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1. 发明申请

WO2012045195A1 PYRROLOPYRIMIDINES AS FAK AND ALK INHIBITERS FOR TREATMENT OF CANCERS AND OTHER DISEASES 审中-公开
标题翻译：吡咯并嘧啶作为治疗癌症和其他疾病的方法和药物不良事件
公开(公告)号：WO2012045195A1
公开(公告)日：2012-04-12
申请号：PCT/CN2010/001578
申请日：2010-10-09
申请人： ABBOTT LABORATORIES , ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD. , VAN CAMP, Jennifer , XU, Xiangdong , OSUMA, Augustine, Toby , GREGG, Robert , LONGENECKER, Kenton, L.
发明人： VAN CAMP, Jennifer , XU, Xiangdong , OSUMA, Augustine, Toby , GREGG, Robert , LONGENECKER, Kenton, L.
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Disclosed are compounds which inhibit the activity of focal adhesion kinase (FAK) and anaplastic lymphoma kinase (ALK), compositions containing the compounds, and methods of treating diseases during which FAK and ALK are expressed. The diseases are, for example, cancers.
摘要翻译：公开了抑制粘着斑激酶（FAK）和间变性淋巴瘤激酶（ALK）活性的化合物，含有该化合物的组合物，以及治疗FAK和ALK表达的疾病的方法。疾病是例如癌症。

2. 发明申请

WO2008073764A2 SUBSTANTIALLY PURE FLUORESCEIN 审中-公开
标题翻译：大量纯白色荧光素
公开(公告)号：WO2008073764A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/086390
申请日：2007-12-04
申请人： ALCON MANUFACTURING, LTD. , BYDLINSKI, Gregory , HARRIS, Gregg, Robert , SCOTT, Britt, S.
发明人： BYDLINSKI, Gregory , HARRIS, Gregg, Robert , SCOTT, Britt, S.
IPC分类号： C07D493/10
CPC分类号： C07D311/82 , A61K31/352 , Y10T436/142222
摘要： The present invention is directed to an improved process for producing substantially pure fluorescein, as well as to substantially pure fluorescein compositions prepared by the process. The invention is particularly directed to the provision of pharmaceutical compositions for use in angiography. The substantially pure fluorescein produced by the process of the present invention is low in color, low in sodium chloride content, and substantially free of pyridine.
摘要翻译：本发明涉及用于生产基本上纯的荧光素以及通过该方法制备的基本上纯的荧光素组合物的改进方法。本发明特别涉及提供用于血管造影术的药物组合物。通过本发明方法生产的基本上纯的荧光素颜色低，氯化钠含量低，并且基本上不含吡啶。

3. 发明申请

WO2006041466A1 DIRECTING PASSENGERS USING COLOR INDICATIONS 审中-公开
标题翻译：使用颜色指示指导乘客
公开(公告)号：WO2006041466A1
公开(公告)日：2006-04-20
申请号：PCT/US2004/032786
申请日：2004-10-05
申请人： OTIS ELEVATOR COMPANY , SANSEVERO, Frank , BAHJAT, Zuhair, S. , TERRY, Harold , PULLING, Richard , STILLION, Daniel, James , SCHREIBER, Kate, M. , DRAUDT, Gregg, Robert , JUDSON, Jared, Alden
发明人： SANSEVERO, Frank , BAHJAT, Zuhair, S. , TERRY, Harold , PULLING, Richard , STILLION, Daniel, James , SCHREIBER, Kate, M. , DRAUDT, Gregg, Robert , JUDSON, Jared, Alden
IPC分类号： B66B1/34
CPC分类号： B66B3/006 , B66B3/00 , B66B2201/4615 , B66B2201/4623 , B66B2201/4653
摘要： An elevator system (20) includes a controller (22) that communicates with a portable device (30) that is adapted to be carried about by a passenger (32). The system provides a color indication (28A - 28E) associated with an elevator car (26A - 26E) that will travel to a passenger's intended destination floor. In one example, the portable device (30) provides a color indication that corresponds to the color indication (28A-28E) associated with the car. Providing the color indication (34) on the portable device (30) assists a passenger (32) in locating the correct car and provides piece of mind to the passenger that they are entering the correct car and will be carried to their intended destination floor.
摘要翻译：电梯系统（20）包括与适于由乘客（32）携带的便携式设备（30）通信的控制器（22）。该系统提供与电梯轿厢（26A-26E）相关联的颜色指示（28A-28E），其将行进到乘客的预定目的地楼层。在一个示例中，便携式设备（30）提供对应于与汽车相关联的颜色指示（28A-28E）的颜色指示。在便携式设备（30）上提供颜色指示（34）帮助乘客（32）定位正确的轿厢，并向乘客提供他们正在进入正确的轿厢并将其运送到其预期目的地楼层的心理。

