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1. 发明申请

WO2014134001A1 METHOD FOR ALIGNING A BIOCHIP 审中-公开
标题翻译：用于调节生物化学的方法
公开(公告)号：WO2014134001A1
公开(公告)日：2014-09-04
申请号：PCT/US2014/018200
申请日：2014-02-25
申请人： ROBERT BOSCH GMBH , LANG, Christoph , HASSIBI, Arjang , KAVUSI, Sam
发明人： LANG, Christoph , HASSIBI, Arjang , KAVUSI, Sam
IPC分类号： H01L21/68 , H01L23/544
CPC分类号： H01L22/12 , H01L21/68 , H01L23/544 , H01L2223/54426 , H01L2223/5448 , H01L2924/0002 , H01L2924/00
摘要： A method of aligning a semiconductor chip includes forming a semiconductor chip with a light-activated circuit including at least one photosite, positioning the semiconductor chip relative to a device, and illuminating the positioned semiconductor chip. The method further includes generating an RF signal with an RF circuit based upon illumination of the at least one photosite, and determining the position of the photosite with respect to the device based upon the generated RF signal.
摘要翻译：对准半导体芯片的方法包括用包括至少一个光泽的光激活电路形成半导体芯片，将半导体芯片相对于器件定位，以及照射所定位的半导体芯片。该方法还包括基于至少一个光斑的照射产生具有RF电路的RF信号，以及基于所生成的RF信号来确定相对于器件的光电子的位置。

2. 发明申请

WO2008082713A2 INTEGRATED SEMICONDUCTOR BIOARRAY 审中-公开
标题翻译：集成半导体生物技术
公开(公告)号：WO2008082713A2
公开(公告)日：2008-07-10
申请号：PCT/US2007076807
申请日：2007-08-24
申请人： CALIFORNIA INST OF TECHN , HASSIBI ARJANG
发明人： HASSIBI ARJANG
IPC分类号： C40B30/04 , C40B60/12 , G06G7/48
CPC分类号： C40B60/12 , B01L3/50857 , B01L2300/0819 , B01L2300/1822 , C40B30/04 , C40B30/10 , C40B40/08 , C40B40/10 , G01N33/54386 , G01N33/557
摘要： A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are able to determine the amounts of those analytes in solution. The invention also provides a fully integrated bioarray for detecting real-time characteristics of affinity based assays.
摘要翻译：用于基于亲和力的测定的生物传感器阵列，系统和方法，其能够同时获得多个分析物的结合特征的高质量测量，并且能够确定溶液中的那些分析物的量。本发明还提供用于检测基于亲和力的测定的实时特征的完全一体化的生物阵列。

3. 发明申请

WO2007143669A2 REAL TIME MICRO ARRAYS 审中-公开
标题翻译：实时微阵列
公开(公告)号：WO2007143669A2
公开(公告)日：2007-12-13
申请号：PCT/US2007070449
申请日：2007-06-05
申请人： CALIFORNIA INST OF TECHN , RIECHMANN JOSE LUIS R , HASSIBI BABAK , VIKALO HARIS , HASSIBI ARJANG
发明人： RIECHMANN JOSE LUIS R , HASSIBI BABAK , VIKALO HARIS , HASSIBI ARJANG
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q2565/501 , C12Q2565/101 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.
摘要翻译：本发明提供了用于测量溶液中分析物与实际上与表面结合的探针的结合的方法和系统。

4. 发明申请

WO2008014485A3 MULTIPLEX Q-PCR ARRAYS 审中-公开
标题翻译：多重QPCR阵列
公开(公告)号：WO2008014485A3
公开(公告)日：2008-07-10
申请号：PCT/US2007074644
申请日：2007-07-27
申请人： CALIFORNIA INST OF TECHN , HASSIBI BABAK , VIKALO HARIS , HASSIBI ARJANG
发明人： HASSIBI BABAK , VIKALO HARIS , HASSIBI ARJANG
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译：本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。例如，使用聚合酶链式反应（PCR）在一系列核酸探针存在下同时扩增样品中的核酸序列。可使用实时微阵列在每个循环期间或之后实时测量对应于多个核酸序列的扩增子的量。测量的产生的扩增子的量可以用于确定样品中核酸序列的原始量。

