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1. 发明申请

WO2013028643A8 PREPARATION OF POLYNUCLEOTIDES ON A SOLID SUBSTRATE FOR SEQUENCING 审中-公开
标题翻译：用于测序的固体基底上的多核苷酸的制备
公开(公告)号：WO2013028643A8
公开(公告)日：2013-04-25
申请号：PCT/US2012051632
申请日：2012-08-20
申请人： INTEGENX INC , TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
发明人： TANNER MICHAEL , JOVANOVICH STEVAN B , VAN GELDER EZRA , HARRIS DENNIS , PARK CHARLES , STERN SETH
IPC分类号： C07H21/04 , C40B30/04
CPC分类号： C07C49/753 , C12Q1/6855 , C12Q2521/507 , C12Q2535/122 , C12Q2565/543
摘要： The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.
摘要翻译：本发明提供用于在固体底物（例如流动池）上进行核酸扩增和测序的方法和装置，包括制备用于大规模并行（下一代）测序的扩增的DNA片段的文库。

2. 发明申请

WO2002058640A1 TOPICAL THERAPEUTIC SKIN CARE SYSTEM 审中-公开
标题翻译：局部治疗皮肤护理系统
公开(公告)号：WO2002058640A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/001876
申请日：2002-01-19
申请人： HARRIS, Dennis, H. , GENERAL, Ronald, E.
发明人： HARRIS, Dennis, H. , GENERAL, Ronald, E.
IPC分类号： A61K6/00
CPC分类号： A61Q17/005 , A61K8/03 , A61K8/34 , A61K8/345 , A61K8/347 , A61K8/67 , A61K8/671 , A61K8/675 , A61K8/8129 , A61K8/97 , A61K8/9706 , A61K31/055 , A61K31/197 , A61K31/455 , A61K45/06 , A61K2800/28 , A61K2800/522 , A61Q19/00 , A61K2300/00
摘要： A two phase optical therapeutic skin treatment is disclosed, including a first phase composition having antibacterial, anti-inflammatory, humectant, antioxidant and exfoliant ingredients, and a second phase having anti-inflammatory, circulatory enhancement and prolonged moisturizing ingredients.
摘要翻译：公开了一种双相光学治疗皮肤治疗剂，其包括具有抗菌，抗炎，保湿剂，抗氧化剂和去角质成分的第一相组合物，以及具有抗炎，循环增强和延长保湿成分的第二相。

3. 发明申请

WO2013028643A1 PREPARATION OF POLYNUCLEOTIDES ON A SOLID SUBSTRATE FOR SEQUENCING 审中-公开
标题翻译：多核苷酸在固体基质上的制备用于测序
公开(公告)号：WO2013028643A1
公开(公告)日：2013-02-28
申请号：PCT/US2012/051632
申请日：2012-08-20
申请人： INTEGENX INC. , TANNER, Michael , JOVANOVICH, Stevan, B. , VAN GELDER, Ezra , HARRIS, Dennis , PARK, Charles , STERN, Seth
发明人： TANNER, Michael , JOVANOVICH, Stevan, B. , VAN GELDER, Ezra , HARRIS, Dennis , PARK, Charles , STERN, Seth
IPC分类号： C07H21/04 , C40B30/04
CPC分类号： C07C49/753 , C12Q1/6855 , C12Q2521/507 , C12Q2535/122 , C12Q2565/543
摘要： The present invention provides methods and devices for performing nucleic acid amplification and sequencing on a solid substrate (e.g., a flow cell), including preparation of libraries of amplified DNA fragments for massively parallel (next-generation) sequencing.
摘要翻译：本发明提供了用于在固体基质（例如流动细胞）上进行核酸扩增和测序的方法和装置，包括用于大规模并行（下一代）扩增的DNA片段文库的制备，测序