4. 发明申请

WO2008060766A3 HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT 审中-公开
标题翻译： HISTAMINE H4受体配体用于治疗疼痛
公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
申请人： ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
发明人： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC分类号： A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC分类号： A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要： This invention discloses histamine H4 receptor ligands for use in a method of treating pain
摘要翻译：本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体

5. 发明申请

WO2006086229A1 THE USE OF SELECTIVE P2X7 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：选择性P2X7受体拮抗剂的使用
公开(公告)号：WO2006086229A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/003865
申请日：2006-02-03
申请人： ABBOTT LABORATORIES , PEREZ-MEDRANO, Arturo , NELSON, Derek, W. , CARROLL, William, A. , KORT, Michael, E. , GREGG, Robert, J. , VOIGHT, Eric, A. , JARVIS, Michael, F. , KOWALUK, Elizabeth, A.
发明人： PEREZ-MEDRANO, Arturo , NELSON, Derek, W. , CARROLL, William, A. , KORT, Michael, E. , GREGG, Robert, J. , VOIGHT, Eric, A. , JARVIS, Michael, F. , KOWALUK, Elizabeth, A.
IPC分类号： A61K31/381 , A61P25/00 , A61P29/00
CPC分类号： A61K31/381 , A61K31/41 , A61K31/4439
摘要： The present invention relates to the use of selective P2X 7 receptor antagonists of formula (I), or a pharmaceutically acceptable salt or prodrug thereof wherein D, R 1 and R 2 are as defined in claim 1, for the treatment of neuropathic pain, chronic inflammatory pain, inflammation, neurodegeneration and for promoting neuroregeneration.
摘要翻译：本发明涉及式（I）的选择性P2X 7受体拮抗剂或其药学上可接受的盐或前药，其中D，R 1和R 2 > 2 如权利要求1中所定义，用于治疗神经性疼痛，慢性炎性疼痛，炎症，神经变性和促进神经再生。

6. 发明申请

WO2013043253A1 COMPRESSION MOLDING OF COMPOSITE MATERIAL QUASI-ISOTROPIC FLAKES 审中-公开
标题翻译：复合材料复合材料的压缩成型
公开(公告)号：WO2013043253A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/047247
申请日：2012-07-18
申请人： THE BOEING COMPANY , BARTEL, Aaron William , GIDEON, David Eric , BOGUCKI, Gregg Robert
发明人： BARTEL, Aaron William , GIDEON, David Eric , BOGUCKI, Gregg Robert
IPC分类号： B29C70/22 , B29C70/30 , B29B11/16 , B29C70/54
CPC分类号： B29C70/46 , B29C70/12 , B29C70/345
摘要： Concepts and technologies are disclosed herein for compression molding of composite material quasi - isotropic flakes (400). According to some embodiments disclosed herein, a first layer (102) formed from a composite component material and a second layer (104) formed from a composite component material are consolidated together to form a quasi - isotropic panel (200). Composite material flakes (400) having quasi - isotropic properties ( "quasi - flakes " ) are obtained from the quasi - isotropic panel. A compression mold (500) is filled with the quasi -flakes (400), and heat is applied to the compression mold to form a part.
摘要翻译：本文公开了用于压缩成型复合材料准各向同性薄片（400）的概念和技术。根据本文公开的一些实施例，由复合构件材料形成的第一层（102）和由复合构件材料形成的第二层（104）被固结在一起以形成准各向同性面板（200）。从准各向同性面板获得具有准各向同性的复合材料薄片（400）（“准薄片”）。压缩模具（500）填充有准（400），并且将热量施加到压缩模具以形成部分。

7. 发明申请

WO2010084341A1 TILE SPACER PUNCH DEVICE 审中-公开
公开(公告)号：WO2010084341A1
公开(公告)日：2010-07-29
申请号：PCT/GB2010/050070
申请日：2010-01-19
申请人： FLANEGAN, Gregg, Robert
发明人： FLANEGAN, Gregg, Robert
IPC分类号： E04F21/00 , E04F15/02
CPC分类号： E04F21/00 , E04F15/02005 , E04F21/0007 , E04F21/0038 , E04F21/0092 , G01B1/00 , G01B3/30 , G01B5/14 , Y10T29/53835
摘要： A tile spacer punch device (10) comprises a rigid elongate body (12) which has a punch element (16) at one end and a grip (18). The punch element (16) has at least three arms (24), each arm (24) is at right angles to an adjacent arm (24). Preferably, the arms (24) intersect and may also be in a common plane. More preferably, four of the said arms (24) are provided. Furthermore, the arms may form part of plates, and the plates may taper inwardly away from the grip.
摘要翻译：瓷砖间隔件冲压装置（10）包括刚性细长体（12），其在一端具有冲头元件（16）和夹具（18）。冲头元件（16）具有至少三个臂（24），每个臂（24）与相邻臂（24）成直角。优选地，臂（24）相交并且也可以在共同的平面中。更优选地，设置四个所述臂（24）。此外，臂可以形成板的一部分，并且板可以从夹具向内渐缩。

