CH2-CH2; Ar是任选取代的苯基或含有1至3个选自氮,氧和硫原子的杂原子的5或6元杂环系,以及环中相邻原子之间的至少一个不饱和键(双键),所述杂环 任选地与苯环稠合,其中取代基(如果存在的话)选自卤素原子,氰基,烷基,烯基,炔基,烷氧基,卤代烷基,卤代烯基,烷硫基和烷基氨基,其中任何一个基团含有最多六个 碳原子 R是氢或氰基或选自烷基,芳基,杂芳基,芳烷基,杂芳基烷基,烯基,芳烯基,炔基,烷氧基羰基,链烷磺酰基,芳烃磺酰基,烯氧基羰基,芳烷基羰基,芳氧基羰基,杂环基烷基,氨基甲酰基,二硫代羧基或X'R (其中X“表示氧或基团NR 4),条件是当R是烯基时,所述基团不具有与式(I)的环氮直接键合的不饱和碳原子; R 1是氢,氰基,羟基,烷基,烷氧基,氨基,硝基,异氰酸根合,酰氨基,羟烷基,任选取代的杂芳基,烷氧基烷基,卤代烷基,卤代羟烷基,芳烷氧基烷基,酰氧基烷基,酰氨基亚氨基,磺酰氧基烷基,氨基烷基,烷氧基羰基氨基,酰基氨基烷基, 酰基或羧酸或其酯或酰胺,或任选被卤素,烷氧基,环烷基,任选取代的芳基,任选取代的杂芳基或氰基取代的链烯基或炔基; R 3和R 4独立地是氢,烷基,芳基,杂芳基,芳烷基,杂芳基烷基,烯基,芳烯基,炔基,杂环基烷基,烷氧基羰基或羧基酰基。 R 3,R 3和R 4的烷基部分含有1至15个碳原子,并且任选地被一个或多个选自卤素,氰基,羧基,羧酰基,氨基甲酰基,烷氧基羰基,烷氧基,亚烷基二氧基 ,羟基,硝基,氨基,酰氨基,亚氨基和膦酸基; 芳基,杂芳基,芳烷基,杂芳基烷基,烯基,芳烯基,炔基,烷氧基羰基,烷磺酰基,芳烃磺酰基,烷氧基羰基,芳烷氧基羰基,芳氧基羰基,杂环基烷基,氨基甲酰基,R 3,R 3和R 4的二硫代羧基部分包含1至15个碳 任选被一个或多个选自卤素,氰基,羧基,羧基酰基,氨基甲酰基,烷氧基羰基,烷氧基,亚烷基二氧基,羟基,硝基,卤代烷基,烷基,氨基,酰氨基,亚氨酸酯基和膦酸基的取代基取代。 或由其衍生的酸加成盐,季铵盐或N,N-氧化物; 杀虫杀螨或杀线虫组合物,其包含式(I)化合物及其合适的载体或稀释剂; 一种防治昆虫,螨虫或线虫害虫的方法,包括用有效量的式(I)化合物或上述组合物处理害虫或害虫的场所。
    • 8. 发明申请
    • BICYCLIC AMINES AS INSECTICIDES
    • 双酚A作为杀虫剂
    • WO1997043286A1
    • 1997-11-20
    • PCT/GB1997001259
    • 1997-05-09
    • ZENECA LIMITEDSALMON, RogerHOTSON, Matthew, Brian
    • ZENECA LIMITED
    • C07D451/02
    • C07D451/02A01N43/90
    • The invention provides novel compounds of formula (I) and formula (II) wherein R represents a group of formula (A) where each of W, X, Y and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y, and Z represent the nitrogen atom, and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R represents a group XR where X represents oxygen or a group NR where R and R are individually selected from hydrogen or a group selected from alkyl, aryl, heteroaryl, aralkyl, heteroarylalkyl, alkenyl, aralkenyl, alkynyl, heterocyclylalkyl, alkoxycarbonyl, and carboxylic acyl groups, said groups comprising from 1 to 15 carbon atoms, said groups being optionally substituted with one or more substituents selected from, halogen, cyano, carboxyl, carboxylic acyl, carbamyl, alkoxycarbonyl, alkoxy, alkylenedioxy, hydroxy, nitro, haloalkyl and alkyl groups; and acid addition salts and quaternary ammonium salts and N-oxides derived therefrom. The compounds have useful insecticidal properties.
    • 本发明提供新的式(I)和式(II)化合物,其中R 1表示式(A)中的基团,其中W,X,Y和Z各自表示基团CR或氮原子,条件是 不多于两个W,X,Y和Z表示氮原子,并且其中每个R独立地选自氢和卤素原子和氰基,氨基,肼基,酰氨基,羟基,烷基,羟基烷基,烷氧基,卤代烷基, 卤代烷氧基,烯基,烯氧基,烷氧基烯基,炔基,羧基酰基,烷氧基羰基,芳基和杂环基,所述基团包含至多6个碳原子,并且其中R 2表示XR 3基团,其中X表示氧或NR 其中R 3和R 4分别选自氢或选自烷基,芳基,杂芳基,芳烷基,杂芳基烷基,烯基,芳烯基,炔基,杂环基烷基,烷氧基羰基和羧酰基的基团,所述基团 包含1至15个碳原子,所述基团是选择性的 被一个或多个选自卤素,氰基,羧基,羧基酰基,氨基甲酰基,烷氧基羰基,烷氧基,亚烷基二氧基,羟基,硝基,卤代烷基和烷基的取代基取代。 和酸加成盐和季铵盐和由其衍生的N-氧化物。 该化合物具有有用的杀虫性质。