4. 发明申请

WO2011100082A1 DISK LASER 审中-公开
标题翻译：磁盘激光
公开(公告)号：WO2011100082A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/020865
申请日：2011-01-11
申请人： THE BOEING COMPANY , GALASSO, D. Anthony , WHELAN, David A. , ULLMAN, Alan Z. , HARRIS, Dennis G.
发明人： GALASSO, D. Anthony , WHELAN, David A. , ULLMAN, Alan Z. , HARRIS, Dennis G.
IPC分类号： H01S3/06 , H01S3/042 , H01S3/16 , F41H13/00
CPC分类号： H01S3/0404 , F42B10/60 , H01S3/0407 , H01S3/042 , H01S3/0604 , H01S3/07 , H01S3/1685 , H01S3/2316 , H01S3/2333 , H01S2301/02
摘要： The different advantageous embodiments provide an apparatus and method comprising a substrate (900, 1300) configured to increase an intensity of light at a desired wavelength. The substrate (900, 1300) has a front side (1302), a back side (1304), and an outer edge (922, 1306). The substrate (900, 1300) is configured to reflect the light received on the front side (1302) of the substrate. The substrate comprises ceramic. The substrate (900, 1300) comprises a plurality of sections (902-918). The method and apparatus also comprise a material (920) configured to attenuate the light passing between the plurality of sections (902 -918). The material (920) surrounds an edge of each section of the plurality of sections. The apparatus and method also comprise a cooling system (808) configured to allow liquid nitrogen to be transmitted through the cooling system (808) and receive heat generated in the substrate (900, 1300) from the back side (1304) of the substrate (900, 1300).
摘要翻译：不同的有利实施例提供了一种装置和方法，包括被配置为增加所需波长的光的强度的基板（900,1300）。基板（900,1300）具有前侧（1302），后侧（1304）和外边缘（922,1306）。衬底（900,1300）被配置为反射接收在衬底的前侧（1302）上的光。衬底包括陶瓷。基板（900,1300）包括多个部分（902-918）。该方法和装置还包括被配置为衰减在多个部分之间通过的光（902-918）的材料（920）。材料（920）围绕多个部分的每个部分的边缘。该设备和方法还包括冷却系统（808），其被配置为允许液氮通过冷却系统（808）传输并且从衬底的背面（1304）接收在衬底（900,1300）中产生的热 900，1300）。

5. 发明申请

WO2005073025A1 TRACTOR DOLLY 审中-公开
标题翻译：牵引车多
公开(公告)号：WO2005073025A1
公开(公告)日：2005-08-11
申请号：PCT/US2004/043781
申请日：2004-12-28
申请人： HARRIS, Dennis, E.
发明人： HARRIS, Dennis, E.
IPC分类号： B60P3/12
CPC分类号： B60P3/127
摘要： A portable dolly (104) for use in towing a tractor (100) including at least one wheel (108) for moving the dolly, a king pin (118) configured for placement in a mating engagement with a fifth wheel (110) on the tractor (100), and a plurality of chains (114) for connecting the dolly to the tractor, wherein the dolly is configured to assist a wrecker (102) with towing the tractor from the tractor's front end without removing the front drive axle and drive shaft on the tractor. A lift mechanism (122) is provided for lifting the tractor off the ground into a position that is suitable for towing.
摘要翻译：一种用于牵引牵引器（100）的便携式台车（104），所述拖拉机包括用于移动所述台车的至少一个轮子（108）;构造成用于放置在与所述第二轮子上的第五轮（110）配合接合的主销拖拉机（100）和用于将小车连接到拖拉机的多个链条（114），其中，所述台车构造成辅助清理器（102）从拖拉机的前端牵引拖拉机而不移除前驱动轴并驱动拖拉机上的轴。提供升降机构（122），用于将拖拉机从地面上提升到适于牵引的位置。

6. 发明申请

WO2003061679A1 COMPOSITION FOR BLOOD SUGAR REGULATION 审中-公开
标题翻译：用于血糖调节的组合物
公开(公告)号：WO2003061679A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001786
申请日：2003-01-21
申请人： HARRIS, Dennis, H., M., D. , MARTIN, Robert
发明人： HARRIS, Dennis, H., M., D. , MARTIN, Robert
IPC分类号： A61K35/78
CPC分类号： A61K36/42 , A61K36/258 , A61K36/27 , A61K36/48 , A61K36/54 , A61K36/8962 , A61K2300/00
摘要： A nutritional supplement formulation for the enhancement of blood sugar regulation, prevention and treatment of insulin resistance, prevention and treatment of dysinsulinemia, prevention and treatment of Syndrome X, and reduction of diabetic complications is disclosed. The formulation combines herbs, minerals and vitamins known to reduce insulin resistance with herbs, minerals and vitamins known to reduce blood sugar levels.
摘要翻译：公开了一种用于增强血糖调节，预防和治疗胰岛素抵抗，预防和治疗胰岛素血症，预防和治疗X综合症以及减少糖尿病并发症的营养补充剂配方。该制剂将已知降低胰岛素抵抗的草药，矿物质和维生素与草药，矿物质和已知降血糖水平的维生素结合在一起。