5. 发明申请

WO2008014485A2 MULTIPLEX Q-PCR ARRAYS 审中-公开
标题翻译： MULTIPLEX Q-PCR阵列
公开(公告)号：WO2008014485A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/074644
申请日：2007-07-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , HASSIBI, Babak , VIKALO, Haris , HASSIBI, Arjang
发明人： HASSIBI, Babak , VIKALO, Haris , HASSIBI, Arjang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译：本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。在核酸探针阵列的存在下，例如使用聚合酶链反应（PCR）同时扩增样品中的核酸序列。可以使用实时微阵列在每个循环期间或之后实时测量与多个核酸序列相对应的扩增子的量。所测量的扩增子的量可用于确定样品中核酸序列的原始量。

6. 发明申请

WO0247266A3 TRANSIENT ELECTRICAL SIGNAL BASED METHODS AND DEVICES FOR CHARACTERIZING MOLECULAR INTERACTION AND/OR MOTION IN A SAMPLE 审中-公开
标题翻译：用于表征样品中分子相互作用和/或运动的瞬态电信号的方法和装置
公开(公告)号：WO0247266A3
公开(公告)日：2002-08-15
申请号：PCT/US0151398
申请日：2001-10-19
申请人： UNIV LELAND STANFORD JUNIOR , POURMAND NADER , HASSIBI ARJANG
发明人： POURMAND NADER , HASSIBI ARJANG
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/542 , G01N33/543
CPC分类号： C12Q1/6834 , C12Q1/6844 , C12Q1/6858 , C12Q1/6869 , G01N33/5438 , C12Q2565/607 , C12Q2565/507 , C12Q2533/101
摘要： Devices for detecting a transient electrical signal in a sample are provided. Also provided are systems that include the subject devices. The subject devices and systems find use in a variety of applications, particularly in the characterization of a sample, and more particularly in the characterization of molecular entities in the sample.
摘要翻译：提供了用于检测样品中的瞬态电信号的装置。还提供了包括主题设备的系统。主题装置和系统可用于各种应用，特别是在样品的表征中，更特别地在样品中的分子实体的表征中。

7. 发明申请

WO2007019424A2 SPECTRAL-SCANNING MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：光谱扫描磁共振成像
公开(公告)号：WO2007019424A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030681
申请日：2006-08-07
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
发明人： AL HAJIMIRI, Seyed , HASSIBI, Arjang , WANG, Hua
IPC分类号： G01V3/00 , A61B5/05
CPC分类号： G01R33/3808 , G01R33/3607 , G01R33/3642 , G01R33/3657 , G01R33/446 , G01R33/5612 , G01R33/56383
摘要： Spectral scanning magnetic resonance imaging methods and systems. In preferred methods and systems of the invention, to measure the resonance spectrum of the target object (18), a plurality of excitation signals in different frequencies and/or waveform shapes are introduced simultaneously to the imaging volume through one or more excitation coils (12,12a), and the response spectrum is measured also in real-time and/or after excitation. Systems of the invention can be compact and portable, with small magnets (10) providing the deterministic inhomogeneous magnetic field. Preferred embodiments include integrated circuit transmitters (22) and receivers (20). Preferred systems of the invention are suitable, for example, for point of care medical diagnostics.
摘要翻译：光谱扫描磁共振成像方法和系统。在本发明的优选方法和系统中，为了测量目标物体（18）的共振谱，通过一个或多个激励线圈（12）将多个不同频率和/或波形形状的激励信号同时引入成像体积，12a），并且响应谱也是在实时和/或激发后测量的。本发明的系统可以紧凑且便于携带，其中提供确定性非均匀磁场的小磁体（10）。优选实施例包括集成电路发射器（22）和接收器（20）。本发明的优选系统例如适用于护理点医疗诊断。