8. 发明申请

WO2008060767A2 MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES 审中-公开
标题翻译：大环苯并芘嘧啶衍生物
公开(公告)号：WO2008060767A2
公开(公告)日：2008-05-22
申请号：PCT/US2007080133
申请日：2007-10-02
申请人： ABBOTT LAB , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
发明人： ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , COWART MARLON D , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC分类号： C07D491/04 , C07D493/04 , C07H17/04
CPC分类号： C07H17/04 , C07D239/70 , C07D403/12 , C07D453/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/04 , C07D495/04 , C07D519/00
摘要： Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.
摘要翻译：本文描述了大环苯并稠合的嘧啶化合物，包含此类化合物的组合物，制备所述化合物的方法以及使用此类化合物和组合物治疗和预防疾病，病症和障碍进展的方法。

9. 发明申请

WO2004099154A2 PYRAZOLE-AMIDES AND SULFONAMIDES AS SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：作为钠通道调节剂的吡唑胺和磺酰胺
公开(公告)号：WO2004099154A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/013530
申请日：2004-04-29
申请人： ABBOTT LABORATORIES , ATKINSON, Robert, N. , DRIZEN, Irene , GREGG, Robert, J. , GROSS, Michael, F. , KORT, Michael E. , SHI, Lei
发明人： ATKINSON, Robert, N. , DRIZEN, Irene , GREGG, Robert, J. , GROSS, Michael, F. , KORT, Michael E. , SHI, Lei
IPC分类号： C07D231/00
CPC分类号： C07D401/04 , A61K31/416 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D231/14 , C07D231/20 , C07D231/22 , C07D231/24 , C07D401/12
摘要： Compounds of the present invention modulate PN3 in mammals and are useful in treating pain in mammals.
摘要翻译：本发明化合物调节哺乳动物中的PN3，可用于治疗哺乳动物的疼痛。

10. 发明申请

WO2009079046A3 SYSTEMS AND METHODS FOR CONTROL OF ENGINE EXHAUST FLOW 审中-公开
标题翻译：用于控制发动机排气流量的系统和方法
公开(公告)号：WO2009079046A3
公开(公告)日：2009-12-17
申请号：PCT/US2008076857
申请日：2008-09-18
申请人： BOEING CO , SHMILOVICH ARVIN , YADLIN YORAM , GREGG ROBERT D III , CLARK ROGER W
发明人： SHMILOVICH ARVIN , YADLIN YORAM , GREGG ROBERT D III , CLARK ROGER W
IPC分类号： B64C23/06
CPC分类号： B64C21/04 , B64C9/38 , Y02T50/166
摘要： Coanda.Effect and lift produced along a surface of an airfoil are increased by- ducting (112) compressed fluid from the engine to the surface of the airfoil. An engine produces exhaust gases that are predominantly directed toward an aft end of the aircraft by a cowling (102) or other structure as an exhaust plume. One or more internal ducts extend (112) from the engine to the surface of the airfoil to thereby transmit a compressed fluid from the engine to the surface in order to suppress flow separation along the surface, thereby causing the engine exhaust flow to remain attached to the surface over a wider span. Such structures and techniques may find particular use in aircraft designed to exploit upper surface blowing (USB) techniques and structures for short takeoff and landing (STOL) performance.
摘要翻译：沿着翼面的表面产生的效应和升力通过将发动机的压缩流体（112）增加到翼型件的表面而增加。发动机产生主要通过整流罩（102）或其它结构作为排气羽流朝向飞行器后端的废气。一个或多个内部管道从发动机延伸（112）到翼型件的表面，从而将压缩流体从发动机传递到表面，以便抑制沿着表面的流动分离，从而使发动机排气流量保持附着于表面越宽越宽。这种结构和技术可以在设计用于利用上表面吹风（USB）技术和用于短起飞和着陆（STOL））性能的结构的飞机中发现。

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