7. 发明申请

WO02089981A3 APPARATUS AND METHOD FOR FILLING AND CLEANING CHANNELS AND INLET PORTS IN MICROCHIPS USED FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译：用于生物分析的微生物灌装和清洁通道和入口口的装置和方法
公开(公告)号：WO02089981A3
公开(公告)日：2003-06-19
申请号：PCT/US0147780
申请日：2001-12-10
申请人： AMERSHAM BIOSCIENCES SV CORP , ROACH DAVID J , LODER ROBERT T JR , ARMSTRONG THOMAS M , HARRIS DENNIS W , JOVANOVICH STEVAN B , JOHNSTON RICHARD F
发明人： ROACH DAVID J , LODER ROBERT T JR , ARMSTRONG THOMAS M , HARRIS DENNIS W , JOVANOVICH STEVAN B , JOHNSTON RICHARD F
IPC分类号： B01L3/00 , B01L99/00 , G01N27/447 , G01N35/00 , G01N35/04 , G01N35/10 , B01L11/00
CPC分类号： G01N27/44791 , B01J2219/0099 , B01L3/5027 , B01L99/00 , G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437
摘要： An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
摘要翻译：公开了一种用于填充和清洁微芯片衬底的通道和入口的装置。将包括管阵列的装置的装置插入到微芯片的每个入口端口中。该装置的管阵列包括由多个真空管包围的多个压力管。与此同时，诸如基质或洗涤剂的加压溶液被引入微芯片上的共同的开口中，通过使用该设备的压头喷射器提供通向微芯片的微通道的通道。当将基质或洗涤溶液泵送通过微芯片衬底的共同的开口和微通道时，将洗涤溶液泵送通过多个压力管，并且通过围绕多个压力管的多个真空管将一切都抽真空。选择各种储存的溶液并通过适当的阀驱动使其流动。该过程可以通过使用适当的阀门和控制硬件/软件手动或容易地进行自动化。

8. 发明申请

WO2003028747A1 INGESTIBLE NERVE AND CIRCULATORY NUTRITIONAL FORMULATION 审中-公开
标题翻译：不可思议的和循环的营养配方
公开(公告)号：WO2003028747A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/031469
申请日：2002-10-03
申请人： HARRIS, Dennis, H. , GENERAL, Ronald, E. , MARTIN, Robert
发明人： HARRIS, Dennis, H. , GENERAL, Ronald, E. , MARTIN, Robert
IPC分类号： A61K35/78
CPC分类号： A61K45/06 , A61K31/355 , A61K31/375 , A61K31/385 , A61K33/30 , A61K33/32 , A61K33/34 , A61K36/48 , A61K36/77 , A61K2300/00
摘要： An ingestible nerve and circulatory nutritional formulation is disclosed, comprising an antioxidant portion, an anti-inflammatory portion, a circulatory enhancement portion, a vasodilator portion, a nerve growth, conduction and regeneration portion, a glycemic control portion, a sorbitol inhibitor portion a lipid reduction portion, a mitochondrial activation portion and a pancreatic stem cell support element portion.
摘要翻译：公开了一种可摄入的神经和循环营养制剂，其包含抗氧化剂部分，抗炎部分，循环增强部分，血管扩张剂部分，神经生长，传导和再生部分，血糖控制部分，山梨醇抑制剂部分还原部分，线粒体激活部分和胰干细胞支持元件部分。

9. 发明申请

WO2002089981A2 APPARATUS AND METHOD FOR FILLING AND CLEANING CHANNELS AND INLET PORTS IN MICROCHIPS USED FOR BIOLOGICAL ANALYSIS 审中-公开
标题翻译：用于生物分析的微生物灌装和清洁通道和入口口的装置和方法
公开(公告)号：WO2002089981A2
公开(公告)日：2002-11-14
申请号：PCT/US2001/047780
申请日：2001-12-10
申请人： AMERSHAM BIOSCIENCES (SV) CORP. , ROACH, David, J. , LODER, Robert, T., Jr. , ARMSTRONG, Thomas, M. , HARRIS, Dennis, W. , JOVANOVICH, Stevan, B. , JOHNSTON, Richard, F.
发明人： ROACH, David, J. , LODER, Robert, T., Jr. , ARMSTRONG, Thomas, M. , HARRIS, Dennis, W. , JOVANOVICH, Stevan, B. , JOHNSTON, Richard, F.
IPC分类号： B01L
CPC分类号： G01N27/44791 , B01J2219/0099 , B01L3/5027 , B01L99/00 , G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437
摘要： An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
摘要翻译：公开了一种用于填充和清洁微芯片衬底的通道和入口的装置。将包括管阵列的装置的装置插入到微芯片的每个入口端口中。该装置的管阵列包括由多个真空管包围的多个压力管。与此同时，诸如基质或洗涤剂的加压溶液被引入到微芯片上的共同的开口中，通过使用该装置的压头喷射器提供通向微芯片的微通道的通道。当将基质或洗涤溶液泵送通过微芯片衬底的共同的开口和微通道时，将洗涤溶液泵送通过多个压力管，并且通过围绕多个压力管的多个真空管将一切都抽真空。选择各种储存的溶液并通过适当的阀驱动使其流动。该过程可以通过使用适当的阀门和控制硬件/软件手动或容易地进行自动化。

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