8. 发明申请

WO03087388A9 BIOLUMINESCENCE REGENERATIVE CYCLE (BRC) FOR NUCLEIC ACID QUANTIFICATION 审中-公开
标题翻译：用于核酸定量的生物发光再生循环（BRC）
公开(公告)号：WO03087388A9
公开(公告)日：2004-05-21
申请号：PCT/US0220690
申请日：2002-06-28
申请人： UNIV LELAND STANFORD JUNIOR , HASSIBI ARJANG , POURMAND NADER
发明人： HASSIBI ARJANG , POURMAND NADER
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6825 , C12Q1/689 , C12Q2565/301 , C12Q2545/114 , C12Q2531/113
摘要： The present invention concerns methods of quantifying nucleic acids using a bioluminescence regenerative cycle (BRC). In BRC, steady state levels of bioluminescence result from processes that produce pyrophosphate. Pyrophosphate reacts with APS in the presence of ATP sulfurylase to produce ATP. The ATP reacts with luciferin in a luciferase-catalyzed reaction, producing light and regenerating pyrophosphate. The pyrophosphate is recycled to produce ATP and the regenerative cycle continues. Because the kinetic properties of ATP sulfurylase are much faster than luciferase, a steady state results wherein concentrations of ATP and pyrophosphate and the rate of light production remain relatively constant. Photons are counted over a time interval to determine the number of target molecules present in the initial sample. The BRC process has a controllable dynamic range up to seven orders of magnitude and is sensitive enough to detect a few thousand molecules of target nucleic acid.
摘要翻译：本发明涉及使用生物发光再生循环（BRC）定量核酸的方法。在BRC中，稳定状态的生物发光水平来自产生焦磷酸的过程。焦磷酸在ATP硫酸化酶存在下与APS反应产生ATP。 ATP在萤光素酶催化的反应中与萤光素反应，产生光并再生焦磷酸。焦磷酸盐被再循环生产ATP，再生循环继续进行。由于ATP硫酸化酶的动力学性质比萤光素酶快得多，所以其中ATP和焦磷酸盐的浓度以及光产生速率保持相对恒定的稳态结果。在一段时间内对光子进行计数以确定初始样品中存在的靶分子的数量。 BRC过程的可控动态范围可达7个数量级，并且足够灵敏以检测几千个目标核酸分子。

9. 发明申请

WO2003087388A3 BIOLUMINESCENCE REGENERATIVE CYCLE (BRC) FOR NUCLEIC ACID QUANTIFICATION 审中-公开
公开(公告)号：WO2003087388A3
公开(公告)日：2003-10-23
申请号：PCT/US2002/020690
申请日：2002-06-28
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD UNIVERSITY , HASSIBI, Arjang , POURMAND, Nader
发明人： HASSIBI, Arjang , POURMAND, Nader
IPC分类号： C12Q1/68
摘要： The present invention concerns methods of quantifying nucleic acids using a bioluminescence regenerative cycle (BRC). In BRC, steady state levels of bioluminescence result from processes that produce pyrophosphate. Pyrophosphate reacts with APS in the presence of ATP sulfurylase to produce ATP. The ATP reacts with luciferin in a luciferase-catalyzed reaction, producing light and regenerating pyrophosphate. The pyrophosphate is recycled to produce ATP and the regenerative cycle continues. Because the kinetic properties of ATP sulfurylase are much faster than luciferase, a steady state results wherein concentrations of ATP and pyrophosphate and the rate of light production remain relatively constant. Photons are counted over a time interval to determine the number of target molecules present in the initial sample. The BRC process has a controllable dynamic range up to seven orders of magnitude and is sensitive enough to detect a few thousand molecules of target nucleic acid.

10. 发明申请

WO2009146242A1 PERFORMING ANALOG-TO-DIGITAL CONVERSION BY COMPUTING DELAY TIME BETWEEN TRAVELING WAVES IN TRANSMISSION LINES 审中-公开
标题翻译：通过计算传输线上的行驶时间之间的延迟时间来执行模拟数字转换
公开(公告)号：WO2009146242A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/043241
申请日：2009-05-08
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , CORNELL UNIVERSITY , HASSIBI, Arjang , AFSHARI, Ehsan , ZHANG, Chaoming , ABRAHAM, Jacob
发明人： HASSIBI, Arjang , AFSHARI, Ehsan , ZHANG, Chaoming , ABRAHAM, Jacob
IPC分类号： H03M1/12
CPC分类号： H03M1/502 , H03M1/0682
摘要： A method and device for converting an analog input electrical signal to a digital signal. A plurality of integrated active and/or passive transmission lines may be implemented with signal-dependant propagation velocities. The delay differences of pulses traveling through these transmission lines are compared, and the collective results are used to evaluate and subsequently quantize the input signal.
摘要翻译：一种用于将模拟输入电信号转换为数字信号的方法和装置。多个集成的有源和/或无源传输线可以用信号相关的传播速度来实现。比较穿过这些传输线的脉冲的延迟差异，并且使用集合结果来评估并随后量化输入信号。

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